NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19113174|ref|NP_596382|]
View 

WD repeat-containing protein [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-346 2.33e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 2.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 118 SSVGSNTDSQLLA--STDQQLRLWKTDfeagidsPLLCQASLSTHvkthnNAPLTSFDWCKTDPsYIVVSSLDTTCTVWD 195
Cdd:cd00200  13 TCVAFSPDGKLLAtgSGDGTIKVWDLE-------TGELLRTLKGH-----TGPVRDVAASADGT-YLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 196 IVAQQSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRS-------LDHS----TIIYEGDSTFwkrngdytn 264
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETgkclttlRGHTdwvnSVAFSPDGTF--------- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 265 asppvsapllrLSACDSDvnlmatfhhnsSDVQMIDIRvPGTAYATLRGHKGDVNAVKWMPgSKSKLATCGDDCVVSLWD 344
Cdd:cd00200 150 -----------VASSSQD-----------GTIKLWDLR-TGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD 205


                ..
gi 19113174 345 LD 346
Cdd:cd00200 206 LS 207
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-346 2.33e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 2.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 118 SSVGSNTDSQLLA--STDQQLRLWKTDfeagidsPLLCQASLSTHvkthnNAPLTSFDWCKTDPsYIVVSSLDTTCTVWD 195
Cdd:cd00200  13 TCVAFSPDGKLLAtgSGDGTIKVWDLE-------TGELLRTLKGH-----TGPVRDVAASADGT-YLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 196 IVAQQSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRS-------LDHS----TIIYEGDSTFwkrngdytn 264
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETgkclttlRGHTdwvnSVAFSPDGTF--------- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 265 asppvsapllrLSACDSDvnlmatfhhnsSDVQMIDIRvPGTAYATLRGHKGDVNAVKWMPgSKSKLATCGDDCVVSLWD 344
Cdd:cd00200 150 -----------VASSSQD-----------GTIKLWDLR-TGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD 205


                ..
gi 19113174 345 LD 346
Cdd:cd00200 206 LS 207
WD40 COG2319
WD40 repeat [General function prediction only];
125-346 9.08e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 9.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 125 DSQLLAST--DQQLRLWktDFEAGidsplLCQASLSTHvkthnNAPLTSFDWCKtDPSYIVVSSLDTTCTVWDIVAQQSK 202
Cdd:COG2319 173 DGKLLASGsdDGTVRLW--DLATG-----KLLRTLTGH-----TGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 203 TQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRSldhstiiyegdstfwkrngdytnasppvSAPLLRLSACDSD 282
Cdd:COG2319 240 RTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLAT----------------------------GELLRTLTGHSGG 290

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113174 283 VNLMAtFHHN-------SSD--VQMIDIRvPGTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWDLD 346
Cdd:COG2319 291 VNSVA-FSPDgkllasgSDDgtVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-344 6.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 6.50e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19113174    304 PGTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWD 344
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
305-344 1.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19113174   305 GTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWD 344
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-346 2.33e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 2.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 118 SSVGSNTDSQLLA--STDQQLRLWKTDfeagidsPLLCQASLSTHvkthnNAPLTSFDWCKTDPsYIVVSSLDTTCTVWD 195
Cdd:cd00200  13 TCVAFSPDGKLLAtgSGDGTIKVWDLE-------TGELLRTLKGH-----TGPVRDVAASADGT-YLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 196 IVAQQSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRS-------LDHS----TIIYEGDSTFwkrngdytn 264
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETgkclttlRGHTdwvnSVAFSPDGTF--------- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 265 asppvsapllrLSACDSDvnlmatfhhnsSDVQMIDIRvPGTAYATLRGHKGDVNAVKWMPgSKSKLATCGDDCVVSLWD 344
Cdd:cd00200 150 -----------VASSSQD-----------GTIKLWDLR-TGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD 205


                ..
gi 19113174 345 LD 346
Cdd:cd00200 206 LS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-344 4.90e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 4.90e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 118 SSVGSNTDSQLLAST--DQQLRLWktDFEAGidsplLCQASLSTHvkthnNAPLTSFDWCKtDPSYIVVSSLDTTCTVWD 195
Cdd:cd00200  97 SSVAFSPDGRILSSSsrDKTIKVW--DVETG-----KCLTTLRGH-----TDWVNSVAFSP-DGTFVASSSQDGTIKLWD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 196 IVAQQSKTQLIAHDKEVYDVAFLKDSINVFVSvGADGSVRMFDLRSLDHSTIiYEGDSTF-----WKRNGDYtnasppvs 270
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGT-LRGHENGvnsvaFSPDGYL-------- 233

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113174 271 apllrLSACDSDvnlmatfhhnsSDVQMIDIRvPGTAYATLRGHKGDVNAVKWMPGSKSkLATCGDDCVVSLWD 344
Cdd:cd00200 234 -----LASGSED-----------GTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
125-346 9.08e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 9.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 125 DSQLLAST--DQQLRLWktDFEAGidsplLCQASLSTHvkthnNAPLTSFDWCKtDPSYIVVSSLDTTCTVWDIVAQQSK 202
Cdd:COG2319 173 DGKLLASGsdDGTVRLW--DLATG-----KLLRTLTGH-----TGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 203 TQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRSldhstiiyegdstfwkrngdytnasppvSAPLLRLSACDSD 282
Cdd:COG2319 240 RTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLAT----------------------------GELLRTLTGHSGG 290

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113174 283 VNLMAtFHHN-------SSD--VQMIDIRvPGTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWDLD 346
Cdd:COG2319 291 VNSVA-FSPDgkllasgSDDgtVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
109-346 1.33e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 1.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 109 PVTKLLWNPssvgsntDSQLLAST--DQQLRLWktDFEAGidsplLCQASLSTHvkthnNAPLTSFDWCkTDPSYIVVSS 186
Cdd:COG2319 206 AVRSVAFSP-------DGKLLASGsaDGTVRLW--DLATG-----KLLRTLTGH-----SGSVRSVAFS-PDGRLLASGS 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 187 LDTTCTVWDIVAQQSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRSldhstiiyegdstfWKRNGDYTNAS 266
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHT 330

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 267 PPVSAplLRLSAcdsDVNLMATfhhNSSD--VQMIDIRvPGTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWD 344
Cdd:COG2319 331 GAVRS--VAFSP---DGKTLAS---GSDDgtVRLWDLA-TGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWD 400


                ..
gi 19113174 345 LD 346
Cdd:COG2319 401 LA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 157-346 4.89e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 4.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 157 LSTHVKTHNNaPLTSFDWCkTDPSYIVVSSLDTTCTVWDIVAQQSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRM 236
Cdd:cd00200   1 LRRTLKGHTG-GVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 237 FDLRSlDHSTIIYEGD-----STFWKRNGDYtnasppvsapllrLSACDSDvnlmatfhhnsSDVQMIDIRvPGTAYATL 311
Cdd:cd00200  78 WDLET-GECVRTLTGHtsyvsSVAFSPDGRI-------------LSSSSRD-----------KTIKVWDVE-TGKCLTTL 131

                       170       180       190
                ....*....|....*....|....*....|....*
gi 19113174 312 RGHKGDVNAVKWMPGSKSkLATCGDDCVVSLWDLD 346
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTF-VASSSQDGTIKLWDLR 165
WD40 COG2319
WD40 repeat [General function prediction only];
125-346 1.09e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 125 DSQLLA--STDQQLRLWktDFEAGidsplLCQASLSTHvkthnNAPLTSFDWCKtDPSYIVVSSLDTTCTVWDIVAQQSK 202
Cdd:COG2319 131 DGKTLAsgSADGTVRLW--DLATG-----KLLRTLTGH-----SGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 203 TQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRSldhstiiyegdstfwkrngdytnasppvSAPLLRLSACDSD 282
Cdd:COG2319 198 RTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLAT----------------------------GKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113174 283 VNLMAtFHHN-------SSD--VQMIDIRvPGTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWDLD 346
Cdd:COG2319 249 VRSVA-FSPDgrllasgSADgtVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
87-346 3.04e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 3.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174  87 LITGDDGNSHLEKAQAATDLEYPVTKLLWNPSSVGSNTDSQLLASTDQQLRLWKTDFEAGidsplLCQASLSTHVKTHNN 166
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----ALLATLLGHTAAVLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 167 APLTSfdwcktDPSYIVVSSLDTTCTVWDIVAQQSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRSldhst 246
Cdd:COG2319  84 VAFSP------DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLAT----- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 247 iiyegdstfWKRNGDYTNASPPVSAplLRLSAcdsDVNLMATfhhNSSD--VQMIDIRvPGTAYATLRGHKGDVNAVKWM 324
Cdd:COG2319 152 ---------GKLLRTLTGHSGAVTS--VAFSP---DGKLLAS---GSDDgtVRLWDLA-TGKLLRTLTGHTGAVRSVAFS 213

                       250       260
                ....*....|....*....|..
gi 19113174 325 PGSKsKLATCGDDCVVSLWDLD 346
Cdd:COG2319 214 PDGK-LLASGSADGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
84-346 8.66e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 8.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174  84 LLKLITGDDGNSHLEKAQAATDLEYPVTKLLWNPSSVGSNTDSQLLAST--DQQLRLWKTDfeagidspllcqASLSTHV 161
Cdd:COG2319  48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAsaDGTVRLWDLA------------TGLLLRT 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 162 KTHNNAPLTSFDWcktDP--SYIVVSSLDTTCTVWDIVAQQSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDL 239
Cdd:COG2319 116 LTGHTGAVRSVAF---SPdgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDL 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 240 RSldhstiiyegdstfwkrngdytnasppvSAPLLRLSACDSDVNLMAtFHHN-------SSD--VQMIDIRvPGTAYAT 310
Cdd:COG2319 192 AT----------------------------GKLLRTLTGHTGAVRSVA-FSPDgkllasgSADgtVRLWDLA-TGKLLRT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 19113174 311 LRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWDLD 346
Cdd:COG2319 242 LTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
125-241 2.59e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 2.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113174 125 DSQLLAST--DQQLRLWktDFEAGidspllcqASLSTHvkTHNNAPLTSFDWcKTDPSYIVVSSLDTTCTVWDIVAQQSK 202
Cdd:COG2319 299 DGKLLASGsdDGTVRLW--DLATG--------KLLRTL--TGHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLATGELL 365

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 19113174 203 TQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFDLRS 241
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-344 6.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 6.50e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19113174    304 PGTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWD 344
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
305-344 1.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19113174   305 GTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWD 344
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 200-238 3.96e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19113174    200 QSKTQLIAHDKEVYDVAFLKDSiNVFVSVGADGSVRMFD 238
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 278-348 5.82e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.47  E-value: 5.82e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113174 278 ACDSDVNLMATfhhNSSD--VQMIDIRvPGTAYATLRGHKGDVNAVKWMPGSKsKLATCGDDCVVSLWDLDQP 348
Cdd:cd00200  16 AFSPDGKLLAT---GSGDgtIKVWDLE-TGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH