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Conserved domains on  [gi|429241005|ref|NP_596478|]
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WD repeat protein Lub1 [Schizosaccharomyces pombe]

Protein Classification

WD repeat PLAP family protein( domain architecture ID 10078051)

WD repeat PLAP family protein containing WD40, PFU, and PUL domains, similar to vertebrate phospholipase A-2-activating protein (PLAP or PLAA), a ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0043130
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-286 1.17e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.17e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   6 LSRELGGHKQDVRGVC-SISNELIGSASRDGTYSVWEQINGEwTPHFYENHEGFVNCVCYVPaidknSRGYIFSGGQDKC 84
Cdd:cd00200    1 LRRTLKGHTGGVTCVAfSPDGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASA-----DGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  85 GILQEVGTNSPSYYLFGHESNICSASALNSETIITGS-WDSTARVWAL--GQCKYVLKGHQSSVWAVLALGEDIFIT-GS 160
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVetGKCLTTLRGHTDWVNSVAFSPDGTFVAsSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 161 ADKLIKIWNGE--KLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQLI 235
Cdd:cd00200  155 QDGTIKLWDLRtgKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWdLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 429241005 236 ASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNG-DLVCGSSDGFVRIF 286
Cdd:cd00200  235 ASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 333-442 1.55e-63

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


:

Pssm-ID: 462670  Cd Length: 111  Bit Score: 206.60  E-value: 1.55e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  333 PGKADGDVVMVRVNND-VEAYQWSQKENEWKKIGQVVDAVGNNRKQLFEGKEYDYVFDVDVADGQAPLKLPYNATENPYQ 411
Cdd:pfam09070   1 PGKKEGQVKMVREGNGvVEAYQWSAAEQQWEKIGDVVGSAGSSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNPYE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 429241005  412 AANRFLELNQLPLSYTDEVVKFIEKNTQGHS 442
Cdd:pfam09070  81 AAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 465-709 4.14e-43

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


:

Pssm-ID: 462428  Cd Length: 261  Bit Score: 156.72  E-value: 4.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  465 PVSQ-LLFSNANVPAMCQRLRSLN--NTKSNPLPAKSIDSLERALSSKKITDTEKNELLETCLSILDSWSLAERFPALDA 541
Cdd:pfam08324   1 PQKTyLSFKKANLDKILKKLGEFNggEPKVLALSPEELATLEALLSFLESSSSASEADIELLLKILTSWPPEDRFPALDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  542 LRLLAIN--SSSDLA-PIFLEVFSRVVKSVPSSGNFesINVMLALRGLSNVVPNITDAEGV----SKLMDCLTSTVPQAS 614
Cdd:pfam08324  81 LRLLALDprVAAYFAeEEGGKTISTLLSLLISSGLY--ALRMLALRLLCNLFSSPLGRQLLlshfDSILSTLASLLSSSL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  615 --SAKDFKIAFATLAMNLSILLIQL---NLENTGIELLSILFSFLDDPSPDNEAFYRALMALGTLCTVPD--IALAASQI 687
Cdd:pfam08324 159 ldSNKNLRIALATLLLNYAVLLHKEkspLSEEDQVELLAALLEALSTEEEDSEALYRLLVALGTLVYAPDgeVLADLAQV 238

                         250       260
                  ....*....|....*....|..
gi 429241005  688 YHAQSIVHGIAErfSQEMRFVD 709
Cdd:pfam08324 239 LDAASWVKKAKK--KKEPRIKE 258
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-286 1.17e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.17e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   6 LSRELGGHKQDVRGVC-SISNELIGSASRDGTYSVWEQINGEwTPHFYENHEGFVNCVCYVPaidknSRGYIFSGGQDKC 84
Cdd:cd00200    1 LRRTLKGHTGGVTCVAfSPDGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASA-----DGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  85 GILQEVGTNSPSYYLFGHESNICSASALNSETIITGS-WDSTARVWAL--GQCKYVLKGHQSSVWAVLALGEDIFIT-GS 160
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVetGKCLTTLRGHTDWVNSVAFSPDGTFVAsSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 161 ADKLIKIWNGE--KLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQLI 235
Cdd:cd00200  155 QDGTIKLWDLRtgKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWdLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 429241005 236 ASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNG-DLVCGSSDGFVRIF 286
Cdd:cd00200  235 ASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 333-442 1.55e-63

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 206.60  E-value: 1.55e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  333 PGKADGDVVMVRVNND-VEAYQWSQKENEWKKIGQVVDAVGNNRKQLFEGKEYDYVFDVDVADGQAPLKLPYNATENPYQ 411
Cdd:pfam09070   1 PGKKEGQVKMVREGNGvVEAYQWSAAEQQWEKIGDVVGSAGSSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNPYE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 429241005  412 AANRFLELNQLPLSYTDEVVKFIEKNTQGHS 442
Cdd:pfam09070  81 AAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 COG2319
WD40 repeat [General function prediction only];
5-289 5.14e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 5.14e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   5 ELSRELGGHKQDVRGVC-SISNELIGSASRDGTYSVWEQINGEWTPHFyENHEGFVNCVcyvpAIDKNSRgYIFSGGQDK 83
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSV----AFSPDGK-LLASGSDDG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  84 CGILQEVGTNSPSYYLFGHESNICSAS-ALNSETIITGSWDSTARVWAL--GQCKYVLKGHQSSVWAVlALGED--IFIT 158
Cdd:COG2319  185 TVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKLLASGSADGTVRLWDLatGKLLRTLTGHSGSVRSV-AFSPDgrLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 159 GSADKLIKIWN--GEKLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQ 233
Cdd:COG2319  264 GSADGTVRLWDlaTGELLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429241005 234 LIASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNGD-LVCGSSDGFVRIFTVD 289
Cdd:COG2319  344 TLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSPDGRtLASGSADGTVRLWDLA 402
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 465-709 4.14e-43

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 156.72  E-value: 4.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  465 PVSQ-LLFSNANVPAMCQRLRSLN--NTKSNPLPAKSIDSLERALSSKKITDTEKNELLETCLSILDSWSLAERFPALDA 541
Cdd:pfam08324   1 PQKTyLSFKKANLDKILKKLGEFNggEPKVLALSPEELATLEALLSFLESSSSASEADIELLLKILTSWPPEDRFPALDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  542 LRLLAIN--SSSDLA-PIFLEVFSRVVKSVPSSGNFesINVMLALRGLSNVVPNITDAEGV----SKLMDCLTSTVPQAS 614
Cdd:pfam08324  81 LRLLALDprVAAYFAeEEGGKTISTLLSLLISSGLY--ALRMLALRLLCNLFSSPLGRQLLlshfDSILSTLASLLSSSL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  615 --SAKDFKIAFATLAMNLSILLIQL---NLENTGIELLSILFSFLDDPSPDNEAFYRALMALGTLCTVPD--IALAASQI 687
Cdd:pfam08324 159 ldSNKNLRIALATLLLNYAVLLHKEkspLSEEDQVELLAALLEALSTEEEDSEALYRLLVALGTLVYAPDgeVLADLAQV 238

                         250       260
                  ....*....|....*....|..
gi 429241005  688 YHAQSIVHGIAErfSQEMRFVD 709
Cdd:pfam08324 239 LDAASWVKKAKK--KKEPRIKE 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-248 2.76e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.76e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 429241005   209 DGEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIWK 248
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
210-247 6.90e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 6.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 429241005  210 GEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIW 247
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-286 1.17e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.17e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   6 LSRELGGHKQDVRGVC-SISNELIGSASRDGTYSVWEQINGEwTPHFYENHEGFVNCVCYVPaidknSRGYIFSGGQDKC 84
Cdd:cd00200    1 LRRTLKGHTGGVTCVAfSPDGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASA-----DGTYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  85 GILQEVGTNSPSYYLFGHESNICSASALNSETIITGS-WDSTARVWAL--GQCKYVLKGHQSSVWAVLALGEDIFIT-GS 160
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVetGKCLTTLRGHTDWVNSVAFSPDGTFVAsSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 161 ADKLIKIWNGE--KLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQLI 235
Cdd:cd00200  155 QDGTIKLWDLRtgKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWdLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 429241005 236 ASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNG-DLVCGSSDGFVRIF 286
Cdd:cd00200  235 ASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 333-442 1.55e-63

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 206.60  E-value: 1.55e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  333 PGKADGDVVMVRVNND-VEAYQWSQKENEWKKIGQVVDAVGNNRKQLFEGKEYDYVFDVDVADGQAPLKLPYNATENPYQ 411
Cdd:pfam09070   1 PGKKEGQVKMVREGNGvVEAYQWSAAEQQWEKIGDVVGSAGSSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNPYE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 429241005  412 AANRFLELNQLPLSYTDEVVKFIEKNTQGHS 442
Cdd:pfam09070  81 AAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 COG2319
WD40 repeat [General function prediction only];
5-289 5.14e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.71  E-value: 5.14e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   5 ELSRELGGHKQDVRGVC-SISNELIGSASRDGTYSVWEQINGEWTPHFyENHEGFVNCVcyvpAIDKNSRgYIFSGGQDK 83
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSV----AFSPDGK-LLASGSDDG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  84 CGILQEVGTNSPSYYLFGHESNICSAS-ALNSETIITGSWDSTARVWAL--GQCKYVLKGHQSSVWAVlALGED--IFIT 158
Cdd:COG2319  185 TVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKLLASGSADGTVRLWDLatGKLLRTLTGHSGSVRSV-AFSPDgrLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 159 GSADKLIKIWN--GEKLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQ 233
Cdd:COG2319  264 GSADGTVRLWDlaTGELLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429241005 234 LIASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNGD-LVCGSSDGFVRIFTVD 289
Cdd:COG2319  344 TLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSPDGRtLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
5-312 9.92e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 9.92e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   5 ELSRELGGHKQDVRGV-CSISNELIGSASRDGTYSVWeQINGEWTPHFYENHEGFVNCVcyvpAIDKNSRgYIFSGGQDK 83
Cdd:COG2319   69 ALLATLLGHTAAVLSVaFSPDGRLLASASADGTVRLW-DLATGLLLRTLTGHTGAVRSV----AFSPDGK-TLASGSADG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  84 CGILQEVGTNSPSYYLFGHESNICSAS-ALNSETIITGSWDSTARVWAL--GQCKYVLKGHQSSVWAVlALGED--IFIT 158
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAfSPDGKLLASGSDDGTVRLWDLatGKLLRTLTGHTGAVRSV-AFSPDgkLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 159 GSADKLIKIWN--GEKLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQ 233
Cdd:COG2319  222 GSADGTVRLWDlaTGKLLRTLTGHSGSVRSVAFSPDGrlLASGSADGTVRLWdLATGELLRTLTGHSGGVNSVAFSPDGK 301

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 234 LIASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNGD-LVCGSSDGFVRIFTVDKVRVAPTevLKNFEERVSQFA 310
Cdd:COG2319  302 LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELLRT--LTGHTGAVTSVA 379


                 ..
gi 429241005 311 IS 312
Cdd:COG2319  380 FS 381
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 465-709 4.14e-43

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 156.72  E-value: 4.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  465 PVSQ-LLFSNANVPAMCQRLRSLN--NTKSNPLPAKSIDSLERALSSKKITDTEKNELLETCLSILDSWSLAERFPALDA 541
Cdd:pfam08324   1 PQKTyLSFKKANLDKILKKLGEFNggEPKVLALSPEELATLEALLSFLESSSSASEADIELLLKILTSWPPEDRFPALDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  542 LRLLAIN--SSSDLA-PIFLEVFSRVVKSVPSSGNFesINVMLALRGLSNVVPNITDAEGV----SKLMDCLTSTVPQAS 614
Cdd:pfam08324  81 LRLLALDprVAAYFAeEEGGKTISTLLSLLISSGLY--ALRMLALRLLCNLFSSPLGRQLLlshfDSILSTLASLLSSSL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  615 --SAKDFKIAFATLAMNLSILLIQL---NLENTGIELLSILFSFLDDPSPDNEAFYRALMALGTLCTVPD--IALAASQI 687
Cdd:pfam08324 159 ldSNKNLRIALATLLLNYAVLLHKEkspLSEEDQVELLAALLEALSTEEEDSEALYRLLVALGTLVYAPDgeVLADLAQV 238

                         250       260
                  ....*....|....*....|..
gi 429241005  688 YHAQSIVHGIAErfSQEMRFVD 709
Cdd:pfam08324 239 LDAASWVKKAKK--KKEPRIKE 258
WD40 COG2319
WD40 repeat [General function prediction only];
5-312 5.86e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 5.86e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   5 ELSRELGGHKQDVRGVCSISNELIGSASRDGTYSVWEQINGEWTPHFyENHEGFVNCVCYVPAidknsRGYIFSGGQDKC 84
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTAAVLSVAFSPD-----GRLLASASADGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  85 GILQEVGTNSPSYYLFGHESNICSAS-ALNSETIITGSWDSTARVWAL--GQCKYVLKGHQSSVWAVlALGED--IFITG 159
Cdd:COG2319  102 VRLWDLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLatGKLLRTLTGHSGAVTSV-AFSPDgkLLASG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 160 SADKLIKIWNGE--KLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQL 234
Cdd:COG2319  181 SDDGTVRLWDLAtgKLLRTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWdLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 235 IASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNGD-LVCGSSDGFVRIFTVDKVRVAPTevLKNFEERVSQFAI 311
Cdd:COG2319  261 LASGSADGTVRLWdlATGELLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSVAF 338


                 .
gi 429241005 312 S 312
Cdd:COG2319  339 S 339
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-290 3.96e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 3.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  99 LFGHESNICSASAL-NSETIITGSWDSTARVWAL--GQCKYVLKGHQSSVWAVLALGEDIFI-TGSADKLIKIWN--GEK 172
Cdd:cd00200    5 LKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLetGELLRTLKGHTGPVRDVAASADGTYLaSGSSDKTIRLWDleTGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 173 LVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIW-- 247
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWdVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWdl 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 429241005 248 KGKECLQCITLPTTSVWSVSSLPNG-DLVCGSSDGFVRIFTVDK 290
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-169 8.37e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 8.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   1 MTSYELSRELGGHKQDVRGVC-SISNELIGSASRDGTYSVWEqINGEWTPHFYENHEGFVNCVCYVPaiDKNSrgyIFSG 79
Cdd:cd00200  122 VETGKCLTTLRGHTDWVNSVAfSPDGTFVASSSQDGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSP--DGEK---LLSS 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005  80 GQDKCGILQEVGTNSPSYYLFGHESNICS-ASALNSETIITGSWDSTARVW--ALGQCKYVLKGHQSSVWAVlALGED-- 154
Cdd:cd00200  196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSvAFSPDGYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSL-AWSPDgk 274

                        170
                 ....*....|....*
gi 429241005 155 IFITGSADKLIKIWN 169
Cdd:cd00200  275 RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-290 2.39e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 2.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 173 LVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW-TSDGEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIW-- 247
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWdLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdl 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 429241005 248 KGKECLQCITLPTTSVWSVSSLPNGDLVCGSS-DGFVRIFTVDK 290
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
2-131 1.53e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005   2 TSYELSRELGGHKQDVRGVC-SISNELIGSASRDGTYSVWEqINGEWTPHFYENHEGFVNCVCYVPaidknSRGYIFSGG 80
Cdd:COG2319  276 ATGELLRTLTGHSGGVNSVAfSPDGKLLASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSP-----DGKTLASGS 349

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 429241005  81 QDKCGILQEVGTNSPSYYLFGHESNICSAS-ALNSETIITGSWDSTARVWAL 131
Cdd:COG2319  350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAfSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 218-312 5.27e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 5.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429241005 218 GHTSFVYSLTYIHNQQLIASCGEDRTIRIW--KGKECLQCITLPTTSVWSVSSLPNGD-LVCGSSDGFVRIFTVDKVRVa 294
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWdlETGELLRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLWDLETGEC- 85

                         90
                 ....*....|....*...
gi 429241005 295 pTEVLKNFEERVSQFAIS 312
Cdd:cd00200   86 -VRTLTGHTSYVSSVAFS 102
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-248 2.76e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.76e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 429241005   209 DGEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIWK 248
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
210-247 6.90e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 6.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 429241005  210 GEFLYELHGHTSFVYSLTYIHNQQLIASCGEDRTIRIW 247
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
132-169 7.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 7.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 429241005  132 GQCKYVLKGHQSSVWAV-LALGEDIFITGSADKLIKIWN 169
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLaFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 132-169 8.51e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 429241005   132 GQCKYVLKGHQSSVWAVLALGED-IFITGSADKLIKIWN 169
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 172-206 3.83e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.83e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 429241005   172 KLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW 206
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGkyLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
172-206 1.03e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 429241005  172 KLVKSILAHNDCVRSLCQIPGG--FASCSNDGVIKLW 206
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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