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Conserved domains on  [gi|45331217|ref|NP_597701|]
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zinc finger protein 526 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 7.94e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.94e-05
                          10        20
                  ....*....|....*....|....*.
gi 45331217   486 HVRNHLRTHTGERPFQCHSCGKTFAS 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-550 8.00e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 8.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45331217 441 QLPCPQCSKSFASASRLS--RHRRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRT--HTGE--RPFQCHS--CGKTFASL 512
Cdd:COG5048 257 ASESPRSSLPTASSQSSSpnESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRN 336

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 45331217 513 ANLSRHQLTHTGARPYQC--LDCGKRFTQSSN------LQQHRRLH 550
Cdd:COG5048 337 DALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLK 382
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 7.94e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.94e-05
                          10        20
                  ....*....|....*....|....*.
gi 45331217   486 HVRNHLRTHTGERPFQCHSCGKTFAS 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-550 8.00e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 8.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45331217 441 QLPCPQCSKSFASASRLS--RHRRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRT--HTGE--RPFQCHS--CGKTFASL 512
Cdd:COG5048 257 ASESPRSSLPTASSQSSSpnESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRN 336

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 45331217 513 ANLSRHQLTHTGARPYQC--LDCGKRFTQSSN------LQQHRRLH 550
Cdd:COG5048 337 DALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLK 382
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 528-550 6.59e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.59e-04
                          10        20
                  ....*....|....*....|...
gi 45331217   528 YQCLDCGKRFTQSSNLQQHRRLH 550
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 7.94e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.94e-05
                          10        20
                  ....*....|....*....|....*.
gi 45331217   486 HVRNHLRTHTGERPFQCHSCGKTFAS 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-550 8.00e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 8.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45331217 441 QLPCPQCSKSFASASRLS--RHRRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRT--HTGE--RPFQCHS--CGKTFASL 512
Cdd:COG5048 257 ASESPRSSLPTASSQSSSpnESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRN 336

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 45331217 513 ANLSRHQLTHTGARPYQC--LDCGKRFTQSSN------LQQHRRLH 550
Cdd:COG5048 337 DALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLK 382
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
443-551 1.92e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45331217 443 PCPQCSKSFASASRLSRHRRAVH--GPPERRHRCGV--CGKGFKKLIHVRNHLRTHTGERPFQC---------------- 502
Cdd:COG5048 291 KSKQCNISFSRSSPLTRHLRSVNhsGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnne 370

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45331217 503 ---------------------HSCGKTFASLANLSRHQLTHTGARPYQC--LDCGKRFTQSSNLQQHRRLHL 551
Cdd:COG5048 371 ppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
498-550 4.83e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.83e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 45331217 498 RPFQCHSCGKTFASLANLSRHQLTHTGARPYQCLD--CGKRFTQSSNLQQHRRLH 550
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 528-550 6.59e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.59e-04
                          10        20
                  ....*....|....*....|...
gi 45331217   528 YQCLDCGKRFTQSSNLQQHRRLH 550
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
514-539 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 45331217   514 NLSRHQLTHTGARPYQCLDCGKRFTQ 539
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 500-522 5.12e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.12e-03
                          10        20
                  ....*....|....*....|...
gi 45331217   500 FQCHSCGKTFASLANLSRHQLTH 522
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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