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Conserved domains on  [gi|19424140|ref|NP_598007|]
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netrin-G2 isoform a precursor [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11079851)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 1.68e-59

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 196.65  E-value: 1.68e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140    60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRypSPLEANITLSWNKSVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140   136 dVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19424140   215 vrdrfAIFAGPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 410-457 2.43e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 2.43e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 19424140   410 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVC 457
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 1.92e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 1.92e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 19424140 286 RCKCNLHANLCTV-REGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGS 332
Cdd:cd00055   1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 354-402 2.51e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 2.51e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 19424140 354 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 402
Cdd:cd00055   2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 1.68e-59

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 196.65  E-value: 1.68e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140    60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRypSPLEANITLSWNKSVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140   136 dVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19424140   215 vrdrfAIFAGPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 60-285 4.16e-35

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 131.71  E-value: 4.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140     60 TCGDP-PERFC----SHENPYLCsNECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRYPspLEANITLSWNKSVELT 134
Cdd:smart00136  25 TCGEPgPERYCklvgHTEQGKKC-DYCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGP--QNVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140    135 DdVVVTFEYGRPTVMVLEKSlDNGRTWQPYQFYAEDCMEAFGMSARRArdMSPSSAHRVLCTEEYSRWAGSKK-EKHVRF 213
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSDIVPLEGgEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19424140    214 -EVRdrfaifagPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYV---QRENLYKYFYAISNIEVIG 285
Cdd:smart00136 178 lEGR--------PSATDFDN-------SPVLQEWVTATNIRVRLTRLRTLGDELmddRPEVTRRYYYAISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 410-457 2.43e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 2.43e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 19424140   410 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVC 457
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 410-447 4.39e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.58  E-value: 4.39e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 19424140 410 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 447
Cdd:cd00055   2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
410-447 1.16e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 45.38  E-value: 1.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19424140    410 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 447
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 1.92e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 1.92e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 19424140 286 RCKCNLHANLCTV-REGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGS 332
Cdd:cd00055   1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 287-323 1.10e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 1.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19424140   287 CKCNLHANL---CTVREGslQCECEHNTTGPDCGRCKKNF 323
Cdd:pfam00053   1 CDCNPHGSLsdtCDPETG--QCLCKPGVTGRHCDRCKPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 354-402 2.51e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 2.51e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 19424140 354 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 402
Cdd:cd00055   2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
60-285 1.68e-59

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 196.65  E-value: 1.68e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140    60 TCG-DPPERFCSHENP---YLCSnECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRypSPLEANITLSWNKSVELTD 135
Cdd:pfam00055  19 TCGlNGPERYCILSGLeggKKCF-ICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGVI--QYENVNLTLDLGKEFHFTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140   136 dVVVTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSPSsahRVLCTEEYSR-WAGSKKEKHVRfe 214
Cdd:pfam00055  96 -LILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGPSRGIKDD---EVICTSEYSDiSPLTGGEVIFS-- 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19424140   215 vrdrfAIFAGPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYVQ--RENLYKYFYAISNIEVIG 285
Cdd:pfam00055 170 -----TLEGRPSANIFDY-------SPELQDWLTATNIRIRLLRLHTLGDELLddPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 60-285 4.16e-35

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 131.71  E-value: 4.16e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140     60 TCGDP-PERFC----SHENPYLCsNECDASNPDLAHPPRLMFDREDEGLATYWQSVTWSRYPspLEANITLSWNKSVELT 134
Cdd:smart00136  25 TCGEPgPERYCklvgHTEQGKKC-DYCDARNPRRSHPAENLTDGNNPNNPTWWQSEPLSNGP--QNVNLTLDLGKEFHVT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19424140    135 DdVVVTFEYGRPTVMVLEKSlDNGRTWQPYQFYAEDCMEAFGMSARRArdMSPSSAHRVLCTEEYSRWAGSKK-EKHVRF 213
Cdd:smart00136 102 Y-VILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGP--ITKGNEDEVICTSEYSDIVPLEGgEIAFSL 177

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19424140    214 -EVRdrfaifagPDLRNMDNlytrmesAKGLKEFFTFTDLRMRLLRPALGGTYV---QRENLYKYFYAISNIEVIG 285
Cdd:smart00136 178 lEGR--------PSATDFDN-------SPVLQEWVTATNIRVRLTRLRTLGDELmddRPEVTRRYYYAISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 410-457 2.43e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 2.43e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 19424140   410 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVC 457
Cdd:pfam00053   1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 410-447 4.39e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.58  E-value: 4.39e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 19424140 410 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 447
Cdd:cd00055   2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
410-447 1.16e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 45.38  E-value: 1.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19424140    410 CNCNQIGSVHDRCN-ETGFCECREGAVGPKCDDCLPTHY 447
Cdd:smart00180   1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 286-332 1.92e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 1.92e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 19424140 286 RCKCNLHANLCTV-REGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGS 332
Cdd:cd00055   1 PCDCNGHGSLSGQcDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 287-323 1.10e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 1.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19424140   287 CKCNLHANL---CTVREGslQCECEHNTTGPDCGRCKKNF 323
Cdd:pfam00053   1 CDCNPHGSLsdtCDPETG--QCLCKPGVTGRHCDRCKPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 354-402 2.51e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 2.51e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 19424140 354 CECYGHSNRCSYIDFLNVVtCVsCKHNTRGQHCQHCRLGYYRNGSAELD 402
Cdd:cd00055   2 CDCNGHGSLSGQCDPGTGQ-CE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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