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Conserved domains on  [gi|19743852|ref|NP_598013|]
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decorin isoform d precursor [Homo sapiens]

Protein Classification

LRRNT and PCC domain-containing protein( domain architecture ID 10635027)

LRRNT and PCC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-85 5.33e-12

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 57.33  E-value: 5.33e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 19743852     54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTL 85
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
61-123 5.03e-07

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 5.03e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19743852  61 HLRVVQCSDLGLDKVPKDLPPDTTL--LDLQNNKITEIKDgDFKNLKNLHVVYLHNNNISVVGSS 123
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE 177
 
Name Accession Description Interval E-value
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-85 5.33e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 57.33  E-value: 5.33e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 19743852     54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTL 85
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-80 2.27e-09

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 50.32  E-value: 2.27e-09
                          10        20
                  ....*....|....*....|....*..
gi 19743852    54 CPFRCQCHLRVVQCSDLGLDKVPKDLP 80
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-123 5.03e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 5.03e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19743852  61 HLRVVQCSDLGLDKVPKDLPPDTTL--LDLQNNKITEIKDgDFKNLKNLHVVYLHNNNISVVGSS 123
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-120 2.21e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 2.21e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 19743852  84 TLLDLQNNKITEIKDgdFKNLKNLHVVYLHNNNISVV 120
Cdd:cd21340  49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV 83
LRR_8 pfam13855
Leucine rich repeat;
84-125 2.87e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 19743852    84 TLLDLQNNKITEIKDGDFKNLKNLHVVYLHNNNISVVGSSDF 125
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF 45
 
Name Accession Description Interval E-value
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-85 5.33e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 57.33  E-value: 5.33e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 19743852     54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTL 85
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-80 2.27e-09

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 50.32  E-value: 2.27e-09
                          10        20
                  ....*....|....*....|....*..
gi 19743852    54 CPFRCQCHLRVVQCSDLGLDKVPKDLP 80
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-123 5.03e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 5.03e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19743852  61 HLRVVQCSDLGLDKVPKDLPPDTTL--LDLQNNKITEIKDgDFKNLKNLHVVYLHNNNISVVGSS 123
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-120 2.21e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 2.21e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 19743852  84 TLLDLQNNKITEIKDgdFKNLKNLHVVYLHNNNISVV 120
Cdd:cd21340  49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV 83
LRR_8 pfam13855
Leucine rich repeat;
84-125 2.87e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 19743852    84 TLLDLQNNKITEIKDGDFKNLKNLHVVYLHNNNISVVGSSDF 125
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF 45
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-118 3.43e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 3.43e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743852  61 HLRVVQCSDLGLDKVPKDLPPDTTL--LDLQNNKITEIKDgDFKNLKNLHVVYLHNNNIS 118
Cdd:COG4886 137 NLKELDLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT 195
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-127 1.42e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.42e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 19743852  84 TLLDLQNNKITEIkdGDFKNLKNLHVVYLHNNNISVVGSSDFCP 127
Cdd:cd21340   5 THLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENLEFLT 46
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-118 1.72e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.72e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19743852  61 HLRvvqCSDLGLDKVPK-DLPPDTTLLDLQNNKITEIKDgdFKNLKNLHVVYLHNNNIS 118
Cdd:cd21340   6 HLY---LNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-118 2.61e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.61e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743852  61 HLRVVQCSDLGLDKVPKDLPPDTTL--LDLQNNKITEIkDGDFKNLKNLHVVYLHNNNIS 118
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLGNLTNLeeLDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT 241
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 86-116 4.11e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 4.11e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19743852    86 LDLQNNKITEIkdGDFKNLKNLHVVYLHNNN 116
Cdd:pfam12799   6 LDLSNNQITDI--PPLAKLPNLETLDLSGNN 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-123 8.16e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 8.16e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19743852  62 LRVVQCSDLGLDKVPKDLPPDTTL--LDLQNNKITEIKDgdFKNLKNLHVVYLHNNNISVVGSS 123
Cdd:COG4886 207 LEELDLSGNQLTDLPEPLANLTNLetLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-118 1.81e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 1.81e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 19743852  84 TLLDLQNNKITEIKDgdFKNLKNLHVVYLHNNNIS 118
Cdd:COG4886 253 EELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT 285
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-127 5.45e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.18  E-value: 5.45e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 19743852  86 LDLQNNKITEIKDGD----FKNLKNLHVVYLHNNNISVVGSSDFCP 127
Cdd:cd00116 198 LDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTDAGAAALAS 243
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-118 6.14e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 35.92  E-value: 6.14e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 19743852  84 TLLDLQNNKITEIKDgdFKNLKNLHVVYLHNNNIS 118
Cdd:cd21340 123 RVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155
LRR_8 pfam13855
Leucine rich repeat;
84-117 6.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 33.65  E-value: 6.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 19743852    84 TLLDLQNNKITEIKDGDFKNLKNLHVVYLHNNNI 117
Cdd:pfam13855  28 KVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 58-126 9.10e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 35.79  E-value: 9.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743852  58 CQCHLRVVQCSDLGL-----DKVPKDLPPDTTL--LDLQNNKITEikDG------DFKNLKNLHVVYLHNNNISVVGSSD 124
Cdd:cd00116 135 LPPALEKLVLGRNRLegascEALAKALRANRDLkeLNLANNGIGD--AGiralaeGLKANCNLEVLDLNNNGLTDEGASA 212


                ..
gi 19743852 125 FC 126
Cdd:cd00116 213 LA 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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