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Conserved domains on  [gi|19526792|ref|NP_598415|]
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hematopoietic progenitor cell antigen CD34 isoform 2 precursor [Mus musculus]

Protein Classification

Herpes_BLLF1 and CD34_antigen domain-containing protein( domain architecture ID 10533843)

Herpes_BLLF1 and CD34_antigen domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 187-382 2.43e-91

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


:

Pssm-ID: 461884  Cd Length: 211  Bit Score: 273.16  E-value: 2.43e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   187 CLELSEASSCEEFKKEKGEDLIQILCEKEEAEADAGASVCSLLLAQSEVRPECLLMVLANSTELP--SKLQLMEKHQSDL 264
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPpkAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   265 RKLGIQSF------NKQDIGSHQSYSRKTLIALVTSGVLLAILGTTGYF--LMNRRSWSPTGERLGEDPYYTENGG-GQG 335
Cdd:pfam06365  81 EELGIQNFtygtecQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYgcLHRRRSKSKAGERLGEELQTVENGYhDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19526792   336 -YSSGPGASPETQGKANVTRGAQENGTGQAT---SRNGHSARQHVVADTEL 382
Cdd:pfam06365 161 tLSVAPDTQSEMQEKPSVNGGAQENGTGSWIvplSRNGHSDRQHVEEDTHL 211
ROM1 super family cl34999
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 28-172 6.59e-04

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5422:

Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 41.80  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   28 LNNLTSATTETSTQGISPsvpTNESVEENITS------SIPGSTS------HYLIYQDSSKTTPAISETMVNFTVTSGIP 95
Cdd:COG5422   98 ATSSTSSLNSNDGDQFSP---ASDSLSFNPSStqsrkdSGPGDGSpvqkrkNPLLPSSSTHGTHPPIVFTDNNGSHAGAP 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   96 SGSGTPHTFSQPQTSPTGILPTTSDSISTSEMTWKSSLPSI---NVSDYSPNNSSFEMTSPTEPYAYTSSSAPSAIKGEI 172
Cdd:COG5422  175 NARSRKEIPSLGSQSMQLPSPHFRQKFSSSDTSNGFSYPSIrknSRHSSNSMPSFPHSSTAVLLKRHSGSSGASLISSNI 254
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 187-382 2.43e-91

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 273.16  E-value: 2.43e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   187 CLELSEASSCEEFKKEKGEDLIQILCEKEEAEADAGASVCSLLLAQSEVRPECLLMVLANSTELP--SKLQLMEKHQSDL 264
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPpkAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   265 RKLGIQSF------NKQDIGSHQSYSRKTLIALVTSGVLLAILGTTGYF--LMNRRSWSPTGERLGEDPYYTENGG-GQG 335
Cdd:pfam06365  81 EELGIQNFtygtecQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYgcLHRRRSKSKAGERLGEELQTVENGYhDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19526792   336 -YSSGPGASPETQGKANVTRGAQENGTGQAT---SRNGHSARQHVVADTEL 382
Cdd:pfam06365 161 tLSVAPDTQSEMQEKPSVNGGAQENGTGSWIvplSRNGHSDRQHVEEDTHL 211
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 28-172 6.59e-04

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 41.80  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   28 LNNLTSATTETSTQGISPsvpTNESVEENITS------SIPGSTS------HYLIYQDSSKTTPAISETMVNFTVTSGIP 95
Cdd:COG5422   98 ATSSTSSLNSNDGDQFSP---ASDSLSFNPSStqsrkdSGPGDGSpvqkrkNPLLPSSSTHGTHPPIVFTDNNGSHAGAP 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   96 SGSGTPHTFSQPQTSPTGILPTTSDSISTSEMTWKSSLPSI---NVSDYSPNNSSFEMTSPTEPYAYTSSSAPSAIKGEI 172
Cdd:COG5422  175 NARSRKEIPSLGSQSMQLPSPHFRQKFSSSDTSNGFSYPSIrknSRHSSNSMPSFPHSSTAVLLKRHSGSSGASLISSNI 254
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 30-171 7.57e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.36  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792    30 NLTSATTETSTQGISPSVPTNESVEENITSSIPGSTShyliyQDSSKTTPAISETMVNFTVTSGIPSGsgtphtfsqpqT 109
Cdd:pfam05109 472 DVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTS-----PTSAVTTPTPNATSPTPAVTTPTPNA-----------T 535

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19526792   110 SPTgiLPTTSDSISTSEMTWKSSLPSINVSDYSPNNS--SFEMTSPTEPYAYTSSSAPSAIKGE 171
Cdd:pfam05109 536 SPT--LGKTSPTSAVTTPTPNATSPTPAVTTPTPNATipTLGKTSPTSAVTTPTPNATSPTVGE 597
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 187-382 2.43e-91

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 273.16  E-value: 2.43e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   187 CLELSEASSCEEFKKEKGEDLIQILCEKEEAEADAGASVCSLLLAQSEVRPECLLMVLANSTELP--SKLQLMEKHQSDL 264
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPpkAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   265 RKLGIQSF------NKQDIGSHQSYSRKTLIALVTSGVLLAILGTTGYF--LMNRRSWSPTGERLGEDPYYTENGG-GQG 335
Cdd:pfam06365  81 EELGIQNFtygtecQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYgcLHRRRSKSKAGERLGEELQTVENGYhDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19526792   336 -YSSGPGASPETQGKANVTRGAQENGTGQAT---SRNGHSARQHVVADTEL 382
Cdd:pfam06365 161 tLSVAPDTQSEMQEKPSVNGGAQENGTGSWIvplSRNGHSDRQHVEEDTHL 211
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 28-172 6.59e-04

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 41.80  E-value: 6.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   28 LNNLTSATTETSTQGISPsvpTNESVEENITS------SIPGSTS------HYLIYQDSSKTTPAISETMVNFTVTSGIP 95
Cdd:COG5422   98 ATSSTSSLNSNDGDQFSP---ASDSLSFNPSStqsrkdSGPGDGSpvqkrkNPLLPSSSTHGTHPPIVFTDNNGSHAGAP 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792   96 SGSGTPHTFSQPQTSPTGILPTTSDSISTSEMTWKSSLPSI---NVSDYSPNNSSFEMTSPTEPYAYTSSSAPSAIKGEI 172
Cdd:COG5422  175 NARSRKEIPSLGSQSMQLPSPHFRQKFSSSDTSNGFSYPSIrknSRHSSNSMPSFPHSSTAVLLKRHSGSSGASLISSNI 254
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 30-171 7.57e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.36  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19526792    30 NLTSATTETSTQGISPSVPTNESVEENITSSIPGSTShyliyQDSSKTTPAISETMVNFTVTSGIPSGsgtphtfsqpqT 109
Cdd:pfam05109 472 DVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTS-----PTSAVTTPTPNATSPTPAVTTPTPNA-----------T 535

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19526792   110 SPTgiLPTTSDSISTSEMTWKSSLPSINVSDYSPNNS--SFEMTSPTEPYAYTSSSAPSAIKGE 171
Cdd:pfam05109 536 SPT--LGKTSPTSAVTTPTPNATSPTPAVTTPTPNATipTLGKTSPTSAVTTPTPNATSPTVGE 597
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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