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Conserved domains on  [gi|120537241|ref|NP_598898|]
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leucine--tRNA ligase, cytoplasmic [Mus musculus]

Protein Classification

Leucyl-tRNA synthetase( domain architecture ID 1003985)

Leucyl-tRNA synthetase (LeuRS) catalyzes the leucylation of tRNA(Leu).

EC:  6.1.1.4
Gene Ontology:  GO:0005524|GO:0004823|GO:0006412

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02959 super family cl33607
aminoacyl-tRNA ligase
3-1064 0e+00

aminoacyl-tRNA ligase


The actual alignment was detected with superfamily member PLN02959:

Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 1518.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    3 GRKGTAKVDFLKEIEKEAQQKWEAEKVFEVSASRlekqKQSSKG-KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRL 81
Cdd:PLN02959    5 GGKSTARRDRLLEIEVAVQKWWEEEKVFEAEAGD----EPPKPGeKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   82 KGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEE-----SSAKPGDIVVRDKAKGKKSKAAAKAGSS 156
Cdd:PLN02959   81 RGANVLLPFAFHCTGMPIKASADKLAREIQQYGNPPVFPEEDEDEAAavaaaKAEAEAAAAPPDKFKGKKSKAVAKSGTQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  157 KYQWDIMKSLGLSDDDIVKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFG 236
Cdd:PLN02959  161 KYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKKGKIVKD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  237 KRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYI 316
Cdd:PLN02959  241 KRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLPPFPGKLKALEGKKVFLAAATLRPETMYGQTNCWVLPDGKYG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  317 GFETANGDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVVYVLPMLTIKEDKGTGVVTSVPS 396
Cdd:PLN02959  321 AYEINDTEVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTILTDKGTGVVTSVPS 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  397 DSPDDLAALRDLKKKQALRTKFGIRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDREKLAEAKEKLYLRGFYD 476
Cdd:PLN02959  401 DSPDDYMALSDLKAKPALRAKYGVKDEWVLPFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKLAEAKRLTYLKGFTD 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  477 GVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEPEKQVMSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFC 556
Cdd:PLN02959  481 GTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWKKKAEKCLSKMNLYS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  557 EESRKNFEASLDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLNGQAESPlgIRPQQMTKDV 636
Cdd:PLN02959  561 DETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGGDMYGKDKSS--IKPEQMTDEV 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  637 WDYVfFKDAPFPKT-QIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEqsDKWPVSVRANGHLLLN 715
Cdd:PLN02959  639 WDFV-FCGGPLPKSsDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAE--EHWPRGFRCNGHLMLN 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  716 SEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMLASCSSLRSGPADSFN 795
Cdd:PLN02959  716 SEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAAESSLRTGPPSTYA 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  796 DRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYR-ELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIW- 873
Cdd:PLN02959  796 DRVFENEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRlSCGSGGMNRDLVWRFMDVQTRLITPICPHYAEHVWr 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  874 TLLGKPDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLRLKNYMMPAKGKKTDKQPAQRPSHCT---IYVAKNYPVWQ 950
Cdd:PLN02959  876 EILKKEGFAVTAGWPVAGEPDLTLKRANKYLQDSIVSFRKLLQKQLAGSKKAKKGGAPVTLPEKKLaglIYVAEKYDGWK 955
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  951 HITLTTLRSHFEANNGKL-PDNKVIA----SELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLMEN 1025
Cdd:PLN02959  956 EECLRILQSKFDSQSRTFaPDAEILEalkeSSVGQEANFKQVQKLCMPFVKFKKDEAIAVGPQALDLKLPFDEIEVLQEN 1035
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*....
gi 120537241 1026 IVYLTNSLELEHIEVKFASEAEDKVREEC----------CPGKPLNVFR 1064
Cdd:PLN02959 1036 LELIKRQLGLEEVEILSASDPDAVAKAGAhasllkqnppSPGNPVAIFV 1084
 
Name Accession Description Interval E-value
PLN02959 PLN02959
aminoacyl-tRNA ligase
3-1064 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 1518.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    3 GRKGTAKVDFLKEIEKEAQQKWEAEKVFEVSASRlekqKQSSKG-KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRL 81
Cdd:PLN02959    5 GGKSTARRDRLLEIEVAVQKWWEEEKVFEAEAGD----EPPKPGeKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   82 KGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEE-----SSAKPGDIVVRDKAKGKKSKAAAKAGSS 156
Cdd:PLN02959   81 RGANVLLPFAFHCTGMPIKASADKLAREIQQYGNPPVFPEEDEDEAAavaaaKAEAEAAAAPPDKFKGKKSKAVAKSGTQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  157 KYQWDIMKSLGLSDDDIVKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFG 236
Cdd:PLN02959  161 KYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKKGKIVKD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  237 KRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYI 316
Cdd:PLN02959  241 KRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLPPFPGKLKALEGKKVFLAAATLRPETMYGQTNCWVLPDGKYG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  317 GFETANGDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVVYVLPMLTIKEDKGTGVVTSVPS 396
Cdd:PLN02959  321 AYEINDTEVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTILTDKGTGVVTSVPS 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  397 DSPDDLAALRDLKKKQALRTKFGIRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDREKLAEAKEKLYLRGFYD 476
Cdd:PLN02959  401 DSPDDYMALSDLKAKPALRAKYGVKDEWVLPFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKLAEAKRLTYLKGFTD 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  477 GVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEPEKQVMSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFC 556
Cdd:PLN02959  481 GTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWKKKAEKCLSKMNLYS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  557 EESRKNFEASLDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLNGQAESPlgIRPQQMTKDV 636
Cdd:PLN02959  561 DETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGGDMYGKDKSS--IKPEQMTDEV 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  637 WDYVfFKDAPFPKT-QIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEqsDKWPVSVRANGHLLLN 715
Cdd:PLN02959  639 WDFV-FCGGPLPKSsDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAE--EHWPRGFRCNGHLMLN 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  716 SEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMLASCSSLRSGPADSFN 795
Cdd:PLN02959  716 SEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAAESSLRTGPPSTYA 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  796 DRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYR-ELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIW- 873
Cdd:PLN02959  796 DRVFENEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRlSCGSGGMNRDLVWRFMDVQTRLITPICPHYAEHVWr 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  874 TLLGKPDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLRLKNYMMPAKGKKTDKQPAQRPSHCT---IYVAKNYPVWQ 950
Cdd:PLN02959  876 EILKKEGFAVTAGWPVAGEPDLTLKRANKYLQDSIVSFRKLLQKQLAGSKKAKKGGAPVTLPEKKLaglIYVAEKYDGWK 955
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  951 HITLTTLRSHFEANNGKL-PDNKVIA----SELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLMEN 1025
Cdd:PLN02959  956 EECLRILQSKFDSQSRTFaPDAEILEalkeSSVGQEANFKQVQKLCMPFVKFKKDEAIAVGPQALDLKLPFDEIEVLQEN 1035
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*....
gi 120537241 1026 IVYLTNSLELEHIEVKFASEAEDKVREEC----------CPGKPLNVFR 1064
Cdd:PLN02959 1036 LELIKRQLGLEEVEILSASDPDAVAKAGAhasllkqnppSPGNPVAIFV 1084
leuS_arch TIGR00395
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ...
14-1059 0e+00

leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273056 [Multi-domain]  Cd Length: 938  Bit Score: 869.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    14 KEIEKEAQQKWEAEKVFEVSASrlekqkqsSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLH 93
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEADPD--------DREKFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKNVLFPLGFH 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    94 CTGMPIKACADKLKREIELYGcppdfpeeeeeeeessakpgdivvrdkakgkkskaaakagsskyqWDIMKSLGLSDDDI 173
Cdd:TIGR00395   73 VTGTPILGLAELIKRRDELTI---------------------------------------------KNYTEVHAIPREEL 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   174 VKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDH 253
Cdd:TIGR00395  108 LKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCPKDGNPVEDH 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   254 DRQTGEGVGPQEYTLVKLKVLEpypsklsglkgKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETaNGDIFICTQRAA 333
Cdd:TIGR00395  186 DLLSGEGVTIVEYILIKFELED-----------GAFYFVAATLRPETVYGVTNCWVNPTITYVIAEV-GGEKWITSKEAF 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   334 RNMSYQGFTkhngvVPVVKELMGEEILGASLSAPLTcYKVVYVLPMLTIKEDKGTGVVTSVPSDSPDDLAALRDLKKKQA 413
Cdd:TIGR00395  254 ENLSYQKLK-----YKPIEEVPGKQFIGKKVHNPVV-GPEVPILPAEFVDTTKGTGVVMSVPAHAPDDYIALEDLLHDPE 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   414 LrtkFGIRDdMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDREKLAEAKEKLYLRGFYDGVML--VDGFKGQKIQH 491
Cdd:TIGR00395  328 Y---LGIKP-VVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIynIPPYKGMKVSE 403
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   492 VKKTIQKNMIDAGDALIYMEP-EKQVMSRSADECVVALC-DQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDW 569
Cdd:TIGR00395  404 AKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKVVeDQWFVKYSDESWKELAHECLEGMRIIPEEVKNAFEGKIDW 483
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   570 LQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDlngqaesplgIRPQQMTKDVWDYVFFKDAPFPK 649
Cdd:TIGR00395  484 LKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDY----------YGNEQMTDEFFDYIFLGKGDVKN 553
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   650 TQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEqsDKWPVSVRANGHLLLNSEKMSKSTGNFLTL 729
Cdd:TIGR00395  554 TNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPE--KFWPRGIVVNGYVMLEGKKMSKSKGNVLTL 631
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   730 SQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEmLASCSSLRSGPADSFNDRVFASEMNAGIIK 809
Cdd:TIGR00395  632 EQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEE-ITKESNLETGEETSFIDRWLESRMNAAIKE 710
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   810 TDQNYEKMMFKEALKTGFFEFQAAKDKYRElATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPV 889
Cdd:TIGR00395  711 TYEAMENFQTRKAVKYALFDLQADVDWYRR-RGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEVGNEGFVSLAKFPE 789
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   890 AG--PVDESLIRSSQYLMEVAHDLRlrlknymmpakgkKTDKQPAQRPSHCTIYVAknyPVWQHITLTTLRSHFEANNGK 967
Cdd:TIGR00395  790 ASepAVDKEVEAAEEYLRNLVRDIQ-------------EIAKIDASKPKRVYLYTS---EDWKSQCLKIVAELFGEDTGE 853
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   968 lpDNKVIASElgslPELKKYMKKVMPFVAMIKENMEKKGprvldlELEFDEQAVLMENIVYLTNSLELEHI-EVKFASEA 1046
Cdd:TIGR00395  854 --DMKKVMEE----PEERKRGKEVISLVKQIIKDEKKED------ELQISEIEVLKAAARFIKKEVGALVIiEFSADSFP 921
                         1050
                   ....*....|...
gi 120537241  1047 EDKVReECCPGKP 1059
Cdd:TIGR00395  922 ENKKR-NAVPGKP 933
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
527-759 1.87e-72

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 244.08  E-value: 1.87e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  527 ALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDwlqehaCSRTYGLGTRLPWdeQWLIESLSDSTIYMAFY 606
Cdd:cd00812   127 KLLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARY 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  607 TVAHLLQGGDlngqaesplgirpqqmtkdvwdyvffkdapfpktqipKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSY 686
Cdd:cd00812   199 TDAHNLEQPY-------------------------------------EGDLEFDREEFEYWYPVDIYIGGKEHAPNHLLY 241
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120537241  687 YIYNHVAMWPEQ--SDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDtvEDANFVE 759
Cdd:cd00812   242 SRFNHKALFDEGlvTDEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
21-757 6.93e-22

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 101.72  E-value: 6.93e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    21 QQKWEAEKVFEVSasrLEKQKQssKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIk 100
Cdd:pfam00133    3 YEFWDEQGYFKPE---LEKRKG--KPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPT- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   101 acadklkreielygcppdfpeeeeeeeessakpgdivvrdkakgkkskaaakagsskyQWDIMKSLGLSDDDIV-KFSEA 179
Cdd:pfam00133   77 ----------------------------------------------------------EQVVEKKLGIKEKKTRhKYGRE 98
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   180 EH------WLDYFPPLAVQDLKTIGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDH 253
Cdd:pfam00133   99 EFrekcreWKMEYADEIRKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNL 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   254 DRQTGEGVGPQEYTLVKLKVlepypsklsglkGKNIFLVAATLRPETMFGQTNCWVRPDMKYIgfetANGDIFICTQRAA 333
Cdd:pfam00133  177 EVEYKDVKGPSIHVAFPLAD------------DEGASLVIWTTTPWTLPGNTAVAVNPEFDYV----ITGEGYILAEALL 240
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   334 RNMSYQGFTKhngvvPVVKELMGEEILGASLSAPLTCYKVvyvlPMLT---IKEDKGTGVVTSVPSDSPDDLAAlrdlkk 410
Cdd:pfam00133  241 KSLYKKGTDK-----KILEDFRGKELEGKEAIHPFVNREI----PIITddyVDMEFGTGAVHIAPAHGENDYEV------ 305
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   411 kqalrtkfGIRDdmvlpfepvpvleipgigNLPAVTVCDElkiqsqndreklaeakeklylrgfyDGVMLVDG--FKGQK 488
Cdd:pfam00133  306 --------GQRH------------------NLEVINPVDD-------------------------DGTFTEEApdFQGVY 334
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   489 IQHVKKTIQKNMIDAGdalIYMEPEKQVMS-----RSADECVVALCDQWYLDYgdENWKKQTFQCLKNMETFCEESRKNF 563
Cdd:pfam00133  335 RFDARKKIVELLTEKG---LLLKIEPFTHSypfcwRSGTPIIPRATPQWFVRM--DELADQALEAVEKVQFVPKSGEKRY 409
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   564 EASLDWLQEHACSRTYGLGTRLPWdeqWLIESLSDstIYMA---FYTVAHLLQGG----DLNGQAESPLGIRPQQMTK-- 634
Cdd:pfam00133  410 FNWLANIQDWCISRQRWWGHPIPA---WVSKDTEE--VVCRgelFELVAGRFEEEgsikWLHREAKDKLGYGKGTLEQde 484
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   635 DVWDyVFFKDAPFPKTQIpkEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKwpvSVRANGhLLL 714
Cdd:pfam00133  485 DVLD-TWFSSGSWPFSTL--GWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFK---NVLVHG-LVR 557
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 120537241   715 NSE--KMSKSTGNFLTLSQAVDKFSADGMRLALADAgDTVEDANF 757
Cdd:pfam00133  558 DEQgrKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINL 601
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
676-890 5.60e-15

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 79.39  E-value: 5.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  676 GKDlIpnhlsyyIYNHVAMWP---EQSD-KWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDT 751
Cdd:COG0143   289 GKD-I-------IRFHAIIWPamlMAAGlPLPKKVFAHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPF 360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  752 VEDANF-VEAMAD------AGIL-----RlytwvewVKEMLAS--CSSLRSGPADSFNDRVFASEMNAGIIKTDQNYEKM 817
Cdd:COG0143   361 GQDGDFsWEDFVArvnsdlANDLgnlasR-------TLSMIHKyfDGKVPEPGELTEADEELLAEAEAALEEVAEAMEAF 433
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  818 MFKEALKT---------GFFEFQA----AKDKYRELATEGMHREL-VFRFIevqTILLTPFCPHLCEHIWTLLGKPDSIM 883
Cdd:COG0143   434 EFRKALEEimalaraanKYIDETApwklAKDEDPERLATVLYTLLeALRIL---AILLKPFLPETAEKILEQLGLEGDEL 510
                         250
                  ....*....|
gi 120537241  884 ---HASWPVA 890
Cdd:COG0143   511 tweDAGWPLP 520
 
Name Accession Description Interval E-value
PLN02959 PLN02959
aminoacyl-tRNA ligase
3-1064 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 1518.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    3 GRKGTAKVDFLKEIEKEAQQKWEAEKVFEVSASRlekqKQSSKG-KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRL 81
Cdd:PLN02959    5 GGKSTARRDRLLEIEVAVQKWWEEEKVFEAEAGD----EPPKPGeKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   82 KGKSCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPEEEEEEEE-----SSAKPGDIVVRDKAKGKKSKAAAKAGSS 156
Cdd:PLN02959   81 RGANVLLPFAFHCTGMPIKASADKLAREIQQYGNPPVFPEEDEDEAAavaaaKAEAEAAAAPPDKFKGKKSKAVAKSGTQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  157 KYQWDIMKSLGLSDDDIVKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFG 236
Cdd:PLN02959  161 KYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKKGKIVKD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  237 KRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYI 316
Cdd:PLN02959  241 KRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLPPFPGKLKALEGKKVFLAAATLRPETMYGQTNCWVLPDGKYG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  317 GFETANGDIFICTQRAARNMSYQGFTKHNGVVPVVKELMGEEILGASLSAPLTCYKVVYVLPMLTIKEDKGTGVVTSVPS 396
Cdd:PLN02959  321 AYEINDTEVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTILTDKGTGVVTSVPS 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  397 DSPDDLAALRDLKKKQALRTKFGIRDDMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDREKLAEAKEKLYLRGFYD 476
Cdd:PLN02959  401 DSPDDYMALSDLKAKPALRAKYGVKDEWVLPFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKLAEAKRLTYLKGFTD 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  477 GVMLVDGFKGQKIQHVKKTIQKNMIDAGDALIYMEPEKQVMSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMETFC 556
Cdd:PLN02959  481 GTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWKKKAEKCLSKMNLYS 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  557 EESRKNFEASLDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDLNGQAESPlgIRPQQMTKDV 636
Cdd:PLN02959  561 DETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGGDMYGKDKSS--IKPEQMTDEV 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  637 WDYVfFKDAPFPKT-QIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEqsDKWPVSVRANGHLLLN 715
Cdd:PLN02959  639 WDFV-FCGGPLPKSsDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAE--EHWPRGFRCNGHLMLN 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  716 SEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMLASCSSLRSGPADSFN 795
Cdd:PLN02959  716 SEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAAESSLRTGPPSTYA 795
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  796 DRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYR-ELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIW- 873
Cdd:PLN02959  796 DRVFENEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRlSCGSGGMNRDLVWRFMDVQTRLITPICPHYAEHVWr 875
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  874 TLLGKPDSIMHASWPVAGPVDESLIRSSQYLMEVAHDLRLRLKNYMMPAKGKKTDKQPAQRPSHCT---IYVAKNYPVWQ 950
Cdd:PLN02959  876 EILKKEGFAVTAGWPVAGEPDLTLKRANKYLQDSIVSFRKLLQKQLAGSKKAKKGGAPVTLPEKKLaglIYVAEKYDGWK 955
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  951 HITLTTLRSHFEANNGKL-PDNKVIA----SELGSLPELKKYMKKVMPFVAMIKENMEKKGPRVLDLELEFDEQAVLMEN 1025
Cdd:PLN02959  956 EECLRILQSKFDSQSRTFaPDAEILEalkeSSVGQEANFKQVQKLCMPFVKFKKDEAIAVGPQALDLKLPFDEIEVLQEN 1035
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*....
gi 120537241 1026 IVYLTNSLELEHIEVKFASEAEDKVREEC----------CPGKPLNVFR 1064
Cdd:PLN02959 1036 LELIKRQLGLEEVEILSASDPDAVAKAGAhasllkqnppSPGNPVAIFV 1084
leuS_arch TIGR00395
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ...
14-1059 0e+00

leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273056 [Multi-domain]  Cd Length: 938  Bit Score: 869.14  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    14 KEIEKEAQQKWEAEKVFEVSASrlekqkqsSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLH 93
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEADPD--------DREKFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKNVLFPLGFH 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    94 CTGMPIKACADKLKREIELYGcppdfpeeeeeeeessakpgdivvrdkakgkkskaaakagsskyqWDIMKSLGLSDDDI 173
Cdd:TIGR00395   73 VTGTPILGLAELIKRRDELTI---------------------------------------------KNYTEVHAIPREEL 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   174 VKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDH 253
Cdd:TIGR00395  108 LKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCPKDGNPVEDH 185
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   254 DRQTGEGVGPQEYTLVKLKVLEpypsklsglkgKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETaNGDIFICTQRAA 333
Cdd:TIGR00395  186 DLLSGEGVTIVEYILIKFELED-----------GAFYFVAATLRPETVYGVTNCWVNPTITYVIAEV-GGEKWITSKEAF 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   334 RNMSYQGFTkhngvVPVVKELMGEEILGASLSAPLTcYKVVYVLPMLTIKEDKGTGVVTSVPSDSPDDLAALRDLKKKQA 413
Cdd:TIGR00395  254 ENLSYQKLK-----YKPIEEVPGKQFIGKKVHNPVV-GPEVPILPAEFVDTTKGTGVVMSVPAHAPDDYIALEDLLHDPE 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   414 LrtkFGIRDdMVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDREKLAEAKEKLYLRGFYDGVML--VDGFKGQKIQH 491
Cdd:TIGR00395  328 Y---LGIKP-VVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIynIPPYKGMKVSE 403
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   492 VKKTIQKNMIDAGDALIYMEP-EKQVMSRSADECVVALC-DQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDW 569
Cdd:TIGR00395  404 AKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKVVeDQWFVKYSDESWKELAHECLEGMRIIPEEVKNAFEGKIDW 483
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   570 LQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGDlngqaesplgIRPQQMTKDVWDYVFFKDAPFPK 649
Cdd:TIGR00395  484 LKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDY----------YGNEQMTDEFFDYIFLGKGDVKN 553
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   650 TQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEqsDKWPVSVRANGHLLLNSEKMSKSTGNFLTL 729
Cdd:TIGR00395  554 TNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPE--KFWPRGIVVNGYVMLEGKKMSKSKGNVLTL 631
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   730 SQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEmLASCSSLRSGPADSFNDRVFASEMNAGIIK 809
Cdd:TIGR00395  632 EQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEE-ITKESNLETGEETSFIDRWLESRMNAAIKE 710
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   810 TDQNYEKMMFKEALKTGFFEFQAAKDKYRElATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPV 889
Cdd:TIGR00395  711 TYEAMENFQTRKAVKYALFDLQADVDWYRR-RGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEVGNEGFVSLAKFPE 789
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   890 AG--PVDESLIRSSQYLMEVAHDLRlrlknymmpakgkKTDKQPAQRPSHCTIYVAknyPVWQHITLTTLRSHFEANNGK 967
Cdd:TIGR00395  790 ASepAVDKEVEAAEEYLRNLVRDIQ-------------EIAKIDASKPKRVYLYTS---EDWKSQCLKIVAELFGEDTGE 853
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   968 lpDNKVIASElgslPELKKYMKKVMPFVAMIKENMEKKGprvldlELEFDEQAVLMENIVYLTNSLELEHI-EVKFASEA 1046
Cdd:TIGR00395  854 --DMKKVMEE----PEERKRGKEVISLVKQIIKDEKKED------ELQISEIEVLKAAARFIKKEVGALVIiEFSADSFP 921
                         1050
                   ....*....|...
gi 120537241  1047 EDKVReECCPGKP 1059
Cdd:TIGR00395  922 ENKKR-NAVPGKP 933
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
61-1059 0e+00

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 746.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   61 LHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKReielygcppdfpeeeeeeeessakpgdivvRD 140
Cdd:PRK12300    1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAERIAR------------------------------GD 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  141 KAkgkkskaaakagsskyQWDIMKSL-GLSDDDIVKFSEAEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDvnPYYDSF 219
Cdd:PRK12300   51 PE----------------TIELYKSLyGIPEEELEKFKDPEYIVEYFSEEAKEDMKRIGYSIDWRREFTTTD--PEYSKF 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  220 VRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLVKLKvlepypsklsglKGKNIFLVAATLRPE 299
Cdd:PRK12300  113 IEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEEPEIVEYTLIKFE------------ESEDLILPAATLRPE 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  300 TMFGQTNCWVRPDMKYIGFETaNGDIFICTQRAARNMSYQGFTkhngvVPVVKELMGEEILGASLSAPLTCyKVVYVLPM 379
Cdd:PRK12300  181 TIFGVTNLWVNPDATYVKAEV-DGEKWIVSKEAAEKLSFQDRD-----VEIIEEIKGSELIGKKVKNPVTG-KEVPILPA 253
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  380 LTIKEDKGTGVVTSVPSDSPDDLAALRDLKKKQALrtkfgirddmVLPFEPVPVLEIPGIGNLPAVTVCDELKIQSQNDR 459
Cdd:PRK12300  254 DFVDPDNGTGVVMSVPAHAPYDYVALRDLKKNKEL----------LDVIEPIPLIEVEGYGEFPAKEVVEKLGIKSQEDP 323
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  460 eKLAEAKEKLYLRGFYDGVMLVD--GFKGQKIQHVKKTIQKNMIDAGDALIYME-PEKQVMSRSADECVVA-LCDQWYLD 535
Cdd:PRK12300  324 -ELEEATKEVYRAEFHKGVLKENtgEYAGKPVREAREKITKDLIEKGIADIMYEfSNRPVYCRCGTECVVKvVKDQWFID 402
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  536 YGDENWKKQTFQCLKNMETFCEESRKNFEASLDWLQEHACSRTYGLGTRLPWDEQWLIESLSDSTIYMAFYTVAHLLQGG 615
Cdd:PRK12300  403 YSDPEWKELAHKALDNMEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPWDEEWIIESLSDSTIYMAYYTIAHKIREY 482
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  616 dlngqaesplGIRPQQMTKDVWDYVF----FKDAPFPKTQIPKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNH 691
Cdd:PRK12300  483 ----------GIKPEQLTPEFFDYVFlgkgDPEEVSKKTGIPKEILEEMREEFLYWYPVDWRHSGKDLIPNHLTFFIFNH 552
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  692 VAMWPEqsDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYT 771
Cdd:PRK12300  553 VAIFPE--EKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLER 630
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  772 WVEWVKEMLascsSLRSGPADSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELaTEGMHRELVF 851
Cdd:PRK12300  631 FYELAKELI----EIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWYLRR-VGEANNKVLR 705
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  852 RFIEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVAGP--VDESLIRSSQYLMEVAHDLRlRLKNYmmpAKGKktdk 929
Cdd:PRK12300  706 EVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDEskIDEEAELAEEYVKRLIEDIR-EILKV---AKIK---- 777
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  930 qpaqrPSHCTIYVAknyPVWQHITLTTLRshfeanngKLPDNKVIASELGSLPELKKYMKKVMPFVAMIKENMEKKGPRV 1009
Cdd:PRK12300  778 -----PKKVYIYVA---PDWKYEVLEIAA--------ENGDVKEAIKELMKDEELRKHGKEVAKLAQKIVKEVLKLDKEV 841
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|..
gi 120537241 1010 LDLELE-FDEQAVLMENIVYLTNSLELEhIEVKFASEAE-DKVREECCPGKP 1059
Cdd:PRK12300  842 RKLILKnIDEEEVLEEAKDFLEKELGVE-VEIYGADDPGkKKKKKKALPLKP 892
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
527-759 1.87e-72

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 244.08  E-value: 1.87e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  527 ALCDQWYLDYGDENWKKQTFQCLKNMETFCEESRKNFEASLDwlqehaCSRTYGLGTRLPWdeQWLIESLSDSTIYMAFY 606
Cdd:cd00812   127 KLLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARY 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  607 TVAHLLQGGDlngqaesplgirpqqmtkdvwdyvffkdapfpktqipKEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSY 686
Cdd:cd00812   199 TDAHNLEQPY-------------------------------------EGDLEFDREEFEYWYPVDIYIGGKEHAPNHLLY 241
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120537241  687 YIYNHVAMWPEQ--SDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDtvEDANFVE 759
Cdd:cd00812   242 SRFNHKALFDEGlvTDEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
757-876 2.17e-50

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 173.55  E-value: 2.17e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  757 FVEAMADAGILRLYTWVEWVKEMLASCSSLrsgPADSFNDRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDK 836
Cdd:cd07959     1 FREEEANSAILRLERFYELAEELIETEGEL---EELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLDW 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 120537241  837 YRELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLL 876
Cdd:cd07959    78 YRERGGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
47-231 1.14e-28

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 117.73  E-value: 1.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   47 KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKReielygcppdfpeeeeee 126
Cdd:cd00812     1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGR------------------ 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  127 eessakpgdivvrdkakgkkskaaakagsskyqwdimkslglsdddivkfsEAEHWLDYFPPLAVQDLKTIGLKVDWRRS 206
Cdd:cd00812    63 ---------------------------------------------------DPEDWTEYNIKKMKEQLKRMGFSYDWRRE 91
                         170       180
                  ....*....|....*....|....*
gi 120537241  207 FITTDvnPYYDSFVRWQFLTLRERN 231
Cdd:cd00812    92 FTTCD--PEYYKFTQWLFLKLYEKG 114
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
14-927 1.35e-25

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 114.39  E-value: 1.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    14 KEIEKEAQQKWEAEKVFEVSASrlekqkqSSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLH 93
Cdd:TIGR00422    8 HEVEKKWYKKWEKSGFFKPDGN-------SNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    94 CTGMPIKACADK-LKREIELYGcppDFPeeeeeeeessakpgdivvRDkakgkkskaaakagsskyqwdimkslglsddd 172
Cdd:TIGR00422   81 HAGIATQVKVEKkLGAEGKTKH---DLG------------------RE-------------------------------- 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   173 ivKFSE-AEHWLDYFPPLAVQDLKTIGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCM 251
Cdd:TIGR00422  108 --EFREkIWEWKEESGGTIKNQIKRLGASLDWSRERFTMD--EGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAIS 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   252 DHDrqtgegvgpQEYTLVKLKvLEPYPSKLSGlkGKNIFLVAATLRPETMFGQTNCWVRP-DMKYigfetangdifictq 330
Cdd:TIGR00422  184 DIE---------VEYKEVKGK-LYYIRYPLAN--GSKDYLVVATTRPETMFGDTAVAVHPeDERY--------------- 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   331 raarnmsyqgftkhngvvpvvKELMGEEILgaslsAPLTCYKVvyvlPMLT---IKEDKGTGVVTSVPSDSPDDLAalrd 407
Cdd:TIGR00422  237 ---------------------KHLIGKKVI-----LPLTGRKI----PIIAdeyVDMEFGTGAVKVTPAHDFNDYE---- 282
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   408 LKKKQALRTKFGIRDDMVLPFEpvpVLEIPGIGNLPAvtvcdelkiqsqndREKLAEAKEKLylrGFYDGVMLVDgfkgQ 487
Cdd:TIGR00422  283 WGKRHNLEFINILDEDGLLNEN---AGKYQGLTRFEA--------------RKKIVEDLKEE---GLLVKIEPHT----H 338
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   488 KIQHVKKTiqKNMIDagdalIYMEPEKQVMSRSADECVVALCDQWYLDYGDENWKKQTFQCLKNMEtfceesrknfeasl 567
Cdd:TIGR00422  339 NVGTCWRS--GTVVE-----PLLSKQWFVKVEKLADKALEAAEEGEIKFVPKRMEKRYLNWLRNIK-------------- 397
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   568 DWlqehaC-SRTYGLGTRLPwdeqwlieslsdstiymAFYTVahllQGGDLNGQAESPLGIRPQQMT--------KDVWD 638
Cdd:TIGR00422  398 DW-----CiSRQLIWGHRIP-----------------VWYCK----ECGEVYVAKEEPLPDDKTNTGpsveleqdTDVLD 451
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   639 yVFFKDA--PFPKTQIPKEKLDqlkqeFEFWYPVDLRASGKDLIPNHLSYYIYNHVAmwpeQSDKWPVS-------VR-A 708
Cdd:TIGR00422  452 -TWFSSSlwPFSTLGWPDETKD-----LKKFYPTDLLVTGYDIIFFWVARMIFRSLA----LTGQVPFKevyihglVRdE 521
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   709 NGHlllnseKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANFVEAMADAG---ILRLYTWVEWVKeMLASCSS 785
Cdd:TIGR00422  522 QGR------KMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESArnfLNKLWNASRFVL-MNLSDDL 594
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   786 LRSGPADSFN--DRVFASEMNAGIIKTDQNYEKMMFKEALKtGFFEFQAAK--DKYRELA-------TEGMHRELVFR-- 852
Cdd:TIGR00422  595 ELSGGEEKLSlaDRWILSKLNRTIKEVRKALDKYRFAEAAK-ALYEFIWNDfcDWYIELVkyrlyngNEAEKKAARDTly 673
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 120537241   853 -FIEVQTILLTPFCPHLCEHIW-TLLGKPDSIMHASWPVAGP--VDESLIRSSQYLMEVAHDLRLRLKNYMMPAKGKKT 927
Cdd:TIGR00422  674 yVLDKALRLLHPFMPFITEEIWqHFKEGADSIMLQSYPVVDAefVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK 752
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
501-746 1.56e-22

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 99.80  E-value: 1.56e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  501 IDAGDALIYMEPE-KQVMSRS-----------ADECVVALCDQWYLDYGDenWKKQTFQCLKNMETFCEESRKNFEASLD 568
Cdd:cd00668    99 YDWSDEYITTEPEySKAVELIfsrlyekgliyRGTHPVRITEQWFFDMPK--FKEKLLKALRRGKIVPEHVKNRMEAWLE 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  569 WLQEHACSRTYGLGTRLPwdeQWLIESLSDSTIYMAFYTvahllqggdlngqaesplgirpqqmtkdvwdyvffkDAPFp 648
Cdd:cd00668   177 SLLDWAISRQRYWGTPLP---EDVFDVWFDSGIGPLGSL------------------------------------GYPE- 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  649 ktqipkekldqLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEqsdKWPVSVRANGHLLLN-SEKMSKSTGNFL 727
Cdd:cd00668   217 -----------EKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGE---IPPKNLLVHGFVLDEgGQKMSKSKGNVI 282
                         250
                  ....*....|....*....
gi 120537241  728 TLSQAVDKFSADGMRLALA 746
Cdd:cd00668   283 DPSDVVEKYGADALRYYLT 301
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
21-757 6.93e-22

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 101.72  E-value: 6.93e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    21 QQKWEAEKVFEVSasrLEKQKQssKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIk 100
Cdd:pfam00133    3 YEFWDEQGYFKPE---LEKRKG--KPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPT- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   101 acadklkreielygcppdfpeeeeeeeessakpgdivvrdkakgkkskaaakagsskyQWDIMKSLGLSDDDIV-KFSEA 179
Cdd:pfam00133   77 ----------------------------------------------------------EQVVEKKLGIKEKKTRhKYGRE 98
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   180 EH------WLDYFPPLAVQDLKTIGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDH 253
Cdd:pfam00133   99 EFrekcreWKMEYADEIRKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNL 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   254 DRQTGEGVGPQEYTLVKLKVlepypsklsglkGKNIFLVAATLRPETMFGQTNCWVRPDMKYIgfetANGDIFICTQRAA 333
Cdd:pfam00133  177 EVEYKDVKGPSIHVAFPLAD------------DEGASLVIWTTTPWTLPGNTAVAVNPEFDYV----ITGEGYILAEALL 240
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   334 RNMSYQGFTKhngvvPVVKELMGEEILGASLSAPLTCYKVvyvlPMLT---IKEDKGTGVVTSVPSDSPDDLAAlrdlkk 410
Cdd:pfam00133  241 KSLYKKGTDK-----KILEDFRGKELEGKEAIHPFVNREI----PIITddyVDMEFGTGAVHIAPAHGENDYEV------ 305
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   411 kqalrtkfGIRDdmvlpfepvpvleipgigNLPAVTVCDElkiqsqndreklaeakeklylrgfyDGVMLVDG--FKGQK 488
Cdd:pfam00133  306 --------GQRH------------------NLEVINPVDD-------------------------DGTFTEEApdFQGVY 334
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   489 IQHVKKTIQKNMIDAGdalIYMEPEKQVMS-----RSADECVVALCDQWYLDYgdENWKKQTFQCLKNMETFCEESRKNF 563
Cdd:pfam00133  335 RFDARKKIVELLTEKG---LLLKIEPFTHSypfcwRSGTPIIPRATPQWFVRM--DELADQALEAVEKVQFVPKSGEKRY 409
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   564 EASLDWLQEHACSRTYGLGTRLPWdeqWLIESLSDstIYMA---FYTVAHLLQGG----DLNGQAESPLGIRPQQMTK-- 634
Cdd:pfam00133  410 FNWLANIQDWCISRQRWWGHPIPA---WVSKDTEE--VVCRgelFELVAGRFEEEgsikWLHREAKDKLGYGKGTLEQde 484
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   635 DVWDyVFFKDAPFPKTQIpkEKLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKwpvSVRANGhLLL 714
Cdd:pfam00133  485 DVLD-TWFSSGSWPFSTL--GWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFK---NVLVHG-LVR 557
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 120537241   715 NSE--KMSKSTGNFLTLSQAVDKFSADGMRLALADAgDTVEDANF 757
Cdd:pfam00133  558 DEQgrKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINL 601
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
796-912 1.62e-16

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 77.44  E-value: 1.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   796 DRVFASEMNAGIIKTDQNYEKMMFKEALKTGFFEFQ---------AAKDKYRELATEGMHRELVFRFIEVQTILLTPFCP 866
Cdd:pfam08264    1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWndlsdwyleLIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 120537241   867 HLCEHIWtllgKPDSIMHASWPV-AGPVDESLIRSSQYLMEVAHDLR 912
Cdd:pfam08264   81 FITEELW----QKESIHLAPWPEdAELEEAELEEAFELRQEIVQAIR 123
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
676-890 5.60e-15

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 79.39  E-value: 5.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  676 GKDlIpnhlsyyIYNHVAMWP---EQSD-KWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDT 751
Cdd:COG0143   289 GKD-I-------IRFHAIIWPamlMAAGlPLPKKVFAHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPF 360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  752 VEDANF-VEAMAD------AGIL-----RlytwvewVKEMLAS--CSSLRSGPADSFNDRVFASEMNAGIIKTDQNYEKM 817
Cdd:COG0143   361 GQDGDFsWEDFVArvnsdlANDLgnlasR-------TLSMIHKyfDGKVPEPGELTEADEELLAEAEAALEEVAEAMEAF 433
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  818 MFKEALKT---------GFFEFQA----AKDKYRELATEGMHREL-VFRFIevqTILLTPFCPHLCEHIWTLLGKPDSIM 883
Cdd:COG0143   434 EFRKALEEimalaraanKYIDETApwklAKDEDPERLATVLYTLLeALRIL---AILLKPFLPETAEKILEQLGLEGDEL 510
                         250
                  ....*....|
gi 120537241  884 ---HASWPVA 890
Cdd:COG0143   511 tweDAGWPLP 520
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
706-898 1.85e-12

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 72.01  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  706 VRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLAL------------ADAGdtVEDAN-FVEamadagilRLYTW 772
Cdd:COG0495   577 VGKDGVVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRLFEmfagpperdlewSDSG--VEGAYrFLN--------RVWRL 646
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  773 VEWVKEMLASCSSLRSGPadsfnDRVFASEMNAGIIKTDQNYEKMMFKEA------LKTGFFEFQAAKDKYRELATEGMh 846
Cdd:COG0495   647 VVDEAEALKLDVADLSEA-----DKELRRALHKTIKKVTEDIERLRFNTAiaalmeLVNALYKAKDSGEADRAVLREAL- 720
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 120537241  847 relvfrfiEVQTILLTPFCPHLCEHIWTLLGKPDSIMHASWPVagpVDESLI 898
Cdd:COG0495   721 --------ETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPE---ADEAAL 761
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
47-244 6.16e-12

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 68.21  E-value: 6.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   47 KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLKreielygcppdfpeeeeee 126
Cdd:cd00668     1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKG------------------- 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  127 eesSAKPGDIVvrdkakgkkskaaakagsskyqwdimkslglsdddIVKFSEA-EHWLDYFPPLAVQDLKTIGLKVDWRR 205
Cdd:cd00668    62 ---GRKKKTIW-----------------------------------IEEFREDpKEFVEEMSGEHKEDFRRLGISYDWSD 103
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 120537241  206 SFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSP 244
Cdd:cd00668   104 EYITTE--PEYSKAVELIFSRLYEKGLIYRGTHPVRITE 140
valS PRK13208
valyl-tRNA synthetase; Reviewed
13-99 2.02e-11

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 68.30  E-value: 2.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   13 LKEIEKEAQQKWEAEKVFevsasrleKQKQSSKGKYFV--TfPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPF 90
Cdd:PRK13208   12 PEELEEKWQKIWEEEGTY--------KFDPDERKPVYSidT-PPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQ 82

                  ....*....
gi 120537241   91 GLHCTGMPI 99
Cdd:PRK13208   83 GWDDNGLPT 91
PLN02563 PLN02563
aminoacyl-tRNA ligase
718-907 1.96e-10

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 65.23  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  718 KMSKSTGNFLTLSQAVDKFSADGMRLaladagdtvedanFVEAMadaGILR-LYTW----VEWVKEMLASCSSLRSG--- 789
Cdd:PLN02563  723 KMSKSRGNVVNPDDVVSEYGADSLRL-------------YEMFM---GPLRdSKTWstsgVEGVHRFLGRTWRLVVGapl 786
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  790 PADSFNDRVFASE----------MNAGIIKTDQNYEKMMFKEALkTGFFEFQAAKDKYRELATEgmhrelvfrFIEVQTI 859
Cdd:PLN02563  787 PDGSFRDGTVVTDeepsleqlrlLHKCIAKVTEEIESTRFNTAI-SAMMEFTNAAYKWDKVPRE---------AIEPFVL 856
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 120537241  860 LLTPFCPHLCEHIWTLLGKPDSIMHASWPVAgpvDESLIRSSQYLMEV 907
Cdd:PLN02563  857 LLSPYAPHLAEELWFRLGHSNSLAYEPWPEA---NPSYLVDDTVVLPV 901
valS PRK05729
valyl-tRNA synthetase; Reviewed
718-926 3.82e-10

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 64.36  E-value: 3.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  718 KMSKSTGNF---LTLsqaVDKFSADGMRLALAdagdtvedanfveAMADAGI-LRL-YTWVE---------W-----VKE 778
Cdd:PRK05729  520 KMSKSKGNVidpLDL---IDKYGADALRFTLA-------------ALASPGRdIRFdEERVEgyrnfanklWnasrfVLM 583
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  779 MLASCSSLRSGPADSFN--DRVFASEMNAGIIKTDQNYEKMMFKEALKT--GFF--EF-----QAAKDKYRELATEGMHR 847
Cdd:PRK05729  584 NLEGADVGELPDPEELSlaDRWILSRLNRTVAEVTEALDKYRFDEAARAlyEFIwnEFcdwylELAKPVLQEAAKRATRA 663
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  848 ELVFRFIEVQtILLTPFCPHLCEHIWTLL---GKPDSIMHASWPVAGPV-DESLIRSSQYLMEVAHDLRlRLKNYMMPAK 923
Cdd:PRK05729  664 TLAYVLEQIL-RLLHPFMPFITEELWQKLaplGIEESIMLAPWPEADEAiDEAAEAEFEWLKELITAIR-NIRAEMNIPP 741

                  ...
gi 120537241  924 GKK 926
Cdd:PRK05729  742 SKK 744
metG PRK00133
methionyl-tRNA synthetase; Reviewed
676-880 4.13e-09

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 60.94  E-value: 4.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  676 GKDLIpnhlsyyiYNHVAMWP---EQSD-KWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALA-DAGD 750
Cdd:PRK00133  291 GKDII--------YFHTLFWPamlEGAGyRLPTNVFAHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAaKLPE 362
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  751 TVEDANFveamadagilrlyTWVEWVK----EM------LAScsslRS----------GPADSFNDRVFASEMNAGIIKT 810
Cdd:PRK00133  363 TIDDLDF-------------NWEDFQQrvnsELvgkvvnFAS----RTagfinkrfdgKLPDALADPELLEEFEAAAEKI 425
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  811 DQNYEKMMFKEALKT---------GFFEFQA----AKDKYRELATEgMHREL-VFRFIevqTILLTPFCPHLCEHIWTLL 876
Cdd:PRK00133  426 AEAYEAREFRKALREimaladfanKYVDDNEpwklAKQDGERLQAV-CSVGLnLFRAL---AIYLKPVLPELAERAEAFL 501

                  ....
gi 120537241  877 GKPD 880
Cdd:PRK00133  502 NLEE 505
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
718-912 7.77e-09

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 60.06  E-value: 7.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  718 KMSKSTGNF---LTLsqaVDKFSADGMRLALAdagdtvedanfveAMADAGI-LRLYT-WVE---------W-----VKE 778
Cdd:COG0525   522 KMSKSKGNVidpLDL---IDKYGADALRFTLA-------------ALASPGRdIKFDEeRVEgyrnfanklWnasrfVLM 585
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  779 MLASCSSLRSGPADSFN--DRVFASEMNAGIIKTDQNYEKMMFKEALKT--GFF--EFQaakDKYRELA-------TEGM 845
Cdd:COG0525   586 NLEGFDPGLDPDPEELSlaDRWILSRLNKTIAEVTEALEKYRFDEAAQAlyDFVwnEFC---DWYLELAkprlyggDEAA 662
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120537241  846 HRE----LVfRFIEVQTILLTPFCPHLCEHIWTLLGKP---DSIMHASWPVAGP--VDESLIRSSQYLMEVAHDLR 912
Cdd:COG0525   663 KREtratLV-YVLEQILRLLHPFMPFITEEIWQKLPPRkegESIMLAPWPEADEelIDEEAEAEFEWLKEVISAIR 737
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
639-757 1.05e-08

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 58.84  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   639 YVFFkDAPFPKTQIPKEkLDQLKQEFEFWYPVDLRAS-----GKDLIpnhlsyyiYNHVAMWP----EQSDKWPVSVRAN 709
Cdd:pfam09334  246 YVWL-DAPIGYISATKE-LSGNEEKWKEWWPNDPDTElvhfiGKDII--------YFHTIFWPamllGAGYRLPTTVFAH 315
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 120537241   710 GHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANF 757
Cdd:pfam09334  316 GYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDF 363
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
709-745 2.21e-08

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 58.19  E-value: 2.21e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 120537241  709 NGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLAL 745
Cdd:COG0215   256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFL 292
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
709-745 3.77e-08

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 55.28  E-value: 3.77e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 120537241  709 NGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLAL 745
Cdd:cd00672   165 TGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
valS PRK14900
valyl-tRNA synthetase; Provisional
695-896 5.91e-08

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 57.31  E-value: 5.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  695 WPEQSDK----WPVSVRANGHLLL--------------------------------NSEKMSKSTGNFLTLSQAVDKFSA 738
Cdd:PRK14900  479 WPEQTDTlrtfYPTSVMETGHDIIffwvarmmmmglhfmgevpfrtvylhpmvrdeKGQKMSKTKGNVIDPLVITEQYGA 558
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  739 DGMRLALAD----------AGDTVEDAN-FVEAMADAGILRLYTWVEWVKEMLASCSSLRSgPADsfndRVFASEMNAGI 807
Cdd:PRK14900  559 DALRFTLAAltaqgrdiklAKERIEGYRaFANKLWNASRFALMNLSGYQERGEDPARLART-PAD----RWILARLQRAV 633
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  808 IKTDQNYEKMMFKEALKTGF-FEFQAAKDKYRELATEGMH----------RELVFRFIEVQTILLTPFCPHLCEHIWTLL 876
Cdd:PRK14900  634 NETVEALEAFRFNDAANAVYaFVWHELCDWYIELAKEALAsedpearrsvQAVLVHCLQTSYRLLHPFMPFITEELWHVL 713
                         250       260
                  ....*....|....*....|....*..
gi 120537241  877 -------GKPDSIMHASWPVAGPVDES 896
Cdd:PRK14900  714 raqvgasAWADSVLAAEYPRKGEADEA 740
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
666-882 7.79e-08

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 56.43  E-value: 7.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  666 FWyPVDLRASGKDLIPNHLSYyiynhvamWPEQ--SDKWPV--SVRANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGM 741
Cdd:PRK11893  252 YW-PADVHLIGKDILRFHAVY--------WPAFlmAAGLPLpkRVFAHGFLTLDGEKMSKSLGNVIDPFDLVDEYGVDAV 322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  742 RLALA-------DaGDTVED----------ANFVEAMADAGILRLYTWVEW-VKEMLASCSSlrsgpadsfnDRVFASEM 803
Cdd:PRK11893  323 RYFLLreipfgqD-GDFSREafinrinadlANDLGNLAQRTLSMIAKNFDGkVPEPGALTEA----------DEALLEAA 391
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  804 NAGIIKTDQNYEKMMFKEALK---------TGFFEFQA----AKDKYRELATEGMHRELVFRFIevqTILLTPFCPHLCE 870
Cdd:PRK11893  392 AALLERVRAAMDNLAFDKALEailalvraaNKYIDEQApwslAKTDPERLATVLYTLLEVLRGI---AVLLQPVMPELAA 468
                         250
                  ....*....|..
gi 120537241  871 HIWTLLGKPDSI 882
Cdd:PRK11893  469 KILDQLGVEEDE 480
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
639-757 6.26e-07

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 52.92  E-value: 6.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  639 YVFFkDAPFPKTQIPKEkLDQLKQEFEFWYPVDLRAS---GKDLIPNHlsyyiynhVAMWP---EQSDKWPVS-VRANGH 711
Cdd:cd00814   204 YVWF-DALIGYISATGY-YNEEWGNSWWWKDGWPELVhfiGKDIIRFH--------AIYWPamlLGAGLPLPTrIVAHGY 273
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 120537241  712 LLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLALADAGDTVEDANF 757
Cdd:cd00814   274 LTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
PLN02563 PLN02563
aminoacyl-tRNA ligase
15-230 2.15e-06

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 52.13  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   15 EIEKEAQQKWEAEKVFevsasRLEKQKQSSKGKYFV--TFPYPYMNGrLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGL 92
Cdd:PLN02563   84 EIEPKWQRYWEENRTF-----RTPDDVDTSKPKFYVldMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGW 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   93 HCTGMPIKACAdklkreIElygcppdfpeeeeeeeeSSAKPGDIVVRdkakgkkskaaakagsskyqwdimkslglsddD 172
Cdd:PLN02563  158 DAFGLPAEQYA------IE-----------------TGTHPKITTLK--------------------------------N 182
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 120537241  173 IVKFSeaehwldyfpplavQDLKTIGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRER 230
Cdd:PLN02563  183 IARFR--------------SQLKSLGFSYDWDREISTTE--PEYYKWTQWIFLQLLKR 224
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
668-748 4.23e-06

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 50.06  E-value: 4.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   668 YPVDLRASGKDLI-PNHlsyyiYNHVAMWPEQSDKWPVSV-RANGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLAL 745
Cdd:pfam01406  206 DQIDIHGGGIDLAfPHH-----ENEIAQSEAAFDKQLANYwLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFL 280

                   ...
gi 120537241   746 ADA 748
Cdd:pfam01406  281 LSV 283
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
46-98 8.84e-06

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 49.55  E-value: 8.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 120537241   46 GKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMP 98
Cdd:cd00817     1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIA 53
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
668-743 1.26e-05

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 49.64  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  668 YPVDLRASGKDLI-PNHlsyyiYNHVAmwpeQS------DKWpvsvrAN-----GHLLLNSEKMSKSTGNFLTLSQAVDK 735
Cdd:PTZ00399  267 DPIDIHSGGIDLKfPHH-----DNELA----QSeayfdkHQW-----VNyflhsGHLHIKGLKMSKSLKNFITIRQALSK 332

                  ....*...
gi 120537241  736 FSADGMRL 743
Cdd:PTZ00399  333 YTARQIRL 340
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
13-99 1.50e-05

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 49.31  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   13 LKEIEKEAQQKWEAEKVFEvsasrleKQKQSSKGK-YFVtF---PyPYMNGRLHLGHTfsLSKC--EFAVGYQRLKGKSC 86
Cdd:COG0060    18 LPKREPEILKFWEENDIYE-------KSREARAGRpKFV-LhdgP-PYANGDIHIGHA--LNKIlkDIIVRYKTMRGFDV 86
                          90
                  ....*....|...
gi 120537241   87 LFPFGLHCTGMPI 99
Cdd:COG0060    87 PYVPGWDCHGLPI 99
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
516-757 3.26e-05

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 47.63  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  516 VMSRSADECVVALCDQWYLDYGDEnwKKQTFQCLKN--METFCEESRKNFEASLDWLQEHACSRTYGLGTRLPwdeQWLI 593
Cdd:cd00817   155 VCSRSGDVIEPLLKPQWFVKVKDL--AKKALEAVKEgdIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIP---AWYC 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  594 ESLSDstIYMAFYTVAHLLQGGDLNGQAESPLGIRPQqmtKDVWDyVFFKDA--PFPKTQIPKEKLDqlkqeFEFWYPVD 671
Cdd:cd00817   230 KDGGH--WVVAREEDEAIDKAAPEACVPCGGEELKQD---EDVLD-TWFSSSlwPFSTLGWPEETKD-----LKKFYPTS 298
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  672 LRASGKDLIPNHLSYYIYNHVAMwpeqSDKWPVS-------VR-ANGhlllnsEKMSKSTGNFLTLSQAVDKFSADGMRL 743
Cdd:cd00817   299 LLVTGHDIIFFWVARMIMRGLKL----TGKLPFKevylhglVRdEDG------RKMSKSLGNVIDPLDVIDGYGADALRF 368
                         250
                  ....*....|....
gi 120537241  744 ALADAGDTVEDANF 757
Cdd:cd00817   369 TLASAATQGRDINL 382
PLN02843 PLN02843
isoleucyl-tRNA synthetase
17-99 5.42e-05

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 47.46  E-value: 5.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241   17 EKEAQQKWEAEKVFEVSASRlekqkqsSKGKYFVTF--PyPYMNGRLHLGHtfSLSKC--EFAVGYQRLKGKSCLFPFGL 92
Cdd:PLN02843    9 EPEIQKLWEENQVYKRVSDR-------NNGESFTLHdgP-PYANGDLHIGH--ALNKIlkDFINRYQLLQGKKVHYVPGW 78

                  ....*..
gi 120537241   93 HCTGMPI 99
Cdd:PLN02843   79 DCHGLPI 85
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
47-88 2.85e-04

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 44.87  E-value: 2.85e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 120537241   47 KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLF 88
Cdd:PRK11893    2 KFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFF 43
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
48-107 3.71e-04

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 44.20  E-value: 3.71e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241    48 YFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLFPFGLHCTGMPIKACADKLK 107
Cdd:pfam09334    1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEG 60
PLN02946 PLN02946
cysteine-tRNA ligase
668-745 5.73e-04

cysteine-tRNA ligase


Pssm-ID: 178532 [Multi-domain]  Cd Length: 557  Bit Score: 44.15  E-value: 5.73e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 120537241  668 YPVDLRASGKDLIPNHLSYYIYNHVAMWPEQSDKWPVSvraNGHLLLNSEKMSKSTGNFLTLSQAVDKFSADGMRLAL 745
Cdd:PLN02946  276 HSFDIHGGGMDLVFPHHENEIAQSCAACCDSNISYWIH---NGFVTVDSEKMSKSLGNFFTIRQVIDLYHPLALRLFL 350
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
14-88 7.63e-04

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 43.84  E-value: 7.63e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120537241   14 KEIEKEAQQKWEAEKVFEVSasrlEKQKQSSKGKYFV-TFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKSCLF 88
Cdd:PTZ00419   31 KEVESGWYEWWEKSGFFKPA----EDAKSLNSGKKFViVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLW 102
cysS PRK14536
cysteinyl-tRNA synthetase; Provisional
670-806 3.18e-03

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 184731 [Multi-domain]  Cd Length: 490  Bit Score: 41.45  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  670 VDLRASGKDLIPNHLSyyiyNHVAmwpeQSD-----KWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDK-FSADGMRL 743
Cdd:PRK14536  234 CDIHIGGVDHIRVHHT----NEIA----QCEaatgkPWVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKgFQPLDYRF 305
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120537241  744 ALADAGDTVEDANFVEAM--ADAGILRLYTWV-EWVKEMLASCSSLRSGPADSFNDRVFASEMNAG 806
Cdd:PRK14536  306 FLLGGHYRSQLAFSWEALktAKAARRSLVRRVaRVVDAARATTGSVRGTLAECAAERVAESRASES 371
PLN02224 PLN02224
methionine-tRNA ligase
656-754 3.62e-03

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 41.62  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120537241  656 KLDQLKQEFEFWYPVDLRASGKDLIPNHLSYYiynhVAMWPEQSDKWPVSVRANGHLLLNSEKMSKSTGNFLTLSQAVDK 735
Cdd:PLN02224  308 KQQNLETAVSFGWPASLHLIGKDILRFHAVYW----PAMLMSAGLELPKMVFGHGFLTKDGMKMGKSLGNTLEPFELVQK 383
                          90       100
                  ....*....|....*....|....*
gi 120537241  736 FSADGMR------LALADAGDTVED 754
Cdd:PLN02224  384 FGPDAVRyfflreVEFGNDGDYSED 408
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
837-876 4.32e-03

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 38.35  E-value: 4.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 120537241  837 YRELATEGMHRELVFRFIEVQTILLTPFCPHLCEHIWTLL 876
Cdd:cd07958    78 YKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
55-114 7.85e-03

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 39.91  E-value: 7.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120537241   55 PYMNGRLHLGHTfsLSKC--EFAVGYQRLKGKSCLFPFGLHCTGMPI-----KACADKLKREIELYG 114
Cdd:cd00818    10 PYANGLPHYGHA--LNKIlkDIINRYKTMQGYYVPRRPGWDCHGLPIelkveKELGISGKKDIEKMG 74
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
858-907 8.62e-03

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 38.69  E-value: 8.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 120537241  858 TILLTPFCPHLCEHIWT-----LLGKPDSImH-ASWPVA--GPVDESLIRSSQYLMEV 907
Cdd:cd07961   122 SRLMAPFTPFITEEIYQnlrreLGDAPESV-HlLDWPEVdeSLIDEELEEAMELVREI 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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