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Conserved domains on  [gi|24308410|ref|NP_612367|]
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mitochondrial import inner membrane translocase subunit Tim29 [Homo sapiens]

Protein Classification

Tim29 domain-containing protein( domain architecture ID 10562769)

Tim29 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tim29 pfam10171
Translocase of the Inner Mitochondrial membrane 29; This is a family of proteins conserved ...
24-186 3.28e-86

Translocase of the Inner Mitochondrial membrane 29; This is a family of proteins conserved from nematodes to humans. The function is not known. However, family members such as the import inner membrane translocase sub-unit Tim29 (C19orf52) found in human, is shown to be required for the stability of the TIM22 complex. TIM22 complex imports and inserts multi-pass trans-membrane proteins into the mitochondrial inner membrane by formation of a twin-pore translocase with components in the outer and inner membranes. TIM29 is integrated into the inner member with the C terminus exposed to the inter-membrane space and able to contact the translocase of the outer membrane. It is required for complex stability and for the addition of the TIMM22 protein to the complex.


:

Pssm-ID: 462977  Cd Length: 163  Bit Score: 253.69  E-value: 3.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308410    24 KPGVWARLGSWARALLRDYAEACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRN 103
Cdd:pfam10171   1 KGTILEKWGKYWKSLLRDYKEVAVDVAKDARERPLKASLYLTLLGGAYYCYKTNPDEQSFEDALLEASNDLLLVSPAIRN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308410   104 RESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQPRWTDFPGRVLDVGFVGRWWVLGAWMRDCD 183
Cdd:pfam10171  81 PTSDKHVQSLEKLRNQGRLRYLSLGLFSLIYEDDYDKDCSLYEAQCKYLKPRWLEFPERIVDVGFLGRWWVLEWKMRDYD 160

                  ...
gi 24308410   184 IND 186
Cdd:pfam10171 161 INE 163
 
Name Accession Description Interval E-value
Tim29 pfam10171
Translocase of the Inner Mitochondrial membrane 29; This is a family of proteins conserved ...
24-186 3.28e-86

Translocase of the Inner Mitochondrial membrane 29; This is a family of proteins conserved from nematodes to humans. The function is not known. However, family members such as the import inner membrane translocase sub-unit Tim29 (C19orf52) found in human, is shown to be required for the stability of the TIM22 complex. TIM22 complex imports and inserts multi-pass trans-membrane proteins into the mitochondrial inner membrane by formation of a twin-pore translocase with components in the outer and inner membranes. TIM29 is integrated into the inner member with the C terminus exposed to the inter-membrane space and able to contact the translocase of the outer membrane. It is required for complex stability and for the addition of the TIMM22 protein to the complex.


Pssm-ID: 462977  Cd Length: 163  Bit Score: 253.69  E-value: 3.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308410    24 KPGVWARLGSWARALLRDYAEACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRN 103
Cdd:pfam10171   1 KGTILEKWGKYWKSLLRDYKEVAVDVAKDARERPLKASLYLTLLGGAYYCYKTNPDEQSFEDALLEASNDLLLVSPAIRN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308410   104 RESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQPRWTDFPGRVLDVGFVGRWWVLGAWMRDCD 183
Cdd:pfam10171  81 PTSDKHVQSLEKLRNQGRLRYLSLGLFSLIYEDDYDKDCSLYEAQCKYLKPRWLEFPERIVDVGFLGRWWVLEWKMRDYD 160

                  ...
gi 24308410   184 IND 186
Cdd:pfam10171 161 INE 163
 
Name Accession Description Interval E-value
Tim29 pfam10171
Translocase of the Inner Mitochondrial membrane 29; This is a family of proteins conserved ...
24-186 3.28e-86

Translocase of the Inner Mitochondrial membrane 29; This is a family of proteins conserved from nematodes to humans. The function is not known. However, family members such as the import inner membrane translocase sub-unit Tim29 (C19orf52) found in human, is shown to be required for the stability of the TIM22 complex. TIM22 complex imports and inserts multi-pass trans-membrane proteins into the mitochondrial inner membrane by formation of a twin-pore translocase with components in the outer and inner membranes. TIM29 is integrated into the inner member with the C terminus exposed to the inter-membrane space and able to contact the translocase of the outer membrane. It is required for complex stability and for the addition of the TIMM22 protein to the complex.


Pssm-ID: 462977  Cd Length: 163  Bit Score: 253.69  E-value: 3.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308410    24 KPGVWARLGSWARALLRDYAEACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATRN 103
Cdd:pfam10171   1 KGTILEKWGKYWKSLLRDYKEVAVDVAKDARERPLKASLYLTLLGGAYYCYKTNPDEQSFEDALLEASNDLLLVSPAIRN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308410   104 RESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQPRWTDFPGRVLDVGFVGRWWVLGAWMRDCD 183
Cdd:pfam10171  81 PTSDKHVQSLEKLRNQGRLRYLSLGLFSLIYEDDYDKDCSLYEAQCKYLKPRWLEFPERIVDVGFLGRWWVLEWKMRDYD 160

                  ...
gi 24308410   184 IND 186
Cdd:pfam10171 161 INE 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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