NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|20336319|ref|NP_619529|]
View 

bcl-2-like protein 11 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Bim_N super family cl06026
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 4.49e-11

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


The actual alignment was detected with superfamily member pfam06773:

Pssm-ID: 429111  Cd Length: 40  Bit Score: 53.17  E-value: 4.49e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 20336319     4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact super family cl07517
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 76-106 5.93e-07

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


The actual alignment was detected with superfamily member pfam08945:

Pssm-ID: 462643  Cd Length: 38  Bit Score: 42.56  E-value: 5.93e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 20336319    76 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 106
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Name Accession Description Interval E-value
Bim_N pfam06773
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 4.49e-11

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


Pssm-ID: 429111  Cd Length: 40  Bit Score: 53.17  E-value: 4.49e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 20336319     4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact pfam08945
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 76-106 5.93e-07

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


Pssm-ID: 462643  Cd Length: 38  Bit Score: 42.56  E-value: 5.93e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 20336319    76 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 106
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Name Accession Description Interval E-value
Bim_N pfam06773
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 4.49e-11

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


Pssm-ID: 429111  Cd Length: 40  Bit Score: 53.17  E-value: 4.49e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 20336319     4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact pfam08945
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 76-106 5.93e-07

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


Pssm-ID: 462643  Cd Length: 38  Bit Score: 42.56  E-value: 5.93e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 20336319    76 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 106
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH