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Conserved domains on  [gi|33342268|ref|NP_620129|]
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R3H domain-containing protein 4 [Homo sapiens]

Protein Classification

R3H domain-containing protein( domain architecture ID 10621380)

R3H domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
R3H-assoc pfam13902
R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, ...
 46-182 2.73e-36

R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, domain-containing proteins. The function is not known.


:

Pssm-ID: 464031  Cd Length: 127  Bit Score: 125.61  E-value: 2.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268    46 RKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGGLPGLEDgdlAPPASPGIFAEACNNATYVEVWNDFMNR 125
Cdd:pfam13902   1 RKPIRRDSAKRREALLKGKEGSRRRRRWENDRLLHELVPRLDEIEDDPD---AEPPLPSDFTVLPTHPENAQLWDDFRNL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 33342268   126 SGEEQERVLRYLEDEgrSKARRRGPGRGEDRRRedpayTPRECFQRISRRLRAVLKR 182
Cdd:pfam13902  78 DEDEQERILASLEQS--EKKRKKHRVSGEDDRE-----SALARFQRIDRRLRAALKR 127
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 188-247 7.26e-05

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


:

Pssm-ID: 460206  Cd Length: 60  Bit Score: 39.78  E-value: 7.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268   188 ETLETWEERLLRFFSVSPQAVYTAMLdNSFERLLLHAVCQYMDLISASADLEGKRQMKVS 247
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPM-SSYERRIIHELAQKYGLESESEGEEPNRRVVVY 59
 
Name Accession Description Interval E-value
R3H-assoc pfam13902
R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, ...
 46-182 2.73e-36

R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, domain-containing proteins. The function is not known.


Pssm-ID: 464031  Cd Length: 127  Bit Score: 125.61  E-value: 2.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268    46 RKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGGLPGLEDgdlAPPASPGIFAEACNNATYVEVWNDFMNR 125
Cdd:pfam13902   1 RKPIRRDSAKRREALLKGKEGSRRRRRWENDRLLHELVPRLDEIEDDPD---AEPPLPSDFTVLPTHPENAQLWDDFRNL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 33342268   126 SGEEQERVLRYLEDEgrSKARRRGPGRGEDRRRedpayTPRECFQRISRRLRAVLKR 182
Cdd:pfam13902  78 DEDEQERILASLEQS--EKKRKKHRVSGEDDRE-----SALARFQRIDRRLRAALKR 127
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 188-247 7.26e-05

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 39.78  E-value: 7.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268   188 ETLETWEERLLRFFSVSPQAVYTAMLdNSFERLLLHAVCQYMDLISASADLEGKRQMKVS 247
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPM-SSYERRIIHELAQKYGLESESEGEEPNRRVVVY 59
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
167-249 1.15e-03

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 36.89  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268    167 ECFQRISRRLRAVLKRSRipmETLETWEERLLRFF-SVSPQAVYTAMldNSFERLLLHAVCQYMDLISASADLEGKRQMK 245
Cdd:smart00393   1 ADFLPVTLDALSYRPRRR---EELIELELEIARFVkSTKESVELPPM--NSYERKIVHELAEKYGLESESFGEGPKRRVV 75


                   ....
gi 33342268    246 VSNR 249
Cdd:smart00393  76 ISKK 79
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 215-247 2.93e-03

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 35.28  E-value: 2.93e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 33342268 215 NSFERLLLHAVCQYMDLISASADLEGKRQMKVS 247
Cdd:cd02325  26 NSYERKLIHDLAEYYGLKSESEGEGPNRRVVIT 58
 
Name Accession Description Interval E-value
R3H-assoc pfam13902
R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, ...
 46-182 2.73e-36

R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, domain-containing proteins. The function is not known.


Pssm-ID: 464031  Cd Length: 127  Bit Score: 125.61  E-value: 2.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268    46 RKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGGLPGLEDgdlAPPASPGIFAEACNNATYVEVWNDFMNR 125
Cdd:pfam13902   1 RKPIRRDSAKRREALLKGKEGSRRRRRWENDRLLHELVPRLDEIEDDPD---AEPPLPSDFTVLPTHPENAQLWDDFRNL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 33342268   126 SGEEQERVLRYLEDEgrSKARRRGPGRGEDRRRedpayTPRECFQRISRRLRAVLKR 182
Cdd:pfam13902  78 DEDEQERILASLEQS--EKKRKKHRVSGEDDRE-----SALARFQRIDRRLRAALKR 127
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 188-247 7.26e-05

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 39.78  E-value: 7.26e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268   188 ETLETWEERLLRFFSVSPQAVYTAMLdNSFERLLLHAVCQYMDLISASADLEGKRQMKVS 247
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPM-SSYERRIIHELAQKYGLESESEGEEPNRRVVVY 59
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
167-249 1.15e-03

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 36.89  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33342268    167 ECFQRISRRLRAVLKRSRipmETLETWEERLLRFF-SVSPQAVYTAMldNSFERLLLHAVCQYMDLISASADLEGKRQMK 245
Cdd:smart00393   1 ADFLPVTLDALSYRPRRR---EELIELELEIARFVkSTKESVELPPM--NSYERKIVHELAEKYGLESESFGEGPKRRVV 75


                   ....
gi 33342268    246 VSNR 249
Cdd:smart00393  76 ISKK 79
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 215-247 2.93e-03

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 35.28  E-value: 2.93e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 33342268 215 NSFERLLLHAVCQYMDLISASADLEGKRQMKVS 247
Cdd:cd02325  26 NSYERKLIHDLAEYYGLKSESEGEGPNRRVVIT 58
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 194-242 3.54e-03

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 35.27  E-value: 3.54e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 33342268 194 EERLLRFFSVSPQAVYTAMLDNSFERLLLHAVCQYMDLISASADLEGKR 242
Cdd:cd02642   9 EKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGGKC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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