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Conserved domains on  [gi|21040249|ref|NP_631904|]
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retinoic acid early transcript 1E isoform 1 precursor [Homo sapiens]

Protein Classification

MHC_I domain-containing protein( domain architecture ID 194)

major histocompatibility complex class I (MHC_I) domain-containing protein similar to Homo sapiens endothelial protein C receptor and retinoic acid early transcript 1L protein

CATH:  3.30.500.10
Gene Ontology:  GO:0006955

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MHC_I super family cl08246
Class I Histocompatibility antigen, domains alpha 1 and 2;
30-195 1.78e-10

Class I Histocompatibility antigen, domains alpha 1 and 2;


The actual alignment was detected with superfamily member pfam14586:

Pssm-ID: 471794  Cd Length: 174  Bit Score: 58.62  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249    30 GHSLCFNFTIKSLSrPGQP-WCEAQVFLNKNLFLQYNSDNNMVKPlGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDI 108
Cdd:pfam14586   2 AHSLRCNLTIKAPT-PADPlWYEAKCLVDEILILHLSNINKTMTS-GDPGETANATEVGECLTQPVNDLCQKLRDKVSNT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249   109 KPQI-KTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLE---KYFRKL 184
Cdd:pfam14586  80 KVDThKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWNDDGDLVqrlKYFIPE 159
                         170
                  ....*....|.
gi 21040249   185 SKGDCDHWLRE 195
Cdd:pfam14586 160 CRQKIDEFLKQ 170
 
Name Accession Description Interval E-value
MHC_I_2 pfam14586
Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are ...
30-195 1.78e-10

Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.


Pssm-ID: 291265  Cd Length: 174  Bit Score: 58.62  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249    30 GHSLCFNFTIKSLSrPGQP-WCEAQVFLNKNLFLQYNSDNNMVKPlGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDI 108
Cdd:pfam14586   2 AHSLRCNLTIKAPT-PADPlWYEAKCLVDEILILHLSNINKTMTS-GDPGETANATEVGECLTQPVNDLCQKLRDKVSNT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249   109 KPQI-KTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLE---KYFRKL 184
Cdd:pfam14586  80 KVDThKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWNDDGDLVqrlKYFIPE 159
                         170
                  ....*....|.
gi 21040249   185 SKGDCDHWLRE 195
Cdd:pfam14586 160 CRQKIDEFLKQ 170
 
Name Accession Description Interval E-value
MHC_I_2 pfam14586
Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are ...
30-195 1.78e-10

Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2; Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.


Pssm-ID: 291265  Cd Length: 174  Bit Score: 58.62  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249    30 GHSLCFNFTIKSLSrPGQP-WCEAQVFLNKNLFLQYNSDNNMVKPlGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDI 108
Cdd:pfam14586   2 AHSLRCNLTIKAPT-PADPlWYEAKCLVDEILILHLSNINKTMTS-GDPGETANATEVGECLTQPVNDLCQKLRDKVSNT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249   109 KPQI-KTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLE---KYFRKL 184
Cdd:pfam14586  80 KVDThKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWNDDGDLVqrlKYFIPE 159
                         170
                  ....*....|.
gi 21040249   185 SKGDCDHWLRE 195
Cdd:pfam14586 160 CRQKIDEFLKQ 170
MHC_I pfam00129
Class I Histocompatibility antigen, domains alpha 1 and 2;
29-197 2.84e-09

Class I Histocompatibility antigen, domains alpha 1 and 2;


Pssm-ID: 395078  Cd Length: 179  Bit Score: 55.09  E-value: 2.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249    29 GGHSLCFNFTikSLSRP--GQPWCEAQVFLNKNLFLQYNSD--NNMVKPLGLLgKKVYATSTWGELTQTLGEVGRDLRML 104
Cdd:pfam00129   1 GSHSLRYFYT--AVSRPglGEPRFIAVGYVDDTQFVRFDSDaaNPRMEPRAPW-IEQEGPEYWERETQIAKGNEQIFREN 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21040249   105 LCDIKPQIKTSDPS--TLQVEMFCQREAE-RCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYf 181
Cdd:pfam00129  78 LRTLLGYYNQSEGGshTLQWMYGCDVGPDgRLLRGYEQFAYDGKDYIALNEDLRSWTAADPAAQITKRKWEAAGEAERQ- 156
                         170
                  ....*....|....*.
gi 21040249   182 RKLSKGDCDHWLREFL 197
Cdd:pfam00129 157 RAYLEGECVEWLRRYL 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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