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Conserved domains on  [gi|21264361|ref|NP_631947|]
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mannan-binding lectin serine protease 2 isoform 2 precursor [Homo sapiens]

Protein Classification

CUB and EGF_CA domain-containing protein( domain architecture ID 11249313)

CUB and EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 2.98e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


:

Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 106.32  E-value: 2.98e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264361     28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 21264361    104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 3.21e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 3.21e-06
                          10        20
                  ....*....|....*....|....*....
gi 21264361   152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 2.98e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 106.32  E-value: 2.98e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264361     28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 21264361    104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 11-136 3.80e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.03  E-value: 3.80e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264361  11 CGSVATplgpkwpEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:cd00041   1 CGGTLT-------ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLL 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21264361  87 ATLCGQEStdterapgKDTFYSLGSSLDITFRSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041  74 GRFCGSTL--------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
CUB pfam00431
CUB domain;
11-134 3.12e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 75.79  E-value: 3.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264361    11 CGSVATPLgpkwpepvFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:pfam00431   1 CGGVLTDS--------SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21264361    87 ATLCGQEstdterAPgkDTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:pfam00431  73 GRFCGSG------IP--EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 3.21e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 3.21e-06
                          10        20
                  ....*....|....*....|....*....
gi 21264361   152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
138-176 4.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21264361    138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHRN 176
Cdd:smart00179   1 DIDECA----SGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 138-175 1.47e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.47e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21264361 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHR 175
Cdd:cd00054   1 DIDECA----SGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
 
Name Accession Description Interval E-value
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 28-134 2.98e-30

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 106.32  E-value: 2.98e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264361     28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73

                           90       100       110
                   ....*....|....*....|....*....|.
gi 21264361    104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 11-136 3.80e-29

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.03  E-value: 3.80e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264361  11 CGSVATplgpkwpEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:cd00041   1 CGGTLT-------ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLL 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21264361  87 ATLCGQEStdterapgKDTFYSLGSSLDITFRSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041  74 GRFCGSTL--------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
CUB pfam00431
CUB domain;
11-134 3.12e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 75.79  E-value: 3.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264361    11 CGSVATPLgpkwpepvFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:pfam00431   1 CGGVLTDS--------SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21264361    87 ATLCGQEstdterAPgkDTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:pfam00431  73 GRFCGSG------IP--EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 152-180 3.21e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 3.21e-06
                          10        20
                  ....*....|....*....|....*....
gi 21264361   152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
138-176 4.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 21264361    138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHRN 176
Cdd:smart00179   1 DIDECA----SGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 138-175 1.47e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.47e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21264361 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHR 175
Cdd:cd00054   1 DIDECA----SGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
138-170 1.00e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 1.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 21264361   138 DIDECQvapGEAPTCDH--HCHNHLGGFYCSCRAG 170
Cdd:pfam07645   1 DVDECA---TGTHNCPAntVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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