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Conserved domains on  [gi|22212931|ref|NP_631981|]
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nucleolar protein 6 isoform gamma [Homo sapiens]

Protein Classification

nucleolar RNA-associated family protein( domain architecture ID 13691699)

nucleolar RNA-associated protein (NRAP) family protein such as nucleolar protein 6 (NOL6) that is involved in RNA binding, localization, and ribosome biogenesis; it interacts with pre-rRNA primary transcripts to facilitate ribosome assembly within the nucleolus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 178-320 4.69e-59

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


:

Pssm-ID: 461061  Cd Length: 144  Bit Score: 195.48  E-value: 4.69e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   178 VDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVC---FSYTNGCHLKPSLLLRPRGKDERL----VT 250
Cdd:pfam03813   1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDDLLkvsFSYLNGDPLKPILVLRPKKTEGKFskskFT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   251 VRLHPCPPPDFFRPCRLLPTKNNVRSAWyrgqspAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSS 320
Cdd:pfam03813  81 IRIIPCAPSGLFPLSKLLPSKNNIRPAT------DSEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-463 3.61e-56

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 187.81  E-value: 3.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   323 GLKDGVALLKVWLRQRELD-KGQGGFTGFLVSMLVVFLV------STRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLC 395
Cdd:pfam17403   1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22212931   396 LSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTP 463
Cdd:pfam17403  81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 466-628 8.36e-44

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465417  Cd Length: 159  Bit Score: 154.73  E-value: 8.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   466 MIRAFDHVLHLrPLSrLQAACHRLKLWPELQDNGGdYVSAALGPLTTLLEQGLGARLNLLAHSRPPvPEWDISQDPPKHK 545
Cdd:pfam17404   1 PLLRFDLVLRI-PLP-LSASLLSKFGPLEKIDFIG-FENALLRKLYSLLKRALGDRAKLIHIQLPS-PSWSISKRKPSPA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   546 DSGTLTLGLLLRPEGLTSVLELGPEA-DQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQkRLIPHQVVTHLLA 624
Cdd:pfam17404  77 NPSSILIGLLLNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE-RLIVEQIVKYILK 155


                  ....
gi 22212931   625 LHAD 628
Cdd:pfam17404 156 RHLG 159
Nrap_D6 super family cl38687
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 668-690 6.32e-03

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


The actual alignment was detected with superfamily member pfam17407:

Pssm-ID: 465420  Cd Length: 128  Bit Score: 37.29  E-value: 6.32e-03
                          10        20
                  ....*....|....*....|...
gi 22212931   668 MVPNVEAILEDFAVLGEGLVQTV 690
Cdd:pfam17407 106 VVLNKEAILEEIARLGGDLVKSI 128
 
Name Accession Description Interval E-value
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 178-320 4.69e-59

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 195.48  E-value: 4.69e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   178 VDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVC---FSYTNGCHLKPSLLLRPRGKDERL----VT 250
Cdd:pfam03813   1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDDLLkvsFSYLNGDPLKPILVLRPKKTEGKFskskFT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   251 VRLHPCPPPDFFRPCRLLPTKNNVRSAWyrgqspAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSS 320
Cdd:pfam03813  81 IRIIPCAPSGLFPLSKLLPSKNNIRPAT------DSEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-463 3.61e-56

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 187.81  E-value: 3.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   323 GLKDGVALLKVWLRQRELD-KGQGGFTGFLVSMLVVFLV------STRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLC 395
Cdd:pfam17403   1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22212931   396 LSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTP 463
Cdd:pfam17403  81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 466-628 8.36e-44

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 154.73  E-value: 8.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   466 MIRAFDHVLHLrPLSrLQAACHRLKLWPELQDNGGdYVSAALGPLTTLLEQGLGARLNLLAHSRPPvPEWDISQDPPKHK 545
Cdd:pfam17404   1 PLLRFDLVLRI-PLP-LSASLLSKFGPLEKIDFIG-FENALLRKLYSLLKRALGDRAKLIHIQLPS-PSWSISKRKPSPA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   546 DSGTLTLGLLLRPEGLTSVLELGPEA-DQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQkRLIPHQVVTHLLA 624
Cdd:pfam17404  77 NPSSILIGLLLNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE-RLIVEQIVKYILK 155


                  ....
gi 22212931   625 LHAD 628
Cdd:pfam17404 156 RHLG 159
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 668-690 6.32e-03

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 37.29  E-value: 6.32e-03
                          10        20
                  ....*....|....*....|...
gi 22212931   668 MVPNVEAILEDFAVLGEGLVQTV 690
Cdd:pfam17407 106 VVLNKEAILEEIARLGGDLVKSI 128
 
Name Accession Description Interval E-value
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 178-320 4.69e-59

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 195.48  E-value: 4.69e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   178 VDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVC---FSYTNGCHLKPSLLLRPRGKDERL----VT 250
Cdd:pfam03813   1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDDLLkvsFSYLNGDPLKPILVLRPKKTEGKFskskFT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   251 VRLHPCPPPDFFRPCRLLPTKNNVRSAWyrgqspAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSS 320
Cdd:pfam03813  81 IRIIPCAPSGLFPLSKLLPSKNNIRPAT------DSEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-463 3.61e-56

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 187.81  E-value: 3.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   323 GLKDGVALLKVWLRQRELD-KGQGGFTGFLVSMLVVFLV------STRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLC 395
Cdd:pfam17403   1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLLqgggpnGNKKLSKGMSSYQLFKATLQFLATTDLTKKPIFFK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22212931   396 LSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTP 463
Cdd:pfam17403  81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 466-628 8.36e-44

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 154.73  E-value: 8.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   466 MIRAFDHVLHLrPLSrLQAACHRLKLWPELQDNGGdYVSAALGPLTTLLEQGLGARLNLLAHSRPPvPEWDISQDPPKHK 545
Cdd:pfam17404   1 PLLRFDLVLRI-PLP-LSASLLSKFGPLEKIDFIG-FENALLRKLYSLLKRALGDRAKLIHIQLPS-PSWSISKRKPSPA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22212931   546 DSGTLTLGLLLRPEGLTSVLELGPEA-DQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQkRLIPHQVVTHLLA 624
Cdd:pfam17404  77 NPSSILIGLLLNPENAFRLVDHGPSAeDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE-RLIVEQIVKYILK 155


                  ....
gi 22212931   625 LHAD 628
Cdd:pfam17404 156 RHLG 159
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 668-690 6.32e-03

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 37.29  E-value: 6.32e-03
                          10        20
                  ....*....|....*....|...
gi 22212931   668 MVPNVEAILEDFAVLGEGLVQTV 690
Cdd:pfam17407 106 VVLNKEAILEEIARLGGDLVKSI 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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