|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
3-704 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 779.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 3 DSSGQQGKGRrvQPQWSPPA--GTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRV 80
Cdd:PTZ00399 14 NGTGQVSKSR--LPEWKKPSkeGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 81 LKDYFKFDVFYCMNITDIDDKIIKRARQNHLfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavq 160
Cdd:PTZ00399 92 LEDYFGYDVFYVMNITDIDDKIIKRAREEKL------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 161 lateplekavqsrltgeevnscvevlleeakdllsdwldstlgcdvtdnSIFSKLPKFWEGDFHRDMEALNVLPPDVLTR 240
Cdd:PTZ00399 123 -------------------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITR 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 241 VSEYVPEIVNFVQKIVDNGYGYVSNGSVYFDTAKFASSeKHSYGKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSPNDF 320
Cdd:PTZ00399 154 VSEYVPEIVDFIQKIIDNGFAYESNGSVYFDVEAFRKA-GHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPNDF 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 321 ALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHL 400
Cdd:PTZ00399 230 ALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHL 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 401 TIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVdiTGQF 480
Cdd:PTZ00399 310 HIKGLKMSKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESE--LTSP 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 481 EKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAArkavRKRPNQALLENIALYLTHMLKIFGA 560
Cdd:PTZ00399 388 QKWTQHDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNS----GEQPSAPLLRSVAQYVTKILSIFGL 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 561 VEEDSSLGFPVGGpgtslSLEATVMPYLQVLSEFREGVRKIAR--------EQKVPEILQLSDALRDNILPELGVRFEDH 632
Cdd:PTZ00399 464 VEGSDGLGSQGQN-----STSENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIEDK 538
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21269877 633 EGLPTVVKLVDRNTLLKEREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDEN 704
Cdd:PTZ00399 539 PDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDET 610
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
29-632 |
4.13e-161 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 473.05 E-value: 4.13e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 29 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 108
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 109 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNscvevlle 188
Cdd:COG0215 81 E------------------------------------------------------------------GESIW-------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 189 eakdllsdwldstlgcDVTDnsifsklpkFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 268
Cdd:COG0215 87 ----------------ELAE---------RYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 269 YFDTAKFassekHSYGKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWH 345
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 346 IECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHS 425
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 426 ARQLRLAFLMHSWKDTLDYSSNTMESALQ-YEKfLNEFFLNVKDILRAPVDITGQFEKWgeeeaelnknfydkKTAIHKA 504
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLER-LYNALRRLEEALGAADSSAEEIEEL--------------REEFIAA 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 505 LCDNVDTRTVMEEMRALVSQCNlymaarKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLgfpVGGPGTSLSLEATV 584
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREIN------KALDEGEDKAALAALAALLRALGGVLGLLLLEPEA---WQGAAEDELLDALI 420
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 21269877 585 MPYLQvlsefregVRKIAREQKvpeILQLSDALRDNILpELGVRFEDH 632
Cdd:COG0215 421 EALIE--------ERAEARKAK---DFARADRIRDELA-ALGIVLEDT 456
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
29-631 |
5.19e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 419.09 E-value: 5.19e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 29 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 108
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 109 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNSCVEVLLE 188
Cdd:TIGR00435 80 N------------------------------------------------------------------GESVYEVSERFIE 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 189 EakdllsdwldstlgcdvtdnsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGS 267
Cdd:TIGR00435 94 A---------------------------------YFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 268 VYFDTAKFassekHSYGKLvpeAVGDQKALQEGEGDLSISAdrlseKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIE 347
Cdd:TIGR00435 141 VYFDVSKF-----KDYGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 348 CSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSAR 427
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 428 QLRLAFLMHSWKDTLDYSsntmESALQYEKFLNEFFLNVKDILRApvDITGQFEkWGEEEAELNKNFYDkktAIHKALCD 507
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFS----EELLEAAKNALERLYKALRVLDT--SLAYSGN-QSLNKFPDEKEFEA---RFVEAMDD 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 508 NVDTR---TVMEEMralVSQCNLYMAarkavrkrpNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATV 584
Cdd:TIGR00435 357 DLNTAnalAVLFEL---AKSINLTFV---------SKADAALLIEHLIFLESRLGLLLGLPSKPVQAGSNDDLGEIEALI 424
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 21269877 585 MPylqvlsefregvRKIAREQKVpeiLQLSDALRDNiLPELGVRFED 631
Cdd:TIGR00435 425 EE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
42-457 |
2.24e-139 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 411.38 E-value: 2.24e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 42 FIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQNHLFEQyrekrpe 121
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGESFR------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 122 aaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevlleeakdllsdwldst 201
Cdd:pfam01406 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 202 lgcdvtdnsifsKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGSVYFDTAKFassek 280
Cdd:pfam01406 74 ------------QLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSdNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 281 HSYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASM 360
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 361 DIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKD 440
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*..
gi 21269877 441 TLDYSsntmESALQYEK 457
Cdd:pfam01406 288 PLDFS----EELLEQAK 300
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
30-445 |
3.56e-110 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 332.62 E-value: 3.56e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 30 HLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFkFDVFYCMNITDIDDKIIKRARQN 109
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 110 HLFeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevllee 189
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 190 akdllsdwldstlgcdvtdnsiFSKLPKFWEGDFHRDMEALNVLPPDVLTRVseyvpeivnfvqkivdngygyvsngsvy 269
Cdd:cd00672 83 ----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 270 fdtakfassekhsygklvpeavgdqkalqegegdlsisadrlsekrspndfalwkaskpgepswpcpwgkgrpgWHIECS 349
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 350 AMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQL 429
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 21269877 430 RLAFLMHSWKDTLDYS 445
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
3-704 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 779.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 3 DSSGQQGKGRrvQPQWSPPA--GTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRV 80
Cdd:PTZ00399 14 NGTGQVSKSR--LPEWKKPSkeGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 81 LKDYFKFDVFYCMNITDIDDKIIKRARQNHLfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavq 160
Cdd:PTZ00399 92 LEDYFGYDVFYVMNITDIDDKIIKRAREEKL------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 161 lateplekavqsrltgeevnscvevlleeakdllsdwldstlgcdvtdnSIFSKLPKFWEGDFHRDMEALNVLPPDVLTR 240
Cdd:PTZ00399 123 -------------------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITR 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 241 VSEYVPEIVNFVQKIVDNGYGYVSNGSVYFDTAKFASSeKHSYGKLVPEAVGDQKALQEGEGDLSISAdrlSEKRSPNDF 320
Cdd:PTZ00399 154 VSEYVPEIVDFIQKIIDNGFAYESNGSVYFDVEAFRKA-GHVYPKLEPESVADEDRIAEGEGALGKVS---GEKRSPNDF 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 321 ALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHL 400
Cdd:PTZ00399 230 ALWKASKPGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHL 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 401 TIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVdiTGQF 480
Cdd:PTZ00399 310 HIKGLKMSKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESE--LTSP 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 481 EKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAArkavRKRPNQALLENIALYLTHMLKIFGA 560
Cdd:PTZ00399 388 QKWTQHDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNS----GEQPSAPLLRSVAQYVTKILSIFGL 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 561 VEEDSSLGFPVGGpgtslSLEATVMPYLQVLSEFREGVRKIAR--------EQKVPEILQLSDALRDNILPELGVRFEDH 632
Cdd:PTZ00399 464 VEGSDGLGSQGQN-----STSENFKPLLEALLRFRDEVRDAAKaemklislDKKKKQLLQLCDKLRDEWLPNLGIRIEDK 538
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21269877 633 EGLPTVVKLVDRNTLLKEREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDEN 704
Cdd:PTZ00399 539 PDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQEDKYSAFDET 610
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
29-632 |
4.13e-161 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 473.05 E-value: 4.13e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 29 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 108
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 109 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNscvevlle 188
Cdd:COG0215 81 E------------------------------------------------------------------GESIW-------- 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 189 eakdllsdwldstlgcDVTDnsifsklpkFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 268
Cdd:COG0215 87 ----------------ELAE---------RYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEADGDV 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 269 YFDTAKFassekHSYGKL---VPEAvgdqkaLQEGEgdlsiSADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWH 345
Cdd:COG0215 142 YFDVRSF-----PDYGKLsgrNLDD------LRAGA-----RVEVDEEKRDPLDFALWKAAKPGEPSWDSPWGRGRPGWH 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 346 IECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHS 425
Cdd:COG0215 206 IECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLLKKYD 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 426 ARQLRLAFLMHSWKDTLDYSSNTMESALQ-YEKfLNEFFLNVKDILRAPVDITGQFEKWgeeeaelnknfydkKTAIHKA 504
Cdd:COG0215 285 PEVLRFFLLSAHYRSPLDFSEEALEEAEKaLER-LYNALRRLEEALGAADSSAEEIEEL--------------REEFIAA 349
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 505 LCDNVDTRTVMEEMRALVSQCNlymaarKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLgfpVGGPGTSLSLEATV 584
Cdd:COG0215 350 MDDDFNTPEALAVLFELVREIN------KALDEGEDKAALAALAALLRALGGVLGLLLLEPEA---WQGAAEDELLDALI 420
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 21269877 585 MPYLQvlsefregVRKIAREQKvpeILQLSDALRDNILpELGVRFEDH 632
Cdd:COG0215 421 EALIE--------ERAEARKAK---DFARADRIRDELA-ALGIVLEDT 456
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
29-631 |
5.19e-140 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 419.09 E-value: 5.19e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 29 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 108
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 109 NhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNSCVEVLLE 188
Cdd:TIGR00435 80 N------------------------------------------------------------------GESVYEVSERFIE 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 189 EakdllsdwldstlgcdvtdnsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGS 267
Cdd:TIGR00435 94 A---------------------------------YFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSdNGD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 268 VYFDTAKFassekHSYGKLvpeAVGDQKALQEGEGDLSISAdrlseKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIE 347
Cdd:TIGR00435 141 VYFDVSKF-----KDYGKL---SKQDLDQLEAGARVDVDEA-----KRNKLDFVLWKSSKEGEPKWDSPWGKGRPGWHIE 207
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 348 CSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSAR 427
Cdd:TIGR00435 208 CSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAF-GKQLAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVLKNYDPE 286
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 428 QLRLAFLMHSWKDTLDYSsntmESALQYEKFLNEFFLNVKDILRApvDITGQFEkWGEEEAELNKNFYDkktAIHKALCD 507
Cdd:TIGR00435 287 ILRYFLLSVHYRSPLDFS----EELLEAAKNALERLYKALRVLDT--SLAYSGN-QSLNKFPDEKEFEA---RFVEAMDD 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 508 NVDTR---TVMEEMralVSQCNLYMAarkavrkrpNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATV 584
Cdd:TIGR00435 357 DLNTAnalAVLFEL---AKSINLTFV---------SKADAALLIEHLIFLESRLGLLLGLPSKPVQAGSNDDLGEIEALI 424
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 21269877 585 MPylqvlsefregvRKIAREQKVpeiLQLSDALRDNiLPELGVRFED 631
Cdd:TIGR00435 425 EE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
42-457 |
2.24e-139 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 411.38 E-value: 2.24e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 42 FIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQNHLFEQyrekrpe 121
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQEGESFR------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 122 aaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevlleeakdllsdwldst 201
Cdd:pfam01406 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 202 lgcdvtdnsifsKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVS-NGSVYFDTAKFassek 280
Cdd:pfam01406 74 ------------QLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSdNGDVYFDVSSF----- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 281 HSYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASM 360
Cdd:pfam01406 137 PDYGKLSGQNLEQLEAGARGEVS--------EGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARKYLGDQI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 361 DIHGGGFDLRFPHHDNELAQSEAYFENDcWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKD 440
Cdd:pfam01406 209 DIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHYRS 287
|
410
....*....|....*..
gi 21269877 441 TLDYSsntmESALQYEK 457
Cdd:pfam01406 288 PLDFS----EELLEQAK 300
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
30-445 |
3.56e-110 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 332.62 E-value: 3.56e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 30 HLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFkFDVFYCMNITDIDDKIIKRARQN 109
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDLG-YKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 110 HLFeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevllee 189
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 190 akdllsdwldstlgcdvtdnsiFSKLPKFWEGDFHRDMEALNVLPPDVLTRVseyvpeivnfvqkivdngygyvsngsvy 269
Cdd:cd00672 83 ----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV---------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 270 fdtakfassekhsygklvpeavgdqkalqegegdlsisadrlsekrspndfalwkaskpgepswpcpwgkgrpgWHIECS 349
Cdd:cd00672 113 --------------------------------------------------------------------------WHIECS 118
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 350 AMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQL 429
Cdd:cd00672 119 AMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAAT-GKPFARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVL 197
|
410
....*....|....*.
gi 21269877 430 RLAFLMHSWKDTLDYS 445
Cdd:cd00672 198 RLALLSSHYRSPLDFS 213
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
29-452 |
8.08e-93 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 299.92 E-value: 8.08e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 29 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIDDKIIKRARQ 108
Cdd:PLN02946 60 LHLYNTMSRKKELFKPKVEGKVGMYVCGVTAYDLSHIGHARVYVTFDVLYRYLK-HLGYEVRYVRNFTDVDDKIIARANE 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 109 nhlfeqyrekrpeaaqLLEDvqaalkPFSvklnettdpdkkqmleriqhavqlateplekavqsrltgeevnscvevlle 188
Cdd:PLN02946 139 ----------------LGED------PIS--------------------------------------------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 189 eakdllsdwldstlgcdvtdnsifskLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 268
Cdd:PLN02946 146 --------------------------LSRRYCEEFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCAYRVDGDV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 269 YFDTAKFASsekhsYGKLVPEAVGDQKAlqeGEgdlSISADrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIEC 348
Cdd:PLN02946 200 YFSVDKFPE-----YGKLSGRKLEDNRA---GE---RVAVD--SRKKNPADFALWKAAKEGEPFWDSPWGPGRPGWHIEC 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 349 SAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFEnDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQ 428
Cdd:PLN02946 267 SAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSCAACC-DSNISYWIHNGFVTVDSEKMSKSLGNFFTIRQVIDLYHPLA 345
|
410 420
....*....|....*....|....
gi 21269877 429 LRLAFLMHSWKDTLDYSSNTMESA 452
Cdd:PLN02946 346 LRLFLLGTHYRSPINYSDVQLESA 369
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
31-452 |
4.08e-66 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 231.91 E-value: 4.08e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 31 LYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDyFKFDVFYCMNITDIDDKIIKRARQNh 110
Cdd:PRK14535 230 IYNTLTRQKEPFAPIDPENVRMYVCGMTVYDYCHLGHARVMVVFDMIARWLRE-CGYPLTYVRNITDIDDKIIARAAEN- 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 111 lfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrltGEEVNSCVEVLLEEa 190
Cdd:PRK14535 308 -----------------------------------------------------------------GETIGELTARFIQA- 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 191 kdllsdwldstlgcdvtdnsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGY-VSNGSVY 269
Cdd:PRK14535 322 --------------------------------MHEDADALGVLRPDIEPKATENIPQMIAMIETLIQNGKAYpAANGDVY 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 270 FDTAKFASsekhsYGKLVPEAVGDQKALQEGEGDlsisadrlSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECS 349
Cdd:PRK14535 370 YAVREFAA-----YGQLSGKSLDDLRAGERVEVD--------GFKRDPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECS 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 350 AMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDC---------------WVRYFLHTGHLTIAGCKMSKSLKNF 414
Cdd:PRK14535 437 AMSENLFGDTFDIHGGGADLQFPHHENEIAQSVGATGHTCghhhaqthhgqsiasHVKYWLHNGFIRVDGEKMSKSLGNF 516
|
410 420 430
....*....|....*....|....*....|....*...
gi 21269877 415 ITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESA 452
Cdd:PRK14535 517 FTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDA 554
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
47-454 |
2.90e-61 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 210.56 E-value: 2.90e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 47 GKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYfKFDVFYCMNITDIDDKIIKRARQnhlfeqyrekrpeaaqll 126
Cdd:PRK12418 7 GGTATMYVCGITPYDATHLGHAATYLAFDLVNRVWRDA-GHDVHYVQNVTDVDDPLLERAAR------------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 127 edvqaalkpfsvklnettdpdkkqmleriqhavqlateplekavqsrlTGEevnscvevlleeakdllsDWLDstLGCDV 206
Cdd:PRK12418 68 ------------------------------------------------DGV------------------DWRD--LAERE 79
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 207 TDnsifskLpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYV----SNGSVYFDTAkfassekhs 282
Cdd:PRK12418 80 IA------L-------FREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYVvddeEYPDVYFSVD--------- 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 283 ygklVPEAVGDQKALQEGEGdLSISADRLSE-----KRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLG 357
Cdd:PRK12418 138 ----ATPQFGYESGYDRATM-LELFAERGGDpdrpgKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSAIALNRLG 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 358 ASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKdALKK--HSARQLRLAFLM 435
Cdd:PRK12418 213 SGFDIQGGGSDLIFPHHEFSAAHAEAATGERRFARHYVHAGMIGLDGEKMSKSRGNLVFVS-RLRAagVDPAAIRLALLA 291
|
410
....*....|....*....
gi 21269877 436 HSWKDTLDYSSNTMESALQ 454
Cdd:PRK12418 292 GHYRADREWTDAVLAEAEA 310
|
|
| mycothiol_MshC |
TIGR03447 |
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ... |
18-454 |
3.56e-61 |
|
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Pssm-ID: 132488 [Multi-domain] Cd Length: 411 Bit Score: 211.12 E-value: 3.56e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 18 WSPPA-----GTQPcRLHLYNSLTRNKEVFIPqdGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYfKFDVFYC 92
Cdd:TIGR03447 3 WPAPAvpalpGTGP-PLRLFDTADGQVRPVEP--GPEAGMYVCGITPYDATHLGHAATYLTFDLVNRVWRDA-GHRVHYV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 93 MNITDIDDKIIKRArqnhlfeqyrekrpeaaqlledvqaalkpfsvklnettdpdkkqmlERiqhavqlateplekavqs 172
Cdd:TIGR03447 79 QNVTDVDDPLFERA----------------------------------------------ER------------------ 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 173 rlTGEevnscvevlleeakdllsDWLDstLGCDVTDNsifsklpkfwegdFHRDMEALNVLPPDVLTRVSEYVPEIVNFV 252
Cdd:TIGR03447 95 --DGV------------------DWRE--LGTSQIDL-------------FREDMEALRVLPPRDYIGAVESIDEVVEMV 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 253 QKIVDNGYGYV----SNGSVYFDTAkfaSSEKHSYGKLVPEAVGDQKALQEGeGDlsisADRLSeKRSPNDFALWKASKP 328
Cdd:TIGR03447 140 EKLLASGAAYIvegpEYPDVYFSID---ATEQFGYESGYDRATMLELFAERG-GD----PDRPG-KRDPLDALLWRAARE 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 329 GEPSWPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMS 408
Cdd:TIGR03447 211 GEPSWDSPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATGVRRMARHYVHAGMIGLDGEKMS 290
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 21269877 409 KSLKNFITIKDaLKK--HSARQLRLAFLMHSWKDTLDYSSNTMESALQ 454
Cdd:TIGR03447 291 KSLGNLVFVSK-LRAagVDPAAIRLGLLAGHYRQDRDWTDAVLAEAEA 337
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
29-566 |
1.04e-60 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 212.09 E-value: 1.04e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 29 LHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIddkiikrarq 108
Cdd:PRK14536 3 LRLYNTLGRQQEEFQPIEHGHVRLYGCGPTVYNYAHIGNLRTYVFQDTLRRTLH-FLGYRVTHVMNITDV---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 109 NHLfeqyrekrpeaaqlledvqaalkpfsvklneTTDPDKKQmleriqhavqlatEPLEKAVQSRltGEEVnscvevlLE 188
Cdd:PRK14536 72 GHL-------------------------------TDDADSGE-------------DKMVKSAQEH--GKSV-------LE 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 189 EAKdllsdwldstlgcdvtdnsifsklpkFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 268
Cdd:PRK14536 99 IAA--------------------------HYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTYCAGGNV 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 269 YFDTAKFASsekhsYGKLVPEAVGDqkaLQEGEgdlSISADrlSEKRSPNDFALWKASKPGEP---SWPCPWGKGRPGWH 345
Cdd:PRK14536 153 YFDIRTFPS-----YGSLASAAVED---LQAGA---RIEHD--TNKRNPHDFVLWFTRSKFENhalTWDSPWGRGYPGWH 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 346 IECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAyFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKK-H 424
Cdd:PRK14536 220 IECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCEA-ATGKPWVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKgF 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 425 SARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVDITGQF------EKWGEEEAELNKNFYDKK 498
Cdd:PRK14536 299 QPLDYRFFLLGGHYRSQLAFSWEALKTAKAARRSLVRRVARVVDAARATTGSVRGTlaecaaERVAESRASESELLLTDF 378
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21269877 499 TAihkALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSS 566
Cdd:PRK14536 379 RA---ALEDDFSTPKALSELQKLVKDTSVPPSLCLSVLQAMDTVLGLGLIQEATASLSAQVPAGPSEE 443
|
|
| cysS |
PRK14534 |
cysteinyl-tRNA synthetase; Provisional |
29-496 |
1.34e-41 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173000 [Multi-domain] Cd Length: 481 Bit Score: 158.48 E-value: 1.34e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 29 LHLYNslTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKdYFKFDVFYCMNITDIddkiikrarq 108
Cdd:PRK14534 3 LKLYN--TKTKDLSELKNFSDVKVYACGPTVYNYAHIGNFRTYIFEDLLIKSLR-LLKYNVNYAMNITDI---------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 109 NHLfeqyrekrpeaaqlledvqaalkpfsvklneTTDPDKKQmleriqhavqlatEPLEKAVQSR-LTGEEVNscvevll 187
Cdd:PRK14534 70 GHL-------------------------------TGDFDDGE-------------DKVVKAARERgLTVYEIS------- 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 188 eeakdllsdwldstlgcdvtdnsifsklpKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGS 267
Cdd:PRK14534 99 -----------------------------RFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEENGFTYFVNGN 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 268 VYFDTAKFassekHSYGKLVPEAVGDQKALQEGEGDLSISadrlseKRSPNDFALWKAS---KPGEPSWPCPWGKGRPGW 344
Cdd:PRK14534 150 VYFDTSCF-----KSYGQMAGINLNDFKDMSVSRVEIDKS------KRNKSDFVLWFTNskfKDQEMKWDSPWGFGYPSW 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 345 HIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFeNDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKH 424
Cdd:PRK14534 219 HLECAAMNLEYFKSTLDIHLGGVDHIGVHHINEIAIAECYL-NKKWCDMFVHGEFLIMEYEKMSKSNNNFITIKDLEDQG 297
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21269877 425 -SARQLRLAFLMHSWKDTLDYSSNTME-SALQYEKFLNE--FFLNVKDilraPVDITGQFEKWGEEEAELNKNFYD 496
Cdd:PRK14534 298 fSPLDFRYFCLTAHYRTQLKFTFNNLKaCKIARENMLNKltYFYSSLD----QFDLNLLNKDLENIEFSLEKEYYD 369
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
383-518 |
7.44e-08 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 56.03 E-value: 7.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 383 AYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLaFLMHS---WKDtLDYSSNTMESAL-QYEKF 458
Cdd:PRK12300 554 AIFPEEKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRL-YLTSSaelLQD-ADWREKEVESVRrQLERF 631
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 459 LnEFFLNVKDIlrAPVDITGQFEKWgeEEAELNKNFydKKTaiHKALcDNVDTRTVMEEM 518
Cdd:PRK12300 632 Y-ELAKELIEI--GGEEELRFIDKW--LLSRLNRII--KET--TEAM-ESFQTRDAVQEA 681
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
367-453 |
9.51e-06 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 49.30 E-value: 9.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 367 FDLRFPHHD---NELAQS----EAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRlaFLMHSWK 439
Cdd:PLN02959 672 FDLRVSGKDliqNHLTFAiynhTAIWAEEHWPRGFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATR--FALADAG 749
|
90
....*....|....*..
gi 21269877 440 DTLD---YSSNTMESAL 453
Cdd:PLN02959 750 DGVDdanFVFETANAAI 766
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
55-117 |
9.97e-06 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 45.93 E-value: 9.97e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21269877 55 CGPTVYDASHMGHARSYISFDILRRVLKDyFKFDVFYCMNITDIDDKIIKRARQNHL-FEQYRE 117
Cdd:cd00802 4 SGITPNGYLHIGHLRTIVTFDFLAQAYRK-LGYKVRCIALIDDAGGLIGDPANKKGEnAKAFVE 66
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
391-437 |
1.98e-04 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 44.06 E-value: 1.98e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 21269877 391 VRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHS 437
Cdd:cd00814 265 PTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRER 311
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
397-437 |
6.69e-04 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 42.66 E-value: 6.69e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 21269877 397 TGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHS 437
Cdd:pfam09334 315 HGYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNR 355
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
343-411 |
1.14e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 39.77 E-value: 1.14e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21269877 343 GWHIECSAMAGTLLGASMDIHGGGFDLRFpHHDNELAQSEAYfeNDCWVRYFLHTGHLTIA-GCKMSKSL 411
Cdd:cd00802 77 EYMFLQAADFLLLYETECDIHLGGSDQLG-HIELGLELLKKA--GGPARPFGLTFGRVMGAdGTKMSKSK 143
|
|
| |
