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Conserved domains on  [gi|21536362|ref|NP_647603|]
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TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2 [Homo sapiens]

Protein Classification

TAF RNA polymerase I subunit A domain-containing protein( domain architecture ID 10633067)

TAF RNA polymerase I subunit A domain-containing protein; TATA box binding protein (TBP) associated factor (TAF) RNA Polymerase I subunit A (TAFA1) is involved in pre-initiation complex (PIC) assembly during RNA polymerase I-dependent transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAF1_subA pfam14929
TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I ...
 1-309 3.53e-158

TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.


:

Pssm-ID: 434323  Cd Length: 365  Bit Score: 447.17  E-value: 3.53e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362     1 MESFNTFANRMKNIGVMNYLKISLQHALYLLHHGMLKDAKRNLSEAETWRHGENTSSREILINLIQAYKGLLQYYTWSEK 80
Cdd:pfam14929  51 VEIYNTFMERLKNLGVKNYLKISLEHALHLLLNGMIEEAKRNLSNAESWRYGETLMSQEKLIKLINAYKGLLDYYLWYSK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362    81 KMELSKLD--KDDYAYNAVAQDVFNHSWKTSANISALIKIPGVWDPFVKSYVEMLEFYGDRDGAQEVLTNYAYDEKFPSN 158
Cdd:pfam14929 131 KPEELQLDdfEDDFSQLNSNQEMHNYFRQAAVNLLALISTPGVWDPFVLPYVQLLEFYGDVDEALEVLNNYAYDKKFPFN 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362   159 PNAHIYLYNFLKRQKAPRSKLIS-VLKILYQIVPSHKLMLEFHTLLRKSEKEEHRKLGLEVLFGVLDFAGCTKNITAWKY 237
Cdd:pfam14929 211 PNAHVYLYQFLKRQQAPRKKLIScVLKILHQLVPSDTLMLELHRLLKKSRKEYHHKLLLEVIFLHLDFAGWKENLTAWKE 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21536362   238 LAKYLKNIL--MGNHL-AWVQEEWNSRKNWWPGFHFSYFWAKSDWKEDTALACEKAFVAGLLLGKGCRYFRYILK 309
Cdd:pfam14929 291 LAKCFKQISvkKNKHPkVFTEEEWKLRKDWWPTFHFSKFLAKSDWKENLELALYKAAVAGILLGKEFKYVKAVSS 365
 
Name Accession Description Interval E-value
TAF1_subA pfam14929
TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I ...
 1-309 3.53e-158

TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.


Pssm-ID: 434323  Cd Length: 365  Bit Score: 447.17  E-value: 3.53e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362     1 MESFNTFANRMKNIGVMNYLKISLQHALYLLHHGMLKDAKRNLSEAETWRHGENTSSREILINLIQAYKGLLQYYTWSEK 80
Cdd:pfam14929  51 VEIYNTFMERLKNLGVKNYLKISLEHALHLLLNGMIEEAKRNLSNAESWRYGETLMSQEKLIKLINAYKGLLDYYLWYSK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362    81 KMELSKLD--KDDYAYNAVAQDVFNHSWKTSANISALIKIPGVWDPFVKSYVEMLEFYGDRDGAQEVLTNYAYDEKFPSN 158
Cdd:pfam14929 131 KPEELQLDdfEDDFSQLNSNQEMHNYFRQAAVNLLALISTPGVWDPFVLPYVQLLEFYGDVDEALEVLNNYAYDKKFPFN 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362   159 PNAHIYLYNFLKRQKAPRSKLIS-VLKILYQIVPSHKLMLEFHTLLRKSEKEEHRKLGLEVLFGVLDFAGCTKNITAWKY 237
Cdd:pfam14929 211 PNAHVYLYQFLKRQQAPRKKLIScVLKILHQLVPSDTLMLELHRLLKKSRKEYHHKLLLEVIFLHLDFAGWKENLTAWKE 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21536362   238 LAKYLKNIL--MGNHL-AWVQEEWNSRKNWWPGFHFSYFWAKSDWKEDTALACEKAFVAGLLLGKGCRYFRYILK 309
Cdd:pfam14929 291 LAKCFKQISvkKNKHPkVFTEEEWKLRKDWWPTFHFSKFLAKSDWKENLELALYKAAVAGILLGKEFKYVKAVSS 365
 
Name Accession Description Interval E-value
TAF1_subA pfam14929
TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I ...
 1-309 3.53e-158

TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.


Pssm-ID: 434323  Cd Length: 365  Bit Score: 447.17  E-value: 3.53e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362     1 MESFNTFANRMKNIGVMNYLKISLQHALYLLHHGMLKDAKRNLSEAETWRHGENTSSREILINLIQAYKGLLQYYTWSEK 80
Cdd:pfam14929  51 VEIYNTFMERLKNLGVKNYLKISLEHALHLLLNGMIEEAKRNLSNAESWRYGETLMSQEKLIKLINAYKGLLDYYLWYSK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362    81 KMELSKLD--KDDYAYNAVAQDVFNHSWKTSANISALIKIPGVWDPFVKSYVEMLEFYGDRDGAQEVLTNYAYDEKFPSN 158
Cdd:pfam14929 131 KPEELQLDdfEDDFSQLNSNQEMHNYFRQAAVNLLALISTPGVWDPFVLPYVQLLEFYGDVDEALEVLNNYAYDKKFPFN 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21536362   159 PNAHIYLYNFLKRQKAPRSKLIS-VLKILYQIVPSHKLMLEFHTLLRKSEKEEHRKLGLEVLFGVLDFAGCTKNITAWKY 237
Cdd:pfam14929 211 PNAHVYLYQFLKRQQAPRKKLIScVLKILHQLVPSDTLMLELHRLLKKSRKEYHHKLLLEVIFLHLDFAGWKENLTAWKE 290

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21536362   238 LAKYLKNIL--MGNHL-AWVQEEWNSRKNWWPGFHFSYFWAKSDWKEDTALACEKAFVAGLLLGKGCRYFRYILK 309
Cdd:pfam14929 291 LAKCFKQISvkKNKHPkVFTEEEWKLRKDWWPTFHFSKFLAKSDWKENLELALYKAAVAGILLGKEFKYVKAVSS 365
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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