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Conserved domains on  [gi|21355885|ref|NP_648614|]
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uncharacterized protein Dmel_CG10752 [Drosophila melanogaster]

Protein Classification

BACK domain-containing protein( domain architecture ID 10657908)

BACK (BTB and C-terminal Kelch) domain-containing protein similar to Vaccinia virus Copenhagen Protein C5

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 172-264 7.23e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


:

Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 67.37  E-value: 7.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885    172 AKDMGMTQVADMMVSRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSL 251
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEH 87

                           90
                   ....*....|...
gi 21355885    252 VRFLMIPAVFILQ 264
Cdd:smart00875  88 VRLPLLSPDYLLE 100
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 366-533 5.09e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 39.89  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885  366 DALTVNESWTSENSAEDLKEPGEYNCAVGGTSSTEDLDAAPNVKQTFYTSAVELDLDLLAKNHSVFDSDLDSSESSSTTT 445
Cdd:NF033609 605 DSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 684

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885  446 SIDSFTDCKNGSGTEVNFHAEHPANSNASSFSDSTTCSGGDSETESVQDSNVACTPNLTPESPTEPATNSAEYSGTVSST 525
Cdd:NF033609 685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764


                 ....*...
gi 21355885  526 YSQTDRIS 533
Cdd:NF033609 765 DSDSDSDS 772
 
Name Accession Description Interval E-value
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 172-264 7.23e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 67.37  E-value: 7.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885    172 AKDMGMTQVADMMVSRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSL 251
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEH 87

                           90
                   ....*....|...
gi 21355885    252 VRFLMIPAVFILQ 264
Cdd:smart00875  88 VRLPLLSPDYLLE 100
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 172-265 4.81e-12

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 62.56  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885   172 AKDMGMTQVADMMVSRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSL 251
Cdd:pfam07707   8 ADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSA 87

                          90
                  ....*....|....
gi 21355885   252 VRFLMIPAVFILQW 265
Cdd:pfam07707  88 VRLPLLSPQYLLNL 101
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 188-262 1.23e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 46.94  E-value: 1.23e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355885 188 VTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVRFLMIPAVFI 262
Cdd:cd18444  30 TMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLALIRLPLLTPQFL 104
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 366-533 5.09e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 39.89  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885  366 DALTVNESWTSENSAEDLKEPGEYNCAVGGTSSTEDLDAAPNVKQTFYTSAVELDLDLLAKNHSVFDSDLDSSESSSTTT 445
Cdd:NF033609 605 DSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 684

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885  446 SIDSFTDCKNGSGTEVNFHAEHPANSNASSFSDSTTCSGGDSETESVQDSNVACTPNLTPESPTEPATNSAEYSGTVSST 525
Cdd:NF033609 685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764


                 ....*...
gi 21355885  526 YSQTDRIS 533
Cdd:NF033609 765 DSDSDSDS 772
 
Name Accession Description Interval E-value
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 172-264 7.23e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 67.37  E-value: 7.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885    172 AKDMGMTQVADMMVSRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSL 251
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEH 87

                           90
                   ....*....|...
gi 21355885    252 VRFLMIPAVFILQ 264
Cdd:smart00875  88 VRLPLLSPDYLLE 100
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 172-265 4.81e-12

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 62.56  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885   172 AKDMGMTQVADMMVSRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSL 251
Cdd:pfam07707   8 ADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSA 87

                          90
                  ....*....|....
gi 21355885   252 VRFLMIPAVFILQW 265
Cdd:pfam07707  88 VRLPLLSPQYLLNL 101
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 188-262 1.23e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 46.94  E-value: 1.23e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355885 188 VTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVRFLMIPAVFI 262
Cdd:cd18444  30 TMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLALIRLPLLTPQFL 104
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 192-259 7.66e-06

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 44.78  E-value: 7.66e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355885 192 FLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVRFLMIPA 259
Cdd:cd18466  33 FLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRKKHVVEVLEPVRFPLLPP 100
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 192-264 2.86e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 43.87  E-value: 2.86e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21355885 192 FLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVRFLMIPAVFILQ 264
Cdd:cd18512  33 FSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEHVRLPLLSREYLVQ 105
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 172-254 3.06e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 42.79  E-value: 3.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885 172 AKDMGMTQVADMMVSRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLiSNYEMRIKYIPRVLSL 251
Cdd:cd18449  13 ANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWL-RHEDDRMQFAAKLMEN 91


                ...
gi 21355885 252 VRF 254
Cdd:cd18449  92 IRF 94
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 204-259 9.28e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 41.54  E-value: 9.28e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21355885 204 MDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVRFLMIPA 259
Cdd:cd18453  36 LNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPA 91
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 192-254 3.00e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 39.98  E-value: 3.00e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21355885 192 FLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVRF 254
Cdd:cd18448  34 FNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQHRKRHLDDLLSQVRL 96
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 172-259 4.73e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 39.62  E-value: 4.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885 172 AKDMGMTQVADMMVSRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSL 251
Cdd:cd18509  14 ADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAY 93


                ....*...
gi 21355885 252 VRFLMIPA 259
Cdd:cd18509  94 IRLPLLPP 101
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 192-234 1.44e-03

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 37.39  E-value: 1.44e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21355885 192 FLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWL 234
Cdd:cd18508  32 FNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWL 74
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 177-253 4.22e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 36.96  E-value: 4.22e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21355885 177 MTQVADMMVSRvtkSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVR 253
Cdd:cd18479  21 LKQSAKRMVEH---KFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIR 94
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 366-533 5.09e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 39.89  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885  366 DALTVNESWTSENSAEDLKEPGEYNCAVGGTSSTEDLDAAPNVKQTFYTSAVELDLDLLAKNHSVFDSDLDSSESSSTTT 445
Cdd:NF033609 605 DSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 684

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885  446 SIDSFTDCKNGSGTEVNFHAEHPANSNASSFSDSTTCSGGDSETESVQDSNVACTPNLTPESPTEPATNSAEYSGTVSST 525
Cdd:NF033609 685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764


                 ....*...
gi 21355885  526 YSQTDRIS 533
Cdd:NF033609 765 DSDSDSDS 772
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 175-258 6.77e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 36.52  E-value: 6.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355885 175 MGMTQVADMMVSRV----TKSFL----VLVSNG-QFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYI 245
Cdd:cd18457   7 LGIRQFAETMMCSSlvdaANKYIqqhfIEVSKSeEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREEYL 86

                        90
                ....*....|....
gi 21355885 246 PRVLSLVRF-LMIP 258
Cdd:cd18457  87 PELLSKVRLpLLRP 100
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 186-262 8.11e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 36.29  E-value: 8.11e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355885 186 SRVTKSFLVLVSNGQFIKMDIDGACTLLRSRHLAVQNEIEIFYSALLWLISNYEMRIKYIPRVLSLVRF-LMIPAVFI 262
Cdd:cd18446  27 NYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLPLLPRVLENVRLpLLDPWYFV 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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