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Conserved domains on  [gi|21357453|ref|NP_650449|]
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uncharacterized protein Dmel_CG31301 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XTBD pfam11952
XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an ...
 34-118 1.91e-44

XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.


:

Pssm-ID: 463409  Cd Length: 85  Bit Score: 149.74  E-value: 1.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357453    34 VDSYKTEYESDEHWDLRRSFMLAHKDRFEEDRLVCLAQTFVNMEFMGCKYPSATMLLVAELSKEIAADFRQKREQRLKRT 113
Cdd:pfam11952   1 VEAYRGEWESDEHWELRREFIERHKDDFPEDRLLSLAQVFANMEFLGCRYPQEVMEKVAELAEGIAAEVREAPKFKLTRT 80


                  ....*
gi 21357453   114 FVSAS 118
Cdd:pfam11952  81 FVSAS 85
R3H_NRF cd02640
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB ...
 331-390 9.47e-27

R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


:

Pssm-ID: 100069  Cd Length: 60  Bit Score: 101.70  E-value: 9.47e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357453 331 FADYRRLIENYVRSDDIRDMQFEPTFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd02640   1 KNDYRQIIQNYAHSDDIRDMVFSPEFSKEERALIHQIAQKYGLKSRSYGSGNDRYLVISK 60
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 280-323 2.30e-08

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


:

Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 49.85  E-value: 2.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 21357453    280 LDPSNKGYRMMRLMGW-TGGGLGRLKQGREEPVCYLLKNNRNGLG 323
Cdd:smart00443   1 ISTSNIGAKLLRKMGWkEGQGLGKNEQGIVEPISAEIKKDRKGLG 45
 
Name Accession Description Interval E-value
XTBD pfam11952
XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an ...
 34-118 1.91e-44

XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.


Pssm-ID: 463409  Cd Length: 85  Bit Score: 149.74  E-value: 1.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357453    34 VDSYKTEYESDEHWDLRRSFMLAHKDRFEEDRLVCLAQTFVNMEFMGCKYPSATMLLVAELSKEIAADFRQKREQRLKRT 113
Cdd:pfam11952   1 VEAYRGEWESDEHWELRREFIERHKDDFPEDRLLSLAQVFANMEFLGCRYPQEVMEKVAELAEGIAAEVREAPKFKLTRT 80


                  ....*
gi 21357453   114 FVSAS 118
Cdd:pfam11952  81 FVSAS 85
R3H_NRF cd02640
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB ...
 331-390 9.47e-27

R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100069  Cd Length: 60  Bit Score: 101.70  E-value: 9.47e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357453 331 FADYRRLIENYVRSDDIRDMQFEPTFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd02640   1 KNDYRQIIQNYAHSDDIRDMVFSPEFSKEERALIHQIAQKYGLKSRSYGSGNDRYLVISK 60
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 280-323 2.30e-08

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 49.85  E-value: 2.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 21357453    280 LDPSNKGYRMMRLMGW-TGGGLGRLKQGREEPVCYLLKNNRNGLG 323
Cdd:smart00443   1 ISTSNIGAKLLRKMGWkEGQGLGKNEQGIVEPISAEIKKDRKGLG 45
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 282-327 4.02e-08

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 49.04  E-value: 4.02e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21357453   282 PSNKGYRMMRLMGWT-GGGLGRLKQGREEPVcyLLKNNRNGLGLINP 327
Cdd:pfam01585   1 TSNIGFKLLQKMGWKeGQGLGKNEQGIAEPI--EAKIKKDRRGLGAE 45
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 333-390 1.42e-07

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 47.87  E-value: 1.42e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 21357453   333 DYRRLIENYVRSDDiRDMQFEPtFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:pfam01424   5 QLAEKLAEFVKDTG-KSLELPP-MSSYERRIIHELAQKYGLESESEGEEPNRRVVVYK 60
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
338-391 3.52e-06

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 44.60  E-value: 3.52e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21357453    338 IENYVRSDdIRDMQFEPtFSKEERTTLHQIARQFGLRSASYGSGESRRLLITKK 391
Cdd:smart00393  28 IARFVKST-KESVELPP-MNSYERKIVHELAEKYGLESESFGEGPKRRVVISKK 79
 
Name Accession Description Interval E-value
XTBD pfam11952
XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an ...
 34-118 1.91e-44

XRN-Two Binding Domain, XTBD; XTBD is a family of eukaryotic proteins that act as an XRN2-binding module. XRN2 is an essential exoribonuclease in eukaryotes that processes and degrades a number of different substrates. XTBD is found on a number of different proteins to link them to XRN, such as PAXT-1.


Pssm-ID: 463409  Cd Length: 85  Bit Score: 149.74  E-value: 1.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357453    34 VDSYKTEYESDEHWDLRRSFMLAHKDRFEEDRLVCLAQTFVNMEFMGCKYPSATMLLVAELSKEIAADFRQKREQRLKRT 113
Cdd:pfam11952   1 VEAYRGEWESDEHWELRREFIERHKDDFPEDRLLSLAQVFANMEFLGCRYPQEVMEKVAELAEGIAAEVREAPKFKLTRT 80


                  ....*
gi 21357453   114 FVSAS 118
Cdd:pfam11952  81 FVSAS 85
R3H_NRF cd02640
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB ...
 331-390 9.47e-27

R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100069  Cd Length: 60  Bit Score: 101.70  E-value: 9.47e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357453 331 FADYRRLIENYVRSDDIRDMQFEPTFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd02640   1 KNDYRQIIQNYAHSDDIRDMVFSPEFSKEERALIHQIAQKYGLKSRSYGSGNDRYLVISK 60
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 333-390 7.20e-11

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 57.24  E-value: 7.20e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21357453 333 DYRRLIENYVRSDDIRDMQFEPTfSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd02325   3 EREEELEAFAKDAAGKSLELPPM-NSYERKLIHDLAEYYGLKSESEGEGPNRRVVITK 59
R3H_Smubp-2_like cd02641
R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and ...
 334-390 1.65e-10

R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.


Pssm-ID: 100070  Cd Length: 60  Bit Score: 56.59  E-value: 1.65e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21357453 334 YRRLIENYVRSDDIRDMQFEPTFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd02641   4 LKAMVKAFMKDPKATELEFPPTLSSHDRLLVHELAEELGLRHESTGEGSDRVITVSK 60
R3H_DEXH_helicase cd06007
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may ...
 343-390 1.98e-09

R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may function as ATP-dependent DNA or RNA helicases. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100077  Cd Length: 59  Bit Score: 53.47  E-value: 1.98e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21357453 343 RSDDIRDMQFEPTFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd06007  12 RASDNEEYEFPSSLTNHERAVIHRLCRKLGLKSKSKGKGSNRRLSVYK 59
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 280-323 2.30e-08

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 49.85  E-value: 2.30e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 21357453    280 LDPSNKGYRMMRLMGW-TGGGLGRLKQGREEPVCYLLKNNRNGLG 323
Cdd:smart00443   1 ISTSNIGAKLLRKMGWkEGQGLGKNEQGIVEPISAEIKKDRKGLG 45
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 282-327 4.02e-08

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 49.04  E-value: 4.02e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21357453   282 PSNKGYRMMRLMGWT-GGGLGRLKQGREEPVcyLLKNNRNGLGLINP 327
Cdd:pfam01585   1 TSNIGFKLLQKMGWKeGQGLGKNEQGIAEPI--EAKIKKDRRGLGAE 45
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 333-390 1.42e-07

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 47.87  E-value: 1.42e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 21357453   333 DYRRLIENYVRSDDiRDMQFEPtFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:pfam01424   5 QLAEKLAEFVKDTG-KSLELPP-MSSYERRIIHELAQKYGLESESEGEEPNRRVVVYK 60
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
338-391 3.52e-06

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 44.60  E-value: 3.52e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21357453    338 IENYVRSDdIRDMQFEPtFSKEERTTLHQIARQFGLRSASYGSGESRRLLITKK 391
Cdd:smart00393  28 IARFVKST-KESVELPP-MNSYERKIVHELAEKYGLESESFGEGPKRRVVISKK 79
R3H_RRM cd02639
R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) ...
 343-390 1.06e-03

R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) domain. Present in this group is the RNA-binding post-transcriptional regulator Cip2 (Csx1-interacting protein 2) involved in counteracting Csx1 function. Csx1 plays a central role in controlling gene expression during oxidative stress. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100068  Cd Length: 60  Bit Score: 37.28  E-value: 1.06e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 21357453 343 RSDDIRD-MQFEPTFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd02639  12 KDDRMRDeLAFPSSLSPAERRIVHLLASRLGLNHVSDGTGERRQVQITK 60
R3H_AAA cd02645
R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) ...
 343-388 1.99e-03

R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100074  Cd Length: 60  Bit Score: 36.49  E-value: 1.99e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 21357453 343 RSDDIRDMQfeptfskeerttlHQIARQFGLRSASYGSGESRRLLI 388
Cdd:cd02645  26 RSAYIRRLQ-------------HDLVERYQLRSESFGSEPNRRLRI 58
R3H_G-patch cd02646
R3H domain of a group of fungal and plant proteins with unknown function, who also contain a ...
 338-390 8.69e-03

R3H domain of a group of fungal and plant proteins with unknown function, who also contain a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the R3H domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100075  Cd Length: 58  Bit Score: 34.47  E-value: 8.69e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 21357453 338 IENYVRSDDIRdMQFePTFSKEERTTLHQIARQFGLRSASYGSGESRRLLITK 390
Cdd:cd02646   8 IEAFLLDSRDS-LSF-PPMDKHGRKTIHKLANCYNLKSKSRGKGKKRFVTVTK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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