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Conserved domains on  [gi|154091032|ref|NP_653191|]
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ankyrin repeat domain-containing protein 22 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-191 1.04e-29

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.81  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  33 NVQDGfNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKftfidylliillmpvlligyflmvsktk 112
Cdd:COG0666  114 NARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---------------------------- 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 154091032 113 qNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQIELMLRKAL 191
Cdd:COG0666  165 -NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-191 1.04e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.81  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  33 NVQDGfNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKftfidylliillmpvlligyflmvsktk 112
Cdd:COG0666  114 NARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---------------------------- 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 154091032 113 qNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQIELMLRKAL 191
Cdd:COG0666  165 -NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-175 1.65e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.77  E-value: 1.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  39 NGDTPLICA--CRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKkkftfidYLLIILLMPVLLIGYFLMV-SKTKqne 115
Cdd:PHA03100 105 NGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLE-------SNKIDLKILKLLIDKGVDInAKNR--- 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032 116 alVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:PHA03100 175 --VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
Ank_2 pfam12796
Ankyrin repeats (3 copies);
44-165 4.15e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 4.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032   44 LICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIdylliillmpvlligyflmvsktkqnealVRMLLD 123
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEI-----------------------------VKLLLE 51

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 154091032  124 aGVEVNATDcYGCTALHYACEMKNQSLIPLLLEARADPTIKN 165
Cdd:pfam12796  52 -HADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 39-68 2.70e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.70e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 154091032    39 NGDTPLICACRRGHVRIVSFLLRRNANVNL 68
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 36-175 1.57e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.54  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  36 DGFNGDTPLICACRRGHVRIVSFLLRRNANVnlknQKER---TCLHYAVKKKFTFIDYLLIIllmpvlligyflmvSKTK 112
Cdd:cd22192   85 DLYQGETALHIAVVNQNLNLVRELIARGADV----VSPRatgTFFRPGPKNLIYYGEHPLSF--------------AACV 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154091032 113 QNEALVRMLLDAGVEVNATDCYGCTALH---------YACEMKNqsLIpLLLEARADP----TIKNKHGESSLDIA 175
Cdd:cd22192  147 GNEEIVRLLIEHGADIRAQDSLGNTVLHilvlqpnktFACQMYD--LI-LSYDKEDDLqpldLVPNNQGLTPFKLA 219
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-191 1.04e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.81  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  33 NVQDGfNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKftfidylliillmpvlligyflmvsktk 112
Cdd:COG0666  114 NARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG---------------------------- 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 154091032 113 qNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQIELMLRKAL 191
Cdd:COG0666  165 -NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-191 2.12e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 2.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  33 NVQDGfNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKftfidylliillmpvlligyflmvsktk 112
Cdd:COG0666  147 NAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG---------------------------- 197

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 154091032 113 qNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQIELMLRKAL 191
Cdd:COG0666  198 -HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-175 3.81e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.69  E-value: 3.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  31 YANVQDGFNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLLIILLMPVLLIGYF----L 106
Cdd:COG0666   45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDgetpL 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 154091032 107 MVSKTKQNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:COG0666  125 HLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-175 1.65e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.77  E-value: 1.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  39 NGDTPLICA--CRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKkkftfidYLLIILLMPVLLIGYFLMV-SKTKqne 115
Cdd:PHA03100 105 NGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLE-------SNKIDLKILKLLIDKGVDInAKNR--- 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032 116 alVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:PHA03100 175 --VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
Ank_2 pfam12796
Ankyrin repeats (3 copies);
44-165 4.15e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 4.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032   44 LICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIdylliillmpvlligyflmvsktkqnealVRMLLD 123
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEI-----------------------------VKLLLE 51

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 154091032  124 aGVEVNATDcYGCTALHYACEMKNQSLIPLLLEARADPTIKN 165
Cdd:pfam12796  52 -HADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 42-189 1.81e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 1.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  42 TPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLLII-----LLMPVLLIgyflmvsktkqNEA 116
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDngvdtSILPIPCI-----------EKD 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154091032 117 LVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQ-IELMLRK 189
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDiIKLLLEK 179
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 42-172 1.34e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.31  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  42 TPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKftFIDYLLIILLMPVLLIGYFLMVSKTKQNEALVRML 121
Cdd:PHA02876 180 TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSK--NIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSL 257

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 154091032 122 L--DAGVEVNATDCYGCTALHYACEMKNQS-LIPLLLEARADPTIKNKHGESSL 172
Cdd:PHA02876 258 LlyDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPL 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
9-132 1.37e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032    9 ICQAAYQNDFGQVWRWVKEDSSyANVQDGfNGDTPLICACRRGHVRIVSFLLrRNANVNLKNQKeRTCLHYAVKKKftfi 88
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD-ANLQDK-NGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNG-RTALHYAARSG---- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 154091032   89 dylliillmpvlligyflmvsktkqNEALVRMLLDAGVEVNATD 132
Cdd:pfam12796  73 -------------------------HLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 118-188 5.40e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 5.40e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154091032 118 VRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQI-ELMLR 188
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVvQLLSR 169
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 33-175 5.49e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 5.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  33 NVQDgFNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKkkftFIDYLLIILL-------MPVLLIGYF 105
Cdd:PHA02874 151 NIED-DNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAE----YGDYACIKLLidhgnhiMNKCKNGFT 225

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154091032 106 LMVSKTKQNEALVRMLLDaGVEVNATDCYGCTALHYACEMK-NQSLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:PHA02874 226 PLHNAIIHNRSAIELLIN-NASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA03095 PHA03095
ankyrin-like protein; Provisional
 39-174 1.23e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  39 NGDTPLIC-ACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTfidylliillmpvlligyflmvsktkqNEAL 117
Cdd:PHA03095  82 CGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNI---------------------------NPKV 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154091032 118 VRMLLDAGVEVNATDCYGCTALHyaCEMKNQ----SLIPLLLEARADPTIKNKHGESSLDI 174
Cdd:PHA03095 135 IRLLLRKGADVNALDLYGMTPLA--VLLKSRnanvELLRLLIDAGADVYAVDDRFRSLLHH 193
Ank_5 pfam13857
Ankyrin repeats (many copies);
121-175 5.96e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 5.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154091032  121 LLDAG-VEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 45-189 4.04e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.25  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  45 ICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYavkkkftfidylliillmpvlligyfLMVSKTKQNEALVRMLLDA 124
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHL--------------------------YLHYSSEKVKDIVRLLLEA 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 154091032 125 GVEVNATDCYGCTALH-YACEMKNQSLIPLLLEARADPTIKNKHGESSLDI---ARRLKFSQIELMLRK 189
Cdd:PHA03095  73 GADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylsGFNINPKVIRLLLRK 141
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
88-175 4.68e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.80  E-value: 4.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  88 IDYLLIILLMPVLLIGYFLMVSKTKQNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKH 167
Cdd:COG0666   40 LLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119


                 ....*...
gi 154091032 168 GESSLDIA 175
Cdd:COG0666  120 GETPLHLA 127
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 54-165 8.61e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.34  E-value: 8.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  54 RIVSFLLRRNANVNLKNQ-KERTCLHYAVKKKFTFIDYLLII----LLMPVLLIGYFLMVSKTKQNEALVRMLLDAGVEV 128
Cdd:PHA02878 148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSyganVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 154091032 129 NATDCYGCTALHYAC-EMKNQSLIPLLLEARADPTIKN 165
Cdd:PHA02878 228 DARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKS 265
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 39-70 1.01e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.43  E-value: 1.01e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 154091032   39 NGDTPLICAC-RRGHVRIVSFLLRRNANVNLKN 70
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-175 1.04e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  32 ANVQD-GFNGDTPL-ICAC-RRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKkkFTFIDYLLIILLMPVL-------- 100
Cdd:PHA03095 108 ADVNAkDKVGRTPLhVYLSgFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLK--SRNANVELLRLLIDAGadvyavdd 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032 101 ----LIGYFLMVSKTkqNEALVRMLLDAGVEVNATDCYGCTALHYACEMKN--QSLIPLLLEARADPTIKNKHGESSLDI 174
Cdd:PHA03095 186 rfrsLLHHHLQSFKP--RARIVRELIRAGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARNRYGQTPLHY 263


                 .
gi 154091032 175 A 175
Cdd:PHA03095 264 A 264
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 39-94 1.05e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.74  E-value: 1.05e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 154091032  39 NGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLLII 94
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 39-163 1.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.68  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  39 NGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLLIILLMPVLL---IGYF-LMVSKTKQN 114
Cdd:PHA02875 101 DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIedcCGCTpLIIAMAKGD 180

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 154091032 115 EALVRMLLDAGVEVNATDCYGC-TALHYACEMKNQSLIPLLLEARADPTI 163
Cdd:PHA02875 181 IAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 106-175 2.40e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 2.40e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154091032 106 LMVSKTKQNEALV-RMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:PHA02876 148 LIKERIQQDELLIaEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECA 218
Ank_2 pfam12796
Ankyrin repeats (3 copies);
114-175 2.82e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.95  E-value: 2.82e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154091032  114 NEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEaRADPTIKNkHGESSLDIA 175
Cdd:pfam12796   9 NLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYA 68
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 55-190 3.92e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.11  E-value: 3.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  55 IVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLLIILLMPVLLI---GYFLMVSKTKQNE-ALVRMLLDAGVEVNA 130
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEddnGCYPIHIAIKHNFfDIIKLLLEKGAYANV 185

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032 131 TDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQIELMLRKA 190
Cdd:PHA02874 186 KDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNA 245
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 55-172 5.55e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 5.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  55 IVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDylliillmpvlligyflmvsktkqNEALVRMLLDAGVEVNATDCY 134
Cdd:PHA03100  50 VVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTD------------------------VKEIVKLLLEYGANVNAPDNN 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 154091032 135 GCTALHYACEMKNQS--LIPLLLEARADPTIKNKHGESSL 172
Cdd:PHA03100 106 GITPLLYAISKKSNSysIVEYLLDNGANVNIKNSDGENLL 145
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 55-175 1.20e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.05  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  55 IVSFLLRRNANVNLKNQKERTCLHYAVKKKF-----TFIDYLLIILLMPvLLIGYFLMVSKTKQNEAL-VRMLLDAGVEV 128
Cdd:PHA02876 357 IVITLLELGANVNARDYCDKTPIHYAAVRNNvviinTLLDYGADIEALS-QKIGTALHFALCGTNPYMsVKTLIDRGANV 435

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 154091032 129 NATDCYGCTALHYACEMKNQ-SLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:PHA02876 436 NSKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIA 483
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 33-175 1.46e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  33 NVQDGFNgDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVkkkftfidylliillmpvlliGYFLmvsktk 112
Cdd:PHA02878 195 NIPDKTN-NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV---------------------GYCK------ 246

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154091032 113 qNEALVRMLLDAGVEVNA-TDCYGCTALHYAceMKNQSLIPLLLEARADPTIKNKHGESSLDIA 175
Cdd:PHA02878 247 -DYDILKLLLEHGVDVNAkSYILGLTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPLSSA 307
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 41-160 1.98e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  41 DTPLICACRRGHV-RIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLLIILL------MPVLLIGYFLMVSKTKQ 113
Cdd:PHA02876 274 NTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLgadvnaADRLYITPLHQASTLDR 353

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 154091032 114 NEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARAD 160
Cdd:PHA02876 354 NKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 39-68 2.70e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.70e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 154091032    39 NGDTPLICACRRGHVRIVSFLLRRNANVNL 68
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-155 3.88e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 3.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 154091032  114 NEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLL 155
Cdd:pfam13637  13 HLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
5-60 4.52e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 4.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154091032    5 YSEPICQAAYQNDFgQVWRWVKEDSSYANVQDGfNGDTPLICACRRGHVRIVSFLL 60
Cdd:pfam13637   1 ELTALHAAAASGHL-ELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 36-175 1.57e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.54  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  36 DGFNGDTPLICACRRGHVRIVSFLLRRNANVnlknQKER---TCLHYAVKKKFTFIDYLLIIllmpvlligyflmvSKTK 112
Cdd:cd22192   85 DLYQGETALHIAVVNQNLNLVRELIARGADV----VSPRatgTFFRPGPKNLIYYGEHPLSF--------------AACV 146

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154091032 113 QNEALVRMLLDAGVEVNATDCYGCTALH---------YACEMKNqsLIpLLLEARADP----TIKNKHGESSLDIA 175
Cdd:cd22192  147 GNEEIVRLLIEHGADIRAQDSLGNTVLHilvlqpnktFACQMYD--LI-LSYDKEDDLqpldLVPNNQGLTPFKLA 219
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 134-166 2.06e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 154091032  134 YGCTALHYACEMKNQ-SLIPLLLEARADPTIKNK 166
Cdd:pfam00023   1 DGNTPLHLAAGRRGNlEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 40-178 3.53e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.62  E-value: 3.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  40 GDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKKKFTFIDYLL--IILLMPVLLIGYFLMVSKTKQNEAL 117
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAAGDLLCTAAKRNDLTA 637

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154091032 118 VRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRL 178
Cdd:PLN03192 638 MKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPTELREL 698
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 5-172 5.20e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.42  E-value: 5.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032   5 YSEPICQAAYQNDFGQVWRWVKedssYANVQDGFNgDTPLICACRRGHV--RIVSFLLRRNANVNLKNQkertclHYAVK 82
Cdd:PHA02859  21 YCNPLFYYVEKDDIEGVKKWIK----FVNDCNDLY-ETPIFSCLEKDKVnvEILKFLIENGADVNFKTR------DNNLS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  83 kkftfidylliillmpvlLIGYFLMVSKTkQNEALVRMLLDAGVEVNATDCYGCTALH-YACEMK-NQSLIPLLLEARAD 160
Cdd:PHA02859  90 ------------------ALHHYLSFNKN-VEPEILKILIDSGSSITEEDEDGKNLLHmYMCNFNvRINVIKLLIDSGVS 150

                        170
                 ....*....|..
gi 154091032 161 PTIKNKHGESSL 172
Cdd:PHA02859 151 FLNKDFDNNNIL 162
Ank_4 pfam13637
Ankyrin repeats (many copies);
40-92 5.27e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 5.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 154091032   40 GDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKK-KFTFIDYLL 92
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNgNVEVLKLLL 54
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 39-67 1.15e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*....
gi 154091032   39 NGDTPLICACRRGHVRIVSFLLRRNANVN 67
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-187 1.23e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 38.82  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  38 FNGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYAVKK-KFTFIDYLLiillmpvlLIGYF----------- 105
Cdd:PHA02875  33 YDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEgDVKAVEELL--------DLGKFaddvfykdgmt 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032 106 -LMVSKTKQNEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSLDIARRLKFSQIE 184
Cdd:PHA02875 105 pLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAIC 184


                 ...
gi 154091032 185 LML 187
Cdd:PHA02875 185 KML 187
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 117-172 1.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.71  E-value: 1.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 154091032 117 LVRMLLDAGVEVNATDCY-GCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSL 172
Cdd:PHA02878 149 ITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPL 205
PHA02946 PHA02946
ankyin-like protein; Provisional
 114-172 3.03e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 37.73  E-value: 3.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 154091032 114 NEALVRMLLDAGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSL 172
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPL 109
Ank_5 pfam13857
Ankyrin repeats (many copies);
25-80 5.42e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 33.86  E-value: 5.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154091032   25 VKEDSSYANVQDGFnGDTPLICACRRGHVRIVSFLLRRNANVNLKNQKERTCLHYA 80
Cdd:pfam13857   2 LEHGPIDLNRLDGE-GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02798 PHA02798
ankyrin-like protein; Provisional
 53-172 7.55e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 36.35  E-value: 7.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154091032  53 VRIVSFLLRRNANVNLKNQKER-TCLHYAVKKKFTFIDYLLIILLMPV-LLIGYFLMVSKTKQNEALVRMLLD------- 123
Cdd:PHA02798 161 IEIIKLLLEKGVDINTHNNKEKyDTLHCYFKYNIDRIDADILKLFVDNgFIINKENKSHKKKFMEYLNSLLYDnkrfkkn 240

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 154091032 124 ------AGVEVNATDCYGCTALHYACEMKNQSLIPLLLEARADPTIKNKHGESSL 172
Cdd:PHA02798 241 ildfifSYIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGNTCL 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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