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Conserved domains on  [gi|40255060|ref|NP_653208|]
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cytochrome b5 domain-containing protein 1 isoform 1 [Homo sapiens]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 21-70 2.58e-10

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 54.93  E-value: 2.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 40255060    21 TPAEVAQHNRPEDLWVSYLGRVYDLTSLAQEYKGnlLLKPIVEVAGQDIS 70
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPG--GEDVILSAAGKDAT 48
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 21-70 2.58e-10

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 54.93  E-value: 2.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 40255060    21 TPAEVAQHNRPEDLWVSYLGRVYDLTSLAQEYKGnlLLKPIVEVAGQDIS 70
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPG--GEDVILSAAGKDAT 48
PLN02252 PLN02252
nitrate reductase [NADPH]
 18-74 4.17e-04

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 40.82  E-value: 4.17e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 40255060   18 RYFTPAEVAQHNRPEDLWVSYLGRVYDLTSLAQEYKGNllLKPIVEVAGQDISHWFD 74
Cdd:PLN02252 518 KQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGG--ADSILINAGTDCTEEFD 572
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 21-70 2.58e-10

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 54.93  E-value: 2.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 40255060    21 TPAEVAQHNRPEDLWVSYLGRVYDLTSLAQEYKGnlLLKPIVEVAGQDIS 70
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPG--GEDVILSAAGKDAT 48
PLN02252 PLN02252
nitrate reductase [NADPH]
 18-74 4.17e-04

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 40.82  E-value: 4.17e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 40255060   18 RYFTPAEVAQHNRPEDLWVSYLGRVYDLTSLAQEYKGNllLKPIVEVAGQDISHWFD 74
Cdd:PLN02252 518 KQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGG--ADSILINAGTDCTEEFD 572
PLN03198 PLN03198
delta6-acyl-lipid desaturase; Provisional
 23-77 1.87e-03

delta6-acyl-lipid desaturase; Provisional


Pssm-ID: 178739 [Multi-domain]  Cd Length: 526  Bit Score: 38.90  E-value: 1.87e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 40255060   23 AEVAQHNRPEDLWVSYLGRVYDLTSLAQEYKGNLLLKPIVEVAGQDISHWFDPKT 77
Cdd:PLN03198 109 SEVAAHNKPNDCWIVIKNKVYDVSDFAAEHPGGSVISTYFGRDGTDAFSSFHAAS 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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