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Conserved domains on  [gi|21389421|ref|NP_653212|]
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neuferricin isoform 1 precursor [Homo sapiens]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 40-101 6.59e-11

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 56.86  E-value: 6.59e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21389421    40 PEELSRYRGgpgDPGLYLALLGRVYDVSSGRRHYE-PGSHYSGFAGRDASRAFVTGDCSEAGL 101
Cdd:pfam00173   2 LEELSKHNG---DGDCWVAINGKVYDVTKFLKEHPgGEDVILSAAGKDATDAFEAIGHSEDAA 61
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 40-101 6.59e-11

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 56.86  E-value: 6.59e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21389421    40 PEELSRYRGgpgDPGLYLALLGRVYDVSSGRRHYE-PGSHYSGFAGRDASRAFVTGDCSEAGL 101
Cdd:pfam00173   2 LEELSKHNG---DGDCWVAINGKVYDVTKFLKEHPgGEDVILSAAGKDATDAFEAIGHSEDAA 61
COG4892 COG4892
Predicted heme/steroid binding protein [General function prediction only];
36-91 1.85e-06

Predicted heme/steroid binding protein [General function prediction only];


Pssm-ID: 443920 [Multi-domain]  Cd Length: 75  Bit Score: 44.82  E-value: 1.85e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21389421  36 RLFIPEELSRYRGGPGDPgLYLALLGRVYDVsSGRRHYEPGSHYSGFAGRDASRAF 91
Cdd:COG4892   2 KEFTLEELAKYNGKDGNP-AYVAVNGKVYDV-TNSRLWKNGTHYGHWAGQDLTDEL 55
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 40-101 6.59e-11

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 56.86  E-value: 6.59e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21389421    40 PEELSRYRGgpgDPGLYLALLGRVYDVSSGRRHYE-PGSHYSGFAGRDASRAFVTGDCSEAGL 101
Cdd:pfam00173   2 LEELSKHNG---DGDCWVAINGKVYDVTKFLKEHPgGEDVILSAAGKDATDAFEAIGHSEDAA 61
COG4892 COG4892
Predicted heme/steroid binding protein [General function prediction only];
36-91 1.85e-06

Predicted heme/steroid binding protein [General function prediction only];


Pssm-ID: 443920 [Multi-domain]  Cd Length: 75  Bit Score: 44.82  E-value: 1.85e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21389421  36 RLFIPEELSRYRGGPGDPgLYLALLGRVYDVsSGRRHYEPGSHYSGFAGRDASRAF 91
Cdd:COG4892   2 KEFTLEELAKYNGKDGNP-AYVAVNGKVYDV-TNSRLWKNGTHYGHWAGQDLTDEL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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