NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21450139|ref|NP_659039|]
View 

photoreceptor ankyrin repeat protein isoform 1 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-139 3.05e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 3.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139   7 QTGLMVACYHGFGSIVALLsccpfL----DVNQQDKDGNTALMLAAQAGHMSLVTLLLNyfAGLDLERRDQRGLTALMKA 82
Cdd:COG0666 121 ETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLA 193

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21450139  83 AIQDRSECVVALLMAGADLSSVDPvRGKTALEWAVLTDSFDTAQKIRQLLRRPQAEQ 139
Cdd:COG0666 194 AENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-139 3.05e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 3.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139   7 QTGLMVACYHGFGSIVALLsccpfL----DVNQQDKDGNTALMLAAQAGHMSLVTLLLNyfAGLDLERRDQRGLTALMKA 82
Cdd:COG0666 121 ETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLA 193

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21450139  83 AIQDRSECVVALLMAGADLSSVDPvRGKTALEWAVLTDSFDTAQKIRQLLRRPQAEQ 139
Cdd:COG0666 194 AENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-105 3.36e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 3.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139    10 LMVACYHGFGSIVALLSCCPFlDVNQQDKDGNTALMLAAQAGHMSLVTLLLNYFAGldleRRDQRGLTALMKAAIQDRSE 89
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 21450139    90 CVVALLMAGADLSSVD 105
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-134 6.05e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139   32 DVNQQDKDGNTAL--MLAAQAGHMSLVTLLLNyfAGLDLERRDQRGLTALmkaAIQDRS-----ECVVALLMAGADLSSV 104
Cdd:PHA03095 109 DVNAKDKVGRTPLhvYLSGFNINPKVIRLLLR--KGADVNALDLYGMTPL---AVLLKSrnanvELLRLLIDAGADVYAV 183

                         90       100       110
                 ....*....|....*....|....*....|.
gi 21450139  105 DpVRGKTALEwaVLTDSFDT-AQKIRQLLRR 134
Cdd:PHA03095 184 D-DRFRSLLH--HHLQSFKPrARIVRELIRA 211
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 39-68 1.88e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 21450139     39 DGNTALMLAAQAGHMSLVTLLLNYFAGLDL 68
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-139 3.05e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 3.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139   7 QTGLMVACYHGFGSIVALLsccpfL----DVNQQDKDGNTALMLAAQAGHMSLVTLLLNyfAGLDLERRDQRGLTALMKA 82
Cdd:COG0666 121 ETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAAANGNLEIVKLLLE--AGADVNARDNDGETPLHLA 193

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21450139  83 AIQDRSECVVALLMAGADLSSVDPvRGKTALEWAVLTDSFDTAQKIRQLLRRPQAEQ 139
Cdd:COG0666 194 AENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-126 3.33e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 97.33  E-value: 3.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139   1 METLESQTGLMVACYHGFGSIVALLsccpfL----DVNQQDKDGNTALMLAAQAGHMSLVTLLLNyfAGLDLERRDQRGL 76
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLL-----LeagaDVNARDKDGETPLHLAAYNGNLEIVKLLLE--AGADVNAQDNDGN 154

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21450139  77 TALMKAAIQDRSECVVALLMAGADLSSVDPvRGKTALEWAVLTDSFDTAQ 126
Cdd:COG0666 155 TPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVK 203
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-105 3.36e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 3.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139    10 LMVACYHGFGSIVALLSCCPFlDVNQQDKDGNTALMLAAQAGHMSLVTLLLNYFAGldleRRDQRGLTALMKAAIQDRSE 89
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 21450139    90 CVVALLMAGADLSSVD 105
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-126 7.56e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 7.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139  10 LMVACYHGFGSIVALLSCCPFLDVNQQDKDGNTALMLAAQAGHMSLVTLLLNyfAGLDLERRDQRGLTALMKAAIQDRSE 89
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE--AGADVNARDKDGETPLHLAAYNGNLE 134

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21450139  90 CVVALLMAGADLSSVDPvRGKTALEWAVLTDSFDTAQ 126
Cdd:COG0666 135 IVKLLLEAGADVNAQDN-DGNTPLHLAAANGNLEIVK 170
Ank_2 pfam12796
Ankyrin repeats (3 copies);
44-126 1.10e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.91  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139    44 LMLAAQAGHMSLVTLLLNYfaGLDLERRDQRGLTALMKAAIQDRSECVvALLMAGADLSSVDpvRGKTALEWAVLTDSFD 123
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN--GADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKD--NGRTALHYAARSGHLE 75


                  ...
gi 21450139   124 TAQ 126
Cdd:pfam12796  76 IVK 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
7-72 1.07e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.07e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21450139     7 QTGLMVACYHGFGSIVALLscCPFLDVNQQDkDGNTALMLAAQAGHMSLVTLLLNYfaGLDLERRD 72
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLL--LEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEK--GADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-126 1.57e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.96  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139  21 IVALLSCCPFLDVNQQDKDGNTALMLAAQAGHMSLVTLLLNyfAGLDLERRDQRGLTALMKAAIQDRSECVVALLMAGAD 100
Cdd:COG0666  35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLA--AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD 112

                        90       100
                ....*....|....*....|....*.
gi 21450139 101 LSSVDPvRGKTALEWAVLTDSFDTAQ 126
Cdd:COG0666 113 VNARDK-DGETPLHLAAYNGNLEIVK 137
Ank_5 pfam13857
Ankyrin repeats (many copies);
59-116 8.06e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 8.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 21450139    59 LLNYFaGLDLERRDQRGLTALMKAAIQDRSECVVALLMAGADLSSVDPvRGKTALEWA 116
Cdd:pfam13857   1 LLEHG-PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDE-EGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
24-79 2.83e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 2.83e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21450139    24 LLSCCPfLDVNQQDKDGNTALMLAAQAGHMSLVTLLLNYfaGLDLERRDQRGLTAL 79
Cdd:pfam13857   1 LLEHGP-IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY--GVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
40-95 3.44e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 3.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 21450139    40 GNTALMLAAQAGHMSLVTLLLNYfaGLDLERRDQRGLTALMKAAIQDRSECVVALL 95
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK--GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-134 6.05e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139   32 DVNQQDKDGNTAL--MLAAQAGHMSLVTLLLNyfAGLDLERRDQRGLTALmkaAIQDRS-----ECVVALLMAGADLSSV 104
Cdd:PHA03095 109 DVNAKDKVGRTPLhvYLSGFNINPKVIRLLLR--KGADVNALDLYGMTPL---AVLLKSrnanvELLRLLIDAGADVYAV 183

                         90       100       110
                 ....*....|....*....|....*....|.
gi 21450139  105 DpVRGKTALEwaVLTDSFDT-AQKIRQLLRR 134
Cdd:PHA03095 184 D-DRFRSLLH--HHLQSFKPrARIVRELIRA 211
Ank_4 pfam13637
Ankyrin repeats (many copies);
10-60 1.20e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 21450139    10 LMVACYHG-FGSIVALLscCPFLDVNQQDKDGNTALMLAAQAGHMSLVTLLL 60
Cdd:pfam13637   5 LHAAAASGhLELLRLLL--EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
79-144 4.60e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.56  E-value: 4.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21450139    79 LMKAAIQDRSECVVALLMAGADLSSVDPvRGKTALEWAVLTDSFDTaqkIRQLLRRPQAE-----QLSLHY 144
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEI---VKLLLEHADVNlkdngRTALHY 67
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-138 6.80e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.16  E-value: 6.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139   32 DVNQQDKDGNTALMLAAqAGHMSLVTLLLNYF-AGLDLERRDQRGLTALMKAAIQDRSECVVALLMAGADLSSVDPvRGK 110
Cdd:PHA03095 214 DPAATDMLGNTPLHSMA-TGSSCKRSLVLPLLiAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSS-DGN 291

                         90       100       110
                 ....*....|....*....|....*....|.
gi 21450139  111 TALEWAVL---TDSFDTAqkirqLLRRPQAE 138
Cdd:PHA03095 292 TPLSLMVRnnnGRAVRAA-----LAKNPSAE 317
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 39-72 9.26e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 9.26e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 21450139    39 DGNTALMLAA-QAGHMSLVTLLLNYFAglDLERRD 72
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGA--DVNARD 33
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 7-105 1.13e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.62  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450139    7 QTGLMVACYHGFGSIVALL---SCcpflDVNQQDKDGNTALMLAAQAGHMSLVTLLLNYFA------------------- 64
Cdd:PLN03192 559 RTPLHIAASKGYEDCVLVLlkhAC----NVHIRDANGNTALWNAISAKHHKIFRILYHFASisdphaagdllctaakrnd 634

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21450139   65 ----------GLDLERRDQRGLTALMKAAIQDRSECVVALLMAGADLSSVD 105
Cdd:PLN03192 635 ltamkellkqGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 39-68 1.88e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 21450139     39 DGNTALMLAAQAGHMSLVTLLLNYFAGLDL 68
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-96 1.92e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 1.92e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21450139   32 DVNQQDKDGNTALMLAAQAGHMSLVTLLLNYfaGLDLERRDQRGLTALMKAAIQDRSEcVVALLM 96
Cdd:PTZ00322 107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEF--GADPTLLDKDGKTPLELAEENGFRE-VVQLLS 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH