NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|40255080|ref|NP_659404|]
View 

rho GTPase-activating protein 36 isoform 1 precursor [Homo sapiens]

Protein Classification

rho GTPase-activating 6 family protein( domain architecture ID 10138145)

rho GTPase-activating 6 family protein (RhoGAP6-like) such as RhoGAP6, also known as ArhGAP6, which is both a GTPase-activating protein (GAP) with specificity for RhoA and a cytoskeletal protein that promotes actin remodelling, and RhoGAP36 (ArhGAP36) which is a potent antagonist of PKA signaling

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 227-432 8.19e-121

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239841  Cd Length: 206  Bit Score: 354.05  E-value: 8.19e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 227 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 306
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 307 PDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSA 386
Cdd:cd04376  81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 40255080 387 LLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 432
Cdd:cd04376 161 LLHKQKSGEREFVQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 227-432 8.19e-121

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 354.05  E-value: 8.19e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 227 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 306
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 307 PDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSA 386
Cdd:cd04376  81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 40255080 387 LLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 432
Cdd:cd04376 161 LLHKQKSGEREFVQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 236-388 1.18e-41

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 146.54  E-value: 1.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080   236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLD-DNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40255080   315 LLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 388
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLL 144
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 233-422 1.77e-41

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 147.03  E-value: 1.77e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080    233 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQ-NVHDVAALLKEFFRDMKDSLLPDDLY 311
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080    312 MSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEdsigidgqlvpGNRMTSTNLALVFGSALLkk 390
Cdd:smart00324  81 EEFIEAAKLEDETErLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLL-- 147

                          170       180       190
                   ....*....|....*....|....*....|..
gi 40255080    391 gkfgkRESRKTKLGIDHYVASVNVVRAMIDNW 422
Cdd:smart00324 148 -----RPPDGEVASLKDIRHQNTVIEFLIENA 174
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 227-432 8.19e-121

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 354.05  E-value: 8.19e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 227 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 306
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 307 PDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSA 386
Cdd:cd04376  81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 40255080 387 LLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 432
Cdd:cd04376 161 LLHKQKSGEREFVQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 236-388 1.18e-41

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 146.54  E-value: 1.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080   236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLD-DNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40255080   315 LLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 388
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLL 144
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 233-422 1.77e-41

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 147.03  E-value: 1.77e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080    233 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQ-NVHDVAALLKEFFRDMKDSLLPDDLY 311
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080    312 MSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEdsigidgqlvpGNRMTSTNLALVFGSALLkk 390
Cdd:smart00324  81 EEFIEAAKLEDETErLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLL-- 147

                          170       180       190
                   ....*....|....*....|....*....|..
gi 40255080    391 gkfgkRESRKTKLGIDHYVASVNVVRAMIDNW 422
Cdd:smart00324 148 -----RPPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 236-421 1.05e-38

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 139.36  E-value: 1.05e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFL 315
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 316 LTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLKKGKFG 394
Cdd:cd00159  81 ELAKIEdEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV-----------NKMTASNLAIVFAPTLLRPPDSD 149

                       170       180
                ....*....|....*....|....*..
gi 40255080 395 KRESRKTKLGIdhyvasvNVVRAMIDN 421
Cdd:cd00159 150 DELLEDIKKLN-------EIVEFLIEN 169
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 235-422 1.45e-26

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 106.24  E-value: 1.45e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ-GLDVVLDDN-QNVHDVAALLKEFFRDMKDSLLPDDLYM 312
Cdd:cd04385  15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdARSVQLREGeYTVHDVADVLKRFLRDLPDPLLTSELHA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 313 SFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKItENCEDSigidgqlvpgNRMTSTNLALVFGSALLKKG 391
Cdd:cd04385  95 EWIEAAELENKDErIARYKELIRRLPPINRATLKVLIGHLYRV-QKHSDE----------NQMSVHNLALVFGPTLFQTD 163

                       170       180       190
                ....*....|....*....|....*....|.
gi 40255080 392 KFGKRESRKtklgidhyvaSVNVVRAMIDNW 422
Cdd:cd04385 164 EHSVGQTSH----------EVKVIEDLIDNY 184
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 233-389 9.29e-26

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 104.40  E-value: 9.29e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 233 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGL-DVVLDDN--QNVHDVAALLKEFFRDMKDSLLPDD 309
Cdd:cd04395  16 PYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGfDIDLQDPrwRDVNVVSSLLKSFFRKLPEPLFTNE 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 310 LYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 388
Cdd:cd04395  96 LYPDFIEANRIEdPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV-----------NKMEPRNLAIVFGPTLV 164


                .
gi 40255080 389 K 389
Cdd:cd04395 165 R 165
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-432 2.58e-25

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 103.32  E-value: 2.58e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHgLSAVGIFTLEYSVQRVRQLREEFDQGLDVvlDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:cd04394  20 VPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGEAC--LSSALPCDVAGLLKQFFRELPEPLLPYDLHEAL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 315 LLTATL-KPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLKKGKF 393
Cdd:cd04394  97 LKAQELpTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSE-----------NKMDSSNLAVIFAPNLFQSEEG 165

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 40255080 394 GKRESRKTKLGIDHYVAsvnVVRAMIDNWDVLFQVPPHI 432
Cdd:cd04394 166 GEKMSSSTEKRLRLQAA---VVQTLIDNASNIGIVPDFI 201
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-389 7.58e-25

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 101.71  E-value: 7.58e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVL----DDNQN-VHDVAALLKEFFRDMKDSLLPDD 309
Cdd:cd04398  16 VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLlispEDYESdIHSVASLLKLFFRELPEPLLTKA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 310 LYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENceDSIgidgqlvpgNRMTSTNLALVFGSALL 388
Cdd:cd04398  96 LSREFIEAAKIEdESRRRDALHGLINDLPDANYATLRALMFHLARIKEH--ESV---------NRMSVNNLAIIWGPTLM 164


                .
gi 40255080 389 K 389
Cdd:cd04398 165 N 165
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-436 6.60e-24

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 99.73  E-value: 6.60e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ--GLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYM 312
Cdd:cd04391  22 VPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLP 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 313 SFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSALLKKG 391
Cdd:cd04391 102 AFYSVQGLPsKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDH-EEK----------NKMNLWNVAMIMAPNLFPPR 170

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 40255080 392 KFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQV 436
Cdd:cd04391 171 GKHSKDNESLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQV 215
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 235-389 2.06e-22

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 94.81  E-value: 2.06e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:cd04377  15 VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQWLRELPEPLMTFELYENF 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40255080 315 LLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSALLK 389
Cdd:cd04377  95 LRAMELEeKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQ-EEV----------NRMSANALAIVFAPCILR 159
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 226-429 2.37e-22

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 95.56  E-value: 2.37e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 226 MSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSL 305
Cdd:cd04375  11 VNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLKQYFRDLPEPL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 306 LPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENcedsigidgqlVPGNRMTSTNLALVFG 384
Cdd:cd04375  91 LTNKLSETFIAIFQYVPKEQrLEAVQCAILLLPDENREVLQTLLYFLSDVAAN-----------SQENQMTATNLAVCLA 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 40255080 385 SAL-----LKKGKFGKRESRKTK--LGIDHY------VASVNVVRAMIDNWDVLFQVP 429
Cdd:cd04375 160 PSLfhlntSRRENSSPARRMQRKksLGKPDQkelsenKAAHQCLAYMIEECNTLFMVP 217
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 233-426 2.60e-21

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 92.13  E-value: 2.60e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 233 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG-LDVVLDD-NQNVHDVAALLKEFFRDMKDSLLPDDL 310
Cdd:cd04386  18 REIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEfYSDPHAVASALKSYLRELPDPLLTYNL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 311 YMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLk 389
Cdd:cd04386  98 YEDWVQAANKPDEDErLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDE-----------NKMSPSNIAIVLAPNLL- 165

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 40255080 390 kgkFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLF 426
Cdd:cd04386 166 ---WAKNEGSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 229-388 8.80e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 90.47  E-value: 8.80e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 229 NPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPD 308
Cdd:cd04404  17 NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTFLRELPEPLLTF 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 309 DLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 388
Cdd:cd04404  97 DLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ-----------NKMTNSNLAVVFGPNLL 165
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 232-389 4.76e-20

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 88.27  E-value: 4.76e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 232 AKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLY 311
Cdd:cd04390  19 PRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQY 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 312 MSFLLTATLKPQDQLSALQLL---VYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 388
Cdd:cd04390  99 EDFLSCAQLLSKDEEKGLGELmkqVSILPKVNYNLLSYICRFLDEVQSNSSV-----------NKMSVQNLATVFGPNIL 167


                .
gi 40255080 389 K 389
Cdd:cd04390 168 R 168
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 236-426 8.96e-20

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 87.35  E-value: 8.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDdNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFL 315
Cdd:cd04402  16 PKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLK-AEPVLLLASVLKDFLRNIPGSLLSSDLYEEWM 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 316 LTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLKKGKFG 394
Cdd:cd04402  95 SALDQENEEEkIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSET-----------NKMDAFNLAVCIAPSLLWPPASS 163

                       170       180       190
                ....*....|....*....|....*....|..
gi 40255080 395 KRESRKTKlgidhyvASVNVVRAMIDNWDVLF 426
Cdd:cd04402 164 ELQNEDLK-------KVTSLVQFLIENCQEIF 188
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 235-392 1.36e-19

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 86.68  E-value: 1.36e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDD--NQNVHDVAALLKEFFRDMKDSLLPDDLYM 312
Cdd:cd04403  16 VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDskWEDIHVITGALKLFFRELPEPLFPYSLFN 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 313 SFllTATLKPQDQ---LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLK 389
Cdd:cd04403  96 DF--VAAIKLSDYeqrVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEK-----------NRMTTQNLAIVFGPTLLR 162


                ...
gi 40255080 390 KGK 392
Cdd:cd04403 163 PEQ 165
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-432 2.46e-19

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 86.65  E-value: 2.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 230 PIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLD-DNQNVHDVAALLKEFFRDMKDSLLPD 308
Cdd:cd04397  22 PGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDlSKENPVQLAALLKKFLRELPDPLLTF 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 309 DLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEdsigIDGQLvpGNRMTSTNLALVFGSAL 387
Cdd:cd04397 102 KLYRLWISSQKIEDEEErKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSH----IDEET--GSKMDIHNLATVITPNI 175

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 40255080 388 LkkgkfgkRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 432
Cdd:cd04397 176 L-------YSKTDNPNTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 233-389 1.03e-18

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 84.48  E-value: 1.03e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 233 KQIPQVVEACCQFIEKHGLsAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDN---QNVHDVAALLKEFFRDMKDSLLPDD 309
Cdd:cd04384  16 QDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDvyiQDIHSVSSLCKLYFRELPNPLLTYQ 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 310 LYMSFLLTATLKPQD-QLSALQLLVYLMPPCHSDTLERLLKALHKITENCedsiGIDGqlvpgnrMTSTNLALVFGSALL 388
Cdd:cd04384  95 LYEKFSEAVSAASDEeRLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYC----SITN-------MHAKNLAIVWAPNLL 163


                .
gi 40255080 389 K 389
Cdd:cd04384 164 R 164
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 235-387 4.06e-18

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 82.41  E-value: 4.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHG-LSAVGIFTLEYSVQRVRQLREEFDQGLDV-VLDDNQ--NVHDVAALLKEFFRDMKDSLLPDDL 310
Cdd:cd04400  22 LPSVVYRCIEYLDKNRaIYEEGIFRLSGSASVIKQLKERFNTEYDVdLFSSSLypDVHTVAGLLKLYLRELPTLILGGEL 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40255080 311 YMSFLLTATLKPQDQLSALQLLVYL--MPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSAL 387
Cdd:cd04400 102 HNDFKRLVEENHDRSQRALELKDLVsqLPQANYDLLYVLFSFLRKIIEH-SDV----------NKMNLRNVCIVFSPTL 169
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 235-387 4.17e-17

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 79.65  E-value: 4.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:cd04382  17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEF 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40255080 315 LLTAT-LKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcedsigidgqlvPGNRMTSTNLALVFGSAL 387
Cdd:cd04382  97 MEAAEiLDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQS------------PECKMDINNLARVFGPTI 158
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-384 4.49e-17

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 79.43  E-value: 4.49e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:cd04393  20 VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLFLQELPEGLIPASLQIRL 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40255080 315 L-LTATLKPQD-QLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFG 384
Cdd:cd04393 100 MqLYQDYNGEDeFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHE-----------NRMTAENLAAVFG 160
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 235-388 5.02e-17

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 79.39  E-value: 5.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDnQNVHD---VAALLKEFFRDMKDSLLPDDLY 311
Cdd:cd04383  18 IPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADD-QNDHDinsVAGVLKLYFRGLENPLFPKERF 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40255080 312 MSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 388
Cdd:cd04383  97 EDLMSCVKLEnPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDE-----------NMMDPYNLAICFGPTLM 163
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 235-389 8.88e-17

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 78.50  E-value: 8.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:cd04407  15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYNDF 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40255080 315 LLTATL-KPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSALLK 389
Cdd:cd04407  95 LRAVELpEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALE-EDV----------NRMSPNALAIVFAPCLLR 159
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 234-426 1.31e-16

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 78.33  E-value: 1.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 234 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG---LDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDL 310
Cdd:cd04372  15 QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDgekADISATVYPDINVITGALKLYFRDLPIPVITYDT 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 311 YMSFLLTATLKPQD-QLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLK 389
Cdd:cd04372  95 YPKFIDAAKISNPDeRLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKD-----------NKMNAENLGIVFGPTLMR 163

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 40255080 390 KgkfgKRESRKTKLGIDHYvaSVNVVRAMIDNWDVLF 426
Cdd:cd04372 164 P----PEDSALTTLNDMRY--QILIVQLLITNEDVLF 194
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 234-391 4.00e-16

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 77.16  E-value: 4.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 234 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMS 313
Cdd:cd04408  15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDD 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 314 FLLTA-------------TLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLA 380
Cdd:cd04408  95 FIALAkelqrdsekaaesPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFED-----------NKMSPNNLG 163

                       170
                ....*....|.
gi 40255080 381 LVFGSALLKKG 391
Cdd:cd04408 164 IVFGPTLLRPL 174
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 235-389 1.17e-15

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 75.54  E-value: 1.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:cd04378  16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDF 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 315 LLTA---------------TLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNL 379
Cdd:cd04378  96 IALAkeiqrdteedkapntPIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE-----------NKMSPNNL 164

                       170
                ....*....|
gi 40255080 380 ALVFGSALLK 389
Cdd:cd04378 165 GIVFGPTLIR 174
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 233-389 7.56e-15

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 73.11  E-value: 7.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 233 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYM 312
Cdd:cd04406  13 RSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYE 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40255080 313 SFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLK 389
Cdd:cd04406  93 EFLRAMGLQERREtVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEET-----------NRMSANALAIVFAPCILR 159
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 233-389 1.61e-14

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 72.10  E-value: 1.61e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 233 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ--GLDVVLDDNqNVHDVAALLKEFFRDMKDSLLPDDL 310
Cdd:cd04373  13 KPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQdhNLDLVSKDF-TVNAVAGALKSFFSELPDPLIPYSM 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 311 YMSfLLTATLKPQD--QLSALQLLVYLMPPCHSDTLERLLKALHKITENCedsigidgqlvPGNRMTSTNLALVFGSALL 388
Cdd:cd04373  92 HLE-LVEAAKINDReqRLHALKELLKKFPPENFDVFKYVITHLNKVSQNS-----------KVNLMTSENLSICFWPTLM 159


                .
gi 40255080 389 K 389
Cdd:cd04373 160 R 160
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 234-432 2.54e-12

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 65.95  E-value: 2.54e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 234 QIPQVVEaccqFIEKHgLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQ-NVHDVAALLKEFFRDMKDSLLPDDLYM 312
Cdd:cd04392  12 QIYQLIE----YLEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLTHAHYP 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 313 SFLLTATL-------------KPQDQLSALQLLVYLMPPCHSDTLERLLKALHKiTENCEDSigidgqlvpgNRMTSTNL 379
Cdd:cd04392  87 AHLQIADLcqfdekgnktsapDKERLLEALQLLLLLLPEENRNLLKLILDLLYQ-TAKHEDK----------NKMSADNL 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 40255080 380 ALVFGSALL--KKGKFGKRESRKTKLGidhyvasvNVVRAMIDNWDVLFQVPPHI 432
Cdd:cd04392 156 ALLFTPHLIcpRNLTPEDLHENAQKLN--------SIVTFMIKHSQKLFKAPAYL 202
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 235-425 2.98e-12

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 66.28  E-value: 2.98e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDV---VLDDNQNVHDVAALLKEFFRDMKDSLLPDDLY 311
Cdd:cd04396  32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYgksFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLY 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 312 MSFLLtATLKPQDQLSAL-------------------QLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgN 372
Cdd:cd04396 112 EEFRN-PLRKRPRILQYMkgrineplntdidqaikeyRDLITRLPNLNRQLLLYLLDLLAVFARNSDK-----------N 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 40255080 373 RMTSTNLALVFGSALLKKgkfgkresRKTKLGIDHYVASVNVVRAMIDNWDVL 425
Cdd:cd04396 180 LMTASNLAAIFQPGILSH--------PDHEMDPKEYKLSRLVVEFLIEHQDKF 224
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 219-389 6.31e-12

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 64.56  E-value: 6.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 219 LLGSKRKMSLnpiakqIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLD--VVLDDNQNVHDVAALLKE 296
Cdd:cd04387   6 STVTKRERSK------VPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKdvSVMLSEMDVNAIAGTLKL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 297 FFRDMKDSLLPDDLYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMT 375
Cdd:cd04387  80 YFRELPEPLFTDELYPNFAEGIALSdPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEV-----------NKMS 148

                       170
                ....*....|....
gi 40255080 376 STNLALVFGSALLK 389
Cdd:cd04387 149 LHNLATVFGPTLLR 162
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 230-392 1.75e-11

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 63.64  E-value: 1.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 230 PIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ---GLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 306
Cdd:cd04379  13 GESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaAVELSEELYPDINVITGVLKDYLRELPEPLI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 307 PDDLYMSFLLTATLKPQDQLS-----ALQLLVYLmPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLAL 381
Cdd:cd04379  93 TPQLYEMVLEALAVALPNDVQtnthlTLSIIDCL-PLSAKATLLLLLDHLSLVLSNSER-----------NKMTPQNLAV 160

                       170
                ....*....|.
gi 40255080 382 VFGSALLKKGK 392
Cdd:cd04379 161 CFGPVLMFCSQ 171
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 234-356 2.74e-11

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 62.45  E-value: 2.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 234 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDnQNVHDVAALLKEFFRDMKDSLLPDDLYMS 313
Cdd:cd04381  19 DLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEE-YEPPTVASLLKQYLRELPEPLLTKELMPR 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40255080 314 F-LLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITE 356
Cdd:cd04381  98 FeEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIA 141
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-389 4.44e-10

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 59.44  E-value: 4.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 314
Cdd:cd04409  16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEF 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 315 L-----------------LTATLKPQDQLSALQLLVYL------MPPCHSDTLERLLKALHKITENCEDsigidgqlvpg 371
Cdd:cd04409  96 IglakesqhvnetqeakkNSDKKWPNMCTELNRILLKSkdllrqLPAPNYNTLQFLIVHLHRVSEQAEE----------- 164

                       170
                ....*....|....*...
gi 40255080 372 NRMTSTNLALVFGSALLK 389
Cdd:cd04409 165 NKMSASNLGIIFGPTLIR 182
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 220-389 1.40e-07

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 52.01  E-value: 1.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 220 LGSKRKMSLNPIAKQIPQVVEA------------CCQFIEKHGLSAVGIFTLEYSVQRVRQL------REEFDQGlDVVL 281
Cdd:cd04374   1 MDGKEPVYHSPGRLQSEVEGEAqlddigfkfvrkCIEAVETRGINEQGLYRVVGVNSKVQKLlslgldPKTSTPG-DVDL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 282 DDNQ-NVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCE 359
Cdd:cd04374  80 DNSEwEIKTITSALKTYLRNLPEPLMTYELHNDFINAAKSENLESrVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSK 159

                       170       180       190
                ....*....|....*....|....*....|
gi 40255080 360 DsigidgqlvpgNRMTSTNLALVFGSALLK 389
Cdd:cd04374 160 K-----------NLMTVSNLGVVFGPTLLR 178
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 216-388 3.02e-05

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 45.41  E-value: 3.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 216 GQRLLGSKRKMSLNP----IAKQIPQVVEACCQFIEKHGLSAVGIF----TLEYSVQRVRQLREEFDQGldVVLDDNQNV 287
Cdd:cd04380  27 GIRNLIDQLELGDNPdyseVPLSIPKEIWRLVDYLYTRGLAQEGLFeepgLPSEPGELLAEIRDALDTG--SPFNSPGSA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 288 HDVAALLKEFFRDMKDSLLPDDLYMSfLLTATLKPQDQLSalQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgq 367
Cdd:cd04380 105 ESVAEALLLFLESLPDPIIPYSLYER-LLEAVANNEEDKR--QVIRISLPPVHRNVFVYLCSFLRELLSESAD------- 174

                       170       180
                ....*....|....*....|.
gi 40255080 368 lvpgNRMTSTNLALVFGSALL 388
Cdd:cd04380 175 ----RGLDENTLATIFGRVLL 191
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 255-389 7.81e-05

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 43.53  E-value: 7.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 255 GIFTLEYSVQRVRQLREEFDQGlDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSfLLTATLKPQDQLSALQLLvy 334
Cdd:cd04389  42 GIFRVPGDIDEVNELKLRVDQW-DYPLSGLEDPHVPASLLKLWLRELEEPLIPDALYQQ-CISASEDPDKAVEIVQKL-- 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 40255080 335 lmPPCHSDTLERLLKALHKITENcedsigidgQLVPGNRMTSTNLALVFGSALLK 389
Cdd:cd04389 118 --PIINRLVLCYLINFLQVFAQP---------ENVAHTKMDVSNLAMVFAPNILR 161
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 255-356 1.72e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 40.01  E-value: 1.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255080 255 GIFTLEYSVQRVRQLREEFDQGLDVVLDD----NQNVHDVAALLKEFFRDMKDSLLPDD-------LYMSFLLTATLKPQ 323
Cdd:cd04399  42 NVWTDPVSLKETHQLRNLLNKPKKPDKEViilkKFEPSTVASVLKLYLLELPDSLIPHDiydlirsLYSAYPPSQEDSDT 121

                        90       100       110
                ....*....|....*....|....*....|...
gi 40255080 324 DQLSALQLLVYLMPPCHSDTLERLLKALHKITE 356
Cdd:cd04399 122 ARIQGLQSTLSQLPKSHIATLDAIITHFYRLIE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH