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Conserved domains on  [gi|282165758|ref|NP_660348|]
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solute carrier family 25 member 43 [Homo sapiens]

Protein Classification

ADP/ATP carrier family protein( domain architecture ID 1000309)

ADP/ATP carrier family protein may provide transport for nucleotides, amino acids, carboxylic acids, fatty acids, cofactors, or inorganic ions across a membrane; similar to mitochondrial adenine nucleotide carriers

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00169 super family cl36523
ADP/ATP transporter on adenylate translocase; Provisional
 17-275 4.11e-26

ADP/ATP transporter on adenylate translocase; Provisional


The actual alignment was detected with superfamily member PTZ00169:

Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 105.62  E-value: 4.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  17 LCAGLAGTLSLSLTAPLELATVLAQV-----GVVRGHArgPWATG-----HRVWRAEGLRALWKGNAVACLRLFPCSAVQ 86
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTqdsipEIKSGKV--PRYSGivncfRRVSKEQGVLSLWRGNTANVIRYFPTQAFN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  87 LAAYRKFVVLFTDDLGHISQW----SSIMAGSLAGMVSTIVTYPTDLIKTRL---IMQNiLEPSYRGLLHAFSTIYQQEG 159
Cdd:PTZ00169  90 FAFKDYFKNMFPKYNQKTDFWkffgVNILSGGLAGASSLLIVYPLDFARTRLasdIGKG-GDREFTGLFDCLMKISKQTG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758 160 FLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQfslpqnfANVCLAAAVTQTL-------SFPFETVKRKMQAQ 232
Cdd:PTZ00169 169 FLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKN-------TNILYKWAVAQTVtilagliSYPFDTVRRRMMMM 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 282165758 233 SPylpHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLK 275
Cdd:PTZ00169 242 SG---RKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLR 281
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 17-275 4.11e-26

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 105.62  E-value: 4.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  17 LCAGLAGTLSLSLTAPLELATVLAQV-----GVVRGHArgPWATG-----HRVWRAEGLRALWKGNAVACLRLFPCSAVQ 86
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTqdsipEIKSGKV--PRYSGivncfRRVSKEQGVLSLWRGNTANVIRYFPTQAFN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  87 LAAYRKFVVLFTDDLGHISQW----SSIMAGSLAGMVSTIVTYPTDLIKTRL---IMQNiLEPSYRGLLHAFSTIYQQEG 159
Cdd:PTZ00169  90 FAFKDYFKNMFPKYNQKTDFWkffgVNILSGGLAGASSLLIVYPLDFARTRLasdIGKG-GDREFTGLFDCLMKISKQTG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758 160 FLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQfslpqnfANVCLAAAVTQTL-------SFPFETVKRKMQAQ 232
Cdd:PTZ00169 169 FLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKN-------TNILYKWAVAQTVtilagliSYPFDTVRRRMMMM 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 282165758 233 SPylpHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLK 275
Cdd:PTZ00169 242 SG---RKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLR 281
Mito_carr pfam00153
Mitochondrial carrier protein;
102-185 2.41e-23

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 92.33  E-value: 2.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  102 GHISQWSSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILEPS-YRGLLHAFSTIYQQEGFLALYRGVSLTVVGALPFSAG 180
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSkGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80


                  ....*
gi 282165758  181 SLLVY 185
Cdd:pfam00153  81 YFGTY 85
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 17-275 4.11e-26

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 105.62  E-value: 4.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  17 LCAGLAGTLSLSLTAPLELATVLAQV-----GVVRGHArgPWATG-----HRVWRAEGLRALWKGNAVACLRLFPCSAVQ 86
Cdd:PTZ00169  12 LMGGISAAISKTAVAPIERVKMLIQTqdsipEIKSGKV--PRYSGivncfRRVSKEQGVLSLWRGNTANVIRYFPTQAFN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  87 LAAYRKFVVLFTDDLGHISQW----SSIMAGSLAGMVSTIVTYPTDLIKTRL---IMQNiLEPSYRGLLHAFSTIYQQEG 159
Cdd:PTZ00169  90 FAFKDYFKNMFPKYNQKTDFWkffgVNILSGGLAGASSLLIVYPLDFARTRLasdIGKG-GDREFTGLFDCLMKISKQTG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758 160 FLALYRGVSLTVVGALPFSAGSLLVYMNLEKIWNGPRDQfslpqnfANVCLAAAVTQTL-------SFPFETVKRKMQAQ 232
Cdd:PTZ00169 169 FLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLFGNDKN-------TNILYKWAVAQTVtilagliSYPFDTVRRRMMMM 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 282165758 233 SPylpHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLK 275
Cdd:PTZ00169 242 SG---RKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLR 281
Mito_carr pfam00153
Mitochondrial carrier protein;
102-185 2.41e-23

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 92.33  E-value: 2.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  102 GHISQWSSIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILEPS-YRGLLHAFSTIYQQEGFLALYRGVSLTVVGALPFSAG 180
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSkGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80


                  ....*
gi 282165758  181 SLLVY 185
Cdd:pfam00153  81 YFGTY 85
Mito_carr pfam00153
Mitochondrial carrier protein;
197-293 1.29e-22

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 90.41  E-value: 1.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  197 DQFSLPQNFANVCLAAAVTQTLSFPFETVKRKMQAQSPYLPHSGgvdvhfSGAVDCFRQIVKAQGVLGLWNGLTANLLKI 276
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKG------RGILDCFKKIYKEEGIRGLYKGLLPNLLRV 74

                          90
                  ....*....|....*..
gi 282165758  277 VPYFGIMFSTFEFCKRI 293
Cdd:pfam00153  75 APAAAIYFGTYETLKRL 91
Mito_carr pfam00153
Mitochondrial carrier protein;
8-101 2.14e-17

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 76.16  E-value: 2.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758    8 GRLTGGQRLLCAGLAGTLSLSLTAPLELATVLAQVGVVRGHARGPWA--TGHRVWRAEGLRALWKGNAVACLRLFPCSAV 85
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRGIldCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAI 80

                          90
                  ....*....|....*.
gi 282165758   86 QLAAYRKFVVLFTDDL 101
Cdd:pfam00153  81 YFGTYETLKRLLLKKL 96
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 210-293 2.59e-08

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 54.39  E-value: 2.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758 210 LAAAVTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEF 289
Cdd:PTZ00169  16 ISAAISKTAVAPIERVKMLIQTQDSIPEIKSGKVPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQAFNFAFKDY 95


                 ....
gi 282165758 290 CKRI 293
Cdd:PTZ00169  96 FKNM 99
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 109-230 8.91e-05

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 43.37  E-value: 8.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758 109 SIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILepsyrgllhAFSTIYQqegflaLYRGVSLTVVGALPFSAGSLLVYMNL 188
Cdd:PTZ00168   6 NLVTGALSGVIVDAVLYPIDSIKTNIQAKKSF---------SFSDIKK------LYSGILPTLVGTVPASAFFYCFYELS 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 282165758 189 EKIWNGPRDQFSLPQNF-ANVCLAAAVTQTLSFPFETVKRKMQ 230
Cdd:PTZ00168  71 KKLLTEYRENISKTNLYlISTSIAEITACIVRLPFEIVKQNMQ 113
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 55-166 7.80e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 37.60  E-value: 7.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282165758  55 TGHRVWRAEGLRA-LWKGNAVACLRLFPCSAVQLAAYRKFVVLFTDDLGHISQ----WSSIMAGSLAGMVSTIVTYPTDL 129
Cdd:PTZ00168 123 TIYEITQREGLPSfLGKSYFVMIVREIPFDCIQYFLWETLKEKAKKDFGKFSKkypsITSAICGGLAGGIAGFLTTPVDV 202

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 282165758 130 IKTRLImqnILEPSYrglLHAFSTIyQQEGFLALYRG 166
Cdd:PTZ00168 203 IKSRQI---IYGKSY---IETVTEI-AEEGYLTFYKG 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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