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Conserved domains on  [gi|21956645|ref|NP_665807|]
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myotrophin [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-104 4.25e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.79  E-value: 4.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVK 85
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90
                ....*....|....*....
gi 21956645  86 LLLSKGADKTVKGPDGLTA 104
Cdd:COG0666 171 LLLEAGADVNARDNDGETP 189
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-104 4.25e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.79  E-value: 4.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVK 85
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90
                ....*....|....*....
gi 21956645  86 LLLSKGADKTVKGPDGLTA 104
Cdd:COG0666 171 LLLEAGADVNARDNDGETP 189
Ank_2 pfam12796
Ankyrin repeats (3 copies);
6-97 5.03e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645     6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEfLLLKGADINAPDKHHiTPLLSAVYEGHVSCVK 85
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVK-LLLEHADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 21956645    86 LLLSKGADKTVK 97
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-103 5.49e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.83  E-value: 5.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    4 KEFM-WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVS 82
Cdd:PHA02874 125 KTFLhYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYA 204

                         90       100
                 ....*....|....*....|.
gi 21956645   83 CVKLLLSKGADKTVKGPDGLT 103
Cdd:PHA02874 205 CIKLLIDHGNHIMNKCKNGFT 225
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 35-63 2.11e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.11e-05
                           10        20
                   ....*....|....*....|....*....
gi 21956645     35 GRKPLHYAADCGQLEILEFLLLKGADINA 63
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 9-72 7.41e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 34.60  E-value: 7.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21956645   9 ALKNGDLDEVKDYVAKGEDVNRT--------------LEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSPratgtffrpgpknlIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-104 4.25e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.79  E-value: 4.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVK 85
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                        90
                ....*....|....*....
gi 21956645  86 LLLSKGADKTVKGPDGLTA 104
Cdd:COG0666 171 LLLEAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-104 3.52e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.48  E-value: 3.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKL 86
Cdd:COG0666 125 HLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKL 204

                        90
                ....*....|....*...
gi 21956645  87 LLSKGADKTVKGPDGLTA 104
Cdd:COG0666 205 LLEAGADVNAKDNDGKTA 222
Ank_2 pfam12796
Ankyrin repeats (3 copies);
6-97 5.03e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645     6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEfLLLKGADINAPDKHHiTPLLSAVYEGHVSCVK 85
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVK-LLLEHADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 21956645    86 LLLSKGADKTVK 97
Cdd:pfam12796  79 LLLEKGADINVK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-118 2.68e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.38  E-value: 2.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVK 85
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21956645  86 LLLSKGADKTVKGPDGLTAF-EATDN---QAIKALLQ 118
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLhLAAANgnlEIVKLLLE 174
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-117 2.12e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 2.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVK 85
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVK 236

                        90       100       110
                ....*....|....*....|....*....|..
gi 21956645  86 LLLSKGADKTVKGPDGLTAFEATDNQAIKALL 117
Cdd:COG0666 237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-103 5.49e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.83  E-value: 5.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    4 KEFM-WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVS 82
Cdd:PHA02874 125 KTFLhYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYA 204

                         90       100
                 ....*....|....*....|.
gi 21956645   83 CVKLLLSKGADKTVKGPDGLT 103
Cdd:PHA02874 205 CIKLLIDHGNHIMNKCKNGFT 225
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 11-103 1.76e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.38  E-value: 1.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   11 KNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQ--LEILEFLLLKGADINA----------------PDKHHITPL 72
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAknrvnyllsygvpiniKDVYGFTPL 196

                         90       100       110
                 ....*....|....*....|....*....|.
gi 21956645   73 LSAVYEGHVSCVKLLLSKGADKTVKGPDGLT 103
Cdd:PHA03100 197 HYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 11-117 2.55e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.58  E-value: 2.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   11 KNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQ---LEILEFLLLKGADINAPDKHHITPLLSAVYEGHV-SCVKL 86
Cdd:PHA03095  23 SNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKL 102

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 21956645   87 LLSKGADKTVKGPDGLTAF------EATDNQAIKALL 117
Cdd:PHA03095 103 LIKAGADVNAKDKVGRTPLhvylsgFNINPKVIRLLL 139
Ank_4 pfam13637
Ankyrin repeats (many copies);
35-88 1.80e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 1.80e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 21956645    35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
7-65 3.55e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 3.55e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 21956645     7 MWALKNGDLDEVKdYVAKGEDVNRTLEGgRKPLHYAADCGQLEILEFLLLKGADINAPD 65
Cdd:pfam12796  35 HLAAKNGHLEIVK-LLLEHADVNLKDNG-RTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 24-118 3.18e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.83  E-value: 3.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   24 KGEDVNRTLEGGRKPLHYAADCGQ-----LEILEFLLLKGADINAPDKHHITPLLSAVYE--GHVSCVKLLLSKGADKTV 96
Cdd:PHA03100  57 NGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNI 136

                         90       100
                 ....*....|....*....|....*...
gi 21956645   97 KGPDGLTAFEA------TDNQAIKALLQ 118
Cdd:PHA03100 137 KNSDGENLLHLylesnkIDLKILKLLID 164
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 18-103 1.76e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 1.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   18 VKDYVAKGEDVN-RTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTV 96
Cdd:PHA02878 150 TKLLLSYGADINmKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229


                 ....*..
gi 21956645   97 KGPDGLT 103
Cdd:PHA02878 230 RDKCGNT 236
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 47-117 1.97e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.97e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21956645   47 QLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQ----AIKALL 117
Cdd:PHA02876 157 ELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSknidTIKAII 231
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-105 2.98e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.03  E-value: 2.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKL 86
Cdd:COG0666 191 HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270

                        90
                ....*....|....*....
gi 21956645  87 LLSKGADKTVKGPDGLTAF 105
Cdd:COG0666 271 LLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 15-106 7.20e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 7.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   15 LDEVKDYVAKGEDVNRTLEGGRKPLH-YAA-DCGQLEILEFLLLKGADINAPDKHHITPLlsAVYEGHVSC----VKLLL 88
Cdd:PHA03095  97 LDVIKLLIKAGADVNAKDKVGRTPLHvYLSgFNINPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLI 174

                         90
                 ....*....|....*...
gi 21956645   89 SKGADKTVKGPDGLTAFE 106
Cdd:PHA03095 175 DAGADVYAVDDRFRSLLH 192
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 16-93 1.38e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 1.38e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21956645   16 DEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
Cdd:PHA03100 173 NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-118 2.17e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 2.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVS 82
Cdd:COG0666  22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21956645  83 CVKLLLSKGADKTVKGPDGLTAFEAT----DNQAIKALLQ 118
Cdd:COG0666 102 IVKLLLEAGADVNARDKDGETPLHLAayngNLEIVKLLLE 141
PHA03095 PHA03095
ankyrin-like protein; Provisional
 18-105 2.22e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 2.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   18 VKDYVAKGEDVNRTLEGGRKPLHYAADCGQLE--ILEFLLLKGADINAPDKHHITPLL-SAVYEGHVSCVKlLLSKGADK 94
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHyAAVFNNPRACRR-LIALGADI 283

                         90
                 ....*....|.
gi 21956645   95 TVKGPDGLTAF 105
Cdd:PHA03095 284 NAVSSDGNTPL 294
Ank_4 pfam13637
Ankyrin repeats (many copies);
8-55 3.19e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 3.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 21956645     8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLL 55
Cdd:pfam13637   7 AAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
26-72 1.02e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 1.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 21956645    26 EDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02946 PHA02946
ankyin-like protein; Provisional
 15-92 6.76e-07

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 46.20  E-value: 6.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   15 LDE--VKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL--LSAVYEGHVSCVKLLLSK 90
Cdd:PHA02946  50 LDErfVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQY 129


                 ..
gi 21956645   91 GA 92
Cdd:PHA02946 130 GA 131
PHA03095 PHA03095
ankyrin-like protein; Provisional
 18-90 6.92e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.17  E-value: 6.92e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21956645   18 VKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSK 90
Cdd:PHA03095 240 VLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 18-93 8.59e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.21  E-value: 8.59e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21956645   18 VKDYVAKGEDVNRTLEGGRKPLHYAA--DCgQLEILEFLLLKGADINAPDKHHITPLLSAVyeGHVSCVKLLLSKGAD 93
Cdd:PHA02876 425 VKTLIDRGANVNSKNKDLSTPLHYACkkNC-KLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAE 499
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 54-106 8.63e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 8.63e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 21956645   54 LLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE 106
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLE 153
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 8-118 9.52e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.03  E-value: 9.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL-LSAVYEGHVSCVKL 86
Cdd:PHA02878 174 YATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLhISVGYCKDYDILKL 253

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 21956645   87 LLSKGADKTVKGP-DGLTAFEAT--DNQAIKALLQ 118
Cdd:PHA02878 254 LLEHGVDVNAKSYiLGLTALHSSikSERKLKLLLE 288
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 35-63 1.82e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 41.47  E-value: 1.82e-06
                          10        20
                  ....*....|....*....|....*....
gi 21956645    35 GRKPLHYAADCGQLEILEFLLLKGADINA 63
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-92 5.64e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 5.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    9 ALKNGDLDEVKDYVAKGEDVNRTL-EGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLL 87
Cdd:PHA02875  75 AVEEGDVKAVEELLDLGKFADDVFyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154


                 ....*
gi 21956645   88 LSKGA 92
Cdd:PHA02875 155 IDHKA 159
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 12-96 6.97e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   12 NGDLDEVKDYV-AKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSK 90
Cdd:PHA02874  11 SGDIEAIEKIIkNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDN 90


                 ....*.
gi 21956645   91 GADKTV 96
Cdd:PHA02874  91 GVDTSI 96
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 35-66 7.42e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 7.42e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 21956645    35 GRKPLHYAAD-CGQLEILEFLLLKGADINAPDK 66
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 38-106 2.07e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.89  E-value: 2.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   38 PLHYAADCGQLEILEFLLLKGADINA-PDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE 106
Cdd:PHA02884  73 PLIYAIDCDNDDAAKLLIRYGADVNRyAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIE 142
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 35-63 2.11e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.11e-05
                           10        20
                   ....*....|....*....|....*....
gi 21956645     35 GRKPLHYAADCGQLEILEFLLLKGADINA 63
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 11-93 2.51e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.97  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   11 KNG-DLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLK-GADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
Cdd:PHA02876 316 KNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLElGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395


                 ....*
gi 21956645   89 SKGAD 93
Cdd:PHA02876 396 DYGAD 400
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 39-93 2.58e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.78  E-value: 2.58e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 21956645   39 LHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGAD 93
Cdd:PLN03192 626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 12-89 2.98e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 2.98e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21956645   12 NGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLS 89
Cdd:PTZ00322  92 SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PHA02798 PHA02798
ankyrin-like protein; Provisional
 15-93 5.32e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 5.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   15 LDEVKDYVAKGEDVNRTLEGGRKPLHYAADCG---QLEILEFLLLKGADINAPDKHHITPLLSAVYEGH---VSCVKLLL 88
Cdd:PHA02798  89 LDIVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLL 168


                 ....*
gi 21956645   89 SKGAD 93
Cdd:PHA02798 169 EKGVD 173
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-93 5.32e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 5.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
Cdd:PHA02875 109 ATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188


                 ....*
gi 21956645   89 SKGAD 93
Cdd:PHA02875 189 DSGAN 193
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 38-103 1.54e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 1.54e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21956645   38 PLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVS-----CVKLLLSKGADKTVKGPDGLT 103
Cdd:PHA03100  38 PLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGIT 108
Ank_5 pfam13857
Ankyrin repeats (many copies);
59-106 2.37e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 2.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 21956645    59 ADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFE 106
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 18-93 3.72e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.51  E-value: 3.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21956645   18 VKDYVAKGEDVNRTLEGGRKPLHYAADCG-QLEILEFLLLKGADINAPDKHHITPLLSA-VYEGHVSCVKLLLSKGAD 93
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAsTLDRNKDIVITLLELGAN 367
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 3-93 4.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.12  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    3 DKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQL-EILEFLLLKGADINAPDKHHITPLLSAVYEGH- 80
Cdd:PHA02876 241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGYd 320

                         90
                 ....*....|...
gi 21956645   81 VSCVKLLLSKGAD 93
Cdd:PHA02876 321 TENIRTLIMLGAD 333
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-88 4.79e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.12  E-value: 4.79e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21956645   24 KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLL 88
Cdd:PHA02876 167 GGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAII 231
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 67-96 5.54e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 5.54e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 21956645     67 HHITPLLSAVYEGHVSCVKLLLSKGADKTV 96
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 9-89 5.56e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.02  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHvSCVKLLL 88
Cdd:PHA02874 164 AIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLI 242


                 .
gi 21956645   89 S 89
Cdd:PHA02874 243 N 243
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 14-103 9.39e-04

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 37.20  E-value: 9.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   14 DLDEVKDYVAKGE-DVNRTL-EGGRKPLH-YAADCG-QLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC--VKLL 87
Cdd:PHA02716 154 DLDLIKYMVDVGIvNLNYVCkKTGYGILHaYLGNMYvDIDILEWLCNNGVNVNLQNNHLITPLHTYLITGNVCAsvIKKI 233

                         90
                 ....*....|....*.
gi 21956645   88 LSKGADKTVKGPDGLT 103
Cdd:PHA02716 234 IELGGDMDMKCVNGMS 249
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-118 1.49e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 36.89  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645    9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADIN-APDKHHITPLLSAVYEGHVSCVKLL 87
Cdd:PHA02875  42 AMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLL 121

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 21956645   88 LSKGADKTVKGPDGLT----AFEATDNQAIKALLQ 118
Cdd:PHA02875 122 IARGADPDIPNTDKFSplhlAVMMGDIKGIELLID 156
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 35-96 2.07e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 36.12  E-value: 2.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21956645   35 GRKPLHYAADCGQLEILEFLLLKGADINAPDKH-HITPLLSAVYEGHVSCVKLLLSKGADKTV 96
Cdd:PHA02875 168 GCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 7-67 3.28e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 35.80  E-value: 3.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21956645    7 MWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67
Cdd:PHA03100 197 HYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
Ank_4 pfam13637
Ankyrin repeats (many copies);
68-105 4.88e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.02  E-value: 4.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21956645    68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAF 105
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETAL 38
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 70-93 6.72e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 32.26  E-value: 6.72e-03
                          10        20
                  ....*....|....*....|....*
gi 21956645    70 TPL-LSAVYEGHVSCVKLLLSKGAD 93
Cdd:pfam00023   4 TPLhLAAGRRGNLEIVKLLLSKGAD 28
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 15-100 6.78e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 35.04  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21956645   15 LDEVKDYVAK----GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGH-VSCVKLLLS 89
Cdd:PHA02876 351 LDRNKDIVITllelGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNpYMSVKTLID 430

                         90
                 ....*....|.
gi 21956645   90 KGADKTVKGPD 100
Cdd:PHA02876 431 RGANVNSKNKD 441
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 9-72 7.41e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 34.60  E-value: 7.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21956645   9 ALKNGDLDEVKDYVAKGEDVNRT--------------LEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPL 72
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSPratgtffrpgpknlIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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