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Conserved domains on  [gi|22208951|ref|NP_665862|]
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ankyrin repeat and SOCS box protein 3 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-230 1.80e-46

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.43  E-value: 1.80e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEI 88
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEI 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  89 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 168
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951 169 CNEDSWqlPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
Cdd:COG0666 216 DNDGKT--ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 384-434 1.15e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239692  Cd Length: 51  Bit Score: 98.71  E-value: 1.15e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 22208951 384 ATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMY 434
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-230 1.80e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.43  E-value: 1.80e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEI 88
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEI 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  89 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 168
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951 169 CNEDSWqlPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
Cdd:COG0666 216 DNDGKT--ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 384-434 1.15e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 98.71  E-value: 1.15e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 22208951 384 ATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMY 434
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-103 7.20e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 7.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHganVNGSHSMCGWNSLHQASFQENAEII 89
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 22208951    90 KLLLRKGANKECQD 103
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 6-235 1.12e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 90.85  E-value: 1.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    6 GFCALHLAASQGHWK---IVQILLEAGADPNATTLEETTPLFLAVENGQ-IDVLRLLLQHGANVNGSHSmCGWNSLHQ-- 79
Cdd:PHA03095  47 GKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDK-VGRTPLHVyl 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   80 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVaaqYGK-----LESLSILISSGANVNCQALDKATPLFIAAQEGHT-- 152
Cdd:PHA03095 126 SGFNINPKVIRLLLRKGADVNALDLYGMTPLAV---LLKsrnanVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPra 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  153 KCVELLLSSGADPDlyCNEDSWQLPIHAAAQMG---HTKILDLL-----IPLTNRACDTGLNkvspvYSAVFGGHEDCLE 224
Cdd:PHA03095 203 RIVRELIRAGCDPA--ATDMLGNTPLHSMATGSsckRSLVLPLLiagisINARNRYGQTPLH-----YAAVFNNPRACRR 275

                        250
                 ....*....|.
gi 22208951  225 iLLRNGYSPDA 235
Cdd:PHA03095 276 -LIALGADINA 285
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 9-161 9.63e-12

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 66.96  E-value: 9.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   9 ALHLAASQGHWKIVQILLEAgaDPNATTLEET-------TPLFLAVENGQIDVLRLLLQHGANVN-----------GSHS 70
Cdd:cd22192  54 ALHVAALYDNLEAAVVLMEA--APELVNEPMTsdlyqgeTALHIAVVNQNLNLVRELIARGADVVspratgtffrpGPKN 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  71 MC--GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFV-AAQYGKL---ESLSILISSGANVNCQALDKA---- 140
Cdd:cd22192 132 LIyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnq 211

                       170       180
                ....*....|....*....|...
gi 22208951 141 --TPLFIAAQEGHTKCVELLLSS 161
Cdd:cd22192 212 glTPFKLAAKEGNIVMFQHLVQK 234
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 385-426 8.92e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 56.40  E-value: 8.92e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 22208951   385 TVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLL 426
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRL---GAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 387-428 1.45e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.10  E-value: 1.45e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 22208951    387 PSLTHLCRLEIRSSLKSerlrsdsyISQLPLPRSLHNYLLYE 428
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 41-66 8.56e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 8.56e-06
                           10        20
                   ....*....|....*....|....*.
gi 22208951     41 TPLFLAVENGQIDVLRLLLQHGANVN 66
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 41-194 5.46e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    41 TPLF-LAVENGQIDVLRLLLQHGANVNgshsmCGWNSLHQAS--FQENAE-IIKLLLRKG--------ANKECQDDF--G 106
Cdd:TIGR00870  54 SALFvAAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVEaILLHLLAAFrksgplelANDQYTSEFtpG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   107 ITPLFVAAQYGKLESLSILISSGANVNCQAldkatplfiaaqeghtKCVELLLSSGADpDLYCNEdswqLPIHAAAQMGH 186
Cdd:TIGR00870 129 ITALHLAAHRQNYEIVKLLLERGASVPARA----------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGS 187


                  ....*...
gi 22208951   187 TKILDLLI 194
Cdd:TIGR00870 188 PSIVALLS 195
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-230 1.80e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.43  E-value: 1.80e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEI 88
Cdd:COG0666  57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN-ARDKDGETPLHLAAYNGNLEI 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  89 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 168
Cdd:COG0666 136 VKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951 169 CNEDSWqlPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
Cdd:COG0666 216 DNDGKT--ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-196 1.54e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 157.04  E-value: 1.54e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQA 80
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLA 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  81 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLS 160
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 22208951 161 SGADPDLYCNEDSwqLPIHAAAQMGHTKILDLLIPL 196
Cdd:COG0666 241 AGADLNAKDKDGL--TALLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-172 2.99e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.47  E-value: 2.99e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQASFQE 84
Cdd:COG0666 119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENG 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  85 NAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 164
Cdd:COG0666 198 HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277


                ....*...
gi 22208951 165 PDLYCNED 172
Cdd:COG0666 278 LAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-230 2.71e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 2.71e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQASFQENAEI 88
Cdd:COG0666  24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLLHAAARNGDLEI 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  89 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 168
Cdd:COG0666 103 VKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951 169 CNEDswQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 230
Cdd:COG0666 183 DNDG--ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-272 8.74e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.97  E-value: 8.74e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  21 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 100
Cdd:COG0666   2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951 101 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDswQLPIHA 180
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG--NTPLHL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951 181 AAQMGHTKILDLLIpltNRACD---TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLvfgFSSPVCMAFQKDCEf 257
Cdd:COG0666 160 AAANGNLEIVKLLL---EAGADvnaRDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND---GKTALDLAAENGNL- 232

                       250
                ....*....|....*
gi 22208951 258 fGIVNILLKYGAQIN 272
Cdd:COG0666 233 -EIVKLLLEAGADLN 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-143 2.45e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 107.73  E-value: 2.45e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQAS 81
Cdd:COG0666 149 QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN-AKDNDGKTALDLAA 227

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951  82 FQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPL 143
Cdd:COG0666 228 ENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 384-434 1.15e-25

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 98.71  E-value: 1.15e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 22208951 384 ATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMY 434
Cdd:cd03722   1 ASVPSLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSDVLRMY 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-103 7.20e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 7.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHganVNGSHSMCGWNSLHQASFQENAEII 89
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 22208951    90 KLLLRKGANKECQD 103
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-167 1.12e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 1.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    77 LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSgANVNCQaLDKATPLFIAAQEGHTKCVE 156
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 22208951   157 LLLSSGADPDL 167
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 6-235 1.12e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 90.85  E-value: 1.12e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    6 GFCALHLAASQGHWK---IVQILLEAGADPNATTLEETTPLFLAVENGQ-IDVLRLLLQHGANVNGSHSmCGWNSLHQ-- 79
Cdd:PHA03095  47 GKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDK-VGRTPLHVyl 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   80 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVaaqYGK-----LESLSILISSGANVNCQALDKATPLFIAAQEGHT-- 152
Cdd:PHA03095 126 SGFNINPKVIRLLLRKGADVNALDLYGMTPLAV---LLKsrnanVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPra 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  153 KCVELLLSSGADPDlyCNEDSWQLPIHAAAQMG---HTKILDLL-----IPLTNRACDTGLNkvspvYSAVFGGHEDCLE 224
Cdd:PHA03095 203 RIVRELIRAGCDPA--ATDMLGNTPLHSMATGSsckRSLVLPLLiagisINARNRYGQTPLH-----YAAVFNNPRACRR 275

                        250
                 ....*....|.
gi 22208951  225 iLLRNGYSPDA 235
Cdd:PHA03095 276 -LIALGADINA 285
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 20-164 7.25e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 88.18  E-value: 7.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   20 KIVQILLEAGADPNATTLEETTPLFLAVEN--GQIDVLRLLLQHGANVNgSHSMCGWNSLHQA--SFQENAEIIKLLLRK 95
Cdd:PHA03100  87 EIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVN-IKNSDGENLLHLYleSNKIDLKILKLLIDK 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   96 GA--NKECQ--------------DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 159
Cdd:PHA03100 166 GVdiNAKNRvnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245


                 ....*
gi 22208951  160 SSGAD 164
Cdd:PHA03100 246 NNGPS 250
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 40-288 1.40e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 84.33  E-value: 1.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   40 TTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLH-----QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 114
Cdd:PHA03100  36 VLPLYLAKEARNIDVVKILLDNGADIN-SSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  115 QyGKLESLSI---LISSGANVNCQALDKATPLFIAAQEGH--TKCVELLLSSGADPDLYCNEDSwqlpihaaaqmghtkI 189
Cdd:PHA03100 115 S-KKSNSYSIveyLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNRVNY---------------L 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  190 LDLLIPLTNRacdtGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDaqACLVFGfSSPVCMAFQKDCEFfgIVNILLKYGA 269
Cdd:PHA03100 179 LSYGVPINIK----DVYGFTPLHYAVYNNNPEFVKYLLDLGANPN--LVNKYG-DTPLHIAILNNNKE--IFKLLLNNGP 249

                        250
                 ....*....|....*....
gi 22208951  270 QINelHLAYCLKYEKFSIF 288
Cdd:PHA03100 250 SIK--TIIETLLYFKDKDL 266
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 10-315 4.37e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 83.57  E-value: 4.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSmcgwnSLHQASFQENAEII 89
Cdd:PHA02876 182 IHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDL-----SLLKAIRNEDLETS 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   90 KLLLRKGANKECQDDFGITPLFVAAQYGKLESL-SILISSGANVNCQALDKATPLFIAAQEGH-TKCVELLLSSGADPDl 167
Cdd:PHA02876 257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVN- 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  168 yCNEDSWQLPIHAAAQMGHTKilDLLIPLTNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYSPDAQA-----CL 239
Cdd:PHA02876 336 -AADRLYITPLHQASTLDRNK--DIVITLLELGANVNARDYcdkTPIHYAAVRNNVVIINTLLDYGADIEALSqkigtAL 412

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  240 VFG--------------------------FSSPVCMAFQKDC------------------------------EFFGIVNI 263
Cdd:PHA02876 413 HFAlcgtnpymsvktlidrganvnsknkdLSTPLHYACKKNCkldviemlldngadvnainiqnqypllialEYHGIVNI 492

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 22208951  264 LLKYGAQINELH-LAYCLKYEKFSiFRYFLRKGCslgpwnhIYEFVNHAIKAQ 315
Cdd:PHA02876 493 LLHYGAELRDSRvLHKSLNDNMFS-FRYIIAHIC-------IQDFIRHDIRNE 537
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1-168 3.70e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 80.45  E-value: 3.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    1 MKTFEGFCALH--LAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV--LRLLLQHGANVNGShSMCGWNS 76
Cdd:PHA03095 112 AKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAV-DDRFRSL 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   77 LHQ--ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI--LISSGANVNCQALDKATPLFIAAQEGHT 152
Cdd:PHA03095 191 LHHhlQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNP 270

                        170
                 ....*....|....*.
gi 22208951  153 KCVELLLSSGADPDLY 168
Cdd:PHA03095 271 RACRRLIALGADINAV 286
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 20-166 6.68e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 79.54  E-value: 6.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   20 KIVQILLEAGADPNATTLEE-TTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQENAEIIKLLLRKGAN 98
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVN-IPDKTNNSPLHHAVKHYNKPIVHILLENGAS 226

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   99 KECQDDFGITPLFVAAQYGK-LESLSILISSGANVNCQA-LDKATPLFIAAQEghTKCVELLLSSGADPD 166
Cdd:PHA02878 227 TDARDKCGNTPLHISVGYCKdYDILKLLLEHGVDVNAKSyILGLTALHSSIKS--ERKLKLLLEYGADIN 294
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 13-272 7.75e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 79.24  E-value: 7.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCgwnslhqasfqENAEIIKLL 92
Cdd:PHA02874  42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILPIPC-----------IEKDMIKTI 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   93 LRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLycNED 172
Cdd:PHA02874 111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV--KDN 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  173 SWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFgGHEDCLEILLRNGYSPDAQaclVFGfSSPVCMAFQ 252
Cdd:PHA02874 189 NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNASINDQD---IDG-STPLHHAIN 263

                        250       260
                 ....*....|....*....|
gi 22208951  253 KDCEfFGIVNILLKYGAQIN 272
Cdd:PHA02874 264 PPCD-IDIIDILLYHKADIS 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
110-194 1.48e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   110 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSgADPDLYCNEDSwqlPIHAAAQMGHTKI 189
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT---ALHYAARSGHLEI 76


                  ....*
gi 22208951   190 LDLLI 194
Cdd:pfam12796  77 VKLLL 81
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 10-133 5.61e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 76.24  E-value: 5.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   10 LHLAASQ--GHWKIVQILLEAGADPNATTLEETTPLFLAVENGQID--VLRLLLQHGANVN-----------GSH----S 70
Cdd:PHA03100 110 LLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvnyllsyGVPinikD 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22208951   71 MCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVN 133
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 10-232 5.98e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 76.24  E-value: 5.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFL-----AVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQ- 83
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVN-APDNNGITPLLYAISKk 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   84 -ENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG--KLESLSILISSGANVNcqALDKatplfiaaqeghtkcVELLLS 160
Cdd:PHA03100 118 sNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDIN--AKNR---------------VNYLLS 180

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22208951  161 SGAD---PDLYCNEdswqlPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYS 232
Cdd:PHA03100 181 YGVPiniKDVYGFT-----PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
Ank_2 pfam12796
Ankyrin repeats (3 copies);
143-236 1.58e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   143 LFIAAQEGHTKCVELLLSSGADPDLYCNEDswQLPIHAAAQMGHTKILDLLIPltNRACDTGLNKVSPVYSAVFGGHEDC 222
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNG--RTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....
gi 22208951   223 LEILLRNGYSPDAQ 236
Cdd:pfam12796  77 VKLLLEKGADINVK 90
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 4-166 2.86e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 74.26  E-value: 2.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQ 83
Cdd:PHA02875  33 YDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATIL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   84 ENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 163
Cdd:PHA02875 113 KKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA 192


                 ...
gi 22208951  164 DPD 166
Cdd:PHA02875 193 NID 195
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 5-133 2.02e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.56  E-value: 2.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQASFQE 84
Cdd:PHA02875 101 DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-IEDCCGCTPLIIAMAKG 179

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 22208951   85 NAEIIKLLLRKGANKecqDDFG----ITPLFVAAQYGKLESLSILISSGANVN 133
Cdd:PHA02875 180 DIAICKMLLDSGANI---DYFGkngcVAALCYAIENNKIDIVRLFIKRGADCN 229
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 384-428 2.93e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 63.67  E-value: 2.93e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 22208951 384 ATVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 428
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRL---ELIKKLPLPPRLKDYLLYE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 9-146 3.24e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.06  E-value: 3.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNgSHSMCGWNSLHQA-SFQENAE 87
Cdd:PHA02878 171 ALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD-ARDKCGNTPLHISvGYCKDYD 249

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   88 IIKLLLRKGANKECQDDF-GITPLFVAAQygKLESLSILISSGANVNCQALDKATPLFIA 146
Cdd:PHA02878 250 ILKLLLEHGVDVNAKSYIlGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSA 307
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 385-428 1.54e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 61.72  E-value: 1.54e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 22208951 385 TVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 428
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRL---DLIDKLPLPPRLKDYLLYK 41
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 13-206 3.17e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 68.09  E-value: 3.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA--NVN--GSHSmcgwnSLHQASFQENAEI 88
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKypDIES-----ELHDAVEEGDVKA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   89 IKLLLRkgANKECQDDF---GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 165
Cdd:PHA02875  84 VEELLD--LGKFADDVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 22208951  166 DLycnEDSWQL-PIHAAAQMGHTKILDLLIpltnracDTGLN 206
Cdd:PHA02875 162 DI---EDCCGCtPLIIAMAKGDIAICKMLL-------DSGAN 193
Ank_2 pfam12796
Ankyrin repeats (3 copies);
5-66 4.50e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 4.50e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951     5 EGFCALHLAASQGHWKIVQILLEaGADPNATTlEETTPLFLAVENGQIDVLRLLLQHGANVN 66
Cdd:pfam12796  29 NGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADIN 88
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-298 4.64e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.74  E-value: 4.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   44 FLAVENGQIDVLRLLLQHGANVN--GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG-KLE 120
Cdd:PHA03095  19 LLNASNVTVEEVRRLLAAGADVNfrGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAtTLD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  121 SLSILISSGANVNCQALDKATPLFI--AAQEGHTKCVELLLSSGADPdlyCNEDSWQL-PIHA-----AAQMghtKILDL 192
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADV---NALDLYGMtPLAVllksrNANV---ELLRL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  193 LI-----PLTNRAC-DTGLN--KVSPVYSAvfggheDCLEILLRNGYSPDAQAclVFGFSSPVCMAFQKDCEFFGIVNIL 264
Cdd:PHA03095 173 LIdagadVYAVDDRfRSLLHhhLQSFKPRA------RIVRELIRAGCDPAATD--MLGNTPLHSMATGSSCKRSLVLPLL 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 22208951  265 LKyGAQINE--------LHLAYClkYEKFSIFRYFLRKGCSL 298
Cdd:PHA03095 245 IA-GISINArnrygqtpLHYAAV--FNNPRACRRLIALGADI 283
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 13-166 6.58e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 67.59  E-value: 6.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   13 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV-----NGSHSMcgWNSL---HQASFQe 84
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVhirdaNGNTAL--WNAIsakHHKIFR- 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   85 naeiIKLLLRKGANKECQDDFgitpLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 164
Cdd:PLN03192 609 ----ILYHFASISDPHAAGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680


                 ..
gi 22208951  165 PD 166
Cdd:PLN03192 681 VD 682
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 9-161 9.63e-12

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 66.96  E-value: 9.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   9 ALHLAASQGHWKIVQILLEAgaDPNATTLEET-------TPLFLAVENGQIDVLRLLLQHGANVN-----------GSHS 70
Cdd:cd22192  54 ALHVAALYDNLEAAVVLMEA--APELVNEPMTsdlyqgeTALHIAVVNQNLNLVRELIARGADVVspratgtffrpGPKN 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  71 MC--GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFV-AAQYGKL---ESLSILISSGANVNCQALDKA---- 140
Cdd:cd22192 132 LIyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHIlVLQPNKTfacQMYDLILSYDKEDDLQPLDLVpnnq 211

                       170       180
                ....*....|....*....|...
gi 22208951 141 --TPLFIAAQEGHTKCVELLLSS 161
Cdd:cd22192 212 glTPFKLAAKEGNIVMFQHLVQK 234
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-297 1.04e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 66.23  E-value: 1.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   88 IIKLLLRKGANKE-----CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT-----KCVEL 157
Cdd:PHA03100  12 IIKVKNIKYIIMEddlndYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  158 LLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIpltNRACDTGLNKV---SPVYSAVFGGHED--CLEILLRNGYS 232
Cdd:PHA03100  92 LLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLL---DNGANVNIKNSdgeNLLHLYLESNKIDlkILKLLIDKGVD 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22208951  233 PDAqaclvfgfsspvcmafqKDceffgIVNILLKYGAQINE--------LHLAycLKYEKFSIFRYFLRKGCS 297
Cdd:PHA03100 169 INA-----------------KN-----RVNYLLSYGVPINIkdvygftpLHYA--VYNNNPEFVKYLLDLGAN 217
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1-164 2.34e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 65.37  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    1 MKTFegfcaLHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA--NVNGSHsmcGWNSLH 78
Cdd:PHA02874 124 LKTF-----LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyaNVKDNN---GESPLH 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   79 QASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKleSLSILISSGANVNCQALDKATPLFIAAQEGHTK-CVEL 157
Cdd:PHA02874 196 NAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASINDQDIDGSTPLHHAINPPCDIdIIDI 273


                 ....*..
gi 22208951  158 LLSSGAD 164
Cdd:PHA02874 274 LLYHKAD 280
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 385-426 8.92e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 56.40  E-value: 8.92e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 22208951   385 TVPSLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLL 426
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRL---GAIDKLPLPPLLKDYLL 39
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
86-295 3.98e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 3.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  86 AEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 165
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951 166 DLycNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQAclvFGFSS 245
Cdd:COG0666  81 NA--KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD---NDGNT 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22208951 246 PVCMAFQKDCEffGIVNILLKYGAQINE--------LHLAycLKYEKFSIFRYFLRKG 295
Cdd:COG0666 156 PLHLAAANGNL--EIVKLLLEAGADVNArdndgetpLHLA--AENGHLEIVKLLLEAG 209
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 20-133 9.25e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 60.53  E-value: 9.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   20 KIVQILLEAGADPNATTLEETTPLFLAVENGQI---DVLRLLLQHGANVNGSHSMCGWNSLHQ--ASFQENAEIIKLLLR 94
Cdd:PHA02989  89 KIVKLLLKFGADINLKTFNGVSPIVCFIYNSNInncDMLRFLLSKGINVNDVKNSRGYNLLHMylESFSVKKDVIKILLS 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 22208951   95 KGANK-ECQDDFGITPLFV----AAQYGKLESLSILISSGANVN 133
Cdd:PHA02989 169 FGVNLfEKTSLYGLTPMNIylrnDIDVISIKVIKYLIKKGVNIE 212
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 4-61 1.56e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 59.91  E-value: 1.56e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 22208951    4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
Cdd:PTZ00322 113 YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 387-428 1.45e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.10  E-value: 1.45e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 22208951    387 PSLTHLCRLEIRSSLKSerlrsdsyISQLPLPRSLHNYLLYE 428
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
108-159 4.58e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 4.58e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22208951   108 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 159
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
9-59 6.21e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 6.21e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 22208951     9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 59
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
141-194 7.12e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 7.12e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 22208951   141 TPLFIAAQEGHTKCVELLLSSGADPDlYCNEDSWQlPIHAAAQMGHTKILDLLI 194
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADIN-AVDGNGET-ALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 41-201 8.55e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 8.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  41 TPLFLAV-ENGQIDVLRLLLQHGANV--NGSHsmcGWNSLHQASFQENAEIIKLLLRKG---ANKECQDDF--GITPLFV 112
Cdd:cd22192  19 SPLLLAAkENDVQAIKKLLKCPSCDLfqRGAL---GETALHVAALYDNLEAAVVLMEAApelVNEPMTSDLyqGETALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951 113 AAQYGKLESLSILISSGANVncqALDKAT-----------------PLFIAAQEGHTKCVELLLSSGADPDlycNEDSW- 174
Cdd:cd22192  96 AVVNQNLNLVRELIARGADV---VSPRATgtffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIR---AQDSLg 169

                       170       180
                ....*....|....*....|....*..
gi 22208951 175 QLPIHaaaqmghtkILdLLIPLTNRAC 201
Cdd:cd22192 170 NTVLH---------IL-VLQPNKTFAC 186
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 2-127 8.81e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 54.38  E-value: 8.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE--------------TTPLFLAVENGQIDVLRLLLQHGANVNG 67
Cdd:cd22194 137 EAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKGVffnpkykhegfyfgETPLALAACTNQPEIVQLLMEKESTDIT 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951  68 SHSMCGWNSLH------QASFQENAEIIKL---LLRKGANKECQ---DDFGITPLFVAAQYGKLESLSILIS 127
Cdd:cd22194 217 SQDSRGNTVLHalvtvaEDSKTQNDFVKRMydmILLKSENKNLEtirNNEGLTPLQLAAKMGKAEILKYILS 288
Ank_4 pfam13637
Ankyrin repeats (many copies);
39-93 9.10e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 9.10e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 22208951    39 ETTPLFLAVENGQIDVLRLLLQHGANVNGSHSmCGWNSLHQASFQENAEIIKLLL 93
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 18-146 1.00e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 53.45  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   18 HWKIVQILLEAGADPNA----TTLEETTPLFLAVENGQIDVLRLLLQHGANVNgshsmcgwnslhqaSFQENAEIiklll 93
Cdd:PHA02884  45 YTDIIDAILKLGADPEApfplSENSKTNPLIYAIDCDNDDAAKLLIRYGADVN--------------RYAEEAKI----- 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 22208951   94 rkgankecqddfgiTPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 146
Cdd:PHA02884 106 --------------TPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELA 144
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 388-429 1.02e-07

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 48.30  E-value: 1.02e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22208951 388 SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 429
Cdd:cd03730   5 SLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKE 46
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 87-171 1.09e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 53.06  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   87 EIIKLLLRKGANKECQDDFG----ITPLFVAAQYGKLESLSILISSGANVNCQALD-KATPLFIAAQEGHTKCVELLLSS 161
Cdd:PHA02884  47 DIIDAILKLGADPEAPFPLSenskTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEaKITPLYISVLHGCLKCLEILLSY 126

                         90
                 ....*....|
gi 22208951  162 GADPDLYCNE 171
Cdd:PHA02884 127 GADINIQTND 136
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 388-428 1.11e-07

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 48.07  E-value: 1.11e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 22208951 388 SLTHLCRLEIRSSLKSERLRSdsyISQLPLPRSLHNYLLYE 428
Cdd:cd03718   5 PLMDLCRRRVRVALGRDRLEE---IEQLPLPPSLKNYLLYQ 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 6-66 1.15e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 1.15e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22208951    6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVN 66
Cdd:PHA03100 192 GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 11-105 2.56e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.98  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   11 HLAASqGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMcGWNSLHQASFQENAEIIK 90
Cdd:PTZ00322  88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKD-GKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*
gi 22208951   91 LLLRkgankECQDDF 105
Cdd:PTZ00322 166 LLSR-----HSQCHF 175
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 386-427 2.74e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 46.82  E-value: 2.74e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22208951 386 VPSLTHLCRLEIRSSLKSERlrsdsyISQLPLPRSLHNYLLY 427
Cdd:cd03717   3 VRSLQHLCRFVIRQCTRRDL------IDQLPLPRRLKDYLKE 38
PHA02798 PHA02798
ankyrin-like protein; Provisional
 20-133 5.63e-07

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 51.76  E-value: 5.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   20 KIVQILLEAGADPNATTLEETTPLFLAVEN-----GQIDVLRLLLQHGANVN-----GSHSMCgwnSLHQASFQENAEII 89
Cdd:PHA02798  52 DIVKLFINLGANVNGLDNEYSTPLCTILSNikdykHMLDIVKILIENGADINkknsdGETPLY---CLLSNGYINNLEIL 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 22208951   90 KLLLRKGANKECQDDFGITPLFVAAQYG---KLESLSILISSGANVN 133
Cdd:PHA02798 129 LFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVDIN 175
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 83-272 6.57e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.60  E-value: 6.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   83 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVEL----- 157
Cdd:PHA02876 155 QDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAiidnr 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  158 ---------LLSSGADPDLYCN-------------EDSWQLPIHAAAQmghTKILDLLIP-LTNRACDTGLNKV---SPV 211
Cdd:PHA02876 235 sninkndlsLLKAIRNEDLETSlllydagfsvnsiDDCKNTPLHHASQ---APSLSRLVPkLLERGADVNAKNIkgeTPL 311

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22208951  212 YSAVFGGHE-DCLEILLRNGYSPDAQACLvfgFSSPVCMAFQKDcEFFGIVNILLKYGAQIN 272
Cdd:PHA02876 312 YLMAKNGYDtENIRTLIMLGADVNAADRL---YITPLHQASTLD-RNKDIVITLLELGANVN 369
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 388-429 1.70e-06

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 44.82  E-value: 1.70e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22208951 388 SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 429
Cdd:cd03731   5 PLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKE 46
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 385-428 1.75e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 44.74  E-value: 1.75e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 22208951 385 TVPSLTHLCRLEIRSSLKSerlRSDSYISQLPLPRSLHNYLLYE 428
Cdd:cd03723   2 TPRSLQHLCRCAIRKLLGS---RCHKLVPQLSLPTSLKNYLLLE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 7-274 2.81e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 2.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    7 FCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLqhgANVNGSHSMCGWNSLHQASFQENA 86
Cdd:PHA02878  38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI---RSINKCSVFYTLVAIKDAFNNRNV 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   87 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDK-ATPLFIAAQEGHTKCVELLLSSGADP 165
Cdd:PHA02878 115 EIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANV 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  166 DL--YCNEDswqlPIHAAAQMGHTKILDLLipLTNRACDTGLNKV--SPV-YSAVFGGHEDCLEILLRNGYSPDAQAClV 240
Cdd:PHA02878 195 NIpdKTNNS----PLHHAVKHYNKPIVHIL--LENGASTDARDKCgnTPLhISVGYCKDYDILKLLLEHGVDVNAKSY-I 267

                        250       260       270
                 ....*....|....*....|....*....|....
gi 22208951  241 FGFsSPVCMAFQKDceffGIVNILLKYGAQINEL 274
Cdd:PHA02878 268 LGL-TALHSSIKSE----RKLKLLLEYGADINSL 296
PHA02946 PHA02946
ankyin-like protein; Provisional
 5-161 3.10e-06

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 49.28  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFL--AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLhQASF 82
Cdd:PHA02946  71 DGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYlsGTDDEVIERINLLVQYGAKINNSVDEEGCGPL-LACT 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   83 QENAEIIKLLLRKGANKECQDDFGITPL--FVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE--GHTKCVELL 158
Cdd:PHA02946 150 DPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKtvKNVDIINLL 229


                 ...
gi 22208951  159 LSS 161
Cdd:PHA02946 230 LPS 232
PHA02798 PHA02798
ankyrin-like protein; Provisional
 31-171 3.33e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 49.06  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   31 DPNATTLEETT-PLFLAVENGQIDVLRLLLQHGANVNG-----SHSMCGWNSlHQASFQENAEIIKLLLRKGANKECQDD 104
Cdd:PHA02798  29 NPNEIVNEYSIfQKYLQRDSPSTDIVKLFINLGANVNGldneySTPLCTILS-NIKDYKHMLDIVKILIENGADINKKNS 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22208951  105 FGITPLFVAAQYG---KLESLSILISSGANVNCQALDKATPLFIAAQEGHT---KCVELLLSSGADPDLYCNE 171
Cdd:PHA02798 108 DGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINTHNNK 180
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 388-428 4.66e-06

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 43.43  E-value: 4.66e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 22208951 388 SLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 428
Cdd:cd03744   5 PLMDLCRRSVRLALGRERL---SEIHTLPLPASLKNYLLYQ 42
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 389-428 5.55e-06

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 43.02  E-value: 5.55e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 22208951 389 LTHLCRLEIRSSLKSERLRsdsYISQLPLPRSLHNYLLYE 428
Cdd:cd03743   6 LMDLCRRSARQALGRHRLH---HIQSLPLPQTLKNYLQYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 89-173 8.16e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 8.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   89 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSsgadpdlY 168
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR-------H 170


                 ....*
gi 22208951  169 CNEDS 173
Cdd:PTZ00322 171 SQCHF 175
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 41-66 8.56e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 8.56e-06
                           10        20
                   ....*....|....*....|....*.
gi 22208951     41 TPLFLAVENGQIDVLRLLLQHGANVN 66
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 5-36 1.06e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.28  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 22208951     5 EGFCALHLAASQ-GHWKIVQILLEAGADPNATT 36
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 86-253 2.59e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.41  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   86 AEIIKLLLRKGANKECQD-DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD 164
Cdd:PHA02878 147 AEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  165 PD---LYCNEdswqlPIHAAAqmGHTKILDLLIPLTNRACDTGLNK----VSPVYSAVFGghEDCLEILLRNGYSPDAqa 237
Cdd:PHA02878 227 TDardKCGNT-----PLHISV--GYCKDYDILKLLLEHGVDVNAKSyilgLTALHSSIKS--ERKLKLLLEYGADINS-- 295

                        170
                 ....*....|....*.
gi 22208951  238 cLVFGFSSPVCMAFQK 253
Cdd:PHA02878 296 -LNSYKLTPLSSAVKQ 310
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 385-427 3.57e-05

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 40.87  E-value: 3.57e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22208951 385 TVPSLTHLCRLEIRSSLKSERlrsdsyISQLPLPRSLHNYLLY 427
Cdd:cd03733   2 VVSSLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTY 38
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 386-427 3.64e-05

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 40.85  E-value: 3.64e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 22208951 386 VPSLTHLCRLEIRSSLkserlRSDsYISQLPLPRSLHNYLLY 427
Cdd:cd03741   3 VQSLQHLCRFVIRKLV-----RRD-HIPALPLPRRLIDYLRE 38
Ank_2 pfam12796
Ankyrin repeats (3 copies);
178-272 4.10e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 4.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   178 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNgyspdAQACLVFGFSSPVCMAFQKDCef 257
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-----ADVNLKDNGRTALHYAARSGH-- 73

                          90
                  ....*....|....*
gi 22208951   258 FGIVNILLKYGAQIN 272
Cdd:pfam12796  74 LEIVKLLLEKGADIN 88
Ank_2 pfam12796
Ankyrin repeats (3 copies);
5-35 4.14e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 4.14e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 22208951     5 EGFCALHLAASQGHWKIVQILLEAGADPNAT 35
Cdd:pfam12796  60 NGRTALHYAARSGHLEIVKLLLEKGADINVK 90
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 386-427 4.29e-05

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 40.74  E-value: 4.29e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 22208951    386 VPSLTHLCRLEIRSSLKSErlrsdsYISQLPLPRSLHNYLLY 427
Cdd:smart00253   7 VPSLQHLCRFTIRRCTRTD------QIKTLPLPPKLKDYLSY 42
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 4-126 4.56e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 45.95  E-value: 4.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE--------------TTPLFLAVENGQIDVLRLLLQH---GANVN 66
Cdd:cd22196  92 YKGQTALHIAIERRNMHLVELLVQNGADVHARASGEffkkkkggpgfyfgELPLSLAACTNQLDIVKFLLENphsPADIS 171

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22208951  67 GSHSMcGWNSLHQA-----SFQENAEIIKL----LLRKGAN-------KECQDDFGITPLFVAAQYGKLESLSILI 126
Cdd:cd22196 172 ARDSM-GNTVLHALvevadNTPENTKFVTKmyneILILGAKirpllklEEITNKKGLTPLKLAAKTGKIGIFAYIL 246
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 41-194 5.46e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.46  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951    41 TPLF-LAVENGQIDVLRLLLQHGANVNgshsmCGWNSLHQAS--FQENAE-IIKLLLRKG--------ANKECQDDF--G 106
Cdd:TIGR00870  54 SALFvAAIENENLELTELLLNLSCRGA-----VGDTLLHAISleYVDAVEaILLHLLAAFrksgplelANDQYTSEFtpG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   107 ITPLFVAAQYGKLESLSILISSGANVNCQAldkatplfiaaqeghtKCVELLLSSGADpDLYCNEdswqLPIHAAAQMGH 186
Cdd:TIGR00870 129 ITALHLAAHRQNYEIVKLLLERGASVPARA----------------CGDFFVKSQGVD-SFYHGE----SPLNAAACLGS 187


                  ....*...
gi 22208951   187 TKILDLLI 194
Cdd:TIGR00870 188 PSIVALLS 195
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 107-304 7.09e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 7.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  107 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLycnedswqLPIHAAAQMGH 186
Cdd:PHA02874  36 TTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI--------LPIPCIEKDMI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  187 TKILD--LLIPLTNRACDTGLnkvspvYSAVFGGHEDCLEILLRngYSPDAQACLVFGfSSPVCMAFQKDceFFGIVNIL 264
Cdd:PHA02874 108 KTILDcgIDVNIKDAELKTFL------HYAIKKGDLESIKMLFE--YGADVNIEDDNG-CYPIHIAIKHN--FFDIIKLL 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 22208951  265 LKYGAQIN------ELHLAYCLKYEKFSIFRYFLRKGcslgpwNHI 304
Cdd:PHA02874 177 LEKGAYANvkdnngESPLHNAAEYGDYACIKLLIDHG------NHI 216
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 4-127 9.97e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 44.79  E-value: 9.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   4 FEGFCALHLAASQGHWKIVQILLEAGADPNAT--------TLEET------TPLFLAVENGQIDVLRLLLQHG---ANVN 66
Cdd:cd22193  74 YEGQTALHIAIERRQGDIVALLVENGADVHAHakgrffqpKYQGEgfyfgeLPLSLAACTNQPDIVQYLLENEhqpADIE 153

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22208951  67 GSHSMcGWNSLHQA-----SFQENAEIIK----LLLRKGAN-------KECQDDFGITPLFVAAQYGKLESLSILIS 127
Cdd:cd22193 154 AQDSR-GNTVLHALvtvadNTKENTKFVTrmydMILIRGAKlcptvelEEIRNNDGLTPLQLAAKMGKIEILKYILQ 229
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 388-428 1.03e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 39.62  E-value: 1.03e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 22208951 388 SLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 428
Cdd:cd03719   5 SLLHLSRLCVRHALGDTRL---GQVSALPLPPAMKRYLLYQ 42
Ank_4 pfam13637
Ankyrin repeats (many copies);
73-126 1.31e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 22208951    73 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILI 126
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
5-46 1.66e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 1.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 22208951     5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLA 46
Cdd:pfam13857  15 EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 386-428 2.23e-04

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 38.64  E-value: 2.23e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22208951 386 VPSLTHLCRLEIRsslkseRLRSDSYISQLPLPRSLHNYLLYE 428
Cdd:cd03746   3 VASLQHLCRMAIR------RVMPTQQVKELPIPSKLLEFLTYR 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
177-227 2.49e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 2.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 22208951   177 PIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 385-427 2.77e-04

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 38.34  E-value: 2.77e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22208951 385 TVPSLTHLCRLEIRSSLKSERlrsdsyISQLPLPRSLHNYLLY 427
Cdd:cd03745   2 VLPSLRHLCRKALRHFLTTYQ------VLALPIPKKMKEFLTY 38
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 389-429 3.70e-04

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 37.92  E-value: 3.70e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 22208951 389 LTHLCRLEIRSSLKSERLRsdsYISQLPLPRSLHNYLLYED 429
Cdd:cd03721   6 LAHLCRLKVRTLIGINRIK---LIDTLPLPPRLIRYLNHQE 43
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 138-167 5.17e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 5.17e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 22208951    138 DKATPLFIAAQEGHTKCVELLLSSGADPDL 167
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 41-66 5.55e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.24  E-value: 5.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 22208951    41 TPLFLAVENGQIDVLRLLLQHGANVN 66
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 9-34 5.60e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 5.60e-04
                           10        20
                   ....*....|....*....|....*.
gi 22208951      9 ALHLAASQGHWKIVQILLEAGADPNA 34
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 41-66 5.88e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 5.88e-04
                          10        20
                  ....*....|....*....|....*..
gi 22208951    41 TPLFLAV-ENGQIDVLRLLLQHGANVN 66
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVN 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 141-167 6.12e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 6.12e-04
                          10        20
                  ....*....|....*....|....*...
gi 22208951   141 TPLFIAA-QEGHTKCVELLLSSGADPDL 167
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNA 31
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 385-425 6.55e-04

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 37.25  E-value: 6.55e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 22208951 385 TVPSLTHLCRLEIrsslksERLRSDsyISQLPLPRSLHNYL 425
Cdd:cd03734   2 SARSLQHLCRLVI------NRLVTD--VDCLPLPRRMADYL 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 4-139 6.83e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 42.17  E-value: 6.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   4 FEGFCALHLAASQGHWKIVQILLEAGAD----PNATTLEETT---------PLFLAVENGQIDVLRLLLQHGANVNGSHS 70
Cdd:cd21882  71 YQGQTALHIAIENRNLNLVRLLVENGADvsarATGRFFRKSPgnlfyfgelPLSLAACTNQEEIVRLLLENGAQPAALEA 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  71 M--CGWNSLHQASFQEN---------AEIIKLLLRKGAN-------KECQDDFGITPLFVAAQYGKLESLSILISSGANV 132
Cdd:cd21882 151 QdsLGNTVLHALVLQADntpensafvCQMYNLLLSYGAHldptqqlEEIPNHQGLTPLKLAAVEGKIVMFQHILQREFSG 230


                ....*..
gi 22208951 133 NCQALDK 139
Cdd:cd21882 231 PYQPLSR 237
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 384-427 7.04e-04

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 37.16  E-value: 7.04e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 22208951 384 ATVPSLTHLCRLEIRSSLKSERLRsdsYISQLPLPRSLHNYLLY 427
Cdd:cd03724   1 ATPSSLCQLCRLCIRNYIGRSRLH---LIPQLQLPTLLKNFLQY 41
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 388-428 1.32e-03

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 36.24  E-value: 1.32e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 22208951 388 SLTHLCRLEIRSSLKSERLrsdSYISQLPLPRSLHNYLLYE 428
Cdd:cd03720   5 SLLSLCRIAVRRALGKQRL---SLICSLPLPDPIKKFLLHE 42
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 41-112 1.45e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.80  E-value: 1.45e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22208951   41 TPLFLAVENGQI--DVLRLLLQHGANVNGSHSMCGWNSLHQ-ASFQENA--EIIKLLLRKGANKECQDDFGITPLFV 112
Cdd:PHA02859  53 TPIFSCLEKDKVnvEILKFLIENGADVNFKTRDNNLSALHHyLSFNKNVepEILKILIDSGSSITEEDEDGKNLLHM 129
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 5-34 1.79e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.70  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 22208951     5 EGFCALHLAASQGHWKIVQILLEAGADPNA 34
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 115-167 2.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 22208951  115 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 167
Cdd:PHA02876 154 QQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNI 206
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 387-426 2.39e-03

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 35.58  E-value: 2.39e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 22208951 387 PSLTHLCRLEIRSSLkSERLRSDSyISQLPLPRSLHNYLL 426
Cdd:cd03727   4 GTLKALARYAVRRSL-GVQYLPEA-VKQLPLPRSVKEYLL 41
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 52-130 2.41e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 38.32  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   52 IDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK-GANKECQDDFGITPLFVAAQYGKLESLSILISSGA 130
Cdd:PHA02736  71 QEKLKLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 106-134 3.01e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 3.01e-03
                           10        20
                   ....*....|....*....|....*....
gi 22208951    106 GITPLFVAAQYGKLESLSILISSGANVNC 134
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 6-59 3.61e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.62  E-value: 3.61e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 22208951    6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 59
Cdd:PHA03095 257 GQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 147-228 4.06e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951  147 AQEGHTKCVELLLSSGADPDlyCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEIL 226
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPN--CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                 ..
gi 22208951  227 LR 228
Cdd:PTZ00322 168 SR 169
TRPV2 cd22197
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ...
 4-120 4.33e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411981 [Multi-domain]  Cd Length: 640  Bit Score: 39.45  E-value: 4.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   4 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE-------------TTPLFLAVENGQIDVLRLLLQHG---ANVNG 67
Cdd:cd22197  92 YRGHSALHIAIEKRSLQCVKLLVENGADVHARACGRffqkkqgtcfyfgELPLSLAACTKQWDVVNYLLENPhqpASLQA 171

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22208951  68 SHSMcGWNSLHQASF-----QENAEII----KLLLRKGAN-------KECQDDFGITPLFVAAQYGKLE 120
Cdd:cd22197 172 QDSL-GNTVLHALVMiadnsPENSALVikmyDGLLQAGARlcptvqlEEISNHEGLTPLKLAAKEGKIE 239
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 4-78 5.28e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 5.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951     4 FEGFCALHLAASQGHWKIVQILLEAGADPNAT-------TLEETT-------PLFLAVENGQIDVLRLLLQHGANVNGSH 69
Cdd:TIGR00870 126 TPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffvKSQGVDsfyhgesPLNAAACLGSPSIVALLSEDPADILTAD 205


                  ....*....
gi 22208951    70 SMcGWNSLH 78
Cdd:TIGR00870 206 SL-GNTLLH 213
PHA02946 PHA02946
ankyin-like protein; Provisional
 33-144 6.66e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 38.88  E-value: 6.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22208951   33 NATTLEETTPLFLAVENGQIDVLRLLLQH---GANVNGSHSMCGWNSLHQASFQEnaeiiklLLRKGANKECQDDFGITP 109
Cdd:PHA02946   3 NIMSAEYYLSLYAKYNSKNLDVFRNMLQAiepSGNYHILHAYCGIKGLDERFVEE-------LLHRGYSPNETDDDGNYP 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 22208951  110 LFVAAQYGKLESLSILISSGANVNCQALDKATPLF 144
Cdd:PHA02946  76 LHIASKINNNRIVAMLLTHGADPNACDKQHKTPLY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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