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coiled-coil domain-containing protein 25 [Mus musculus]
NFACT family protein( domain architecture ID 10529311)
NFACT (NEMF, FbpA, Caliban, and Tae2) family protein containing a DUF814 domain, may act in ribosome quality control (RQC) by adding a poly-Ala tail to abortively translated proteins to tag them for degradation, or be exported and behave as a fibronectin-binding adhesin associated with virulence; similar to vertebrate coiled-coil domain-containing protein 25 and yeast protein JLP2
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
NFACT-R_1 | pfam05670 | NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ... |
1-112 | 3.51e-49 | |||
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important. : Pssm-ID: 428576 [Multi-domain] Cd Length: 111 Bit Score: 155.85 E-value: 3.51e-49
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Name | Accession | Description | Interval | E-value | |||
NFACT-R_1 | pfam05670 | NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ... |
1-112 | 3.51e-49 | |||
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important. Pssm-ID: 428576 [Multi-domain] Cd Length: 111 Bit Score: 155.85 E-value: 3.51e-49
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RqcH | COG1293 | Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ... |
12-100 | 5.10e-08 | |||
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440904 [Multi-domain] Cd Length: 578 Bit Score: 52.15 E-value: 5.10e-08
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Name | Accession | Description | Interval | E-value | |||
NFACT-R_1 | pfam05670 | NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ... |
1-112 | 3.51e-49 | |||
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important. Pssm-ID: 428576 [Multi-domain] Cd Length: 111 Bit Score: 155.85 E-value: 3.51e-49
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RqcH | COG1293 | Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ... |
12-100 | 5.10e-08 | |||
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440904 [Multi-domain] Cd Length: 578 Bit Score: 52.15 E-value: 5.10e-08
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Blast search parameters | ||||
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