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Conserved domains on  [gi|22212927|ref|NP_667345|]
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transcriptional repressor NF-X1 isoform 3 [Homo sapiens]

Protein Classification

transcriptional repressor NF-X1( domain architecture ID 11616330)

transcriptional repressor NF-X1 is a transcription factor that regulates the expression of class II major histocompatibility complex (MHC) genes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RING-CH-C4HC3_NFX1 cd16696
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar ...
356-409 2.29e-27

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain.


:

Pssm-ID: 438357 [Multi-domain]  Cd Length: 55  Bit Score: 104.82  E-value: 2.29e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22212927 356 YECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQA-DGQSGWRCPACQ 409
Cdd:cd16696   1 YECMVCCEVVRVMAPVWSCSSCYHVFHLNCIKKWARSPAAQAeDNSGGWRCPACQ 55
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
622-674 3.94e-12

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


:

Pssm-ID: 100116  Cd Length: 49  Bit Score: 61.59  E-value: 3.94e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 22212927 622 CGKVCGKPLPCGsldfIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTS 674
Cdd:cd06008   1 CGEVCGKPLPCG----NHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
496-544 9.51e-10

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


:

Pssm-ID: 100116  Cd Length: 49  Bit Score: 54.66  E-value: 9.51e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22212927 496 CSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGT 544
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
711-763 4.82e-08

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


:

Pssm-ID: 100116  Cd Length: 49  Bit Score: 50.04  E-value: 4.82e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 22212927 711 CPLICGRKLRCGLHRCEEPCHRGNCQTCWQASfdELTCHCGASviYPPVPCGT 763
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETV--KKKCRCGKT--TKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
557-599 5.92e-08

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


:

Pssm-ID: 100116  Cd Length: 49  Bit Score: 49.65  E-value: 5.92e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22212927 557 CLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQlvRCCPCGQT 599
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVK--KKCRCGKT 41
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
684-732 1.04e-05

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


:

Pssm-ID: 100116  Cd Length: 49  Bit Score: 43.10  E-value: 1.04e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22212927 684 CDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHR 732
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
 
Name Accession Description Interval E-value
RING-CH-C4HC3_NFX1 cd16696
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar ...
356-409 2.29e-27

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain.


Pssm-ID: 438357 [Multi-domain]  Cd Length: 55  Bit Score: 104.82  E-value: 2.29e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22212927 356 YECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQA-DGQSGWRCPACQ 409
Cdd:cd16696   1 YECMVCCEVVRVMAPVWSCSSCYHVFHLNCIKKWARSPAAQAeDNSGGWRCPACQ 55
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
622-674 3.94e-12

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 61.59  E-value: 3.94e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 22212927 622 CGKVCGKPLPCGsldfIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTS 674
Cdd:cd06008   1 CGEVCGKPLPCG----NHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
496-544 9.51e-10

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 54.66  E-value: 9.51e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22212927 496 CSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGT 544
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
711-763 4.82e-08

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 50.04  E-value: 4.82e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 22212927 711 CPLICGRKLRCGLHRCEEPCHRGNCQTCWQASfdELTCHCGASviYPPVPCGT 763
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETV--KKKCRCGKT--TKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
557-599 5.92e-08

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 49.65  E-value: 5.92e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22212927 557 CLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQlvRCCPCGQT 599
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVK--KKCRCGKT 41
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
684-732 1.04e-05

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 43.10  E-value: 1.04e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22212927 684 CDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHR 732
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
COG5219 COG5219
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
357-409 6.73e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227544 [Multi-domain]  Cd Length: 1525  Bit Score: 43.50  E-value: 6.73e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 22212927  357 ECMVC---CELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQadgqsgwRCPACQ 409
Cdd:COG5219 1471 ECAICysvLDMVDRSLPSKRCATCKNKFHTRCLYKWFASSARS-------NCPLCR 1519
zf-NF-X1 pfam01422
NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following ...
567-585 7.04e-03

NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA.


Pssm-ID: 460205  Cd Length: 19  Bit Score: 34.81  E-value: 7.04e-03
                          10
                  ....*....|....*....
gi 22212927   567 CGNHTCSQVCHPQPCQQCP 585
Cdd:pfam01422   1 CGNHTCEEVCHEGPCPPCP 19
 
Name Accession Description Interval E-value
RING-CH-C4HC3_NFX1 cd16696
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar ...
356-409 2.29e-27

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1 and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFX1 contains an N-terminal PAM2 motif, a C4HC3-type RING-CH finger, a Cys-rich region that harbors several NFX1-type zinc fingers, and a C-terminal R3H domain.


Pssm-ID: 438357 [Multi-domain]  Cd Length: 55  Bit Score: 104.82  E-value: 2.29e-27
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22212927 356 YECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQA-DGQSGWRCPACQ 409
Cdd:cd16696   1 YECMVCCEVVRVMAPVWSCSSCYHVFHLNCIKKWARSPAAQAeDNSGGWRCPACQ 55
RING-CH-C4HC3_NFX1-like cd16492
RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1, NF-X1-type ...
356-409 1.57e-18

RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1, NF-X1-type zinc finger protein NFXL1, and similar proteins; NF-X1, also known as nuclear transcription factor, X box-binding protein 1, is a novel cysteine-rich sequence-specific DNA-binding protein that interacts with the conserved X-box motif of the human major histocompatibility complex (MHC) class II genes via a repeated Cys-His domain. It functions as a cytokine-inducible transcriptional repressor that plays an important role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by interferon gamma (IFN- gamma). NFXL1, also known as NF-X1-type zinc finger protein NFXL1 or ovarian zinc finger protein (OZFP), is encoded by a novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. This subfamily also includes NF-X1 homologs from insects, plants, and fungi. Drosophila melanogaster shuttle craft (STC) is a DNA- or RNA-binding protein required for proper axon guidance in the central nervous system. It functions as a putative transcription factor and plays an essential role in the completion of embryonic development. In contrast to NF-X1, STC contains an RD domain. The Arabidopsis genome encodes two NF-X1 homologs, AtNFXL1 and AtNFXL2, both of which function as regulators of salt stress responses. The AtNFXL1 protein is a nuclear factor that positively affects adaptation to salt stress. It also functions as a negative regulator of the type A trichothecene phytotoxin-induced defense response. AtNFXL2 controls abscisic acid (ABA) levels and suppresses ABA responses. It may also prevent unnecessary and costly stress adaptation under favorable conditions. FKBP12-associated protein 1 (FAP1) is a dosage suppressor of rapamycin toxicity in budding yeast. It is localized in the cytoplasm, but upon rapamycin treatment translocates to the nucleus. FAP1 interacts with FKBP12 in a rapamycin-sensitive manner. It is a proline-rich protein containing a novel cysteine-rich DNA-binding motif. Unique structural features of the NFX1 and NFXL proteins are the Cys-rich region and a specific RING-CH finger motif with an unusual arrangement of zinc-coordinating residues. The Cys-rich region is required for binding to specific promoter elements. It frequently comprises more than 500 amino acids and harbors several NFX1-type zinc finger domains, characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The RING-CH finger, also known as vRING or RINGv, may have E3 ligase activity. It is characterized by a C4HC3-type Zn ligand signature and additional conserved amino acids, rather than the C3H2C3-type cysteines and histidines arrangement in canonical RING-H2 finger. In addition to the Cys-rich region and RING-CH finger, NFX1 contains a PAM2 motif in the N-terminus and a R3H domain in the C-terminus.


Pssm-ID: 438155 [Multi-domain]  Cd Length: 58  Bit Score: 79.79  E-value: 1.57e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22212927 356 YECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQ----SGWRCPACQ 409
Cdd:cd16492   1 YECMICTENVGRNQSIWSCSRCYRVFHLSCIKKWAKNSEEKAEQVknddDSWRCPGCQ 58
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
622-674 3.94e-12

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 61.59  E-value: 3.94e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 22212927 622 CGKVCGKPLPCGsldfIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTS 674
Cdd:cd06008   1 CGEVCGKPLPCG----NHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
RING-CH-C4HC3_NFXL1 cd16697
RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box ...
357-408 1.86e-10

RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box binding-like 1 (NFXL1) and similar proteins; NFXL1, also known as NF-X1-type zinc finger protein NFXL1, or ovarian zinc finger protein (OZFP), is encoded by the novel human cytoplasm-distribution zinc finger protein (CDZFP) gene. It is a putative zinc finger protein with a C4HC3-type RING-CH finger and a Cys-rich region that harbors several NFX1-type zinc fingers.


Pssm-ID: 438358  Cd Length: 63  Bit Score: 56.97  E-value: 1.86e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22212927 357 ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWAR---------SPASQADGQSGWRCPAC 408
Cdd:cd16697   2 TCLICIESIKRNDAIWSCSGCFCIFHLPCIQKWAKdsiflvslrSASDFPQKELPWHCPKC 62
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
496-544 9.51e-10

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 54.66  E-value: 9.51e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22212927 496 CSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGT 544
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
711-763 4.82e-08

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 50.04  E-value: 4.82e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 22212927 711 CPLICGRKLRCGLHRCEEPCHRGNCQTCWQASfdELTCHCGASviYPPVPCGT 763
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETV--KKKCRCGKT--TKEVPCGE 49
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
557-599 5.92e-08

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 49.65  E-value: 5.92e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22212927 557 CLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQlvRCCPCGQT 599
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVK--KKCRCGKT 41
NF-X1-zinc-finger cd06008
Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear ...
684-732 1.04e-05

Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger co-occurs with atypical RING-finger and R3H domains. Human NF-X1 is involved in the transcriptional repression of major histocompatibility complex class II genes. The drosophila homolog encoded by stc (shuttle craft) plays a role in embryonic development, and the Arabidopsis homologue AtNFXL1 has been shown to function in the response to trichothecene and other defense mechanisms.


Pssm-ID: 100116  Cd Length: 49  Bit Score: 43.10  E-value: 1.04e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 22212927 684 CDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHR 732
Cdd:cd06008   1 CGEVCGKPLPCGNHKCEQLCHEGPCPPCPETVKKKCRCGKTTKEVPCGE 49
RING-H2 cd16448
H2 subclass of RING (RING-H2) fingers and its variants; The RING finger is a specialized type ...
358-409 3.75e-04

H2 subclass of RING (RING-H2) fingers and its variants; The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers: some have different Cys/His patterns while some lack a single Cys or His residue at typical Zn ligand positions (the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can indeed chelate Zn in a RING finger as well). This family corresponds to the H2 subclass of RING (RING-H2) finger proteins that are characterized by containing C3H2C3-type canonical RING-H2 fingers or noncanonical RING-H2 finger variants, including C4HC3- (RING-CH alias RINGv), C3H3C2-, C3H2C2D-, C3DHC3-, and C4HC2H-type modified RING-H2 fingers. The canonical RING-H2 finger has been defined as C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers. It binds two Zn ions in a unique "cross-brace" arrangement, which distinguishes it from tandem zinc fingers and other similar motifs. RING-H2 finger can be found in a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serves as a scaffold for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enables efficient transfer of ubiquitin from E2 to the substrates.


Pssm-ID: 438112 [Multi-domain]  Cd Length: 43  Bit Score: 38.92  E-value: 3.75e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 22212927 358 CMVCCELVRVTAPVWsCQSCYHVFHLNCIKKWARSpasqadgqSGWRCPACQ 409
Cdd:cd16448   1 CVICLEEFEEGDVVR-LLPCGHVFHLACILRWLES--------GNNTCPLCR 43
COG5219 COG5219
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
357-409 6.73e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227544 [Multi-domain]  Cd Length: 1525  Bit Score: 43.50  E-value: 6.73e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 22212927  357 ECMVC---CELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQadgqsgwRCPACQ 409
Cdd:COG5219 1471 ECAICysvLDMVDRSLPSKRCATCKNKFHTRCLYKWFASSARS-------NCPLCR 1519
mRING-H2-C3DHC3_ZFPL1 cd16487
Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) ...
377-410 2.32e-03

Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins; ZFPL1, also known as zinc finger protein MCG4, is a novel mitotic Golgi phosphoprotein required for cis-Golgi integrity and efficient endoplasmic reticulum (ER)-to-Golgi transport via directly interacting with the cis-Golgi matrix protein GM130. ZFPL1 is a widely expressed integral membrane protein with two predicted zinc fingers at its N-terminus. One is a novel type of zinc finger, and the other is a modified RING-H2 finger that lacks the fourth zinc-binding residue of the consensus C3H2C3-type RING-H2 finger. It also contains a bipartite nuclear localization signal (NLS), and a leucine zipper at the C-terminus.


Pssm-ID: 438150 [Multi-domain]  Cd Length: 57  Bit Score: 36.89  E-value: 2.32e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 22212927 377 CYHVFHLNCIKKWARS-PASQAdgQSGWRCPACQN 410
Cdd:cd16487  21 CYDLFHWSCLNEYAAQlPANTA--PAGYTCPQCKG 53
zf-NF-X1 pfam01422
NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following ...
567-585 7.04e-03

NF-X1 type zinc finger; This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA.


Pssm-ID: 460205  Cd Length: 19  Bit Score: 34.81  E-value: 7.04e-03
                          10
                  ....*....|....*....
gi 22212927   567 CGNHTCSQVCHPQPCQQCP 585
Cdd:pfam01422   1 CGNHTCEEVCHEGPCPPCP 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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