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Conserved domains on  [gi|42544198|ref|NP_671736|]
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fibrinogen-like protein 1 precursor [Homo sapiens]

Protein Classification

fibrinogen-related domain-containing protein( domain architecture ID 10053370)

fibrinogen-related domain-containing protein contains a C terminal globular domain similar to that of fibrinogen, and may be involved in one or more of a variety of binding interactions and functions including complement activation, signaling and regulation

PubMed:  1304888
SCOP:  4002544

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
78-304 7.21e-123

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


:

Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 7.21e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198  78 RQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVqkhGEYWL 156
Cdd:cd00087   1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMdTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---GEFWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198 157 GNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAgnfhpevqwwaSHQRMKFST 236
Cdd:cd00087  78 GLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALS-----------YHNGMKFST 146
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544198 237 WDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRP 304
Cdd:cd00087 147 FDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGGHRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
78-304 7.21e-123

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 7.21e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198  78 RQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVqkhGEYWL 156
Cdd:cd00087   1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMdTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---GEFWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198 157 GNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAgnfhpevqwwaSHQRMKFST 236
Cdd:cd00087  78 GLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALS-----------YHNGMKFST 146
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544198 237 WDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRP 304
Cdd:cd00087 147 FDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGGHRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
79-304 2.49e-116

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 333.86  E-value: 2.49e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198     79 QYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVqkhGEYWLG 157
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMeTDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA---GEFWLG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198    158 NKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDslagnfhpevQWWASHQRMKFSTW 237
Cdd:smart00186  78 NENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGD----------ASLTYHNGMQFSTY 147
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42544198    238 DRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSgpyTAKTDNGIVWYTWHGWWYSLKSVVMKIRP 304
Cdd:smart00186 148 DRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP---NNNYDNGINWATWKGSWYSLKFTEMKIRP 211
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
80-304 2.13e-86

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 258.61  E-value: 2.13e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198    80 YADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFvqKHGEYWLGN 158
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMeTDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNL--SPGEFWLGN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198   159 KNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSL--AGNFHpevqwwASHQRMKFST 236
Cdd:pfam00147  80 DKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtAGRSM------TYHNGMQFST 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544198   237 WDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKtDNGIVWYTWHGWWYSLKSVVMKIRP 304
Cdd:pfam00147 154 WDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-QNGIIWATWKGRWYSMKKAEMKIRP 220
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
83-123 6.09e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 51.02  E-value: 6.09e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 42544198   83 CSEIFNDGYKL-SGFYKIKP--LQSPAEFSVYCDM-SDGGGWTVI 123
Cdd:NF040941   2 CWEILQAGPSApSGVYWIDPdgMGGLAPFQVYCDMtTDGGGWTLV 46
 
Name Accession Description Interval E-value
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
78-304 7.21e-123

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 7.21e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198  78 RQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVqkhGEYWL 156
Cdd:cd00087   1 PLPRDCSEVLQRGGRTSGVYTIQPPGSNEPFQVYCDMdTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLD---GEFWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198 157 GNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAgnfhpevqwwaSHQRMKFST 236
Cdd:cd00087  78 GLEKIHLLTSQGPYELRIDLEDWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALS-----------YHNGMKFST 146
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544198 237 WDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRP 304
Cdd:cd00087 147 FDRDNDGASGNCAESYSGGWWYNSCHASNLNGRYYSGGHRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
79-304 2.49e-116

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 333.86  E-value: 2.49e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198     79 QYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVqkhGEYWLG 157
Cdd:smart00186   1 LPRDCSDVLQNGGKTSGLYTIYPDGSSRPLKVYCDMeTDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLA---GEFWLG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198    158 NKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDslagnfhpevQWWASHQRMKFSTW 237
Cdd:smart00186  78 NENIHLLTSQGKYELRIDLEDWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGD----------ASLTYHNGMQFSTY 147
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42544198    238 DRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSgpyTAKTDNGIVWYTWHGWWYSLKSVVMKIRP 304
Cdd:smart00186 148 DRDNDKYSGNCAEEYGGGWWYNNCHAANLNGRYYP---NNNYDNGINWATWKGSWYSLKFTEMKIRP 211
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
80-304 2.13e-86

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 258.61  E-value: 2.13e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198    80 YADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDM-SDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFvqKHGEYWLGN 158
Cdd:pfam00147   2 GRDCSDVYNKGAKTSGLYTIRPDGATKPFEVYCDMeTDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNL--SPGEFWLGN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42544198   159 KNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSL--AGNFHpevqwwASHQRMKFST 236
Cdd:pfam00147  80 DKIHLLTKQGPYVLRIDLEDWNGETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtAGRSM------TYHNGMQFST 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42544198   237 WDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKtDNGIVWYTWHGWWYSLKSVVMKIRP 304
Cdd:pfam00147 154 WDRDNDSPDGNCALSYGGGWWYNNCHAANLNGVYYYGGTYSK-QNGIIWATWKGRWYSMKKAEMKIRP 220
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
83-123 6.09e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 51.02  E-value: 6.09e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 42544198   83 CSEIFNDGYKL-SGFYKIKP--LQSPAEFSVYCDM-SDGGGWTVI 123
Cdd:NF040941   2 CWEILQAGPSApSGVYWIDPdgMGGLAPFQVYCDMtTDGGGWTLV 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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