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Conserved domains on  [gi|22538493|ref|NP_683682|]
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RCC1-like G exchanging factor-like protein isoform 2 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-437 6.13e-36

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 135.49  E-value: 6.13e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493  55 AARAD-RVFVWGFSFSGALGVPSfvvpssgpgpragarprRRIQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184  12 ALKSDgTVWCWGDNSYGQLGDGT-----------------TTDRSTPVRVPGLSNVVAVAAGGDHTcaLKADGT-----V 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 132 WGMGLNKDSQLGfhrsrkDKTRGYEyvlePSPVSLPLDrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRkvv 211
Cdd:COG5184  70 WCWGNNSYGQLG------DGTTTDR----TTPVKVPGL----TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD--- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 212 eneiYSESHRVHRMQDFDGQ--VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLagvNVIQVA 289
Cdd:COG5184 133 ----GTTTNRLTPVQVDAGLsgVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS---GVVAVA 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 290 TYGDCCLAVSADGGLFGWGNSEYLQL---ASVTDSTQVNVPrclhfsGVGKVRQAACGGT-GCAVLNGeGHVFVWG---Y 362
Cdd:COG5184 206 AGGDHSCALKSDGTVWCWGSNSSGQLgdgTTTDRATPVQVA------GLTGVVAIAAGGShTCALKSD-GTVWCWGdnsY 278

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22538493 363 GILGKGpNLVESAVPEMIPptlfGLTefnpeiQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Cdd:COG5184 279 GQLGDG-TTTDRSTPVKVP----GLS------GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-437 6.13e-36

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 135.49  E-value: 6.13e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493  55 AARAD-RVFVWGFSFSGALGVPSfvvpssgpgpragarprRRIQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184  12 ALKSDgTVWCWGDNSYGQLGDGT-----------------TTDRSTPVRVPGLSNVVAVAAGGDHTcaLKADGT-----V 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 132 WGMGLNKDSQLGfhrsrkDKTRGYEyvlePSPVSLPLDrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRkvv 211
Cdd:COG5184  70 WCWGNNSYGQLG------DGTTTDR----TTPVKVPGL----TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD--- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 212 eneiYSESHRVHRMQDFDGQ--VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLagvNVIQVA 289
Cdd:COG5184 133 ----GTTTNRLTPVQVDAGLsgVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS---GVVAVA 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 290 TYGDCCLAVSADGGLFGWGNSEYLQL---ASVTDSTQVNVPrclhfsGVGKVRQAACGGT-GCAVLNGeGHVFVWG---Y 362
Cdd:COG5184 206 AGGDHSCALKSDGTVWCWGSNSSGQLgdgTTTDRATPVQVA------GLTGVVAIAAGGShTCALKSD-GTVWCWGdnsY 278

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22538493 363 GILGKGpNLVESAVPEMIPptlfGLTefnpeiQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Cdd:COG5184 279 GQLGDG-TTTDRSTPVKVP----GLS------GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
232-261 8.54e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.80  E-value: 8.54e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 22538493   232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQ 261
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-437 6.13e-36

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 135.49  E-value: 6.13e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493  55 AARAD-RVFVWGFSFSGALGVPSfvvpssgpgpragarprRRIQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184  12 ALKSDgTVWCWGDNSYGQLGDGT-----------------TTDRSTPVRVPGLSNVVAVAAGGDHTcaLKADGT-----V 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 132 WGMGLNKDSQLGfhrsrkDKTRGYEyvlePSPVSLPLDrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRkvv 211
Cdd:COG5184  70 WCWGNNSYGQLG------DGTTTDR----TTPVKVPGL----TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD--- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 212 eneiYSESHRVHRMQDFDGQ--VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLagvNVIQVA 289
Cdd:COG5184 133 ----GTTTNRLTPVQVDAGLsgVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS---GVVAVA 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 290 TYGDCCLAVSADGGLFGWGNSEYLQL---ASVTDSTQVNVPrclhfsGVGKVRQAACGGT-GCAVLNGeGHVFVWG---Y 362
Cdd:COG5184 206 AGGDHSCALKSDGTVWCWGSNSSGQLgdgTTTDRATPVQVA------GLTGVVAIAAGGShTCALKSD-GTVWCWGdnsY 278

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22538493 363 GILGKGpNLVESAVPEMIPptlfGLTefnpeiQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Cdd:COG5184 279 GQLGDG-TTTDRSTPVKVP----GLS------GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 178-444 2.77e-32

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 125.47  E-value: 2.77e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 178 QVSCGRAHSLVLTDREGVFSMGNNSYGQCGrkvveNEIYSESHRVHRMQDFDGqVVQVACGQDHSLFLTDKGEVYSCGWG 257
Cdd:COG5184   2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLG-----DGTTTDRSTPVRVPGLSN-VVAVAAGGDHTCALKADGTVWCWGNN 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 258 ADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASvTDSTQVNVPRcLHFSGVGK 337
Cdd:COG5184  76 SYGQLGDGTTTDRTTPVKVPG---LTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPV-QVDAGLSG 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 338 VRQAACGG-TGCAVLNGeGHVFVWG---YGILGKGpNLVESAVPEMIPptlfGLTEfnpeiqVSRIRCGLSHFAALTNKG 413
Cdd:COG5184 151 VVAIAAGGyHTCALKSD-GTVWCWGansYGQLGDG-TTTDRPTPVQVG----GLSG------VVAVAAGGDHSCALKSDG 218

                       250       260       270
                ....*....|....*....|....*....|.
gi 22538493 414 ELFVWGKNIRGCLGIGRLEDQYFPWRAPAPS 444
Cdd:COG5184 219 TVWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 233-437 1.44e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 103.90  E-value: 1.44e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGdlaGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 312
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG---LSNVVAVAAGGDHTCALKADGTVWCWGNNSY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 313 LQL--ASVTDSTQ-VNVPrclhfsGVGKVRQAACGG-TGCAVLNGeGHVFVWG---YGILGKGPNlVESAVPEMIPPTLF 385
Cdd:COG5184  78 GQLgdGTTTDRTTpVKVP------GLTGVVAVAAGYyHSCALKSD-GTVWCWGdnsSGQLGDGTT-TNRLTPVQVDAGLS 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 22538493 386 GltefnpeiqVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Cdd:COG5184 150 G---------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTP 192
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 55-274 5.80e-15

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 75.78  E-value: 5.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493  55 AARAD-RVFVWGFSFSGALGVPSFVVpssgpgpragarprrriQPVPYRLELDQKISSAACGYGFT--LLSSKTadvtkV 131
Cdd:COG5184 163 ALKSDgTVWCWGANSYGQLGDGTTTD-----------------RPTPVQVGGLSGVVAVAAGGDHScaLKSDGT-----V 220

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493 132 WGMGLNKDSQLGfhrsrkdkTRGYEYVLEPSPVSLPldrpqeTRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKvv 211
Cdd:COG5184 221 WCWGSNSSGQLG--------DGTTTDRATPVQVAGL------TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-- 284

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22538493 212 eneiySESHRVHRMQ-DFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPT 274
Cdd:COG5184 285 -----TTTDRSTPVKvPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
232-261 8.54e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.80  E-value: 8.54e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 22538493   232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQ 261
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
301-351 3.44e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.05  E-value: 3.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 22538493   301 DGGLFGWGNSEYLQLASVTDSTQvNVPRCLHFSGVGKVRQAACGGTGCAVL 351
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENV-LVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
195-245 1.01e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 42.50  E-value: 1.01e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22538493   195 VFSMGNNSYGQCGRKVVENEIYSEshrvhRMQDFDGQ-VVQVACGQDHSLFL 245
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQ-----KVEGLSGNkVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
176-205 1.17e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 1.17e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 22538493   176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQ 205
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
248-298 4.09e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.96  E-value: 4.09e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 22538493   248 KGEVYSCGWGADGQTGLGHYNITSSPTKLGGdLAGVNVIQVATYGDCCLAV 298
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG-LSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
396-425 5.52e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.02  E-value: 5.52e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 22538493   396 VSRIRCGLSHFAALTNKGELFVWGKNIRGC 425
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
130-189 1.74e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 36.34  E-value: 1.74e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22538493   130 KVWGMGLNKDSQLGfHRSRKDktrgyeyVLEPSPVSLPLDRpqetRVLQVSCGRAHSLVL 189
Cdd:pfam00415   3 RVYTWGRNDYGQLG-LGTTEN-------VLVPQKVEGLSGN----KVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
412-437 4.79e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 35.19  E-value: 4.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 22538493   412 KGELFVWGKNIRGCLGIGRLEDQYFP 437
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVP 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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