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Conserved domains on  [gi|1890262188|ref|NP_689477|]
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zinc transporter ZIP13 isoform b precursor [Homo sapiens]

Protein Classification

ZIP family transporter( domain architecture ID 10495033)

ZIP family transporter may function as a zinc transporter, mediating the uptake of zinc in bacteria or the transport of zinc from one cellular compartment to another in eukaryotes

Gene Ontology:  GO:0046873|GO:0030001
PubMed:  23046653|10748254
TCDB:  2.A.5

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
65-358 2.21e-45

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


:

Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 158.31  E-value: 2.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188  65 LDTWICSLLGSLMVGLSGVFPLLVIPLemgtMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAWAytcSASPGGEGQS 144
Cdd:pfam02535   1 LLLKIYAIFAILIISLIGGLLPLLVPK----ISKLRPSSKLLSLLLAFASGVLLGTAFLHLLPEALE---ALESLCLSDH 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 145 LQQQQQLGLWVIAGILTFLALEKMF-----------------------------LDSKEEGTSQAPNKDPTAAA----AA 191
Cdd:pfam02535  74 GWHFPFAGLIVLLGFLLVLLVEKLLtyykhrptpgpadnshshlatvksvsnveVTESEEGEDHGHLHGHDDDSdellHK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 192 LNGGHCLAQPAAEPGLGAVVRSIKVSGYLNLLANTIDNFTHGLAVAasFLVSKKIGLLTTMAILLHEIPHEVGDFAILLR 271
Cdd:pfam02535 154 GHQGPSDSIHEQSDEDGEPLASQRVRAILLELGIILHSFFEGLALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQ 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 272 AGFDRWSAAKLQLSTALGGLLGAGFAICTQSPKGV---EETAAWVLPFTSGGFLYIALVNVLP-DLL-EEEDPWRSLQQL 346
Cdd:pfam02535 232 AGFSRKKAVLLALLFALTTPLGILIGIGVSSIGNSpgaDITSGILLAFSAGTFLYVALVELLPhELLrNKSSEKLSLLQL 311
                         330
                  ....*....|..
gi 1890262188 347 LLLCAGIVVMVL 358
Cdd:pfam02535 312 LALLLGFALMAL 323
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
65-358 2.21e-45

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 158.31  E-value: 2.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188  65 LDTWICSLLGSLMVGLSGVFPLLVIPLemgtMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAWAytcSASPGGEGQS 144
Cdd:pfam02535   1 LLLKIYAIFAILIISLIGGLLPLLVPK----ISKLRPSSKLLSLLLAFASGVLLGTAFLHLLPEALE---ALESLCLSDH 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 145 LQQQQQLGLWVIAGILTFLALEKMF-----------------------------LDSKEEGTSQAPNKDPTAAA----AA 191
Cdd:pfam02535  74 GWHFPFAGLIVLLGFLLVLLVEKLLtyykhrptpgpadnshshlatvksvsnveVTESEEGEDHGHLHGHDDDSdellHK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 192 LNGGHCLAQPAAEPGLGAVVRSIKVSGYLNLLANTIDNFTHGLAVAasFLVSKKIGLLTTMAILLHEIPHEVGDFAILLR 271
Cdd:pfam02535 154 GHQGPSDSIHEQSDEDGEPLASQRVRAILLELGIILHSFFEGLALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQ 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 272 AGFDRWSAAKLQLSTALGGLLGAGFAICTQSPKGV---EETAAWVLPFTSGGFLYIALVNVLP-DLL-EEEDPWRSLQQL 346
Cdd:pfam02535 232 AGFSRKKAVLLALLFALTTPLGILIGIGVSSIGNSpgaDITSGILLAFSAGTFLYVALVELLPhELLrNKSSEKLSLLQL 311
                         330
                  ....*....|..
gi 1890262188 347 LLLCAGIVVMVL 358
Cdd:pfam02535 312 LALLLGFALMAL 323
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
67-362 1.77e-27

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 108.35  E-value: 1.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188  67 TWICSLLGSLMVglsgvfpllviplemgtMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAWAYTCSASPGGEgqslq 146
Cdd:COG0428    14 AGLATLLGALLA-----------------LFFKRLSKRLLSLLLGFAAGVMLAASFFELLPEALELGEGPLLAAL----- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 147 qqqqlglWVIAGILTFLALEKMFLdskeegtsqapnkdptaaaaalnggHCLAQPAAEPGLGAvvrsikvSGYLNLLANT 226
Cdd:COG0428    72 -------GFLLGALLLFLLDRLLP-------------------------HEHRGAEPAKAHLR-------RGLLIALGIT 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 227 IDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAAKL----QLSTALGGLLGAGFAictqs 302
Cdd:COG0428   113 LHNFPEGLAIGVAFAADPALGLALALAIALHNIPEGLAVAAPLRAAGYSRRKALLLgllsGLVEPLGALLGYLLL----- 187
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 303 pKGVEETAAWVLPFTSGGFLYIALVNVLPDLLEEEDPWrslQQLLLLCAGIVVMVLFSLF 362
Cdd:COG0428   188 -SLSPALLPYLLAFAAGAMLYVVVDELIPEAHREGHSR---LATLGLLLGFLLMMLLDVL 243
 
Name Accession Description Interval E-value
Zip pfam02535
ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative ...
65-358 2.21e-45

ZIP Zinc transporter; The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.


Pssm-ID: 396884 [Multi-domain]  Cd Length: 325  Bit Score: 158.31  E-value: 2.21e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188  65 LDTWICSLLGSLMVGLSGVFPLLVIPLemgtMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAWAytcSASPGGEGQS 144
Cdd:pfam02535   1 LLLKIYAIFAILIISLIGGLLPLLVPK----ISKLRPSSKLLSLLLAFASGVLLGTAFLHLLPEALE---ALESLCLSDH 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 145 LQQQQQLGLWVIAGILTFLALEKMF-----------------------------LDSKEEGTSQAPNKDPTAAA----AA 191
Cdd:pfam02535  74 GWHFPFAGLIVLLGFLLVLLVEKLLtyykhrptpgpadnshshlatvksvsnveVTESEEGEDHGHLHGHDDDSdellHK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 192 LNGGHCLAQPAAEPGLGAVVRSIKVSGYLNLLANTIDNFTHGLAVAasFLVSKKIGLLTTMAILLHEIPHEVGDFAILLR 271
Cdd:pfam02535 154 GHQGPSDSIHEQSDEDGEPLASQRVRAILLELGIILHSFFEGLALG--VSSSSDTGISLFIAILFHKIPEGLGLGAILLQ 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 272 AGFDRWSAAKLQLSTALGGLLGAGFAICTQSPKGV---EETAAWVLPFTSGGFLYIALVNVLP-DLL-EEEDPWRSLQQL 346
Cdd:pfam02535 232 AGFSRKKAVLLALLFALTTPLGILIGIGVSSIGNSpgaDITSGILLAFSAGTFLYVALVELLPhELLrNKSSEKLSLLQL 311
                         330
                  ....*....|..
gi 1890262188 347 LLLCAGIVVMVL 358
Cdd:pfam02535 312 LALLLGFALMAL 323
ZupT COG0428
Zinc transporter ZupT [Inorganic ion transport and metabolism];
67-362 1.77e-27

Zinc transporter ZupT [Inorganic ion transport and metabolism];


Pssm-ID: 440197 [Multi-domain]  Cd Length: 243  Bit Score: 108.35  E-value: 1.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188  67 TWICSLLGSLMVglsgvfpllviplemgtMLRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEAWAYTCSASPGGEgqslq 146
Cdd:COG0428    14 AGLATLLGALLA-----------------LFFKRLSKRLLSLLLGFAAGVMLAASFFELLPEALELGEGPLLAAL----- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 147 qqqqlglWVIAGILTFLALEKMFLdskeegtsqapnkdptaaaaalnggHCLAQPAAEPGLGAvvrsikvSGYLNLLANT 226
Cdd:COG0428    72 -------GFLLGALLLFLLDRLLP-------------------------HEHRGAEPAKAHLR-------RGLLIALGIT 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 227 IDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAAKL----QLSTALGGLLGAGFAictqs 302
Cdd:COG0428   113 LHNFPEGLAIGVAFAADPALGLALALAIALHNIPEGLAVAAPLRAAGYSRRKALLLgllsGLVEPLGALLGYLLL----- 187
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1890262188 303 pKGVEETAAWVLPFTSGGFLYIALVNVLPDLLEEEDPWrslQQLLLLCAGIVVMVLFSLF 362
Cdd:COG0428   188 -SLSPALLPYLLAFAAGAMLYVVVDELIPEAHREGHSR---LATLGLLLGFLLMMLLDVL 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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