NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|22748667|ref|NP_689509|]
View 

sodium/potassium-transporting ATPase subunit alpha-3 isoform 1 [Homo sapiens]

Protein Classification

sodium/potassium-transporting P-type ATPase subunit alpha( domain architecture ID 11490177)

sodium/potassium-transporting P-type ATPase subunit alpha is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and/or potassium ions across the plasma membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
17-1013 0e+00

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


:

Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 2192.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     17 KERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWI 96
Cdd:TIGR01106    1 KKKRDLDELKKEVEMDDHKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     97 GAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVV 176
Cdd:TIGR01106   81 GAILCFLAYGIQASTEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    177 VGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTV 256
Cdd:TIGR01106  161 VGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    257 MGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTL 336
Cdd:TIGR01106  241 MGRIASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    337 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAG 416
Cdd:TIGR01106  321 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGVSFDKSSATWLALSRIAG 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    417 LCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLV 496
Cdd:TIGR01106  401 LCNRAVFKAGQENVPILKRAVAGDASESALLKCIELCLGSVMEMRERNPKVVEIPFNSTNKYQLSIHENEDPRDPRHLLV 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    497 MKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFV 576
Cdd:TIGR01106  481 MKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLGFCHLYLPDEQFPEGFQFDTDDVNFPTDNLCFV 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    577 GLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIH 656
Cdd:TIGR01106  561 GLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVH 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    657 GTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 736
Cdd:TIGR01106  641 GSDLKDMTSEQLDEILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    737 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEA 816
Cdd:TIGR01106  721 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEK 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    817 AESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQW 896
Cdd:TIGR01106  801 AESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPLHLVGLRVQWDDRWINDLEDSYGQEW 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    897 TYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPS 976
Cdd:TIGR01106  881 TYEQRKYVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPT 960
                          970       980       990
                   ....*....|....*....|....*....|....*..
gi 22748667    977 WWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY 1013
Cdd:TIGR01106  961 WWFCAFPYSLLIFVYDEIRKLIIRRNPGGWVEKETYY 997
 
Name Accession Description Interval E-value
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
17-1013 0e+00

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 2192.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     17 KERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWI 96
Cdd:TIGR01106    1 KKKRDLDELKKEVEMDDHKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     97 GAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVV 176
Cdd:TIGR01106   81 GAILCFLAYGIQASTEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    177 VGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTV 256
Cdd:TIGR01106  161 VGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    257 MGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTL 336
Cdd:TIGR01106  241 MGRIASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    337 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAG 416
Cdd:TIGR01106  321 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGVSFDKSSATWLALSRIAG 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    417 LCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLV 496
Cdd:TIGR01106  401 LCNRAVFKAGQENVPILKRAVAGDASESALLKCIELCLGSVMEMRERNPKVVEIPFNSTNKYQLSIHENEDPRDPRHLLV 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    497 MKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFV 576
Cdd:TIGR01106  481 MKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLGFCHLYLPDEQFPEGFQFDTDDVNFPTDNLCFV 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    577 GLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIH 656
Cdd:TIGR01106  561 GLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVH 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    657 GTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 736
Cdd:TIGR01106  641 GSDLKDMTSEQLDEILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    737 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEA 816
Cdd:TIGR01106  721 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEK 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    817 AESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQW 896
Cdd:TIGR01106  801 AESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPLHLVGLRVQWDDRWINDLEDSYGQEW 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    897 TYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPS 976
Cdd:TIGR01106  881 TYEQRKYVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPT 960
                          970       980       990
                   ....*....|....*....|....*....|....*..
gi 22748667    977 WWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY 1013
Cdd:TIGR01106  961 WWFCAFPYSLLIFVYDEIRKLIIRRNPGGWVEKETYY 997
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
52-1010 0e+00

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 2109.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVI 131
Cdd:cd02608    1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEEEPSNDNLYLGIVLAAVVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:cd02608   81 VTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  212 SEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVF 291
Cdd:cd02608  161 SEPQTRSPEFTHENPLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEHFIHIITGVAVF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  292 LGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 371
Cdd:cd02608  241 LGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  372 TQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIE 451
Cdd:cd02608  321 TQNRMTVAHMWFDNQIHEADTTEDQSGASFDKSSATWLALSRIAGLCNRAEFKAGQENVPILKRDVNGDASESALLKCIE 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  452 LSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNA 531
Cdd:cd02608  401 LSCGSVMEMRERNPKVAEIPFNSTNKYQLSIHENEDPGDPRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNA 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  532 YLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 611
Cdd:cd02608  481 YLELGGLGERVLGFCHLYLPDDKFPEGFKFDTDEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  612 ITAKAIAKGVGIisegnetvediaarlnipvsqvnprdakacvihgtdlkdftseqideilqnhteIVFARTSPQQKLII 691
Cdd:cd02608  561 ITAKAIAKGVGI------------------------------------------------------IVFARTSPQQKLII 586
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  692 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 771
Cdd:cd02608  587 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 666
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  772 SNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQ 851
Cdd:cd02608  667 SNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQ 746
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  852 ALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRR 931
Cdd:cd02608  747 ALAGFFTYFVIMAENGFLPSDLLGLRVQWDDKYVNDLEDSYGQEWTYEQRKILEYTCHTAFFVSIVVVQWADLIICKTRR 826
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22748667  932 NSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKE 1010
Cdd:cd02608  827 NSVFQQGMKNKILNFGLFFETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPFSLLIFVYDEVRKLIIRRNPGGWVEKE 905
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
34-1001 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 912.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   34 HKMSVEEVCRKYNTDcVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAygiqagted 113
Cdd:COG0474    9 HALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL--------- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  114 dpsgDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADL 193
Cdd:COG0474   79 ----GDWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  194 RIISAHGCKVDNSSLTGESEPQTRSPDCTHDN--PLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGK 271
Cdd:COG0474  155 RLLEAKDLQVDESALTGESVPVEKSADPLPEDapLGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEK 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  272 TPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNL 351
Cdd:COG0474  235 TPLQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRL 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  352 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTsfdksshtwvALSHIAGLCNRAVFKGGQdnip 431
Cdd:COG0474  315 PAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDPALE----------ELLRAAALCSDAQLEEET---- 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  432 vlkrdVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDpndNRYLLVMKGAPERILDRCSTI 511
Cdd:COG0474  381 -----GLGDPTEGALLVAAAKAGLDVEELRKEYPRVDEIPFDSERKRMSTVHEDPD---GKRLLIVKGAPEVVLALCTRV 452
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  512 LLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDdvnfttdnLCFVGLMSMIDPPRAAVPD 591
Cdd:COG0474  453 LTGGGVVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELPADPELDSEDDESD--------LTFLGLVGMIDPPRPEAKE 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  592 AVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNEtvediaarlnipvsqvnprdakacVIHGTDLKDFTSEQIDEI 671
Cdd:COG0474  525 AIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR------------------------VLTGAELDAMSDEELAEA 580
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  672 LQNHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTG 751
Cdd:COG0474  581 VEDVD--VFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAA 658
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  752 VEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRT 831
Cdd:COG0474  659 VEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDE 738
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  832 DKLVNERLISMAYgqIGMIQALGGFFSYFVILAENGflpgnlvgirlnwddrtvndledsygqqwTYEQrkvveftCHTA 911
Cdd:COG0474  739 PILSRFLLLRILL--LGLLIAIFTLLTFALALARGA-----------------------------SLAL-------ARTM 780
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  912 FFVSIVVVQWADLIICKTRRNSVFQQGM-KNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFV 990
Cdd:COG0474  781 AFTTLVLSQLFNVFNCRSERRSFFKSGLfPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLYLL 860
                        970
                 ....*....|.
gi 22748667  991 YDEIRKLILRR 1001
Cdd:COG0474  861 LVELVKLLRRR 871
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
36-773 2.80e-99

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 333.19  E-value: 2.80e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    36 MSVEEVCRKYNTDcVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLaygiqagTEDdp 115
Cdd:PRK10517   52 MPEEELWKTFDTH-PEGLNEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISYA-------TED-- 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   116 sgdnLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIR------EGEKMQVNAEEVVVGDLVEIKGGDRV 189
Cdd:PRK10517  122 ----LFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVPGDIIKLAAGDMI 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   190 PADLRIISAHGCKVDNSSLTGESEP---QTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASG 266
Cdd:PRK10517  198 PADLRILQARDLFVAQASLTGESLPvekFATTRQPEHSNPLECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVSE 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   267 LEvgKTPIAieiehFIQLITGVAV----FLGVSFFILSLILGYT---WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAK 339
Cdd:PRK10517  278 QD--SEPNA-----FQQGISRVSWllirFMLVMAPVVLLINGYTkgdWWEAALFALSVAVGLTPEMLPMIVTSTLARGAV 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   340 RMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHmwfdnqiHeadttEDQSGTSFDKSSHTWVALSHiaglcn 419
Cdd:PRK10517  351 KLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN-------H-----TDISGKTSERVLHSAWLNSH------ 412
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   420 ravFKGGQDNIpvlkRDVagdasesALLKCIELSSGSVKLmrERNKKVAEIPFNSTNKyQLSIHETEDpnDNRYLLVMKG 499
Cdd:PRK10517  413 ---YQTGLKNL----LDT-------AVLEGVDEESARSLA--SRWQKIDEIPFDFERR-RMSVVVAEN--TEHHQLICKG 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   500 APERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDdvnfttdnLCFVGLM 579
Cdd:PRK10517  474 ALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESD--------LILEGYI 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   580 SMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGnetvediaarlnipvsqvnprdakacVIHGTD 659
Cdd:PRK10517  546 AFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE--------------------------VLIGSD 599
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   660 LKDFTSEQIDEILQNHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMI 739
Cdd:PRK10517  600 IETLSDDELANLAERTT--LFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADII 676
                         730       740       750
                  ....*....|....*....|....*....|....
gi 22748667   740 LLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN 773
Cdd:PRK10517  677 LLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSN 710
E1-E2_ATPase pfam00122
E1-E2 ATPase;
153-344 1.14e-46

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.05  E-value: 1.14e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    153 NMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAhGCKVDNSSLTGESEPQTRSPdcthdnpletRNI 232
Cdd:pfam00122    1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEG-SASVDESLLTGESLPVEKKK----------GDM 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    233 TFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVI 312
Cdd:pfam00122   70 VYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRALL 149
                          170       180       190
                   ....*....|....*....|....*....|..
gi 22748667    313 FLIGIIVANVPEGLLATVTVCLTLTAKRMARK 344
Cdd:pfam00122  150 RALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
30-104 1.11e-24

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 98.42  E-value: 1.11e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22748667      30 AMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLA 104
Cdd:smart00831    1 ELDWHALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
17-1013 0e+00

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 2192.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     17 KERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWI 96
Cdd:TIGR01106    1 KKKRDLDELKKEVEMDDHKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     97 GAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVV 176
Cdd:TIGR01106   81 GAILCFLAYGIQASTEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    177 VGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTV 256
Cdd:TIGR01106  161 VGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    257 MGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTL 336
Cdd:TIGR01106  241 MGRIASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    337 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAG 416
Cdd:TIGR01106  321 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGVSFDKSSATWLALSRIAG 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    417 LCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLV 496
Cdd:TIGR01106  401 LCNRAVFKAGQENVPILKRAVAGDASESALLKCIELCLGSVMEMRERNPKVVEIPFNSTNKYQLSIHENEDPRDPRHLLV 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    497 MKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFV 576
Cdd:TIGR01106  481 MKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLGFCHLYLPDEQFPEGFQFDTDDVNFPTDNLCFV 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    577 GLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIH 656
Cdd:TIGR01106  561 GLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVH 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    657 GTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 736
Cdd:TIGR01106  641 GSDLKDMTSEQLDEILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAA 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    737 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEA 816
Cdd:TIGR01106  721 DMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEK 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    817 AESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQW 896
Cdd:TIGR01106  801 AESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPLHLVGLRVQWDDRWINDLEDSYGQEW 880
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    897 TYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPS 976
Cdd:TIGR01106  881 TYEQRKYVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPT 960
                          970       980       990
                   ....*....|....*....|....*....|....*..
gi 22748667    977 WWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY 1013
Cdd:TIGR01106  961 WWFCAFPYSLLIFVYDEIRKLIIRRNPGGWVEKETYY 997
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
52-1010 0e+00

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 2109.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVI 131
Cdd:cd02608    1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEEEPSNDNLYLGIVLAAVVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:cd02608   81 VTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  212 SEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVF 291
Cdd:cd02608  161 SEPQTRSPEFTHENPLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEHFIHIITGVAVF 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  292 LGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 371
Cdd:cd02608  241 LGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  372 TQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIE 451
Cdd:cd02608  321 TQNRMTVAHMWFDNQIHEADTTEDQSGASFDKSSATWLALSRIAGLCNRAEFKAGQENVPILKRDVNGDASESALLKCIE 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  452 LSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNA 531
Cdd:cd02608  401 LSCGSVMEMRERNPKVAEIPFNSTNKYQLSIHENEDPGDPRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNA 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  532 YLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 611
Cdd:cd02608  481 YLELGGLGERVLGFCHLYLPDDKFPEGFKFDTDEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  612 ITAKAIAKGVGIisegnetvediaarlnipvsqvnprdakacvihgtdlkdftseqideilqnhteIVFARTSPQQKLII 691
Cdd:cd02608  561 ITAKAIAKGVGI------------------------------------------------------IVFARTSPQQKLII 586
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  692 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 771
Cdd:cd02608  587 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 666
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  772 SNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQ 851
Cdd:cd02608  667 SNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQ 746
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  852 ALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRR 931
Cdd:cd02608  747 ALAGFFTYFVIMAENGFLPSDLLGLRVQWDDKYVNDLEDSYGQEWTYEQRKILEYTCHTAFFVSIVVVQWADLIICKTRR 826
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22748667  932 NSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKE 1010
Cdd:cd02608  827 NSVFQQGMKNKILNFGLFFETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPFSLLIFVYDEVRKLIIRRNPGGWVEKE 905
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
34-1001 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 912.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   34 HKMSVEEVCRKYNTDcVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAygiqagted 113
Cdd:COG0474    9 HALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL--------- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  114 dpsgDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADL 193
Cdd:COG0474   79 ----GDWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  194 RIISAHGCKVDNSSLTGESEPQTRSPDCTHDN--PLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGK 271
Cdd:COG0474  155 RLLEAKDLQVDESALTGESVPVEKSADPLPEDapLGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEK 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  272 TPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNL 351
Cdd:COG0474  235 TPLQKQLDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRL 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  352 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTsfdksshtwvALSHIAGLCNRAVFKGGQdnip 431
Cdd:COG0474  315 PAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDPALE----------ELLRAAALCSDAQLEEET---- 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  432 vlkrdVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDpndNRYLLVMKGAPERILDRCSTI 511
Cdd:COG0474  381 -----GLGDPTEGALLVAAAKAGLDVEELRKEYPRVDEIPFDSERKRMSTVHEDPD---GKRLLIVKGAPEVVLALCTRV 452
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  512 LLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDdvnfttdnLCFVGLMSMIDPPRAAVPD 591
Cdd:COG0474  453 LTGGGVVPLTEEDRAEILEAVEELAAQGLRVLAVAYKELPADPELDSEDDESD--------LTFLGLVGMIDPPRPEAKE 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  592 AVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNEtvediaarlnipvsqvnprdakacVIHGTDLKDFTSEQIDEI 671
Cdd:COG0474  525 AIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR------------------------VLTGAELDAMSDEELAEA 580
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  672 LQNHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTG 751
Cdd:COG0474  581 VEDVD--VFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAA 658
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  752 VEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRT 831
Cdd:COG0474  659 VEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDE 738
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  832 DKLVNERLISMAYgqIGMIQALGGFFSYFVILAENGflpgnlvgirlnwddrtvndledsygqqwTYEQrkvveftCHTA 911
Cdd:COG0474  739 PILSRFLLLRILL--LGLLIAIFTLLTFALALARGA-----------------------------SLAL-------ARTM 780
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  912 FFVSIVVVQWADLIICKTRRNSVFQQGM-KNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFV 990
Cdd:COG0474  781 AFTTLVLSQLFNVFNCRSERRSFFKSGLfPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLYLL 860
                        970
                 ....*....|.
gi 22748667  991 YDEIRKLILRR 1001
Cdd:COG0474  861 LVELVKLLRRR 871
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
52-827 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 649.29  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQlFGGFSILLWIGAILcflAYGIQAGTEDdpsgdnlylGIVLAAVVI 131
Cdd:cd02089    1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQ-FKDFMVIVLLAAAV---ISGVLGEYVD---------AIVIIAIVI 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:cd02089   68 LNAVLGFVQEYKAEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLRVEESSLTGE 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  212 SEPQTRSPD--CTHDNPL-ETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGV 288
Cdd:cd02089  148 SEPVEKDADtlLEEDVPLgDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAIA 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  289 AVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKT 368
Cdd:cd02089  228 ALIICALVFALGLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKT 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  369 GTLTQNRMTVAHMWFDnqiheadttedqsgtsfdksshtwvalshiaglcnravfkggqdnipvlkrdvaGDASESALLK 448
Cdd:cd02089  308 GTLTQNKMTVEKIYTI------------------------------------------------------GDPTETALIR 333
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  449 CIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPndnrYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAF 528
Cdd:cd02089  334 AARKAGLDKEELEKKYPRIAEIPFDSERKLMTTVHKDAGK----YIVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKI 409
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  529 QNAYLELGGLGERVLGFCHYYLPEEQFPkgfafDCDDVnftTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTG 608
Cdd:cd02089  410 LAVNEEFSEEALRVLAVAYKPLDEDPTE-----SSEDL---ENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITG 481
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  609 DHPITAKAIAKGVGIISEGNEtvediaarlnipvsqvnprdakacVIHGTDLKDFTSEQIDEILQNHTeiVFARTSPQQK 688
Cdd:cd02089  482 DHKLTARAIAKELGILEDGDK------------------------ALTGEELDKMSDEELEKKVEQIS--VYARVSPEHK 535
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  689 LIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAY 768
Cdd:cd02089  536 LRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRY 615
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 22748667  769 TLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPR 827
Cdd:cd02089  616 LLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKPR 674
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
52-996 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 648.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQlfggFS-----ILLWIGAILCFLAYGIQAgteddpsgdnlylgIVL 126
Cdd:cd02080    1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQ----FNnpliyILLAAAVVTAFLGHWVDA--------------IVI 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  127 AAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNS 206
Cdd:cd02080   63 FGVVLINAIIGYIQEGKAEKALAAIKNMLSPEATVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQIDES 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  207 SLTGESEPQTRspdctHDNPLET-------RNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIE 279
Cdd:cd02080  143 ALTGESVPVEK-----QEGPLEEdtplgdrKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIA 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  280 HFIQLITGVAVFLGVSFFILSLILG-YTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLG 358
Cdd:cd02080  218 KFSKALLIVILVLAALTFVFGLLRGdYSLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLG 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  359 STSTICSDKTGTLTQNRMTVAHMWFdnqiheadttedqsgtsfdksshtwvalshiagLCNRA--VFKGGQDnipvlkrD 436
Cdd:cd02080  298 SVTVICSDKTGTLTRNEMTVQAIVT---------------------------------LCNDAqlHQEDGHW-------K 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  437 VAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHetedPNDNRYLLVMKGAPERILDRCSTILLQGK 516
Cdd:cd02080  338 ITGDPTEGALLVLAAKAGLDPDRLASSYPRVDKIPFDSAYRYMATLH----RDDGQRVIYVKGAPERLLDMCDQELLDGG 413
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  517 EQPLDeemKEAFQNAYLELGGLGERVLGFChyYLPEEQFPKGFAFDCDDVNFTtdnlcFVGLMSMIDPPRAAVPDAVGKC 596
Cdd:cd02080  414 VSPLD---RAYWEAEAEDLAKQGLRVLAFA--YREVDSEVEEIDHADLEGGLT-----FLGLQGMIDPPRPEAIAAVAEC 483
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  597 RSAGIKVIMVTGDHPITAKAIAKGVGIISEGNetvediaarlnipvsqvnprdakacVIHGTDLKDFTSEQIDEILQNHT 676
Cdd:cd02080  484 QSAGIRVKMITGDHAETARAIGAQLGLGDGKK-------------------------VLTGAELDALDDEELAEAVDEVD 538
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  677 eiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGR 756
Cdd:cd02080  539 --VFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGR 616
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  757 LIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPrtdklvN 836
Cdd:cd02080  617 RVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDP------S 690
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  837 ERLISM-AYGQIGMIQAL--GGFFSYFvilaengflpgnlvgirlNWDDRTVNDLEdsygqqwtyeqrkvvefTCHTAFF 913
Cdd:cd02080  691 EPLLSReLIWRILLVSLLmlGGAFGLF------------------LWALDRGYSLE-----------------TARTMAV 735
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  914 VSIVVVQWADLIICKTRRNSVFQQGM-KNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYD 992
Cdd:cd02080  736 NTIVVAQIFYLFNCRSLHRSILKLGVfSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFIVV 815

                 ....
gi 22748667  993 EIRK 996
Cdd:cd02080  816 ELEK 819
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
34-861 4.06e-164

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 507.98  E-value: 4.06e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   34 HKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQlfggFS-----ILLwIGAILCFlaygIQ 108
Cdd:cd02083    1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQ----FDdllvrILL-LAAIISF----VL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  109 AGTEDDPSGDNLY-------LGIVLAAVVIItgcfsyYQEAKSSKIMESFKNMVPQQALVIREGEKMQ-VNAEEVVVGDL 180
Cdd:cd02083   72 ALFEEGEEGVTAFvepfvilLILIANAVVGV------WQERNAEKAIEALKEYEPEMAKVLRNGKGVQrIRARELVPGDI 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  181 VEIKGGDRVPADLRIISAHGC--KVDNSSLTGESEP---QTRS-PDCTHDNPlETRNITFFSTNCVEGTARGVVVATGDR 254
Cdd:cd02083  146 VEVAVGDKVPADIRIIEIKSTtlRVDQSILTGESVSvikHTDVvPDPRAVNQ-DKKNMLFSGTNVAAGKARGVVVGTGLN 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  255 TVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSL------ILGYTWLEAVIFLIGIIV----ANVPE 324
Cdd:cd02083  225 TEIGKIRDEMAETEEEKTPLQQKLDEFGEQLSKVISVICVAVWAINIghfndpAHGGSWIKGAIYYFKIAValavAAIPE 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  325 GLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-FDNQIHEADTTE-DQSGTSFD 402
Cdd:cd02083  305 GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFiLDKVEDDSSLNEfEVTGSTYA 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  403 --------------KSSHTWVALSHIAGLCNRAV-----FKGGQDNIpvlkrdvaGDASESALLKCIE-------LSSGS 456
Cdd:cd02083  385 pegevfkngkkvkaGQYDGLVELATICALCNDSSldyneSKGVYEKV--------GEATETALTVLVEkmnvfntDKSGL 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  457 VKLMR---------ERNKKVAEIPFnSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQ-GKEQPLDEEMKE 526
Cdd:cd02083  457 SKRERanacndvieQLWKKEFTLEF-SRDRKSMSVYCSPTKASGGNKLFVKGAPEGVLERCTHVRVGgGKVVPLTAAIKI 535
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  527 AFQNAYLELGGLGERVLGFChyYLPEEQFPKGFAFDcDDVNFTTD--NLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVI 604
Cdd:cd02083  536 LILKKVWGYGTDTLRCLALA--TKDTPPKPEDMDLE-DSTKFYKYetDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVI 612
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  605 MVTGDHPITAKAIAKGVGIISEgNETVEDIAarlnipvsqvnprdakacvIHGTDLKDFTSEQIDEILQNHTeiVFARTS 684
Cdd:cd02083  613 VITGDNKGTAEAICRRIGIFGE-DEDTTGKS-------------------YTGREFDDLSPEEQREACRRAR--LFSRVE 670
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  685 PQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIaGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 764
Cdd:cd02083  671 PSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQ 749
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  765 SIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRtDKLVNERLIsMAY 844
Cdd:cd02083  750 FIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPD-EPLISGWLF-FRY 827
                        890       900
                 ....*....|....*....|
gi 22748667  845 GQIGM---IQALGGFFSYFV 861
Cdd:cd02083  828 LAIGTyvgLATVGAFAWWFM 847
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
36-840 6.13e-163

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 502.06  E-value: 6.13e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     36 MSVEEVCRKYNTDCVQGLTHSkaQEILARD---GPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAIlcflAYGIQAGTE 112
Cdd:TIGR01522    7 LSVEETCSKLQTDLQNGLNSS--QEASHRRafhGWNEFDVEEDESLWKKFLSQFVKNPLILLLIASA----VISVFMGNI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    113 DDPsgdnlyLGIVLAAVVIITGCFsyYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPAD 192
Cdd:TIGR01522   81 DDA------VSITLAILIVVTVGF--VQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPAD 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    193 LRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPL----ETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLE 268
Cdd:TIGR01522  153 LRIVEAVDLSIDESNLTGETTPVSKVTAPIPAATNgdlaERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIE 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    269 VGKTPIAIEIEH------FIQLItGVAVFLGVSFFilsliLGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMA 342
Cdd:TIGR01522  233 KPKTPLQKSMDLlgkqlsLVSFG-VIGVICLVGWF-----QGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMS 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    343 RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTtedqsGTSFDKSSHTWVALSH--------- 413
Cdd:TIGR01522  307 KKRAIVRKLPSVETLGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLN-----AVSLNQFGEVIVDGDVlhgfytvav 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    414 -----IAGLCNRAVFKGGQDNIpvlkrdvAGDASESALLKCIElsSGSVKLMRERNKKVAEIPFNSTNKYQLSihETEDP 488
Cdd:TIGR01522  382 srileAGNLCNNAKFRNEADTL-------LGNPTDVALIELLM--KFGLDDLRETYIRVAEVPFSSERKWMAV--KCVHR 450
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    489 NDNRYLLVMKGAPERILDRCSTILLQ-GKEQPLDEEMKEAFQNAYLELGGLGERVLGFChyYLPEeqfpkgfafdcddvn 567
Cdd:TIGR01522  451 QDRSEMCFMKGAYEQVLKYCTYYQKKdGKTLTLTQQQRDVIQEEAAEMASAGLRVIAFA--SGPE--------------- 513
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    568 ftTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEdiaarlnipvsqvnp 647
Cdd:TIGR01522  514 --KGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAVSIARRLGMPSKTSQSVS--------------- 576
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    648 rdakacvihGTDLKDFTSEQIDEILQnhTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA 727
Cdd:TIGR01522  577 ---------GEKLDAMDDQQLSQIVP--KVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIGVAMGQT 645
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    728 GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMV 807
Cdd:TIGR01522  646 GTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWINILMDGP 725
                          810       820       830
                   ....*....|....*....|....*....|...
gi 22748667    808 PAISLAYEAAESDIMKRQPRnPRTDKLVNERLI 840
Cdd:TIGR01522  726 PAQSLGVEPVDKDVMRKPPR-PRNDKILTKDLI 757
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
66-840 7.77e-153

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 473.04  E-value: 7.77e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   66 GPNALTPPPTTPEWVKFCRQlFGGFSILLWIGAILCFLaygIQAGTEDDPSgdnlylgIVLAAVVIITGCFsyYQEAKSS 145
Cdd:cd02085    6 GPNEFKVEDEEPLWKKYLEQ-FKNPLILLLLGSAVVSV---VMKQYDDAVS-------ITVAILIVVTVAF--VQEYRSE 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  146 KIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEP--QTRSPDCTH 223
Cdd:cd02085   73 KSLEALNKLVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPcsKTTEVIPKA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  224 DN-PLETR-NITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIE------HFIQL-ITGVAVFLGv 294
Cdd:cd02085  153 SNgDLTTRsNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDklgkqlSLYSFiIIGVIMLIG- 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  295 sffilsLILGYTWLEavIFLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLT 372
Cdd:cd02085  232 ------WLQGKNLLE--MFTIGVslAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLT 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  373 QNRMTVAHMWfdnqiheadttedqsgtsfdksshtwvalshIAGLCNRAVFkggQDNIPvlkrdvAGDASESALLKCIEl 452
Cdd:cd02085  304 KNEMTVTKIV-------------------------------TGCVCNNAVI---RNNTL------MGQPTEGALIALAM- 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  453 sSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQ-PLDEEMKEAFQNA 531
Cdd:cd02085  343 -KMGLSDIRETYIRKQEIPFSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSAlPLTQQQRSEINEE 421
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  532 YLELGGLGERVLGFCHyyLPEeqfpkgfafdcddvnftTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHP 611
Cdd:cd02085  422 EKEMGSKGLRVLALAS--GPE-----------------LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQ 482
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  612 ITAKAIAKGVGIISEGNETVEdiaarlnipvsqvnprdakacvihGTDLKDFTSEQIDEILQNHTeiVFARTSPQQKLII 691
Cdd:cd02085  483 ETAIAIGSSLGLYSPSLQALS------------------------GEEVDQMSDSQLASVVRKVT--VFYRASPRHKLKI 536
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  692 VEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLT 771
Cdd:cd02085  537 VKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLS 616
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22748667  772 SNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNpRTDKLVNERLI 840
Cdd:cd02085  617 TSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRN-VKDPILTRSLI 684
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
125-812 6.08e-149

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 454.08  E-value: 6.08e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    125 VLAAVVIITGCFSYYQEAKSSKIMESFKNMV--PQQALVIREGEKMqVNAEEVVVGDLVEIKGGDRVPADLRIISAhGCK 202
Cdd:TIGR01494    1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLvnTATVLVLRNGWKE-ISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAF 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    203 VDNSSLTGESEPQTRSPDCTHDNPletrnitFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPI---AIEIE 279
Cdd:TIGR01494   79 VDESSLTGESLPVLKTALPDGDAV-------FAGTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLqskADKFE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    280 HFIqlITGVAVFLGVSFFILSLILGYT---WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVET 356
Cdd:TIGR01494  152 NFI--FILFLLLLALAVFLLLPIGGWDgnsIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEE 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    357 LGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTtedqsgtsfdksSHTWVAlshiaglcnravfkgGQDNIPVlkrd 436
Cdd:TIGR01494  230 LGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEEASL------------ALALLA---------------ASLEYLS---- 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    437 vaGDASESALLKCIElSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETedpNDNRYLLVMKGAPERILDRCstillqgk 516
Cdd:TIGR01494  279 --GHPLERAIVKSAE-GVIKSDEINVEYKILDVFPFSSVLKRMGVIVEG---ANGSDLLFVKGAPEFVLERC-------- 344
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    517 eqpldeEMKEAFQNAYLELGGLGERVLGFCHYYLPeeqfpkgfafdcddvnfttDNLCFVGLMSMIDPPRAAVPDAVGKC 596
Cdd:TIGR01494  345 ------NNENDYDEKVDEYARQGLRVLAFASKKLP-------------------DDLEFLGLLTFEDPLRPDAKETIEAL 399
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    597 RSAGIKVIMVTGDHPITAKAIAKGVGIisegnetvediaarlnipvsqvnprdakacvihgtdlkdftseqideilqnht 676
Cdd:TIGR01494  400 RKAGIKVVMLTGDNVLTAKAIAKELGI----------------------------------------------------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    677 eIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAgsDVSKQAADMILLDDNFASIVTGVEEGR 756
Cdd:TIGR01494  427 -DVFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGR 503
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 22748667    757 LIFDNLKKSIAYTLTSNIPEITPFLLFImaniplplgtitilCIDLGTDMVPAISL 812
Cdd:TIGR01494  504 KTFSNIKKNIFWAIAYNLILIPLALLLI--------------VIILLPPLLAALAL 545
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
52-873 4.75e-148

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 464.24  E-value: 4.75e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFlayGIQAGTEddpsgdnlylGIVLAAVVI 131
Cdd:cd02086    1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSF---AVKDWIE----------GGVIAAVIA 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:cd02086   68 LNVIVGFIQEYKAEKTMDSLRNLSSPNAHVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGE 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  212 SEPQTRSPDCT----HDNPLETR-NITFFSTNCVEGTARGVVVATGDRTVMGRIATL---ASGLEVGKTPIAIEIEHFIQ 283
Cdd:cd02086  148 SLPVIKDAELVfgkeEDVSVGDRlNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAlrgKGGLISRDRVKSWLYGTLIV 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  284 LITGVAVFLGVS---------------FFILSLILGYTWL---------EAVIFLIGIIVANVPEGLLATVTVCLTLTAK 339
Cdd:cd02086  228 TWDAVGRFLGTNvgtplqrklsklaylLFFIAVILAIIVFavnkfdvdnEVIIYAIALAISMIPESLVAVLTITMAVGAK 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  340 RMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqiheadttedqsgtsfdksshtwvalshIAGLCN 419
Cdd:cd02086  308 RMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWI------------------------------PAALCN 357
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  420 RA-VFKGGQDNIPVlkrdVAGDASESAL-LKCIELSSGSVKLMRERNKK---VAEIPFNSTNKYQLSIHETEDPNDnrYL 494
Cdd:cd02086  358 IAtVFKDEETDCWK----AHGDPTEIALqVFATKFDMGKNALTKGGSAQfqhVAEFPFDSTVKRMSVVYYNNQAGD--YY 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  495 LVMKGAPERILDRCSTILLQGKEQPLDEE-MKEAFQNAYlELGGLGERVLGFCHYYLPEEQFPKGFAFDC----DDVNft 569
Cdd:cd02086  432 AYMKGAVERVLECCSSMYGKDGIIPLDDEfRKTIIKNVE-SLASQGLRVLAFASRSFTKAQFNDDQLKNItlsrADAE-- 508
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  570 tDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIIsEGNETVEDIAarlnipvsqvnprD 649
Cdd:cd02086  509 -SDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGIL-PPNSYHYSQE-------------I 573
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  650 AKACVIHGTDLKDFTSEQIDEILQnhTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGS 729
Cdd:cd02086  574 MDSMVMTASQFDGLSDEEVDALPV--LPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGS 651
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  730 DVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFL--LFIMANIPL---PLGTITILCIDLGT 804
Cdd:cd02086  652 DVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQVILLLigLAFKDEDGLsvfPLSPVEILWINMVT 731
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  805 DMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISM-AYGQIGMIQALGGFfsyfvILAENGFLPGNL 873
Cdd:cd02086  732 SSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTfVYGTFMGVLCLASF-----TLVIYGIGNGDL 796
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
66-836 2.32e-147

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 455.89  E-value: 2.32e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   66 GPNALTPPPTTPEWvKFCRQLFGGFS-ILLWIGAILCFlayGIQAGTEDDPSGDNLY----LGIVLA--AVVIITGCFSY 138
Cdd:cd02081    9 GKNEIPPKPPKSFL-QLVWEALQDPTlIILLIAAIVSL---GLGFYTPFGEGEGKTGwiegVAILVAviLVVLVTAGNDY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  139 YQEAK----SSKIMEsfknmvpQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEP 214
Cdd:cd02081   85 QKEKQfrklNSKKED-------QKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTGESDP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  215 QTRSPDCTHDNPLetrnitFFS-TNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLG 293
Cdd:cd02081  158 IKKTPDNQIPDPF------LLSgTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIVA 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  294 VSFFILSLI--------------LGYTWLEAV-IFLIG--IIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVET 356
Cdd:cd02081  232 ALTFIVLIIrfiidgfvndgksfSAEDLQEFVnFFIIAvtIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACET 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  357 LGSTSTICSDKTGTLTQNRMTVAHMWFdnqiheadttedqsgtsfdksshtwvalshiaglcnravfkggqdnipvlkrd 436
Cdd:cd02081  312 MGNATAICSDKTGTLTQNRMTVVQGYI----------------------------------------------------- 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  437 vaGDASESALLKCIELSSGSVKLMRERN--KKVAEIPFNSTNKYQLSIHETEDPNdnrYLLVMKGAPERILDRCSTIL-L 513
Cdd:cd02081  339 --GNKTECALLGFVLELGGDYRYREKRPeeKVLKVYPFNSARKRMSTVVRLKDGG---YRLYVKGASEIVLKKCSYILnS 413
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  514 QGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEeQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAV 593
Cdd:cd02081  414 DGEVVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSP-DEEPTAERDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAV 492
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  594 GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVediaarlnipvsqvnprdakacVIHGTDLKDFTSEQIDEILQ 673
Cdd:cd02081  493 AKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGL----------------------VLEGKEFRELIDEEVGEVCQ 550
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  674 NHTEI------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFAS 747
Cdd:cd02081  551 EKFDKiwpklrVLARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSS 630
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  748 IVTGVEEGRLIFDNLKKSIAYTLTSNIPEItpFLLFIMA--NIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQ 825
Cdd:cd02081  631 IVKAVMWGRNVYDSIRKFLQFQLTVNVVAV--ILAFIGAvvTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRK 708
                        810
                 ....*....|.
gi 22748667  826 PRNpRTDKLVN 836
Cdd:cd02081  709 PYG-RDKPLIS 718
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
139-867 6.52e-147

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 461.17  E-value: 6.52e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    139 YQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRS 218
Cdd:TIGR01116   55 WQERNAEKAIEALKEYESEHAKVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKH 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    219 PDCTHDNPL---ETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVS 295
Cdd:TIGR01116  135 TESVPDERAvnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICIL 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    296 FFILSL------ILGYTWLEAVIFLIGIIVA----NVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICS 365
Cdd:TIGR01116  215 VWVINIghfndpALGGGWIQGAIYYFKIAVAlavaAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICS 294
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    366 DKTGTLTQNRMTVAHMWF----DNQIHEADTTedqsGTSFD-----------KSSHTWVALSH---IAGLCNRAVFKGGQ 427
Cdd:TIGR01116  295 DKTGTLTTNQMSVCKVVAldpsSSSLNEFCVT----GTTYApeggvikddgpVAGGQDAGLEElatIAALCNDSSLDFNE 370
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    428 DNIPVLKrdvAGDASESALLKCIE---LSSGSV-------------KLMRERNKKVAEIPFNSTNKyQLSIHETEDPNDN 491
Cdd:TIGR01116  371 RKGVYEK---VGEATEAALKVLVEkmgLPATKNgvsskrrpalgcnSVWNDKFKKLATLEFSRDRK-SMSVLCKPSTGNK 446
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    492 rylLVMKGAPERILDRCSTILL-QGKEQPLDEEMKEAFQNAYLELGGL-GERVLGFCHYYLPEeqfPKGFAFDCDDVNFT 569
Cdd:TIGR01116  447 ---LFVKGAPEGVLERCTHILNgDGRAVPLTDKMKNTILSVIKEMGTTkALRCLALAFKDIPD---PREEDLLSDPANFE 520
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    570 T--DNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEgNETVEDIAarlnipvsqvnp 647
Cdd:TIGR01116  521 AieSDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSP-DEDVTFKS------------ 587
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    648 rdakacvIHGTDLKDFTSEQIDEILQNhtEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiA 727
Cdd:TIGR01116  588 -------FTGREFDEMGPAKQRAACRS--AVLFSRVEPSHKSELVELLQEQGEIVAMTGDGVNDAPALKKADIGIAMG-S 657
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    728 GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMV 807
Cdd:TIGR01116  658 GTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGL 737
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22748667    808 PAISLAYEAAESDIMKRQPRNPRtDKLVNERLIsMAYGQIGM---IQALGGFFSYFVILAENG 867
Cdd:TIGR01116  738 PATALGFNPPDKDIMWKPPRRPD-EPLITGWLF-FRYLVVGVyvgLATVGGFVWWYLLTHFTG 798
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
52-846 3.46e-131

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 411.45  E-value: 3.46e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAygiqagteddpsGDnLYLGIVLAAVVI 131
Cdd:cd07538    1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL------------GD-PREGLILLIFVV 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:cd07538   68 VIIAIEVVQEWRTERALEALKNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDESTLTGE 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  212 SEPQTRSPDCTHDNPLE--TRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVA 289
Cdd:cd07538  148 SVPVWKRIDGKAMSAPGgwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCALAA 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  290 VFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTG 369
Cdd:cd07538  228 LVFCALIVAVYGVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  370 TLTQNRMTVAHMWFdnqiheadttedqsgtsfdksshtwvalshiaglcnravfkggqdnipvlkrdvagdasesallkc 449
Cdd:cd07538  308 TLTKNQMEVVELTS------------------------------------------------------------------ 321
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  450 ielssgsvklmrernkKVAEIPFNSTNKYQLSIHETedpnDNRYLLVMKGAPERILDRCStillqgkeqpLDEEMKEAFQ 529
Cdd:cd07538  322 ----------------LVREYPLRPELRMMGQVWKR----PEGAFAAAKGSPEAIIRLCR----------LNPDEKAAIE 371
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  530 NAYLELGGLGERVLGFCHYYLPEEQFPKgfafDCDDVNFttdnlCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGD 609
Cdd:cd07538  372 DAVSEMAGEGLRVLAVAACRIDESFLPD----DLEDAVF-----IFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGD 442
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  610 HPITAKAIAKGVGIisegnetvediaarlnipvsqvnprDAKACVIHGTDLKDFTSEQIDEILqNHTEIvFARTSPQQKL 689
Cdd:cd07538  443 NPATAKAIAKQIGL-------------------------DNTDNVITGQELDAMSDEELAEKV-RDVNI-FARVVPEQKL 495
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  690 IIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYT 769
Cdd:cd07538  496 RIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYV 575
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22748667  770 LTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPrTDKLVNERLISMAYGQ 846
Cdd:cd07538  576 FAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPP-DEPLFGPRLVIKAILQ 651
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
124-815 1.40e-127

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 401.41  E-value: 1.40e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  124 IVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRE--GEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGC 201
Cdd:cd07539   61 VLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRApaGRTQTVPAESLVPGDVIELRAGEVVPADARLLEADDL 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  202 KVDNSSLTGESEPQTRSPDCTHDNPL-ETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEvGKTPIAIEIEH 280
Cdd:cd07539  141 EVDESALTGESLPVDKQVAPTPGAPLaDRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVAPVE-TATGVQAQLRE 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  281 FIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGST 360
Cdd:cd07539  220 LTSQLLPLSLGGGAAVTGLGLLRGAPLRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRV 299
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  361 STICSDKTGTLTQNRMTVAhmwfdnQIHeadttedqsgtsfdksshtwvalshiaglcnravfkggqdniPVLkrdvagd 440
Cdd:cd07539  300 DTICFDKTGTLTENRLRVV------QVR------------------------------------------PPL------- 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  441 asesallkcielssgsvklmrernkkvAEIPFNSTNKYQLSIHETedpNDNRYLLVMKGAPERILDRCSTILLQGKEQPL 520
Cdd:cd07539  325 ---------------------------AELPFESSRGYAAAIGRT---GGGIPLLAVKGAPEVVLPRCDRRMTGGQVVPL 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  521 DEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQfpkgfafdCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAG 600
Cdd:cd07539  375 TEADRQAIEEVNELLAGQGLRVLAVAYRTLDAGT--------THAVEAVVDDLELLGLLGLADTARPGAAALIAALHDAG 446
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  601 IKVIMVTGDHPITAKAIAKgvgiisegnetvediaaRLNIPVSQVnprdakacVIHGTDLKDFTSEQIDEILQNHTeiVF 680
Cdd:cd07539  447 IDVVMITGDHPITARAIAK-----------------ELGLPRDAE--------VVTGAELDALDEEALTGLVADID--VF 499
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  681 ARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 760
Cdd:cd07539  500 ARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQ 579
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 22748667  761 NLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYE 815
Cdd:cd07539  580 NVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
19-846 1.37e-120

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 392.22  E-value: 1.37e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     19 RRDLDDLKKEVAMTEHKM-SVEEVCRKYNTDCVQGLTHSKAQEILARD--GPNALTPPPTTPEWvKFCRQLFGGFSILLW 95
Cdd:TIGR01517   25 LTDLTDIFKKAMPLYEKLgGAEGIATKLKTDLNEGVRLSSSTLERREKvyGKNELPEKPPKSFL-QIVWAALSDQTLILL 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     96 IGA-----ILCFLAYGIQAGTEDDPSGDNLYLGIVLAA--VVIITGCFSYYQEAKSSKIMESFKNmvpQQALVIREGEKM 168
Cdd:TIGR01517  104 SVAavvslVLGLYVPSVGEDKADTETGWIEGVAILVSVilVVLVTAVNDYKKELQFRQLNREKSA---QKIAVIRGGQEQ 180
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    169 QVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDcthDNPletrnITFFSTNCVEGTARGVV 248
Cdd:TIGR01517  181 QISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPV---QDP-----FLLSGTVVNEGSGRMLV 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    249 VATGDRTVMGRIATLASGLEVGKTPIAieiEHFIQLITGVAVFLGVSFFILSLIL---------------------GYTW 307
Cdd:TIGR01517  253 TAVGVNSFGGKLMMELRQAGEEETPLQ---EKLSELAGLIGKFGMGSAVLLFLVLslryvfriirgdgrfedteedAQTF 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    308 LEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQI 387
Cdd:TIGR01517  330 LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQR 409
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    388 HEADTTEDQSGTSFdKSSHTWVALSHIAGLCNRAVFKGGqdnipvlKRDVAGDASESALLKCIELS---SGSVKLMRERN 464
Cdd:TIGR01517  410 FNVRDEIVLRNLPA-AVRNILVEGISLNSSSEEVVDRGG-------KRAFIGSKTECALLDFGLLLllqSRDVQEVRAEE 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    465 KKVAEIPFNSTNKYqLSIHETEDpnDNRYLLVMKGAPERILDRCSTILLQGKE-QPLDEEMKEAFQNAYLELGGLGERVL 543
Cdd:TIGR01517  482 KVVKIYPFNSERKF-MSVVVKHS--GGKYREFRKGASEIVLKPCRKRLDSNGEaTPISEDDKDRCADVIEPLASDALRTI 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    544 GFCHYYLPEEQFPKGfafdcddvNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI 623
Cdd:TIGR01517  559 CLAYRDFAPEEFPRK--------DYPNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGI 630
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    624 ISEGnetvediaarlnipvsqvnprdakACVIHGTDLKDFTSEQIDEILQNHteIVFARTSPQQKLIIVEGCQRQGAIVA 703
Cdd:TIGR01517  631 LTFG------------------------GLAMEGKEFRSLVYEEMDPILPKL--RVLARSSPLDKQLLVLMLKDMGEVVA 684
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    704 VTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITpfLLF 783
Cdd:TIGR01517  685 VTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVI--LTF 762
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22748667    784 IMANIP----LPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPrNPRTDKLVNERLISMAYGQ 846
Cdd:TIGR01517  763 VGSCISsshtSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKP-IGRNAPLISRSMWKNILGQ 828
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
52-773 1.76e-118

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 381.60  E-value: 1.76e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGdnlylGIVLAAVVI 131
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFDLVG-----ALIILLMVL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEK-MQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTG 210
Cdd:cd02077   76 ISGLLDFIQEIRSLKAAEKLKKMVKNTATVIRDGSKyMEIPIDELVPGDIVYLSAGDMIPADVRIIQSKDLFVSQSSLTG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  211 ESEP---QTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEvGKTPIAIEIEHFIQLItg 287
Cdd:cd02077  156 ESEPvekHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSITEKR-PETSFDKGINKVSKLL-- 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  288 vAVFLGVSFFILSLILGYT---WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTIC 364
Cdd:cd02077  233 -IRFMLVMVPVVFLINGLTkgdWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILC 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  365 SDKTGTLTQNRMTVA-HMWFDNQihEADTTEDqsgtsfdkssHTWVALSHIAGLCN---RAVFKGG-QDNIPVLKRDVag 439
Cdd:cd02077  312 TDKTGTLTQDKIVLErHLDVNGK--ESERVLR----------LAYLNSYFQTGLKNlldKAIIDHAeEANANGLIQDY-- 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  440 dasesallkcielssgsvklmrernKKVAEIPFNsTNKYQLSIHETEdpNDNRYLLVMKGAPERILDRCSTILLQGKEQP 519
Cdd:cd02077  378 -------------------------TKIDEIPFD-FERRRMSVVVKD--NDGKHLLITKGAVEEILNVCTHVEVNGEVVP 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  520 LDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEeqfpkgfafdcDDVNFTTD---NLCFVGLMSMIDPPRAAVPDAVGKC 596
Cdd:cd02077  430 LTDTLREKILAQVEELNREGLRVLAIAYKKLPA-----------PEGEYSVKdekELILIGFLAFLDPPKESAAQAIKAL 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  597 RSAGIKVIMVTGDHPITAKAIAKGVGIISEGnetvediaarlnipvsqvnprdakacVIHGTDLKDFTSEQIDEILQNHT 676
Cdd:cd02077  499 KKNGVNVKILTGDNEIVTKAICKQVGLDINR--------------------------VLTGSEIEALSDEELAKIVEETN 552
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  677 eiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASIVTGVEEGR 756
Cdd:cd02077  553 --IFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGR 629
                        730
                 ....*....|....*..
gi 22748667  757 LIFDNLKKSIAYTLTSN 773
Cdd:cd02077  630 KTFGNILKYIKMTASSN 646
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
34-873 2.40e-117

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 385.90  E-value: 2.40e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     34 HKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFlaygiqaGTED 113
Cdd:TIGR01523    8 FSDIADEAAEFIGTSIPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISF-------AMHD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    114 DPSGDnlylgiVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADL 193
Cdd:TIGR01523   81 WIEGG------VISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVPGDICLLKTGDTIPADL 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    194 RIISAHGCKVDNSSLTGESEPQTRSPDCT----HDNPLETR-NITFFSTNCVEGTARGVVVATGDRTVMGRIAT------ 262
Cdd:TIGR01523  155 RLIETKNFDTDEALLTGESLPVIKDAHATfgkeEDTPIGDRiNLAFSSSAVTKGRAKGICIATALNSEIGAIAAglqgdg 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    263 -LASGLEVGK--------TPIAIEIEHFIQLITGVAV---------FLGVSFFILSLILGYTWL---------EAVIFLI 315
Cdd:TIGR01523  235 gLFQRPEKDDpnkrrklnKWILKVTKKVTGAFLGLNVgtplhrklsKLAVILFCIAIIFAIIVMaahkfdvdkEVAIYAI 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    316 GIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW------------- 382
Cdd:TIGR01523  315 CLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWiprfgtisidnsd 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    383 ----------------------------------FDNQIHEADTTEDQSGTSFDKSSHTwvalshiAGLCNRA-VFKGGQ 427
Cdd:TIGR01523  395 dafnpnegnvsgiprfspyeyshneaadqdilkeFKDELKEIDLPEDIDMDLFIKLLET-------AALANIAtVFKDDA 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    428 DNIPVLKRD----------------VAGDASESALLKCIELSSGSVKLMRERNKK-----VAEIPFNSTNKYQLSIHEte 486
Cdd:TIGR01523  468 TDCWKAHGDpteiaihvfakkfdlpHNALTGEEDLLKSNENDQSSLSQHNEKPGSaqfefIAEFPFDSEIKRMASIYE-- 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    487 DPNDNRYLLVMKGAPERILDRCSTI--LLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFChyylpEEQFPKGFAFDCD 564
Cdd:TIGR01523  546 DNHGETYNIYAKGAFERIIECCSSSngKDGVKISPLEDCDRELIIANMESLAAEGLRVLAFA-----SKSFDKADNNDDQ 620
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    565 DVNFTTD------NLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIIsegnetvediaarl 638
Cdd:TIGR01523  621 LKNETLNrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGII-------------- 686
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    639 niPVSQVNPRD--AKACVIHGTDLKDFTSEQIDEIlqNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALK 716
Cdd:TIGR01523  687 --PPNFIHDRDeiMDSMVMTGSQFDALSDEEVDDL--KALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLK 762
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    717 KADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEItpfLLFIMANI-------- 788
Cdd:TIGR01523  763 MANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEA---ILLIIGLAfrdengks 839
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    789 PLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLI-SMAYgqiGMIQALGGFFSYFVILAenG 867
Cdd:TIGR01523  840 VFPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIdMFAY---GFFLGGSCLASFTGILY--G 914

                   ....*.
gi 22748667    868 FLPGNL 873
Cdd:TIGR01523  915 FGSGNL 920
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
362-812 2.97e-110

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 344.44  E-value: 2.97e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  362 TICSDKTGTLTQNRMTVAHMWFdnqiheadttedqsgtsfdksshtwvalshiaglcnravfkggqdnipvlkrdvagda 441
Cdd:cd01431    1 VICSDKTGTLTKNGMTVTKLFI---------------------------------------------------------- 22
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  442 sesallkcielssgsvklmrernkkvAEIPFNSTNKYQLSIHEtedpNDNRYLLVMKGAPERILDRCSTillqgkeqPLD 521
Cdd:cd01431   23 --------------------------EEIPFNSTRKRMSVVVR----LPGRYRAIVKGAPETILSRCSH--------ALT 64
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  522 EEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQfpkgfafdcdDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGI 601
Cdd:cd01431   65 EEDRNKIEKAQEESAREGLRVLALAYREFDPET----------SKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGI 134
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  602 KVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAArlnipvsqvnprdakacvihgtdlkDFTSEQIDEILQnHTEIVFA 681
Cdd:cd01431  135 KVVMITGDNPLTAIAIAREIGIDTKASGVILGEEA-------------------------DEMSEEELLDLI-AKVAVFA 188
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  682 RTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 761
Cdd:cd01431  189 RVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDN 268
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 22748667  762 LKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISL 812
Cdd:cd01431  269 IKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
52-997 2.37e-108

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 354.61  E-value: 2.37e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALtPPPTTPEWVKFCRQLFGGFSILLWIGAILcflaygiQAGTEDDPSGdnlylgIVLAAVVI 131
Cdd:cd02076    1 GLTSEEAAKRLKEYGPNEL-PEKKENPILKFLSFFWGPIPWMLEAAAIL-------AAALGDWVDF------AIILLLLL 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:cd02076   67 INAGIGFIEERQAGNAVAALKKSLAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALTGE 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  212 SEPQTRSPDcthDNPletrnitFFSTNCVEGTARGVVVATGDRTVMGRIATLasgleVGKTPiaiEIEHFIQLITGVAVF 291
Cdd:cd02076  147 SLPVTKHPG---DEA-------YSGSIVKQGEMLAVVTATGSNTFFGKTAAL-----VASAE---EQGHLQKVLNKIGNF 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  292 LGVSFFILSLIL-------GYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTIC 364
Cdd:cd02076  209 LILLALILVLIIvivalyrHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILC 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  365 SDKTGTLTQNRMTVahmwFDNQIHEADTTEDqsgtsfdksshtwvaLSHIAGLCNRavfKGGQDNIpvlkrdvagdasES 444
Cdd:cd02076  289 SDKTGTLTLNKLSL----DEPYSLEGDGKDE---------------LLLLAALASD---TENPDAI------------DT 334
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  445 ALLKcielSSGSVKLMRERNKKVAEIPFNSTNKYqlSIHETEDPNDNRYlLVMKGAPERILDRCStillqgkeqpLDEEM 524
Cdd:cd02076  335 AILN----ALDDYKPDLAGYKQLKFTPFDPVDKR--TEATVEDPDGERF-KVTKGAPQVILELVG----------NDEAI 397
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  525 KEAFQNAYLELGGLGERVLGFCHYYlPEEQFPkgfafdcddvnfttdnlcFVGLMSMIDPPRAAVPDAVGKCRSAGIKVI 604
Cdd:cd02076  398 RQAVEEKIDELASRGYRSLGVARKE-DGGRWE------------------LLGLLPLFDPPRPDSKATIARAKELGVRVK 458
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  605 MVTGDHPITAKAIAKGVGIISegnetvediaarlNIPVSQVNPRDAKACVIHGTDLKDFTsEQIDeilqnhteiVFARTS 684
Cdd:cd02076  459 MITGDQLAIAKETARQLGMGT-------------NILSAERLKLGGGGGGMPGSELIEFI-EDAD---------GFAEVF 515
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  685 PQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 764
Cdd:cd02076  516 PEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKS 594
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  765 SIAYTLTSNIpEITPFL---LFIMANIPLPLgtITILCIDLGTDMvPAISLAYEAAESDimkrqprnPRTDKLVNERLIS 841
Cdd:cd02076  595 YVIYRIAETL-RILVFFtlgILILNFYPLPL--IMIVLIAILNDG-ATLTIAYDNVPPS--------PRPVRWNMPELLG 662
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  842 MAyGQIGMIQALGGFFsYFVILAENGFlpgnlvgirlnwddrtVNDLEDSYGQQwtyeqrkvveftcHTAFFVSIVVVqw 921
Cdd:cd02076  663 IA-TVLGVVLTISSFL-LLWLLDDQGW----------------FEDIVLSAGEL-------------QTILYLQLSIS-- 709
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22748667  922 ADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLS-YCPGMDValrmyPLKPSWWFCAFPYSFLIFVYDEIRKL 997
Cdd:cd02076  710 GHLTIFVTRTRGPFWRPRPSPLLFIAVVLTQILATLLAvYGWFMFA-----GIGWGWALLVWIYALVWFVVLDFVKL 781
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
36-773 2.80e-99

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 333.19  E-value: 2.80e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    36 MSVEEVCRKYNTDcVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLaygiqagTEDdp 115
Cdd:PRK10517   52 MPEEELWKTFDTH-PEGLNEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISYA-------TED-- 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   116 sgdnLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIR------EGEKMQVNAEEVVVGDLVEIKGGDRV 189
Cdd:PRK10517  122 ----LFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVPGDIIKLAAGDMI 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   190 PADLRIISAHGCKVDNSSLTGESEP---QTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASG 266
Cdd:PRK10517  198 PADLRILQARDLFVAQASLTGESLPvekFATTRQPEHSNPLECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVSE 277
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   267 LEvgKTPIAieiehFIQLITGVAV----FLGVSFFILSLILGYT---WLEAVIFLIGIIVANVPEGLLATVTVCLTLTAK 339
Cdd:PRK10517  278 QD--SEPNA-----FQQGISRVSWllirFMLVMAPVVLLINGYTkgdWWEAALFALSVAVGLTPEMLPMIVTSTLARGAV 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   340 RMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHmwfdnqiHeadttEDQSGTSFDKSSHTWVALSHiaglcn 419
Cdd:PRK10517  351 KLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLEN-------H-----TDISGKTSERVLHSAWLNSH------ 412
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   420 ravFKGGQDNIpvlkRDVagdasesALLKCIELSSGSVKLmrERNKKVAEIPFNSTNKyQLSIHETEDpnDNRYLLVMKG 499
Cdd:PRK10517  413 ---YQTGLKNL----LDT-------AVLEGVDEESARSLA--SRWQKIDEIPFDFERR-RMSVVVAEN--TEHHQLICKG 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   500 APERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDdvnfttdnLCFVGLM 579
Cdd:PRK10517  474 ALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESD--------LILEGYI 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   580 SMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGnetvediaarlnipvsqvnprdakacVIHGTD 659
Cdd:PRK10517  546 AFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE--------------------------VLIGSD 599
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   660 LKDFTSEQIDEILQNHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMI 739
Cdd:PRK10517  600 IETLSDDELANLAERTT--LFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADII 676
                         730       740       750
                  ....*....|....*....|....*....|....
gi 22748667   740 LLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN 773
Cdd:PRK10517  677 LLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSN 710
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
52-881 4.92e-98

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 326.21  E-value: 4.92e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667     52 GLTHSKAQEILARDGPNALtPPPTTPEWVKFCRQLFGGFSILLWIGAIlcflaygIQAGTEDDPSGdnlylgIVLAAVVI 131
Cdd:TIGR01647    1 GLTSAEAKKRLAKYGPNEL-PEKKVSPLLKFLGFFWNPLSWVMEAAAI-------IAIALENWVDF------VIILGLLL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:TIGR01647   67 LNATIGFIEENKAGNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGE 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    212 SEPQTRspdcthdnplETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGktpiaieIEHFIQLITGVAVF 291
Cdd:TIGR01647  147 SLPVTK----------KTGDIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETG-------SGHLQKILSKIGLF 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    292 LGVSFFILSLIL--------GYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTI 363
Cdd:TIGR01647  210 LIVLIGVLVLIElvvlffgrGESFREGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDIL 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    364 CSDKTGTLTQNRMTvahmwfdnqIHEADTTEDqsgtSFDKSShtwVALshIAGLCNRavfKGGQDnipvlkrdvagdase 443
Cdd:TIGR01647  290 CSDKTGTLTLNKLS---------IDEILPFFN----GFDKDD---VLL--YAALASR---EEDQD--------------- 333
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    444 sALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSihETEDPNDNRYLLVMKGAPERILDRCSTillqgkeqplDEE 523
Cdd:TIGR01647  334 -AIDTAVLGSAKDLKEARDGYKVLEFVPFDPVDKRTEA--TVEDPETGKRFKVTKGAPQVILDLCDN----------KKE 400
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    524 MKEAFQNAYLELGGLGERVLGFCHYYLPEEQFpkgfafdcddvnfttdnlcFVGLMSMIDPPRAAVPDAVGKCRSAGIKV 603
Cdd:TIGR01647  401 IEEKVEEKVDELASRGYRALGVARTDEEGRWH-------------------FLGLLPLFDPPRHDTKETIERARHLGVEV 461
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    604 IMVTGDHPITAKAIAKGVGIISegnetvediaarlNIPVSQVNPRDakacvihgtDLKDFTSEQIDEILQNHTEivFART 683
Cdd:TIGR01647  462 KMVTGDHLAIAKETARRLGLGT-------------NIYTADVLLKG---------DNRDDLPSGLGEMVEDADG--FAEV 517
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    684 SPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAmgIAG-SDVSKQAADMILLDDNFASIVTGVEEGRLIFDNL 762
Cdd:TIGR01647  518 FPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIA--VAGaTDAARSAADIVLTEPGLSVIVDAILESRKIFQRM 595
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    763 KKSIAYTLTSNIP-EITPFLLFIMANIPLPlgTITILCIDLGTDmVPAISLAYEAAESdimkrqPRNPRTDKLVNERLIS 841
Cdd:TIGR01647  596 KSYVIYRIAETIRiVFFFGLLILILNFYFP--PIMVVIIAILND-GTIMTIAYDNVKP------SKLPQRWNLREVFTMS 666
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 22748667    842 MAYgqiGMIQALGGFFSYFVILAENGFLPgnLVGIRLNWD 881
Cdd:TIGR01647  667 TVL---GIYLVISTFLLLAIALDTTFFID--KFGLQLLHG 701
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
52-815 1.07e-86

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 292.65  E-value: 1.07e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   52 GLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAygiqagteddPSGDNLylgiVLAAVVI 131
Cdd:cd02609    1 GLTTKEVEERQAEGKVNDQVEPVSRSVWQIVRENVFTLFNLINFVIAVLLILV----------GSYSNL----AFLGVII 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGE 211
Cdd:cd02609   67 VNTVIGIVQEIRAKRQLDKLSILNAPKVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGE 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  212 SEPQTRSPDCThdnpletrnitFFS-TNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAV 290
Cdd:cd02609  147 SDLIPKKAGDK-----------LLSgSFVVSGAAYARVTAVGAESYAAKLTLEAKKHKLINSELLNSINKILKFTSFIII 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  291 FLGVSFFILSLIL-GYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTG 369
Cdd:cd02609  216 PLGLLLFVEALFRrGGGWRQAVVSTVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTG 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  370 TLTQNRMTVaHMWFDNQIHEADTTEDQSG---TSFDKSSHTWVALshiaglcnRAVFKgGQDNIPVlkrdvagdasesal 446
Cdd:cd02609  296 TITEGKMKV-ERVEPLDEANEAEAAAALAafvAASEDNNATMQAI--------RAAFF-GNNRFEV-------------- 351
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  447 lkcielssgsvklmrernkkVAEIPFNSTNKY---QLSIHETedpndnrYLLvmkGAPERILdrcstillqgkeqpldEE 523
Cdd:cd02609  352 --------------------TSIIPFSSARKWsavEFRDGGT-------WVL---GAPEVLL----------------GD 385
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  524 MKEAFQNAYLELGGLGERVLGFCHYY--LPEEQFPkgfafdcddvnfttDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGI 601
Cdd:cd02609  386 LPSEVLSRVNELAAQGYRVLLLARSAgaLTHEQLP--------------VGLEPLALILLTDPIRPEAKETLAYFAEQGV 451
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  602 KVIMVTGDHPITAKAIAKGVGIisEGNEtvEDIAARLNIpvsqvnprdakacvihgtdlkdfTSEQIDEILQNHTeiVFA 681
Cdd:cd02609  452 AVKVISGDNPVTVSAIAKRAGL--EGAE--SYIDASTLT-----------------------TDEELAEAVENYT--VFG 502
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  682 RTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 761
Cdd:cd02609  503 RVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNN 581
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 22748667  762 LKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYE 815
Cdd:cd02609  582 IERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALE 635
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
33-773 4.00e-84

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 291.54  E-value: 4.00e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    33 EHKMSVEEVCRKYNTDCvQGLTHSKAQEILARDGPNALT---PPPTTpewvkfcRQLFGGFS-----ILLWIGAILCFLA 104
Cdd:PRK15122   27 EAANSLEETLANLNTHR-QGLTEEDAAERLQRYGPNEVAhekPPHAL-------VQLLQAFNnpfiyVLMVLAAISFFTD 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   105 YGI--QAGTEDDPSGdnlylGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIR------EGEKMQVNAEEVV 176
Cdd:PRK15122   99 YWLplRRGEETDLTG-----VIIILTMVLLSGLLRFWQEFRSNKAAEALKAMVRTTATVLRrghagaEPVRREIPMRELV 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   177 VGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEP----------QTRSPDCTHD---NPLETRNITFFSTNCVEGT 243
Cdd:PRK15122  174 PGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPvekydtlgavAGKSADALADdegSLLDLPNICFMGTNVVSGT 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   244 ARGVVVATGDRTVMGriaTLASGLeVGKTPIAieieHFIQLITGVA----VFLGVSFFILSLILGYT---WLEAVIFLIG 316
Cdd:PRK15122  254 ATAVVVATGSRTYFG---SLAKSI-VGTRAQT----AFDRGVNSVSwlliRFMLVMVPVVLLINGFTkgdWLEALLFALA 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   317 IIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHmwfdnqiHeadttEDQ 396
Cdd:PRK15122  326 VAVGLTPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEH-------H-----LDV 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   397 SGTSFDKS-SHTWVALSHIAGLCN---RAVFKGGQDNipvlkrdvagdasesallkcielsSGSVKLMRERnkKVAEIPF 472
Cdd:PRK15122  394 SGRKDERVlQLAWLNSFHQSGMKNlmdQAVVAFAEGN------------------------PEIVKPAGYR--KVDELPF 447
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   473 NSTNKyQLSIhETEDpNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLgfchyYLPE 552
Cdd:PRK15122  448 DFVRR-RLSV-VVED-AQGQHLLICKGAVEEMLAVATHVRDGDTVRPLDEARRERLLALAEAYNADGFRVL-----LVAT 519
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   553 EQFPKGfafDCDDVNFTTD--NLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIisegnet 630
Cdd:PRK15122  520 REIPGG---ESRAQYSTADerDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTAKICREVGL------- 589
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   631 vediaarlnipvsqvNPRDakacVIHGTDLKDFTSEQIDEILQNHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN 710
Cdd:PRK15122  590 ---------------EPGE----PLLGTEIEAMDDAALAREVEERT--VFAKLTPLQKSRVLKALQANGHTVGFLGDGIN 648
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22748667   711 DSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN 773
Cdd:PRK15122  649 DAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYLNMTASSN 710
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
120-795 1.57e-60

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 217.11  E-value: 1.57e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    120 LYLGIVLAAVVIITgCFSY------YQEAKSSKIMESFKNMVPQQALVIR-EGEKMQVNAEEVVVGDLVEIKGGDRVPAD 192
Cdd:TIGR01525   13 YAMGLVLEGALLLF-LFLLgetleeRAKSRASDALSALLALAPSTARVLQgDGSEEEVPVEELQVGDIVIVRPGERIPVD 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    193 LRIISAHGcKVDNSSLTGESEPQTRSPDctHDNPLETRNitffstncVEGTARGVVVATGDRTVMGRIATLASGLEVGKT 272
Cdd:TIGR01525   92 GVVISGES-EVDESALTGESMPVEKKEG--DEVFAGTIN--------GDGSLTIRVTKLGEDSTLAQIVELVEEAQSSKA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    273 PIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE 352
Cdd:TIGR01525  161 PIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGD 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    353 AVETLGSTSTICSDKTGTLTQNRMTVahmwfdNQIHeadttedqsgtsfdksshtwvalshiaglcnravfkggqdnipv 432
Cdd:TIGR01525  241 ALEKLAKVKTVVFDKTGTLTTGKPTV------VDIE-------------------------------------------- 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    433 lkrdVAGDASESALL---KCIELSSG---SVKLMRERNKKVAEIPfnstnkyqlsihetedPNDNRYlLVMKGApERILD 506
Cdd:TIGR01525  271 ----PLDDASEEELLalaAALEQSSShplARAIVRYAKERGLELP----------------PEDVEE-VPGKGV-EATVD 328
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    507 RCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQfpkgfafdcddvnfttdnlcFVGLMSMIDPPR 586
Cdd:TIGR01525  329 GGREVRIGNPRFLGNRELAIEPISASPDLLNEGESQGKTVVFVAVDGE--------------------LLGVIALRDQLR 388
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    587 AAVPDAVGK-CRSAGIKVIMVTGDHPITAKAIAKGVGIISEgnetvediaarlnipvsqvnprdakacvihgtdlkdfts 665
Cdd:TIGR01525  389 PEAKEAIAAlKRAGGIKLVMLTGDNRSAAEAVAAELGIDDE--------------------------------------- 429
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    666 eqideilqnhteiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNF 745
Cdd:TIGR01525  430 -------------VHAELLPEDKLAIVKKLQEEGGPVAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDL 495
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|
gi 22748667    746 ASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEItpfLLFIMANIPLPLGTI 795
Cdd:TIGR01525  496 RSLPTAIDLSRKTRRIIKQNLAWALGYNLVAI---PLAAGGLLPLWLAVL 542
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
127-753 1.54e-59

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 217.70  E-value: 1.54e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  127 AAVVIITgcFS----YYQE---AKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAH 199
Cdd:COG2217  178 AAAMIIF--LLllgrYLEArakGRARAAIRALLSLQPKTARVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGE 255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  200 GCkVDNSSLTGESEPQTRSPDcthdnplE-----TRNitffstncVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPI 274
Cdd:COG2217  256 SS-VDESMLTGESLPVEKTPG-------DevfagTIN--------LDGSLRVRVTKVGSDTTLARIIRLVEEAQSSKAPI 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  275 AIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGL-LATVTVCLTLTAkRMARKNCLVKNLEA 353
Cdd:COG2217  320 QRLADRIARYFVPAVLAIAALTFLVWLLFGGDFSTALYRAVAVLVIACPCALgLATPTAIMVGTG-RAARRGILIKGGEA 398
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  354 VETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEAD------TTEDQSgtsfdksshtwvalSH-IAglcnRAVFKGG 426
Cdd:COG2217  399 LERLAKVDTVVFDKTGTLTEGKPEVTDVVPLDGLDEDEllalaaALEQGS--------------EHpLA----RAIVAAA 460
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  427 QD-NIPVLKRD----VAGdasesallkcielsSGsVKlmrernkkvAEIpfnstnkyqlsihetedpNDNRYLLvmkGAP 501
Cdd:COG2217  461 KErGLELPEVEdfeaIPG--------------KG-VE---------ATV------------------DGKRVLV---GSP 495
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  502 ErildrcstiLLQGKEQPLDEEMKEAFQnaylELGGLGERVLGFChyylpeeqfpkgfafdCDDVnfttdnlcFVGLMSM 581
Cdd:COG2217  496 R---------LLEEEGIDLPEALEERAE----ELEAEGKTVVYVA----------------VDGR--------LLGLIAL 538
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  582 IDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGiisegnetvediaarlnipvsqvnprdakacvihgtdlk 661
Cdd:COG2217  539 ADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELG--------------------------------------- 579
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  662 dftseqIDEilqnhteiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILL 741
Cdd:COG2217  580 ------IDE--------VRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLM 644
                        650
                 ....*....|..
gi 22748667  742 DDNFASIVTGVE 753
Cdd:COG2217  645 RDDLRGVPDAIR 656
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
120-800 2.60e-57

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 207.56  E-value: 2.60e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    120 LYLGIVLAAVVIITgCFSY------YQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADL 193
Cdd:TIGR01512   13 VAIGEYLEGALLLL-LFSIgetleeYASGRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDG 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    194 RIISAHGcKVDNSSLTGESEPQTRSPDCThdNPLETRNitffstncVEGTARGVVVATGDRTVMGRIATLASGLEVGKTP 273
Cdd:TIGR01512   92 EVLSGTS-SVDESALTGESVPVEKAPGDE--VFAGAIN--------LDGVLTIEVTKLPADSTIAKIVNLVEEAQSRKAP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    274 IAIEIEHFIQLITGVAVFLGVSFFILSLILG-YTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE 352
Cdd:TIGR01512  161 TQRFIDRFARYYTPAVLAIALAAALVPPLLGaGPFLEWIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    353 AVETLGSTSTICSDKTGTLTQNRMTVAhmwfdnQIHeadttedqsgtsfdksshtwvalshiaglcnravfkggqdnipv 432
Cdd:TIGR01512  241 ALEALAKIKTVAFDKTGTLTTGKPKVT------DVH-------------------------------------------- 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    433 lkrdVAGDASESALLKCIelssgsvklmrernkKVAEipfnstnkyQLSIHetedpndnryllVMKGAperILDRcstil 512
Cdd:TIGR01512  271 ----PADGHSESEVLRLA---------------AAAE---------QGSTH------------PLARA---IVDY----- 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    513 LQGKEQPLDEEMKEAFQnaylelgglGERVLGFCH---YYLPEEQFPKGFAFDCDDVNFTTDNLC--------FVGLMSM 581
Cdd:TIGR01512  303 ARARELAPPVEDVEEVP---------GEGVRAVVDggeVRIGNPRSLSEAVGASIAVPESAGKTIvlvardgtLLGYIAL 373
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    582 IDPPRAAVPDAVGKCRSAGIKVI-MVTGDHPITAKAIAKGVGIisegnetvediaarlnipvsqvnprdakacvihgtdl 660
Cdd:TIGR01512  374 SDELRPDAAEAIAELKALGIKRLvMLTGDRRAVAEAVARELGI------------------------------------- 416
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    661 kdftseqideilqnhtEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMIL 740
Cdd:TIGR01512  417 ----------------DEVHAELLPEDKLEIVKELREKAGPVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVL 480
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22748667    741 LDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSnipeITPF-LLFIMANIPLPLGTI-----TILCI 800
Cdd:TIGR01512  481 LNDDLSRLPQAIRLARRTRRIIKQNVVIALGI----ILVLiLLALFGVLPLWLAVLghegsTVLVI 542
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
143-774 6.74e-53

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 196.28  E-value: 6.74e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  143 KSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHgCKVDNSSLTGESEPQTRSPDCT 222
Cdd:cd02079  111 RARSALKALLSLAPETATVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGE-SSVDESSLTGESLPVEKGAGDT 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  223 hdnpletrnITFFSTNcVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLI 302
Cdd:cd02079  190 ---------VFAGTIN-LNGPLTIEVTKTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPL 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  303 LGYTWLEAVIFLIGIIVANVPEGL-LATVTVcLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAhm 381
Cdd:cd02079  260 VGGPPSLALYRALAVLVVACPCALgLATPTA-IVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVT-- 336
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  382 wfdnqihEADTTEDQSGTSFD--------KSSHTwvalshIAglcnRAVFkggqdnipvlkrdvagDASESALLKCIELS 453
Cdd:cd02079  337 -------EIEPLEGFSEDELLalaaaleqHSEHP------LA----RAIV----------------EAAEEKGLPPLEVE 383
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  454 SgsvklmrernkkVAEIPfnstnkyqlsihetedpndnryllvMKGAPERILDRcsTILLqGKEQPLDEEMKEAFQNAYL 533
Cdd:cd02079  384 D------------VEEIP-------------------------GKGISGEVDGR--EVLI-GSLSFAEEEGLVEAADALS 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  534 ELGGLGERVLGfchyylpeeqfpkgfafdCDDVnfttdnlcFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPIT 613
Cdd:cd02079  424 DAGKTSAVYVG------------------RDGK--------LVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAA 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  614 AKAIAKGVGIisegnetvediaarlnipvsqvnprdakacvihgtdlkdftseqideilqnhtEIVFARTSPQQKLIIVE 693
Cdd:cd02079  478 AQAVAKELGI-----------------------------------------------------DEVHAGLLPEDKLAIVK 504
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  694 GCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN 773
Cdd:cd02079  505 ALQAEGGPVAMVGDGINDAPALAQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYN 583

                 .
gi 22748667  774 I 774
Cdd:cd02079  584 A 584
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
127-763 6.49e-52

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 193.85  E-value: 6.49e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  127 AAVVIIT----GcfsYYQEAKS----SKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISA 198
Cdd:cd02094  104 AAAVIITfillG---KYLEARAkgktSEAIKKLLGLQPKTARVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEG 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  199 HGCkVDNSSLTGESEPQTRSPDcthDNpletrniTFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAiei 278
Cdd:cd02094  181 ESS-VDESMLTGESLPVEKKPG---DK-------VIGGTINGNGSLLVRATRVGADTTLAQIIRLVEEAQGSKAPIQ--- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  279 eHFIQLITGVAV----FLGVSFFILSLILGYT--WLEAVIFLIGIIVANVPEGL-LATVTVCLTLTaKRMARKNCLVKNL 351
Cdd:cd02094  247 -RLADRVSGVFVpvviAIAILTFLVWLLLGPEpaLTFALVAAVAVLVIACPCALgLATPTAIMVGT-GRAAELGILIKGG 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  352 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEAD------TTEDQSgtsfdksshtwvalSH-IAglcnRAVFK 424
Cdd:cd02094  325 EALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDEDEllrlaaSLEQGS--------------EHpLA----KAIVA 386
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  425 GGQD-NIPVLKRD---------VAGDASESALLkcielsSGSVKLMRERNkkvAEIPfnstnkyqlsihetedpndnryl 494
Cdd:cd02094  387 AAKEkGLELPEVEdfeaipgkgVRGTVDGRRVL------VGNRRLMEENG---IDLS----------------------- 434
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  495 lvmkgaperildrcstillqgkeqpldeemkeAFQNAYLELGGLGERVlgfchyylpeeqfpkgfafdcddVNFTTDNlC 574
Cdd:cd02094  435 --------------------------------ALEAEALALEEEGKTV-----------------------VLVAVDG-E 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  575 FVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIisegnetvediaarlnipvsqvnprdakacv 654
Cdd:cd02094  459 LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI------------------------------- 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  655 ihgtdlkdftseqideilqnhtEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQ 734
Cdd:cd02094  508 ----------------------DEVIAEVLPEDKAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIE 564
                        650       660
                 ....*....|....*....|....*....
gi 22748667  735 AADMILLDDNFASIVTGVEEGRLIFDNLK 763
Cdd:cd02094  565 SADIVLMRGDLRGVVTAIDLSRATMRNIK 593
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
124-735 7.78e-47

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 182.56  E-value: 7.78e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    124 IVLAAVVIItgCFSYYQeakSSKIMESFKNMV--PQQALVIREGEKMQVNAEEVVVGDLVEIKG--GDRVPADLRIISAH 199
Cdd:TIGR01657  199 IVFMSSTSI--SLSVYQ---IRKQMQRLRDMVhkPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSGS 273
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    200 gCKVDNSSLTGESEPQTRSP---DCTHDNPL-----ETRNITFFSTNCV-------EGTARGVVVATGDRTVMGRIatLA 264
Cdd:TIGR01657  274 -CIVNESMLTGESVPVLKFPipdNGDDDEDLflyetSKKHVLFGGTKILqirpypgDTGCLAIVVRTGFSTSKGQL--VR 350
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    265 SGLEVGKTPIAIEIEHFIQLITgVAVFLGVSF---FILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRM 341
Cdd:TIGR01657  351 SILYPKPRVFKFYKDSFKFILF-LAVLALIGFiytIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARL 429
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    342 ARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHiaglcnrA 421
Cdd:TIGR01657  430 KKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDLRGVQGLSGNQEFLKIVTEDSSLKPSITHKALATCH-------S 502
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    422 VFKggqdnipvLKRDVAGDASESALLKCIELSsgsvkLMRERNKKVAEIPFNSTNK----YQLSIHE------------- 484
Cdd:TIGR01657  503 LTK--------LEGKLVGDPLDKKMFEATGWT-----LEEDDESAEPTSILAVVRTddppQELSIIRrfqfssalqrmsv 569
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    485 -TEDPNDNRYLLVMKGAPERILDRCSTillqgkeqpldEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDC 563
Cdd:TIGR01657  570 iVSTNDERSPDAFVKGAPETIQSLCSP-----------ETVPSDYQEVLKSYTREGYRVLALAYKELPKLTLQKAQDLSR 638
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    564 DDVNfttDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAA------- 636
Cdd:TIGR01657  639 DAVE---SNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPSNTLILAEAEppesgkp 715
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    637 ------------RLNIPVSQvnPRDAKACVIHGTDLKDFT---------------SEQIDEILQNHTeiVFARTSPQQKL 689
Cdd:TIGR01657  716 nqikfevidsipFASTQVEI--PYPLGQDSVEDLLASRYHlamsgkafavlqahsPELLLRLLSHTT--VFARMAPDQKE 791
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 22748667    690 IIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM-----GIAGSDVSKQA 735
Cdd:TIGR01657  792 TLVELLQKLDYTVGMCGDGANDCGALKQADVGISLseaeaSVAAPFTSKLA 842
E1-E2_ATPase pfam00122
E1-E2 ATPase;
153-344 1.14e-46

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.05  E-value: 1.14e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    153 NMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAhGCKVDNSSLTGESEPQTRSPdcthdnpletRNI 232
Cdd:pfam00122    1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEG-SASVDESLLTGESLPVEKKK----------GDM 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    233 TFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVI 312
Cdd:pfam00122   70 VYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRALL 149
                          170       180       190
                   ....*....|....*....|....*....|..
gi 22748667    313 FLIGIIVANVPEGLLATVTVCLTLTAKRMARK 344
Cdd:pfam00122  150 RALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
139-800 4.25e-46

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 175.90  E-value: 4.25e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  139 YQEAKSSKIMESFKNMVPQQALVI-REGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTR 217
Cdd:cd07551   94 YAMGRSKRAITALMQLAPETARRIqRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEK 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  218 SPDCThdnpletrniTFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQL-ITGVAVFLGVSF 296
Cdd:cd07551  173 TPGDE----------VFAGTINGSGALTVRVTKLSSDTVFAKIVQLVEEAQSEKSPTQSFIERFERIyVKGVLLAVLLLL 242
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  297 FILSLILGYTWLEAviFLIGII--VANVPEGL-LATVTVCLTLTAkRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQ 373
Cdd:cd07551  243 LLPPFLLGWTWADS--FYRAMVflVVASPCALvASTPPATLSAIA-NAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTE 319
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  374 NRMTVAHMWFDNQIHEADTTedQSGTSFDKSShtwvalSH-IAglcnRAVFKggqdnipvlkrdvAGDASESALLKCIEL 452
Cdd:cd07551  320 GKPRVTDVIPAEGVDEEELL--QVAAAAESQS------EHpLA----QAIVR-------------YAEERGIPRLPAIEV 374
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  453 SS----GSVKLMRERNKKVAeipfnstnKYQLsIHETEDPndnryllvmkgaperildrcstillqGKEQPLDEEMKEAf 528
Cdd:cd07551  375 EAvtgkGVTATVDGQTYRIG--------KPGF-FGEVGIP--------------------------SEAAALAAELESE- 418
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  529 qnaylelgglGERVLgfchyylpeeqfpkgfAFDCDDVnfttdnlcFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTG 608
Cdd:cd07551  419 ----------GKTVV----------------YVARDDQ--------VVGLIALMDTPRPEAKEAIAALRLGGIKTIMLTG 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  609 DHPITAKAIAKGVGiisegnetvediaarlnipvsqvnprdakacvihgtdlkdftseqIDEilqnhteiVFARTSPQQK 688
Cdd:cd07551  465 DNERTAEAVAKELG---------------------------------------------IDE--------VVANLLPEDK 491
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  689 LIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGR----LIFDNLKK 764
Cdd:cd07551  492 VAIIRELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRkmrrIIKQNLIF 570
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....
gi 22748667  765 S---IAYTLTSNipeitpfllfIMANIPLPLGTI-----TILCI 800
Cdd:cd07551  571 AlavIALLIVAN----------LFGLLNLPLGVVghegsTLLVI 604
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
143-795 6.53e-46

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 174.39  E-value: 6.53e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    143 KSSKIMESFKNMVPQQALVIR-EGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTRspdc 221
Cdd:TIGR01511   77 RASDALSKLAKLQPSTATLLTkDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPK---- 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    222 thdnplETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIaieiEHFIQLITGVAVFLGVSFFILSL 301
Cdd:TIGR01511  152 ------KVGDPVIAGTVNGTGSLVVRATATGEDTTLAQIVRLVRQAQQSKAPI----QRLADKVAGYFVPVVIAIALITF 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    302 ILgytWLEAVIFLIGIIVANVPEGL-LATVTVCLTLTAkRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 380
Cdd:TIGR01511  222 VI---WLFALEFAVTVLIIACPCALgLATPTVIAVATG-LAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTD 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    381 MWFDNqihEADTTEDQS-GTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIpvlkRDVAGDASEsALLKCIELSSGSVKL 459
Cdd:TIGR01511  298 VHVFG---DRDRTELLAlAAALEAGSEHPLAKAIVSYAKEKGITLVTVSDF----KAIPGIGVE-GTVEGTKIQLGNEKL 369
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    460 MRERNkkvaeIPFNSTNKyqlsihetedpndnryllvmkgaperildrcstillQGKEqpldeemkeafqnaylelgglg 539
Cdd:TIGR01511  370 LGENA-----IKIDGKAG------------------------------------QGST---------------------- 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    540 ervlgfchyylpeeqfpkgfafdcddVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAK 619
Cdd:TIGR01511  387 --------------------------VVLVAVNGELAGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAK 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    620 GVGIisegnetvediaarlnipvsqvnprdakacvihgtdlkdftseqideilqnhteIVFARTSPQQKLIIVEGCQRQG 699
Cdd:TIGR01511  441 ELGI------------------------------------------------------DVRAEVLPDDKAALIKKLQEKG 466
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    700 AIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIpeitp 779
Cdd:TIGR01511  467 PVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQNLLWAFGYNV----- 540
                          650
                   ....*....|....*.
gi 22748667    780 FLLFIMANIPLPLGTI 795
Cdd:TIGR01511  541 IAIPIAAGVLYPIGIL 556
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
86-872 1.68e-42

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 167.04  E-value: 1.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   86 LFGGFSILLWigailcflaygiqagteddpSGDNLY---LGIVLAAVVIItgCFSYYQEAKSSKIMesfKNMV--PQQAL 160
Cdd:cd07542   36 VFQLFSVILW--------------------SSDDYYyyaACIVIISVISI--FLSLYETRKQSKRL---REMVhfTCPVR 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  161 VIREGEKMQVNAEEVVVGDLVEIKG-GDRVPADLRIISAhGCKVDNSSLTGESEP--QTRSPDCTHDNPLETRNITFFST 237
Cdd:cd07542   91 VIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSG-SCIVNESMLTGESVPvtKTPLPDESNDSLWSIYSIEDHSK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  238 N---C----------VEGTARGVVVATGDRTVMGRIatLASGLEVGKTPIAIEIEHFIQLITgVAVFLGVSFFILSLIL- 303
Cdd:cd07542  170 HtlfCgtkviqtrayEGKPVLAVVVRTGFNTTKGQL--VRSILYPKPVDFKFYRDSMKFILF-LAIIALIGFIYTLIILi 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  304 --GYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahm 381
Cdd:cd07542  247 lnGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLTEDGLDL--- 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  382 W----------FDNQIHEADttedQSGTSFDKSSHTWVAL--SHiaglcnravfkggqdNIPVLKRDVAGDASEsalLKC 449
Cdd:cd07542  324 WgvrpvsgnnfGDLEVFSLD----LDLDSSLPNGPLLRAMatCH---------------SLTLIDGELVGDPLD---LKM 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  450 IELSSGSVKLMRErnkkvaeIPFNSTNKYQLSIheTEDPNDNRYLLVMKGAPERILDRCSTillqgkeqpldEEMKEAFQ 529
Cdd:cd07542  382 FEFTGWSLEILRQ-------FPFSSALQRMSVI--VKTPGDDSMMAFTKGAPEMIASLCKP-----------ETVPSNFQ 441
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  530 NAYLELGGLGERVLGFCHYYLP----EEQFPKGFAFDCDdvnfttdnLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIM 605
Cdd:cd07542  442 EVLNEYTKQGFRVIALAYKALEsktwLLQKLSREEVESD--------LEFLGLIVMENRLKPETAPVINELNRANIRTVM 513
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  606 VTGDHPITAKAIAKGVGIISEGNETvediaarlnIPVSQVNPRDAKACVIHgtdlkdftseqiDEILQNHTeiVFARTSP 685
Cdd:cd07542  514 VTGDNLLTAISVARECGMISPSKKV---------ILIEAVKPEDDDSASLT------------WTLLLKGT--VFARMSP 570
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  686 QQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM-----GIAGSDVSKQAadmillddNFASIVTGVEEGR--LI 758
Cdd:cd07542  571 DQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLseaeaSVAAPFTSKVP--------DISCVPTVIKEGRaaLV 642
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  759 --FDNLKKSIAYTLtsnIPEITPFLLFIMANIplpLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPrnprTDKLVN 836
Cdd:cd07542  643 tsFSCFKYMALYSL---IQFISVLILYSINSN---LGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRP----PASLVS 712
                        810       820       830
                 ....*....|....*....|....*....|....*.
gi 22748667  837 ERLISMAYGQIgMIQALGGFFSYFVILAENGFLPGN 872
Cdd:cd07542  713 PPVLVSLLGQI-VLILLFQVIGFLIVRQQPWYIPPE 747
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
154-770 1.61e-40

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 158.72  E-value: 1.61e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  154 MVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTRSPD-------CTHDNP 226
Cdd:cd07546   96 LVPETALREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAGdkvfagsINVDGV 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  227 LETRnitffstncvegtargVVVATGDRTVmGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFIL-SLILG- 304
Cdd:cd07546  175 LRIR----------------VTSAPGDNAI-DRILHLIEEAEERRAPIERFIDRFSRWYTPAIMAVALLVIVVpPLLFGa 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  305 --YTWLEA--VIFLIGI---IVANVPegllATVTVCLTLTAKRMArkncLVKNLEAVETLGSTSTICSDKTGTLTQNRMT 377
Cdd:cd07546  238 dwQTWIYRglALLLIGCpcaLVISTP----AAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPV 309
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  378 VAHMWFDNQIHEADTTEdQSGTSFDKSSHTwvalshiagLCNRAVFKGGQDNIPVLKRDVAGDASESALlkcielsSGSV 457
Cdd:cd07546  310 VTDVVPLTGISEAELLA-LAAAVEMGSSHP---------LAQAIVARAQAAGLTIPPAEEARALVGRGI-------EGQV 372
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  458 klmrernkkvaeipfnstnkyqlsihetedpNDNRYLLvmkGAPERILDRcSTILLQGKEQPLDEEMKEAFqnayleLGG 537
Cdd:cd07546  373 -------------------------------DGERVLI---GAPKFAADR-GTLEVQGRIAALEQAGKTVV------VVL 411
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  538 LGERVLgfchyylpeeqfpkgfafdcddvnfttdnlcfvGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI 617
Cdd:cd07546  412 ANGRVL---------------------------------GLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAI 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  618 AKGVGIisegnetvediaarlnipvsqvnprDAKAcvihgtdlkdftseqidEILqnhteivfartsPQQKLIIVEGCQR 697
Cdd:cd07546  459 AAELGL-------------------------DFRA-----------------GLL------------PEDKVKAVRELAQ 484
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22748667  698 QGAiVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL 770
Cdd:cd07546  485 HGP-VAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIAL 555
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
127-770 1.59e-38

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 152.96  E-value: 1.59e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  127 AAVVIITGCFSYYQEA----KSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcK 202
Cdd:cd07545   62 AAMVVFLFAISEALEAysmdRARRSIRSLMDIAPKTALVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGES-S 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  203 VDNSSLTGESEPQTRSPDCThdnpletrniTFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFI 282
Cdd:cd07545  141 VNQAAITGESLPVEKGVGDE----------VFAGTLNGEGALEVRVTKPAEDSTIARIIHLVEEAQAERAPTQAFVDRFA 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  283 QLITGVAVFLGVSFFILS-LILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTS 361
Cdd:cd07545  211 RYYTPVVMAIAALVAIVPpLFFGGAWFTWIYRGLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLK 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  362 TICSDKTGTLTQNRMTVAHMWFDNqiheaDTTEDQS---GTSFDKSSHTWVAlSHIAGlcnravfKGGQDNIPVLK---- 434
Cdd:cd07545  291 TVAFDKTGTLTKGKPVVTDVVVLG-----GQTEKELlaiAAALEYRSEHPLA-SAIVK-------KAEQRGLTLSAveef 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  435 RDVAGDASEsALLKCIELSSGSVKLMRERNkkvaeipfnstnkyqlsihetedpndnryllvmkgaperildRCSTILLQ 514
Cdd:cd07545  358 TALTGRGVR-GVVNGTTYYIGSPRLFEELN------------------------------------------LSESPALE 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  515 GKEQPLDEEMKEAFqnayleLGGLGERVLgfchyylpeeqfpkgfafdcddvnfttdnlcfvGLMSMIDPPRAAVPDAVG 594
Cdd:cd07545  395 AKLDALQNQGKTVM------ILGDGERIL---------------------------------GVIAVADQVRPSSRNAIA 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  595 KCRSAGI-KVIMVTGDHPITAKAIAKGVGiisegnetVEDIAARLnipvsqvnprdakacvihgtdlkdftseqideilq 673
Cdd:cd07545  436 ALHQLGIkQTVMLTGDNPQTAQAIAAQVG--------VSDIRAEL----------------------------------- 472
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  674 nhteivfartSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVE 753
Cdd:cd07545  473 ----------LPQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVR 542
                        650
                 ....*....|....*..
gi 22748667  754 EGRLIFDNLKKSIAYTL 770
Cdd:cd07545  543 LSRKTLAIIKQNIAFAL 559
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
789-998 3.27e-37

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 137.76  E-value: 3.27e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    789 PLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPrTDKLVNERLISMAYGQiGMIQALGGFFSYFVILAENGF 868
Cdd:pfam00689    1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKP-KEPLFSRKMLRRILLQ-GLLIAILTLLVFFLGLLGFGI 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    869 LPGNlvgirlnwddrtvndledsygqqwtyeqrkvvefTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGM-KNKILIFG 947
Cdd:pfam00689   79 SESQ----------------------------------NAQTMAFNTLVLSQLFNALNARSLRRSLFKIGLfSNKLLLLA 124
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 22748667    948 LFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLI 998
Cdd:pfam00689  125 ILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
120-753 1.53e-36

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 146.70  E-value: 1.53e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  120 LYLGIVLAAVVI---ITGCFSY--YQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLR 194
Cdd:cd07544   68 LLVGEYWASLIIllmLTGGEALedYAQRRASRELTALLDRAPRIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGE 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  195 IISAHGCkVDNSSLTGESEPQTRSPdcthdnpleTRNITFFSTNcveGTARGVVVAT---GDRTVMGRIATLAsglEVGK 271
Cdd:cd07544  148 VVSGTAT-LDESSLTGESKPVSKRP---------GDRVMSGAVN---GDSALTMVATklaADSQYAGIVRLVK---EAQA 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  272 TPiaieiEHFIQLitgvAVFLGVSFFILSLIL-GYTWL---EAVIFLIGIIVANvPEGLLATVTVCLTLTAKRMARKNCL 347
Cdd:cd07544  212 NP-----APFVRL----ADRYAVPFTLLALAIaGVAWAvsgDPVRFAAVLVVAT-PCPLILAAPVAIVSGMSRSSRRGIL 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  348 VKNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwfdNQIHEADT-TED---QSGTSFDKSShtwvalSHIaglcnravf 423
Cdd:cd07544  282 VKDGGVLEKLARAKTVAFDKTGTLTYGQPKV------VDVVPAPGvDADevlRLAASVEQYS------SHV--------- 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  424 kggqdnipvlkrdvagdasesallkcieLSSGSVKLMRERN---KKVAEIpfnstnkyqlsiheTEDPNdnryllvmKGA 500
Cdd:cd07544  341 ----------------------------LARAIVAAARERElqlSAVTEL--------------TEVPG--------AGV 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  501 PERILDRCSTIllqGKEQPLDEEMKEAFQNAYLELGGLGERVLgfchyylpeeqfpkgfafdCDDVnfttdnlcFVGLMS 580
Cdd:cd07544  371 TGTVDGHEVKV---GKLKFVLARGAWAPDIRNRPLGGTAVYVS-------------------VDGK--------YAGAIT 420
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  581 MIDPPRAAVPDAVGKCRSAGI-KVIMVTGDHPITAKAIAKGVGIisegnetvediaarlnipvsqvnprdakacvihgtd 659
Cdd:cd07544  421 LRDEVRPEAKETLAHLRKAGVeRLVMLTGDRRSVAEYIASEVGI------------------------------------ 464
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  660 lkdftseqiDEilqnhteiVFARTSPQQKLIIVEGcQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMI 739
Cdd:cd07544  465 ---------DE--------VRAELLPEDKLAAVKE-APKAGPTIMVGDGVNDAPALAAADVGIAMGARGSTAASEAADVV 526
                        650
                 ....*....|....
gi 22748667  740 LLDDNFASIVTGVE 753
Cdd:cd07544  527 ILVDDLDRVVDAVA 540
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
122-732 7.37e-36

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 146.58  E-value: 7.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  122 LGIVLAAVVIITGCFsYYQEAKSSKIMESFKNmvPQQALVIREGEKMQ-VNAEEVVVGDLVEIKG-GDRVPADLRIISAH 199
Cdd:cd02082   54 ITVVFMTTINSLSCI-YIRGVMQKELKDACLN--NTSVIVQRHGYQEItIASNMIVPGDIVLIKRrEVTLPCDCVLLEGS 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  200 gCKVDNSSLTGESEPQTR------SPDCTHDNPLETRNITFFSTNCVEGTA-------RGVVVATGDRTVMGRIatLASG 266
Cdd:cd02082  131 -CIVTEAMLTGESVPIGKcqiptdSHDDVLFKYESSKSHTLFQGTQVMQIIppeddilKAIVVRTGFGTSKGQL--IRAI 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  267 LEVGKTPIAIEIEHFIQLITgVAVFLGVSFFilslilgYTWLEA--------VIFL--IGIIVANVPEGLLATVTVCLTL 336
Cdd:cd02082  208 LYPKPFNKKFQQQAVKFTLL-LATLALIGFL-------YTLIRLldielpplFIAFefLDILTYSVPPGLPMLIAITNFV 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  337 TAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSsHTWVALSHiag 416
Cdd:cd02082  280 GLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIGYQLKGQNQTFDPIQCQDPNNISIE-HKLFAICH--- 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  417 lcnravfkggqdniPVLKRD--VAGDASESALLKCI--------ELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETE 486
Cdd:cd02082  356 --------------SLTKINgkLLGDPLDVKMAEAStwdldydhEAKQHYSKSGTKRFYIIQVFQFHSALQRMSVVAKEV 421
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  487 D--PNDNRYLLVMKGAPERILDRCSTIllqgkeqPLDeemkeaFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCD 564
Cdd:cd02082  422 DmiTKDFKHYAFIKGAPEKIQSLFSHV-------PSD------EKAQLSTLINEGYRVLALGYKELPQSEIDAFLDLSRE 488
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  565 DVNfttDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVedIAARLNIPVSQ 644
Cdd:cd02082  489 AQE---ANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIINRKNPTI--IIHLLIPEIQK 563
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  645 VNprdakacvihgtdlkdftseQIDEILQNHTEiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM 724
Cdd:cd02082  564 DN--------------------STQWILIIHTN-VFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISL 622

                 ....*...
gi 22748667  725 GIAGSDVS 732
Cdd:cd02082  623 AEADASFA 630
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
156-774 2.00e-34

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 140.10  E-value: 2.00e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  156 PQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCkVDNSSLTGESEPQTRSPDCThdnpletrniTFF 235
Cdd:cd07550   99 ERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEKREGDL----------VFA 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  236 STNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPI---AIEIEHFIQLITgvavfLGVSFFILSLILGYTWLEAVI 312
Cdd:cd07550  168 STVVEEGQLVIRAERVGRETRAARIAELIEQSPSLKARIqnyAERLADRLVPPT-----LGLAGLVYALTGDISRAAAVL 242
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  313 ---FLIGIIVAnVPEGLLATVTVCltltakrmARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTV-AHMWFDNQIH 388
Cdd:cd07550  243 lvdFSCGIRLS-TPVAVLSALNHA--------ARHGILVKGGRALELLAKVDTVVFDKTGTLTEGEPEVtAIITFDGRLS 313
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  389 EADTTedqsgtsfdksshTWVA-----LSH-IAglcnRAVFKGGQD-NIPVLKRD-----VA-GDASEsalLKCIELSSG 455
Cdd:cd07550  314 EEDLL-------------YLAAsaeehFPHpVA----RAIVREAEErGIEHPEHEeveyiVGhGIAST---VDGKRIRVG 373
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  456 SVKLMRERNkkvaeipfnstnkyqlsIHETEDPNDNRYLLVMKGaperildrCSTILLqgkeqpldeemkeafqnaylel 535
Cdd:cd07550  374 SRHFMEEEE-----------------IILIPEVDELIEDLHAEG--------KSLLYV---------------------- 406
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  536 gGLGERVLGFCHYYlpeeqfpkgfafdcddvnfttdnlcfvglmsmiDPPRAAVPDAVGKCRSAGIK-VIMVTGDHPITA 614
Cdd:cd07550  407 -AIDGRLIGVIGLS---------------------------------DPLRPEAAEVIARLRALGGKrIIMLTGDHEQRA 452
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  615 KAIAKGVGIisegnetvediaarlnipvsqvnprdakacvihgtdlkdftseqiDEilqnhteiVFARTSPQQKLIIVEG 694
Cdd:cd07550  453 RALAEQLGI---------------------------------------------DR--------YHAEALPEDKAEIVEK 479
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  695 CQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNI 774
Cdd:cd07550  480 LQAEGRTVAFVGDGINDSPALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNT 558
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
154-749 2.03e-34

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 140.90  E-value: 2.03e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  154 MVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTRSPDCThdnpletrnIT 233
Cdd:cd07552  128 LLPKTAHLVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGES-SVNESMVTGESKPVEKKPGDE---------VI 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  234 FFSTNcVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLG-VSFFILSLILGYTwlEAVI 312
Cdd:cd07552  198 GGSVN-GNGTLEVKVTKTGEDSYLSQVMELVAQAQASKSRAENLADKVAGWLFYIALGVGiIAFIIWLILGDLA--FALE 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  313 FLIGIIVANVPEGL-LAT--VTVCLTLTAkrmARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMwfdnqIHE 389
Cdd:cd07552  275 RAVTVLVIACPHALgLAIplVVARSTSIA---AKNGLLIRNREALERARDIDVVLFDKTGTLTEGKFGVTDV-----ITF 346
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  390 ADTTEDQsgtsfdksshtwvALSHIAGLCNRavfkggqdnipvlkrdvagdaSESALLKCIelssgsVKLMRERNKKVAE 469
Cdd:cd07552  347 DEYDEDE-------------ILSLAAALEAG---------------------SEHPLAQAI------VSAAKEKGIRPVE 386
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  470 IP-FNSTNKYQLSIHetedPNDNRYLLVMKGAPERILDRcstillqgkeqpLDEEMKEafqnaylELGGLGERVlgfchY 548
Cdd:cd07552  387 VEnFENIPGVGVEGT----VNGKRYQVVSPKYLKELGLK------------YDEELVK-------RLAQQGNTV-----S 438
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  549 YLPEEqfpkgfafdcDDVnfttdnlcfVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGiisegn 628
Cdd:cd07552  439 FLIQD----------GEV---------IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELG------ 493
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  629 etvediaarlnipvsqvnprdakacvihgtdlkdftseqIDEilqnhteiVFARTSPQQKLIIVEGCQRQGAIVAVTGDG 708
Cdd:cd07552  494 ---------------------------------------IDE--------YFAEVLPEDKAKKVKELQAEGKKVAMVGDG 526
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
gi 22748667  709 VNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIV 749
Cdd:cd07552  527 VNDAPALAQADVGIAIG-AGTDVAIESADVVLVKSDPRDIV 566
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
417-511 6.52e-34

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 125.02  E-value: 6.52e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    417 LCNRAVFKGgqdNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETedPNDNRYLLV 496
Cdd:pfam13246    2 LCNSAAFDE---NEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVAEIPFNSDRKRMSTVHKL--PDDGKYRLF 76
                           90
                   ....*....|....*
gi 22748667    497 MKGAPERILDRCSTI 511
Cdd:pfam13246   77 VKGAPEIILDRCTTI 91
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
146-724 1.32e-32

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 136.36  E-value: 1.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  146 KIMESFKNM--VPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDR---VPADLRIISAHgCKVDNSSLTGESEPQTR--- 217
Cdd:cd07543   73 KNLSEFRTMgnKPYTIQVYRDGKWVPISSDELLPGDLVSIGRSAEdnlVPCDLLLLRGS-CIVNEAMLTGESVPLMKepi 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  218 ----SPDCTHDNPLETRNITFFSTNCVEGTAR-------------GVVVATGDRTVMGRIA-TLASGLEvGKTpiAIEIE 279
Cdd:cd07543  152 edrdPEDVLDDDGDDKLHVLFGGTKVVQHTPPgkgglkppdggclAYVLRTGFETSQGKLLrTILFSTE-RVT--ANNLE 228
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  280 HFIqlitgvavflgvsfFILSLIL------GYTW--------------LEAVIFLIGIIVANVPEGLLATVTVCLTLTAK 339
Cdd:cd07543  229 TFI--------------FILFLLVfaiaaaAYVWiegtkdgrsryklfLECTLILTSVVPPELPMELSLAVNTSLIALAK 294
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  340 RMarknclVKNLEA--VETLGSTSTICSDKTGTLTQNRMTV---AHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALshi 414
Cdd:cd07543  295 LY------IFCTEPfrIPFAGKVDICCFDKTGTLTSDDLVVegvAGLNDGKEVIPVSSIEPVETILVLASCHSLVKL--- 365
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  415 aglcnravfkggqdnipvLKRDVAGDASESALLKCI---ELSSGSVKLMRERNKKVAEI---PFNSTNKYQLSIHETEDP 488
Cdd:cd07543  366 ------------------DDGKLVGDPLEKATLEAVdwtLTKDEKVFPRSKKTKGLKIIqrfHFSSALKRMSVVASYKDP 427
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  489 NDN--RYLLVMKGAPErildrcsTILLQGKEQPLDeemkeaFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDV 566
Cdd:cd07543  428 GSTdlKYIVAVKGAPE-------TLKSMLSDVPAD------YDEVYKEYTRQGSRVLALGYKELGHLTKQQARDYKREDV 494
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  567 NfttDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISegNETVEDIAarlnipvsqvn 646
Cdd:cd07543  495 E---SDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKELGIVD--KPVLILIL----------- 558
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22748667  647 PRDAKACvihgtDLKDFTSEQideilqnhteiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM 724
Cdd:cd07543  559 SEEGKSN-----EWKLIPHVK-----------VFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
95-756 5.05e-28

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 121.21  E-value: 5.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   95 WIGAILC-FLAYGIQAGTEDDPSGDNLYLGIVLAAVVIitgcFSYYQEA----KSSKIMESFKNMVPQ-QALVIREGEKM 168
Cdd:cd02078   31 EIGSIITtVLTFFPLLFSGGGPAGFNLAVSLWLWFTVL----FANFAEAiaegRGKAQADSLRKTKTEtQAKRLRNDGKI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  169 Q-VNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTRSPDctHDNPLETRnitffSTNCVEGTARGV 247
Cdd:cd02078  107 EkVPATDLKKGDIVLVEAGDIIPADGEVIEGVA-SVDESAITGESAPVIRESG--GDRSSVTG-----GTKVLSDRIKVR 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  248 VVATGDRTVMGRIATLASGLEVGKTP--IAIEIehFIQLITGVAVFLGVSFFILSLILGYTwlEAVIFLIGIIVANVPE- 324
Cdd:cd02078  179 ITANPGETFLDRMIALVEGASRQKTPneIALTI--LLVGLTLIFLIVVATLPPFAEYSGAP--VSVTVLVALLVCLIPTt 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  325 --GLLATVTVCltlTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLT-QNRMTVahmwfdnQIHEADTTEDQsgtsf 401
Cdd:cd02078  255 igGLLSAIGIA---GMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITlGNRQAT-------EFIPVGGVDEK----- 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  402 dksshtwvALSHIAGLCNRAvfkggqDNIPvlkrdvagdasESallKCIelssgsVKLMRERNKKVAE--------IPFN 473
Cdd:cd02078  320 --------ELADAAQLASLA------DETP-----------EG---RSI------VILAKQLGGTERDldlsgaefIPFS 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  474 STNKYQlsiheTEDPNDNRYllVMKGAPERIldrcstillQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHyylpee 553
Cdd:cd02078  366 AETRMS-----GVDLPDGTE--IRKGAVDAI---------RKYVRSLGGSIPEELEAIVEEISKQGGTPLVVAE------ 423
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  554 qfpkgfafdcddvnfttdNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIisegnetved 633
Cdd:cd02078  424 ------------------DDRVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV---------- 475
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  634 iaarlnipvsqvnprdakacvihgtdlKDFtseqideilqnhteivFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP 713
Cdd:cd02078  476 ---------------------------DDF----------------LAEAKPEDKLELIRKEQAKGKLVAMTGDGTNDAP 512
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|...
gi 22748667  714 ALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGR 756
Cdd:cd02078  513 ALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPTKLIEVVEIGK 554
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
156-770 1.46e-27

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 119.00  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  156 PQQALVIR-EGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTRSPDcthdNPLE--TRNI 232
Cdd:cd02092  125 ARGAQRLQaDGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTS-ELDRSLLTGESAPVTVAPG----DLVQagAMNL 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  233 TffstncveGTARGVVVATGDRTVMGRIATLASGLEVGK---TPIAieiEHFIQLITGVAVFLGVSFFILSLILGYTWLE 309
Cdd:cd02092  200 S--------GPLRLRATAAGDDTLLAEIARLMEAAEQGRsryVRLA---DRAARLYAPVVHLLALLTFVGWVAAGGDWRH 268
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  310 AVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRmtvahmwfdnqihe 389
Cdd:cd02092  269 ALLIAVAVLIITCPCALGLAVPAVQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGS-------------- 334
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  390 adttedqsgtsfdksshtwvalshiaglcnravfkggqdniPVLKRDVAGDASESALLKCIELSSgsvklmrernkkvae 469
Cdd:cd02092  335 -----------------------------------------PRLVGAHAISADLLALAAALAQAS--------------- 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  470 ipfnstnKYQLSihetedpndnRYLLVMKGAPERILDRCSTILLQGKEQPLDEEM----KEAFQNAYLELGGLGERVLGF 545
Cdd:cd02092  359 -------RHPLS----------RALAAAAGARPVELDDAREVPGRGVEGRIDGARvrlgRPAWLGASAGVSTASELALSK 421
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  546 chyylpEEQFPKGFAFDcddvnfttdnlcfvglmsmiDPPRAAVPDAVGKCRSAGIKVIMVTGDHPitakaiakgvgiis 625
Cdd:cd02092  422 ------GGEEAARFPFE--------------------DRPRPDAREAISALRALGLSVEILSGDRE-------------- 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  626 egnETVEDIAARLNIPvsqvnprDAKACVihgtdlkdftseqideilqnhteivfartSPQQKLIIVEGCQRQGAIVAVT 705
Cdd:cd02092  462 ---PAVRALARALGIE-------DWRAGL-----------------------------TPAEKVARIEELKAQGRRVLMV 502
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22748667  706 GDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFA----SIVTGVEEGRLIFDNLKKSIAYTL 770
Cdd:cd02092  503 GDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLApvpeAIEIARRARRLIRQNFALAIGYNV 570
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
154-770 8.62e-26

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 114.32  E-value: 8.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   154 MVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTRSPDcthdnpletrnit 233
Cdd:PRK11033  240 LVPETATRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSPFA-SFDESALTGESIPVERATG------------- 305
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   234 ffstncvEGTARGVVVAtgDRTV------------MGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFIL-S 300
Cdd:PRK11033  306 -------EKVPAGATSV--DRLVtlevlsepgasaIDRILHLIEEAEERRAPIERFIDRFSRIYTPAIMLVALLVILVpP 376
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   301 LILGYTWLEAV-----IFLIGI---IVANVPegllATVTVCLTLTAKRMArkncLVKNLEAVETLGSTSTICSDKTGTLT 372
Cdd:PRK11033  377 LLFAAPWQEWIyrgltLLLIGCpcaLVISTP----AAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLT 448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   373 QNRMTVAhmwfdnQIHEADttedqsGTSFDksshTWVALShiaglcnRAVFKGgqdnipvlkrdvagdaSESALLKCIel 452
Cdd:PRK11033  449 EGKPQVT------DIHPAT------GISES----ELLALA-------AAVEQG----------------STHPLAQAI-- 487
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   453 ssgsvklmrernkkVAEipfnsTNKYQLSIHETEDpndnRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEafQNAY 532
Cdd:PRK11033  488 --------------VRE-----AQVRGLAIPEAES----QRALAGSGIEGQVNGERVLICAPGKLPPLADAFAG--QINE 542
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   533 LELGGLGERVLgfchyyLPEEQfpkgfafdcddvnfttdnlcFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPI 612
Cdd:PRK11033  543 LESAGKTVVLV------LRNDD--------------------VLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPR 596
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   613 TAKAIAKGVGIisegnetveDIAARLnIPVSQVNprdakacvihgtdlkdftseQIDEILQNHTeivfartspqqkliiv 692
Cdd:PRK11033  597 AAAAIAGELGI---------DFRAGL-LPEDKVK--------------------AVTELNQHAP---------------- 630
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22748667   693 egcqrqgaiVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL 770
Cdd:PRK11033  631 ---------LAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLRGLAQMIELSRATHANIRQNITIAL 698
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
158-736 1.72e-25

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 113.80  E-value: 1.72e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  158 QALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIIS---AHG-CKVDNSSLTGESEPQTRSPDCTHDNPLETRNI- 232
Cdd:cd02073   84 PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSssePDGlCYVETANLDGETNLKIRQALPETALLLSEEDLa 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  233 ----------------TF-------------FSTNCV-------EGTAR--GVVVATGDRT-VM---GRIATLASGLE-- 268
Cdd:cd02073  164 rfsgeieceqpnndlyTFngtlelnggrelpLSPDNLllrgctlRNTEWvyGVVVYTGHETkLMlnsGGTPLKRSSIEkk 243
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  269 VGKTPIAIeiehFIQLITgVAVFLGV-----------SFFILSLILGYTW-LEAV-IFLIGIIVAN--VPEGLLATVTVC 333
Cdd:cd02073  244 MNRFIIAI----FCILIV-MCLISAIgkgiwlskhgrDLWYLLPKEERSPaLEFFfDFLTFIILYNnlIPISLYVTIEVV 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  334 LTLTAKRMA----------RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTvahmwFDNqiheadttedqsgTSFDK 403
Cdd:cd02073  319 KFLQSFFINwdldmydeetDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIME-----FKK-------------CSING 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  404 SSHT-WVALShiagLCNRAV--FKGGQDNIPVlkrdvagDAS---ESALLKC-----IELSSGSVKLMRERNKKVAE--- 469
Cdd:cd02073  381 VDYGfFLALA----LCHTVVpeKDDHPGQLVY-------QASspdEAALVEAardlgFVFLSRTPDTVTINALGEEEeye 449
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  470 ----IPFNSTNKYQLSIHETedpNDNRYLLVMKGAPERILDRCSTillqgKEQPLDEEMKEAFQNAYLElgGLgeRVLGF 545
Cdd:cd02073  450 ilhiLEFNSDRKRMSVIVRD---PDGRILLYCKGADSVIFERLSP-----SSLELVEKTQEHLEDFASE--GL--RTLCL 517
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  546 CHYYLPEEQFpKGFAFDCDDVNFTTDN---------------LCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDH 610
Cdd:cd02073  518 AYREISEEEY-EEWNEKYDEASTALQNreelldevaeeiekdLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDK 596
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  611 PITAKAIAKGVGIISEGNETVediaarlnipvsqvnprdakACVIHGTDLKdftseqidEILQNHTEIVFA--------- 681
Cdd:cd02073  597 QETAINIGYSCRLLSEDMENL--------------------ALVIDGKTLT--------YALDPELERLFLelalkckav 648
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 22748667  682 ---RTSPQQKLIIVEGCQR-QGAIVAVTGDGVNDSPALKKADIGVamGIAGSDvSKQAA 736
Cdd:cd02073  649 iccRVSPLQKALVVKLVKKsKKAVTLAIGDGANDVSMIQEAHVGV--GISGQE-GMQAA 704
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
30-104 1.11e-24

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 98.42  E-value: 1.11e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22748667      30 AMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLA 104
Cdd:smart00831    1 ELDWHALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
119-736 3.15e-24

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 110.16  E-value: 3.15e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    119 NLYLGIV-LAAVVIITG---CFSYYQEAKSSKimeSFKNmvpQQALVIREGEK-MQVNAEEVVVGDLVEIKGGDRVPADL 193
Cdd:TIGR01652   49 YRGTSIVpLAFVLIVTAikeAIEDIRRRRRDK---EVNN---RLTEVLEGHGQfVEIPWKDLRVGDIVKVKKDERIPADL 122
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    194 RIISAHG----CKVDNSSLTGESEPQTR-SPDCT-------------------------------------HDNPLETRN 231
Cdd:TIGR01652  123 LLLSSSEpdgvCYVETANLDGETNLKLRqALEETqkmldeddiknfsgeieceqpnaslysfqgnmtingdRQYPLSPDN 202
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    232 ITFfsTNCV---EGTARGVVVATGDRTvmgRIATLASGLEVGKTPIAIEIEHFIQLITGV--------AVFLGV------ 294
Cdd:TIGR01652  203 ILL--RGCTlrnTDWVIGVVVYTGHDT---KLMRNATQAPSKRSRLEKELNFLIIILFCLlfvlclisSVGAGIwndahg 277
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    295 --SFFILSLILGYTWLEAVI--FLIGIIVAN--VPEGLLATVTVCLTLTAKRMAR-------KN---CLVKNLEAVETLG 358
Cdd:TIGR01652  278 kdLWYIRLDVSERNAAANGFfsFLTFLILFSslIPISLYVSLELVKSVQAYFINSdlqmyheKTdtpASVRTSNLNEELG 357
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    359 STSTICSDKTGTLTQNRMT--------VAHMWFDNQIhEADTTEDQS------------GTSFDKSSHTWVALSHIA--- 415
Cdd:TIGR01652  358 QVEYIFSDKTGTLTQNIMEfkkcsiagVSYGDGFTEI-KDGIRERLGsyvenensmlveSKGFTFVDPRLVDLLKTNkpn 436
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    416 -----------GLCNRAVFKGGQDNiPVLKRDVAGDASESALLKC--------IELSSGSVKL-MRER-NKKVAEI---- 470
Cdd:TIGR01652  437 akrinefflalALCHTVVPEFNDDG-PEEITYQAASPDEAALVKAardvgfvfFERTPKSISLlIEMHgETKEYEIlnvl 515
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    471 PFNSTNKYQLSIheTEDPnDNRYLLVMKGAPERILDRcstiLLQGKEQPLDEEMK--EAFQNAYLELGGLGERVLGFCHY 548
Cdd:TIGR01652  516 EFNSDRKRMSVI--VRNP-DGRIKLLCKGADTVIFKR----LSSGGNQVNEETKEhlENYASEGLRTLCIAYRELSEEEY 588
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    549 ylpeEQFPKGFafdcDDVNFTTD---------------NLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPIT 613
Cdd:TIGR01652  589 ----EEWNEEY----NEASTALTdreekldvvaesiekDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVET 660
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    614 AKAIAKGVGIISEG------NETVEDIAARLNIPVSQvNPRDA------------KACVIHGTDLKDFTSEQI-DEILQ- 673
Cdd:TIGR01652  661 AINIGYSCRLLSRNmeqiviTSDSLDATRSVEAAIKF-GLEGTseefnnlgdsgnVALVIDGKSLGYALDEELeKEFLQl 739
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22748667    674 --NHTEIVFARTSPQQKLIIVEGCQ-RQGAIVAVTGDGVNDSPALKKADIGVamGIAGSDvSKQAA 736
Cdd:TIGR01652  740 alKCKAVICCRVSPSQKADVVRLVKkSTGKTTLAIGDGANDVSMIQEADVGV--GISGKE-GMQAV 802
copA PRK10671
copper-exporting P-type ATPase CopA;
143-766 6.92e-23

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 105.21  E-value: 6.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   143 KSSKIMESFKNMVPQQA-LVIREGEKmQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCkVDNSSLTGESEPQTRSP-D 220
Cdd:PRK10671  309 RSSKALEKLLDLTPPTArVVTDEGEK-SVPLADVQPGMLLRLTTGDRVPVDGEITQGEAW-LDEAMLTGEPIPQQKGEgD 386
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   221 CTHDNPLETRNITFFSTNcvegtargvvvATGDRTVMGRIATL-----ASGLEVGKtpIAIEIEH-FIQLITGVAVFLGV 294
Cdd:PRK10671  387 SVHAGTVVQDGSVLFRAS-----------AVGSHTTLSRIIRMvrqaqSSKPEIGQ--LADKISAvFVPVVVVIALVSAA 453
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   295 --SFFILSLILGYTwleAVIFLIGIIVAnVPEGL-LATvTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 371
Cdd:PRK10671  454 iwYFFGPAPQIVYT---LVIATTVLIIA-CPCALgLAT-PMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTL 528
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   372 TQNRMTVAHMWFDNQIHEADTTEdQSGTSFDKSSHTwvalshiagLCNRAVFKGGQDNIPVLKR-------DVAGDASES 444
Cdd:PRK10671  529 TEGKPQVVAVKTFNGVDEAQALR-LAAALEQGSSHP---------LARAILDKAGDMTLPQVNGfrtlrglGVSGEAEGH 598
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   445 ALLKcielssGSVKLMRErnkkvaeipfnstnkYQLSIHETEDPNDNrylLVMKGAPERILdrcstiLLQGKeqpldeem 524
Cdd:PRK10671  599 ALLL------GNQALLNE---------------QQVDTKALEAEITA---QASQGATPVLL------AVDGK-------- 640
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   525 keafqnaylelgglgervlgfchyylpeeqfpkgfafdcddvnfttdnlcFVGLMSMIDPPRAAVPDAVGKCRSAGIKVI 604
Cdd:PRK10671  641 --------------------------------------------------AAALLAIRDPLRSDSVAALQRLHKAGYRLV 670
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   605 MVTGDHPITAKAIAKGVGIisegnetVEDIAARLnipvsqvnPrDAKACVIhgtdlkdftseqideilqnhteivfarts 684
Cdd:PRK10671  671 MLTGDNPTTANAIAKEAGI-------DEVIAGVL--------P-DGKAEAI----------------------------- 705
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   685 pqQKLiivegcQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 764
Cdd:PRK10671  706 --KRL------QSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGVADALAISRATLRNMKQ 776

                  ..
gi 22748667   765 SI 766
Cdd:PRK10671  777 NL 778
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
138-756 7.94e-23

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 104.24  E-value: 7.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  138 YYQE---AKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISahGCK-VDNSSLTGESE 213
Cdd:cd07548   87 LFQDlavERSRKSIKALLDIRPDYANLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLK--GESfLDTSALTGESV 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  214 PQTRSPdctHDNPLE-TRNITFFSTNCVEgtargvvvATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFL 292
Cdd:cd07548  165 PVEVKE---GSSVLAgFINLNGVLEIKVT--------KPFKDSAVAKILELVENASARKAPTEKFITKFARYYTPIVVFL 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  293 GVSFFILSLILGY-----TWL-EAVIFLIgI-----IVANVPEGLLATVtvcltltaKRMARKNCLVKNLEAVETLGSTS 361
Cdd:cd07548  234 ALLLAVIPPLFSPdgsfsDWIyRALVFLV-IscpcaLVISIPLGYFGGI--------GAASRKGILIKGSNYLEALSQVK 304
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  362 TICSDKTGTLTqnrmtvahmwfdnqiheadttedqsgtsfdksshtwvalshiaglcnRAVFKggqdnipVLKRDVAGDA 441
Cdd:cd07548  305 TVVFDKTGTLT-----------------------------------------------KGVFK-------VTEIVPAPGF 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  442 SESALLK---CIELSSgsvklmrerNKKVAEIPFNSTNKyQLSIHETEDPNDnrylLVMKGaperILDRC-STILLQGKE 517
Cdd:cd07548  331 SKEELLKlaaLAESNS---------NHPIARSIQKAYGK-MIDPSEIEDYEE----IAGHG----IRAVVdGKEILVGNE 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  518 QPLDEEmkeafqnaylelgglgervlgfchyylpeeqfpkGFAFDCDDVNFTT----DNLCFVGLMSMIDPPRAAVPDAV 593
Cdd:cd07548  393 KLMEKF----------------------------------NIEHDEDEIEGTIvhvaLDGKYVGYIVISDEIKEDAKEAI 438
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  594 GKCRSAGIK-VIMVTGDHPITAKAIAKGVGIisegnetvEDIAARLnIPVSQVnprdakacvihgtdlkdftsEQIDEIL 672
Cdd:cd07548  439 KGLKELGIKnLVMLTGDRKSVAEKVAKKLGI--------DEVYAEL-LPEDKV--------------------EKVEELK 489
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  673 QNHteivfartspQQKLIIVegcqrqgaivavtGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGV 752
Cdd:cd07548  490 AES----------KGKVAFV-------------GDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAEAI 546

                 ....
gi 22748667  753 EEGR 756
Cdd:cd07548  547 KIAR 550
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
157-736 8.35e-22

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 101.91  E-value: 8.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  157 QQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIIS----AHGCKVDNSSLTGESEPQTR-SPDCTHDNP----- 226
Cdd:cd07536   83 KQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRtsepQGSCYVETAQLDGETDLKLRvAVSCTQQLPalgdl 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  227 -----------------------------------LETRNITFFSTNCVE-GTARGVVVATGDRTVMGRIATLAsglEVG 270
Cdd:cd07536  163 mkisayvecqkpqmdihsfegnftledsdppihesLSIENTLLRASTLRNtGWVIGVVVYTGKETKLVMNTSNA---KNK 239
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  271 KTPIAIEIEHFIQLITGVAVFLGVSFFILSLILG--------------YTWLE-AVIFLIGIIVAN--VPEGLLATVTVC 333
Cdd:cd07536  240 VGLLDLELNRLTKALFLALVVLSLVMVTLQGFWGpwygeknwyikkmdTTSDNfGRNLLRFLLLFSyiIPISLRVNLDMV 319
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  334 LTLTAKRMARKN----------CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTvahmwfdnqiheadttedqsgtsFDK 403
Cdd:cd07536  320 KAVYAWFIMWDEnmyyigndtgTVARTSTIPEELGQVVYLLTDKTGTLTQNEMI-----------------------FKR 376
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  404 SshtwvalsHIAGlcnraVFKGGQdnipvlkrdvagdasesallkciELSSGSVKLMrernkkvaeiPFNSTNKYQLSIh 483
Cdd:cd07536  377 C--------HIGG-----VSYGGQ-----------------------VLSFCILQLL----------EFTSDRKRMSVI- 409
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  484 eTEDPNDNRYLLVMKGAPERILDRCSTillqgkeqplDEEMKEaFQNAYLELGGLGERVLGFCHYYLPEEQF-------- 555
Cdd:cd07536  410 -VRDESTGEITLYMKGADVAISPIVSK----------DSYMEQ-YNDWLEEECGEGLRTLCVAKKALTENEYqewesryt 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  556 -PKGFAFD-----CDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIIS---- 625
Cdd:cd07536  478 eASLSLHDrslrvAEVVESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSrtqd 557
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  626 -----EGNETVEDIAARLNIPVSQVNPRDAKAC--VIHGTDLK---DFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGC 695
Cdd:cd07536  558 ihllrQDTSRGERAAITQHAHLELNAFRRKHDValVIDGDSLEvalKYYRHEFVELACQCPAVICCRVSPTQKARIVTLL 637
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 22748667  696 Q-RQGAIVAVTGDGVNDSPALKKADIGVamGIAGSDvSKQAA 736
Cdd:cd07536  638 KqHTGRRTLAIGDGGNDVSMIQAADCGV--GISGKE-GKQAS 676
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
178-800 5.64e-19

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 92.19  E-value: 5.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  178 GDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTrspdcthdnpLETRNITFFSTNCVEGTARGVVVATGDRTVM 257
Cdd:cd07553  149 GDVYLVASGQRVPVDGKLLSEQA-SIDMSWLTGESLPRI----------VERGDKVPAGTSLENQAFEIRVEHSLAESWS 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  258 GRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTwlEAVIFLIGIIVANVPEGLLATVTVCLTLT 337
Cdd:cd07553  218 GSILQKVEAQEARKTPRDLLADKIIHYFTVIALLIAVAGFGVWLAIDLS--IALKVFTSVLIVACPCALALATPFTDEIA 295
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  338 AKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRmtvahmwfdnqiheadttedQSGTSFDKSSHTWVALSHIAGL 417
Cdd:cd07553  296 LARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGK--------------------SSFVMVNPEGIDRLALRAISAI 355
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  418 CNravfkggqdnipvlkrdvagdASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQlsihetedpNDNRYLLVm 497
Cdd:cd07553  356 EA---------------------HSRHPISRAIREHLMAKGLIKAGASELVEIVGKGVSGNS---------SGSLWKLG- 404
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  498 kgapeRILDRCstillqgkeqpldeemkeafqnaylelgGLGErvlgfchyylpeeqfpkgfafdcDDVNFTTDNLcFVG 577
Cdd:cd07553  405 -----SAPDAC----------------------------GIQE-----------------------SGVVIARDGR-QLL 427
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  578 LMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGiisegnetvediaarlnipvsqvnprdakacvihg 657
Cdd:cd07553  428 DLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLG----------------------------------- 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  658 tdlKDFTSeqideilqnhteiVFARTSPQQKLIIVEGCQrQGAIVAVtGDGVNDSPALKKADIGVAmgIAGS-DVSKQAA 736
Cdd:cd07553  473 ---LDPRQ-------------LFGNLSPEEKLAWIESHS-PENTLMV-GDGANDALALASAFVGIA--VAGEvGVSLEAA 532
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22748667  737 DMILLDDNFASIVTGVEEGR----LIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCI 800
Cdd:cd07553  533 DIYYAGNGIGGIRDLLTLSKqtikAIKGLFAFSLLYNLVAIGLALSGWISPLVAAILMPLSSITILGI 600
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
33-100 5.59e-17

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 76.06  E-value: 5.59e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22748667     33 EHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAIL 100
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
164-756 6.32e-17

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 85.91  E-value: 6.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   164 EGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGcKVDNSSLTGESEPQTRSPDCTHDNPLETRNItffSTNCVEGT 243
Cdd:PRK14010  112 DGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLA-TVDESAITGESAPVIKESGGDFDNVIGGTSV---ASDWLEVE 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   244 argvVVATGDRTVMGRIATLASGLEVGKTPIaiEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVP 323
Cdd:PRK14010  188 ----ITSEPGHSFLDKMIGLVEGATRKKTPN--EIALFTLLMTLTIIFLVVILTMYPLAKFLNFNLSIAMLIALAVCLIP 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   324 E---GLLATVTVCltlTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQ-NRMTvahmwfdnqiheadttedqsgt 399
Cdd:PRK14010  262 TtigGLLSAIGIA---GMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYgNRMA---------------------- 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   400 sfdkSSHTWVALSHIAGLCNRAVFKGGQDNIPVlkrdvagdasesallkcielSSGSVKLMRERNkkvAEIPFNSTNKYQ 479
Cdd:PRK14010  317 ----DAFIPVKSSSFERLVKAAYESSIADDTPE--------------------GRSIVKLAYKQH---IDLPQEVGEYIP 369
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   480 LSIHETEDPNDNRYLLVMKGAPERILDRCSTillQGKEQPLDeemKEAFQNAYLELGGLGERVLgfchyylpeeqfpkgf 559
Cdd:PRK14010  370 FTAETRMSGVKFTTREVYKGAPNSMVKRVKE---AGGHIPVD---LDALVKGVSKKGGTPLVVL---------------- 427
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   560 afdcddvnfttDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIisegnetvediaarln 639
Cdd:PRK14010  428 -----------EDNEILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGV---------------- 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667   640 ipvsqvnprdakacvihgtdlkdftseqideilqnhtEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKAD 719
Cdd:PRK14010  481 -------------------------------------DRFVAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEAN 523
                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 22748667   720 IGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGR 756
Cdd:PRK14010  524 VGLAMN-SGTMSAKEAANLIDLDSNPTKLMEVVLIGK 559
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
165-736 3.26e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 83.61  E-value: 3.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  165 GEKMQVNAEEVVVGDLVEIKGGDRVPADLRIIS----AHGCKVDNSSLTGESEPQTRSP--------------------- 219
Cdd:cd07541   89 GETVEIPSSDIKVGDLIIVEKNQRIPADMVLLRtsekSGSCFIRTDQLDGETDWKLRIAvpctqklpeegilnsisavya 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  220 -----------------DCTHDNPLETRNITFFSTNCVEGTARGVVVATGD--RTVMGriaTLASGLEVGKtpIAIEIEH 280
Cdd:cd07541  169 eapqkdihsfygtftinDDPTSESLSVENTLWANTVVASGTVIGVVVYTGKetRSVMN---TSQPKNKVGL--LDLEINF 243
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  281 FIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLI---GIIvanvPEGLLATVTVCLTLTAKRMAR-KN---CLVKNLEA 353
Cdd:cd07541  244 LTKILFCAVLALSIVMVALQGFQGPWYIYLFRFLIlfsSII----PISLRVNLDMAKIVYSWQIEHdKNipgTVVRTSTI 319
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  354 VETLGSTSTICSDKTGTLTQNRMT--VAHMwfdnqiheadttedqsGT-SFDKSSHTWVALShiaglcnraVFkggqdni 430
Cdd:cd07541  320 PEELGRIEYLLSDKTGTLTQNEMVfkKLHL----------------GTvSYGGQNLNYEILQ---------IF------- 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  431 pvlkrdvagdasesallkcielssgsvklmrernkkvaeiPFNSTNKYQLSIheTEDPNDNRYLLVMKGAP--------- 501
Cdd:cd07541  368 ----------------------------------------PFTSESKRMGII--VREEKTGEITFYMKGADvvmskivqy 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  502 -ERILDRCSTILLQG------KEQPLDEEMKEAFQNAYLE-LGGLGERVLGFCH--YYLPEEqfpkgfafdcddvnftTD 571
Cdd:cd07541  406 nDWLEEECGNMAREGlrtlvvAKKKLSEEEYQAFEKRYNAaKLSIHDRDLKVAEvvESLERE----------------LE 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  572 NLCFVGLMsmiDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNE--------TVEDIAARLNipvS 643
Cdd:cd07541  470 LLCLTGVE---DKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLVSRGQYihvfrkvtTREEAHLELN---N 543
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  644 QVNPRDaKACVIHGTDL----KDFTSEQIDEILQNhTEIVFARTSPQQKLIIVEGCQ-RQGAIVAVTGDGVNDSPALKKA 718
Cdd:cd07541  544 LRRKHD-CALVIDGESLevclKYYEHEFIELACQL-PAVVCCRCSPTQKAQIVRLIQkHTGKRTCAIGDGGNDVSMIQAA 621
                        650
                 ....*....|....*...
gi 22748667  719 DIGVamGIAGSDvSKQAA 736
Cdd:cd07541  622 DVGV--GIEGKE-GKQAS 636
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
589-719 3.64e-07

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 51.43  E-value: 3.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667    589 VPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIIsegnetvediaarlnipvsqvnprdakacvihgtDLKDFTSEQI 668
Cdd:pfam00702  103 AAEALKALKERGIKVAILTGDNPEAAEALLRLLGLD----------------------------------DYFDVVISGD 148
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 22748667    669 DEilqnhteiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKAD 719
Cdd:pfam00702  149 DV--------GVGKPKPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAAG 191
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
591-754 1.81e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 46.67  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  591 DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI----ISE-GnetvediaarlnipvsqvnprdakACVIHGTD----LK 661
Cdd:COG0561   26 EALRRLREKGIKVVIATGRPLRSALPLLEELGLddplITSnG------------------------ALIYDPDGevlyER 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  662 DFTSEQIDEIL----QNHTEIVFARTSPQQKL-IIVEG----------CQRQG----AIVAVtGDGVNDSPALKKADIGV 722
Cdd:COG0561   82 PLDPEDVREILellrEHGLHLQVVVRSGPGFLeILPKGvskgsalkklAERLGippeEVIAF-GDSGNDLEMLEAAGLGV 160
                        170       180       190
                 ....*....|....*....|....*....|..
gi 22748667  723 AMGIAGSDVsKQAADMILLDDNFASIVTGVEE 754
Cdd:COG0561  161 AMGNAPPEV-KAAADYVTGSNDEDGVAEALEK 191
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
591-739 2.22e-04

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 43.75  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  591 DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI-----------ISEGN---------ETVEDI---AARLNIPVSQVNp 647
Cdd:cd07517   24 EAIAALKEKGILVVIATGRAPFEIQPIVKALGIdsyvsyngqyvFFEGEviyknplpqELVERLtefAKEQGHPVSFYG- 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748667  648 rdakACVIHgtdlkdFTSEQIDEILQNHTEIVFARTSPQQKLII------VEGCQR-------QGAIVAVTGDGVNDSPA 714
Cdd:cd07517  103 ----QLLLF------EDEEEEQKYEELRPELRFVRWHPLSTDVIpkggskAKGIQKviehlgiKKEETMAFGDGLNDIEM 172
                        170       180
                 ....*....|....*....|....*
gi 22748667  715 LKKADIGVAMGIAGSDVsKQAADMI 739
Cdd:cd07517  173 LEAVGIGIAMGNAHEEL-KEIADYV 196
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
702-748 1.20e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.84  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 22748667    702 VAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASI 748
Cdd:pfam08282  206 VIAFGDGENDIEMLEAAGLGVAMGNA-SPEVKAAADYVTDSNNEDGV 251
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
702-739 3.31e-03

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 40.33  E-value: 3.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 22748667    702 VAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMI 739
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH