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Conserved domains on  [gi|45439342|ref|NP_689542|]
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leucine-rich repeat protein 1 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-316 2.57e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.33  E-value: 2.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTlqkSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT---NLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45439342 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQpkvLPVIK 316
Cdd:COG4886 189 LSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTD---LPELG 247
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-316 2.57e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.33  E-value: 2.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTlqkSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT---NLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45439342 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQpkvLPVIK 316
Cdd:COG4886 189 LSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTD---LPELG 247
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-304 4.80e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 4.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 175 CLKSLRKLDLSHNHIKKLpATIGDLIHLQELNLNDNHLES-----FSVAlCHSTLQKSLRSLDLSKNKIKAlpvqfcqLQ 249
Cdd:cd21340  66 NLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPgekltFDPR-SLAALSNSLRVLNISGNNIDS-------LE 136

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 45439342 250 ELKNLKlddneliqfpckigqliNLRFLSAARNKL----PFLPSEFRNLSLEYLDLFGN 304
Cdd:cd21340 137 PLAPLR-----------------NLEQLDASNNQIsdleELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
178-238 8.72e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 8.72e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45439342   178 SLRKLDLSHNHIKKL-PATIGDLIHLQELNLNDNHLESFS-VALCHStlqKSLRSLDLSKNKI 238
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSpGAFSGL---PSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
178-337 2.17e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  178 SLRKLDLSHNHIKKLPATIGDLIHLQELNLND-----NHLESF--SVALCHS-------TLQKSLRSLDLSKNKIKALP- 242
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATLPDTIQEMELSINRitelpERLPSAlqSLDLFHNkisclpeNLPEELRYLSVYDNSIRTLPa 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  243 ----------VQFCQLQ--------ELKNLKLDDNELIQFPCKIGQliNLRFLSAARNKLPFLPsEFRNLSLEYLDLFGN 304
Cdd:PRK15370 301 hlpsgithlnVQSNSLTalpetlppGLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLP-ETLPPTITTLDVSRN 377

                        170       180       190
                 ....*....|....*....|....*....|....
gi 45439342  305 TFEQ-PKVLPviklqAPLTLLESSARTILhnRIP 337
Cdd:PRK15370 378 ALTNlPENLP-----AALQIMQASRNNLV--RLP 404
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-316 2.57e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 112.33  E-value: 2.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTlqkSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT---NLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45439342 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQpkvLPVIK 316
Cdd:COG4886 189 LSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTD---LPELG 247
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
155-304 2.03e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 2.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTlqkSLRSLDLS 234
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLT---NLKELDLS 190

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 235 KNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN 304
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-325 3.83e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 3.83e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTlqkSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT---NLEELDLSGNQLTDLPEPLANLTNLETLD 234

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 256 LDDNELIQFPcKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLE 325
Cdd:COG4886 235 LSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
192-304 6.50e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 6.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 192 LPATIGDLIHLQELNLNDN-HLESFsvalchstlqKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQ 270
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNeELSNL----------TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGN 157

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45439342 271 LINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGN 304
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-332 7.19e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 7.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 176 LKSLRKLDLSHNHIKKLPAtIGDLIHLQELNLNDNHLESFSvalcHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
Cdd:COG4886 227 LTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45439342 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTIL 332
Cdd:COG4886 302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-304 4.80e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 4.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 175 CLKSLRKLDLSHNHIKKLpATIGDLIHLQELNLNDNHLES-----FSVAlCHSTLQKSLRSLDLSKNKIKAlpvqfcqLQ 249
Cdd:cd21340  66 NLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPgekltFDPR-SLAALSNSLRVLNISGNNIDS-------LE 136

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 45439342 250 ELKNLKlddneliqfpckigqliNLRFLSAARNKL----PFLPSEFRNLSLEYLDLFGN 304
Cdd:cd21340 137 PLAPLR-----------------NLEQLDASNNQIsdleELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
178-238 8.72e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 8.72e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45439342   178 SLRKLDLSHNHIKKL-PATIGDLIHLQELNLNDNHLESFS-VALCHStlqKSLRSLDLSKNKI 238
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSpGAFSGL---PSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 177-285 1.65e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 177 KSLRKLDLSHNHI-----KKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKS--LRSLDLSKNKI-----KALpvq 244
Cdd:COG5238 264 TTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNktLHTLNLAYNGIgaqgaIAL--- 340

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 45439342 245 FCQLQE---LKNLKLDDNE--------LIQFPCKIGQlinLRFLSAARNKLP 285
Cdd:COG5238 341 AKALQEnttLHSLDLSDNQigdegaiaLAKYLEGNTT---LRELNLGKNNIG 389
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
178-337 2.17e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  178 SLRKLDLSHNHIKKLPATIGDLIHLQELNLND-----NHLESF--SVALCHS-------TLQKSLRSLDLSKNKIKALP- 242
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATLPDTIQEMELSINRitelpERLPSAlqSLDLFHNkisclpeNLPEELRYLSVYDNSIRTLPa 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  243 ----------VQFCQLQ--------ELKNLKLDDNELIQFPCKIGQliNLRFLSAARNKLPFLPsEFRNLSLEYLDLFGN 304
Cdd:PRK15370 301 hlpsgithlnVQSNSLTalpetlppGLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLP-ETLPPTITTLDVSRN 377

                        170       180       190
                 ....*....|....*....|....*....|....
gi 45439342  305 TFEQ-PKVLPviklqAPLTLLESSARTILhnRIP 337
Cdd:PRK15370 378 ALTNlPENLP-----AALQIMQASRNNLV--RLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 178-318 8.71e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 8.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  178 SLRKLDLSHNHIK-KLPATIGDLIHLQELNLNDNHLesfsVALCHSTL--QKSLRSLDLSKNKIKA-LPVQFCQLQELKN 253
Cdd:PLN00113 165 SLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL----VGQIPRELgqMKSLKWIYLGYNNLSGeIPYEIGGLTSLNH 240

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  254 LKLDDNELI-QFPCKIGQLINLRFLSAARNKL--PFLPSEFRNLSLEYLDLFGNTF--EQPKVlpVIKLQ 318
Cdd:PLN00113 241 LDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLsgPIPPSIFSLQKLISLDLSDNSLsgEIPEL--VIQLQ 308
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 182-304 1.19e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  182 LDLSHNHIK-KLPATIGDLIHLQELNLNDNhleSFSVALCHSTLQKSLRSLDLSKNKIK-ALPVQFCQLQELKNLKLDDN 259
Cdd:PLN00113 433 LDISNNNLQgRINSRKWDMPSLQMLSLARN---KFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSEN 509

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 45439342  260 ELI-QFPCKIGQLINLRFLSAARNKL----PFLPSEFRNLSLeyLDLFGN 304
Cdd:PLN00113 510 KLSgEIPDELSSCKKLVSLDLSHNQLsgqiPASFSEMPVLSQ--LDLSQN 557
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 176-261 1.55e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 176 LKSLRKLDLSHNHI-----KKLPATIGDLIHLQELNLNDNHLESFSVALCHS---TLQKSLRSLDLSKNKIKALPVQ-FC 246
Cdd:cd00116 192 NCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALASallSPNISLLTLSLSCNDITDDGAKdLA 271

                        90
                ....*....|....*....
gi 45439342 247 QLQE----LKNLKLDDNEL 261
Cdd:cd00116 272 EVLAekesLLELDLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 182-306 1.90e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  182 LDLSHNHIK-KLPATIGDLIHLQELNLNDNHLESF---SVALChstlqKSLRSLDLSKNKIKA-LPVQFCQLQELKNLKL 256
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEipkSLGAC-----RSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDI 435

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 45439342  257 DDNELI-QFPCKIGQLINLRFLSAARNK-LPFLPSEFRNLSLEYLDLFGNTF 306
Cdd:PLN00113 436 SNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSFGSKRLENLDLSRNQF 487
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
157-288 2.97e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  157 EHLQTSYCGLVRVDMRMLCL-----KSLRKLDLSHNHIKKLPATIGDLIhlQELNLNDNHLESFSVAL------------ 219
Cdd:PRK15370 258 ERLPSALQSLDLFHNKISCLpenlpEELRYLSVYDNSIRTLPAHLPSGI--THLNVQSNSLTALPETLppglktleagen 335

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45439342  220 ----CHSTLQKSLRSLDLSKNKIKALPVQFCqlQELKNLKLDDNELIQFPCKIGQLinLRFLSAARNKLPFLP 288
Cdd:PRK15370 336 altsLPASLPPELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPAA--LQIMQASRNNLVRLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 177-261 5.66e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 5.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  177 KSLRKLDLSHNHIKK-LPATIGDLIHLQELNLNDNHLESF---SVALChstlqKSLRSLDLSKNKIKA-LPVQFCQLQEL 251
Cdd:PLN00113 475 KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEipdELSSC-----KKLVSLDLSHNQLSGqIPASFSEMPVL 549

                         90
                 ....*....|
gi 45439342  252 KNLKLDDNEL 261
Cdd:PLN00113 550 SQLDLSQNQL 559
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
179-313 7.44e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 7.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  179 LRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCH-----------STLQKSLRSLDLSKNKIK---ALPVQ 244
Cdd:PRK15387 244 LRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKlwifgnqltslPVLPPGLQELSVSDNQLAslpALPSE 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342  245 FCQL--------------QELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEyldlfGNTFEQPK 310
Cdd:PRK15387 324 LCKLwaynnqltslptlpSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVS-----GNRLTSLP 398


                 ...
gi 45439342  311 VLP 313
Cdd:PRK15387 399 VLP 401
PLN03150 PLN03150
hypothetical protein; Provisional
 192-261 9.30e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 9.30e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45439342  192 LPATIGDLIHLQELNLNDNHLE-SFSVALCHSTlqkSLRSLDLSKNKIK-ALPVQFCQLQELKNLKLDDNEL 261
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSIT---SLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 177-242 1.35e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.35e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45439342 177 KSLRKLDLSHNHIKKLpATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALP 242
Cdd:cd21340 120 NSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
201-261 1.36e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.36e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45439342   201 HLQELNLNDNHLESfsvaLCHSTLQ--KSLRSLDLSKNKIKAL-PVQFCQLQELKNLKLDDNEL 261
Cdd:pfam13855   2 NLRSLDLSNNRLTS----LDDGAFKglSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
176-212 3.48e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 45439342   176 LKSLRKLDLSHNHIKKL-PATIGDLIHLQELNLNDNHL 212
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 177-212 5.56e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 5.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 45439342   177 KSLRKLDLSHNHIKKLPAtIGDLIHLQELNLNDNHL 212
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 178-212 1.35e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 1.35e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 45439342  178 SLRKLDLSHNHIK-KLPATIGDLIHLQELNLNDNHL 212
Cdd:PLN03150 467 SLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
202-308 2.46e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 2.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 202 LQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIqfpckiGQLINLRFLSAAR 281
Cdd:COG4886  49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL------SNLTNLESLDLSG 122

                        90       100
                ....*....|....*....|....*...
gi 45439342 282 NKLPFLPSEFRNL-SLEYLDLFGNTFEQ 308
Cdd:COG4886 123 NQLTDLPEELANLtNLKELDLSNNQLTD 150
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 155-240 5.99e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 5.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45439342 155 SLEHLQTSYCGLVRVDMRMLC-----LKSLRKLDLSHNHI------KKLPATIGDLIHLQELNLNDNHLESFSV-ALCHS 222
Cdd:cd00116 194 NLEVLDLNNNGLTDEGASALAetlasLKSLEVLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDITDDGAkDLAEV 273

                        90
                ....*....|....*....
gi 45439342 223 TLQK-SLRSLDLSKNKIKA 240
Cdd:cd00116 274 LAEKeSLLELDLRGNKFGE 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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