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Conserved domains on  [gi|154937334|ref|NP_689550|]
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uncharacterized protein C16orf46 isoform 2 [Homo sapiens]

Protein Classification

DUF4529 domain-containing protein( domain architecture ID 10633259)

DUF4529 domain-containing protein similar to Homo sapiens protein C16orf46

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4529 pfam15032
Protein of unknown function (DUF4529); This family of proteins is functionally uncharacterized. ...
1-395 0e+00

Protein of unknown function (DUF4529); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. The proteins contain a conserved VLPPLK sequence motif.


:

Pssm-ID: 464457  Cd Length: 406  Bit Score: 748.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334    1 MDLCQKNETDLENAENNEIQFTEETEPTYTCPDGKSEKNHVYCLLDVSDITLEQDEKAKEFIIGTGWEEAVQGWGRTSPA 80
Cdd:pfam15032   1 MDLCQKNETDLENGENNEIQSTEETELTFTCPDERSEKNHVCCLLNISDITLEQDEKANEFVIGTGWEEAVQGWGKTSPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334   81 ACIWPRKIPKKARVGEGACSDCLVCVNLSHWSLQTKPPT-----------EGGPEKDQSSPSQTQAAPQGPSTASRAISD 149
Cdd:pfam15032  81 ACIWPRKKLKKARVGESAGSSCLLCVSLSQGSLEARPPSeagklesgavaEVGPEKDQGSPSQTQGPPQGPTTASREISK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  150 ICFPTYFRAEKKSLQIKEFIWCNKDWAIPGTNRGKASGNPSGGAHRGLSIPGPLTSRALLVLPPLKASLSNALDVLGKKS 229
Cdd:pfam15032 161 ICFPTYSHGEKKSLQIKEFIWCMEDWAIPETVRGKAPRNPSGGADRGLSISDSLTSKALLVLPPLKASPPNGLDVLGKKS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  230 KNSFLQSEEKVLDVEKDGCVAYAYGLKTADGKGEKRASELAKHPMVNDTPSSPSPAAQISLLTDPEQRCLHWSLLSEKNL 309
Cdd:pfam15032 241 KNFFLQPEEKVLSVEKDECVACAYGLKTVDGKGEKRPLELAKHLKVNDTPPFPSPAARTSLLADPEPCCLHWSLLPEKSL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  310 ACPPDPSNVRYLAALQLLQKRGVQSYKSKFKAKEPRSPVITRKHVLPKAKQENRPQMLETKVFPRPVLPSLTVSRVIIPV 389
Cdd:pfam15032 321 LCPPNPSNVHYLATLQLLQKQGMQSYKAKFKAKEPRPPMNTQKHILTEAKQENRPQMLETKVFPRPLLPSLTVSRVVIPV 400

                  ....*.
gi 154937334  390 STHRIL 395
Cdd:pfam15032 401 STHRLL 406
 
Name Accession Description Interval E-value
DUF4529 pfam15032
Protein of unknown function (DUF4529); This family of proteins is functionally uncharacterized. ...
1-395 0e+00

Protein of unknown function (DUF4529); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. The proteins contain a conserved VLPPLK sequence motif.


Pssm-ID: 464457  Cd Length: 406  Bit Score: 748.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334    1 MDLCQKNETDLENAENNEIQFTEETEPTYTCPDGKSEKNHVYCLLDVSDITLEQDEKAKEFIIGTGWEEAVQGWGRTSPA 80
Cdd:pfam15032   1 MDLCQKNETDLENGENNEIQSTEETELTFTCPDERSEKNHVCCLLNISDITLEQDEKANEFVIGTGWEEAVQGWGKTSPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334   81 ACIWPRKIPKKARVGEGACSDCLVCVNLSHWSLQTKPPT-----------EGGPEKDQSSPSQTQAAPQGPSTASRAISD 149
Cdd:pfam15032  81 ACIWPRKKLKKARVGESAGSSCLLCVSLSQGSLEARPPSeagklesgavaEVGPEKDQGSPSQTQGPPQGPTTASREISK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  150 ICFPTYFRAEKKSLQIKEFIWCNKDWAIPGTNRGKASGNPSGGAHRGLSIPGPLTSRALLVLPPLKASLSNALDVLGKKS 229
Cdd:pfam15032 161 ICFPTYSHGEKKSLQIKEFIWCMEDWAIPETVRGKAPRNPSGGADRGLSISDSLTSKALLVLPPLKASPPNGLDVLGKKS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  230 KNSFLQSEEKVLDVEKDGCVAYAYGLKTADGKGEKRASELAKHPMVNDTPSSPSPAAQISLLTDPEQRCLHWSLLSEKNL 309
Cdd:pfam15032 241 KNFFLQPEEKVLSVEKDECVACAYGLKTVDGKGEKRPLELAKHLKVNDTPPFPSPAARTSLLADPEPCCLHWSLLPEKSL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  310 ACPPDPSNVRYLAALQLLQKRGVQSYKSKFKAKEPRSPVITRKHVLPKAKQENRPQMLETKVFPRPVLPSLTVSRVIIPV 389
Cdd:pfam15032 321 LCPPNPSNVHYLATLQLLQKQGMQSYKAKFKAKEPRPPMNTQKHILTEAKQENRPQMLETKVFPRPLLPSLTVSRVVIPV 400

                  ....*.
gi 154937334  390 STHRIL 395
Cdd:pfam15032 401 STHRLL 406
 
Name Accession Description Interval E-value
DUF4529 pfam15032
Protein of unknown function (DUF4529); This family of proteins is functionally uncharacterized. ...
1-395 0e+00

Protein of unknown function (DUF4529); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. The proteins contain a conserved VLPPLK sequence motif.


Pssm-ID: 464457  Cd Length: 406  Bit Score: 748.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334    1 MDLCQKNETDLENAENNEIQFTEETEPTYTCPDGKSEKNHVYCLLDVSDITLEQDEKAKEFIIGTGWEEAVQGWGRTSPA 80
Cdd:pfam15032   1 MDLCQKNETDLENGENNEIQSTEETELTFTCPDERSEKNHVCCLLNISDITLEQDEKANEFVIGTGWEEAVQGWGKTSPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334   81 ACIWPRKIPKKARVGEGACSDCLVCVNLSHWSLQTKPPT-----------EGGPEKDQSSPSQTQAAPQGPSTASRAISD 149
Cdd:pfam15032  81 ACIWPRKKLKKARVGESAGSSCLLCVSLSQGSLEARPPSeagklesgavaEVGPEKDQGSPSQTQGPPQGPTTASREISK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  150 ICFPTYFRAEKKSLQIKEFIWCNKDWAIPGTNRGKASGNPSGGAHRGLSIPGPLTSRALLVLPPLKASLSNALDVLGKKS 229
Cdd:pfam15032 161 ICFPTYSHGEKKSLQIKEFIWCMEDWAIPETVRGKAPRNPSGGADRGLSISDSLTSKALLVLPPLKASPPNGLDVLGKKS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  230 KNSFLQSEEKVLDVEKDGCVAYAYGLKTADGKGEKRASELAKHPMVNDTPSSPSPAAQISLLTDPEQRCLHWSLLSEKNL 309
Cdd:pfam15032 241 KNFFLQPEEKVLSVEKDECVACAYGLKTVDGKGEKRPLELAKHLKVNDTPPFPSPAARTSLLADPEPCCLHWSLLPEKSL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154937334  310 ACPPDPSNVRYLAALQLLQKRGVQSYKSKFKAKEPRSPVITRKHVLPKAKQENRPQMLETKVFPRPVLPSLTVSRVIIPV 389
Cdd:pfam15032 321 LCPPNPSNVHYLATLQLLQKQGMQSYKAKFKAKEPRPPMNTQKHILTEAKQENRPQMLETKVFPRPLLPSLTVSRVVIPV 400

                  ....*.
gi 154937334  390 STHRIL 395
Cdd:pfam15032 401 STHRLL 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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