izumo sperm-egg fusion protein 2 isoform 1 precursor [Homo sapiens]
IZUMO domain-containing protein( domain architecture ID 10633211)
IZUMO domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||
IZUMO | pfam15005 | Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of ... |
21-164 | 3.20e-57 | |||
Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific. : Pssm-ID: 464437 Cd Length: 142 Bit Score: 177.84 E-value: 3.20e-57
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Name | Accession | Description | Interval | E-value | |||
IZUMO | pfam15005 | Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of ... |
21-164 | 3.20e-57 | |||
Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific. Pssm-ID: 464437 Cd Length: 142 Bit Score: 177.84 E-value: 3.20e-57
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Name | Accession | Description | Interval | E-value | |||
IZUMO | pfam15005 | Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of ... |
21-164 | 3.20e-57 | |||
Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific. Pssm-ID: 464437 Cd Length: 142 Bit Score: 177.84 E-value: 3.20e-57
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Blast search parameters | ||||
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