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Conserved domains on  [gi|116089333|ref|NP_689588|]
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kelch domain-containing protein 7A [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 430-505 4.27e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


:

Pssm-ID: 350559  Cd Length: 77  Bit Score: 127.50  E-value: 4.27e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116089333 430 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDS 505
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
510-729 9.08e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.91  E-value: 9.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 510 CYDDEQDVWRPLARMPPEAVSRGCAIcSLFNYLFVVSGCQG--PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVAL 587
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTGanPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 588 DGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAhTATVRAKEIFVTGGslrfllFRFSAQEQRWWAGPTG 663
Cdd:COG3055  121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLAPL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116089333 664 GSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPyPDAFQCAVVDNLIYCVG 729
Cdd:COG3055  194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTP-RHGHAAVLTDGKVYVIG 258
 
Name Accession Description Interval E-value
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 430-505 4.27e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 127.50  E-value: 4.27e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116089333 430 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDS 505
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
510-729 9.08e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.91  E-value: 9.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 510 CYDDEQDVWRPLARMPPEAVSRGCAIcSLFNYLFVVSGCQG--PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVAL 587
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTGanPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 588 DGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAhTATVRAKEIFVTGGslrfllFRFSAQEQRWWAGPTG 663
Cdd:COG3055  121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLAPL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116089333 664 GSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPyPDAFQCAVVDNLIYCVG 729
Cdd:COG3055  194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTP-RHGHAAVLTDGKVYVIG 258
PHA03098 PHA03098
kelch-like protein; Provisional
 531-729 5.16e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 65.94  E-value: 5.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 531 RGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYD 606
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWK 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 607 PRLDRWDFAPPLPSDTFALAhtATVRAKEIFVTGGSLRF-----LLFRFSAQEQRWWAG-PT-----GGSKDRTAEMVAV 675
Cdd:PHA03098 365 PGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNdellkTVECFSLNTNKWSKGsPLpishyGGCAIYHDGKIYV 442

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116089333 676 NGFLYRFDLNRSLGIaVYRCSASTRLWYECATYRTPYPDAFQCaVVDNLIYCVG 729
Cdd:PHA03098 443 IGGISYIDNIKVYNI-VESYNPVTNKWTELSSLNFPRINASLC-IFNNKIYVVG 494
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 578-619 3.97e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 3.97e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 116089333  578 ARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLP 619
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
590-620 2.17e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 2.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 116089333   590 HLYAIGG----ECLNSVERYDPRLDRWDFAPPLPS 620
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPT 35
 
Name Accession Description Interval E-value
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 430-505 4.27e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 127.50  E-value: 4.27e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116089333 430 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDS 505
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
510-729 9.08e-21

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 92.91  E-value: 9.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 510 CYDDEQDVWRPLARMPPEAVSRGCAIcSLFNYLFVVSGCQG--PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVAL 587
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTGanPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 588 DGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAhTATVRAKEIFVTGGslrfllFRFSAQEQRWWAGPTG 663
Cdd:COG3055  121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLAPL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116089333 664 GSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPyPDAFQCAVVDNLIYCVG 729
Cdd:COG3055  194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTP-RHGHAAVLTDGKVYVIG 258
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
518-641 1.59e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.73  E-value: 1.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 518 WRPLARMPpEAVSRGCAiCSLFNYLFVVSGCQGPGhqPSSRVFCYNPLTGIWSEVCPLN-QARPHCRLVALDGHLYAIGG 596
Cdd:COG3055    3 WSSLPDLP-TPRSEAAA-ALLDGKVYVAGGLSGGS--ASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGG 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116089333 597 --------ECLNSVERYDPRLDRWDFAPPLPSDTFalAHTATVRAKEIFVTGG 641
Cdd:COG3055   79 ftganpssTPLNDVYVYDPATNTWTKLAPMPTPRG--GATALLLDGKIYVVGG 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
488-644 2.46e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.18  E-value: 2.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 488 LRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMpPEAVSRGCAICSLFNYLFVVSGCQGPGHqpssrvfcynplTG 567
Cdd:COG3055  119 LLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPL-PTPRDHLAAAVLPDGKILVIGGRNGSGF------------SN 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 568 IWSEVCPLNQARPHCRLVALDGHLYAIGGEC--LNSVERYDPRLDRWDFAPPLPsdtFALAHTATVRAK-EIFVTGGSLR 644
Cdd:COG3055  186 TWTTLAPLPTARAGHAAAVLGGKILVFGGESgfSDEVEAYDPATNTWTALGELP---TPRHGHAAVLTDgKVYVIGGETK 262
PHA03098 PHA03098
kelch-like protein; Provisional
 531-729 5.16e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 65.94  E-value: 5.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 531 RGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYD 606
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWK 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 607 PRLDRWDFAPPLPSDTFALAhtATVRAKEIFVTGGSLRF-----LLFRFSAQEQRWWAG-PT-----GGSKDRTAEMVAV 675
Cdd:PHA03098 365 PGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNdellkTVECFSLNTNKWSKGsPLpishyGGCAIYHDGKIYV 442

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116089333 676 NGFLYRFDLNRSLGIaVYRCSASTRLWYECATYRTPYPDAFQCaVVDNLIYCVG 729
Cdd:PHA03098 443 IGGISYIDNIKVYNI-VESYNPVTNKWTELSSLNFPRINASLC-IFNNKIYVVG 494
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
569-729 4.50e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 61.33  E-value: 4.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 569 WSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPsdTFALAHTATVRAK-EIFVTGG-- 641
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGlsggSASNSFEVYDPATNTWSELAPLP--GPPRHHAAAVAQDgKLYVFGGft 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 642 ----SLRFL--LFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF---DLNRSLGiAVYRCSASTRLWYECATYRTPy 712
Cdd:COG3055   81 ganpSSTPLndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVggwDDGGNVA-WVEVYDPATGTWTQLAPLPTP- 158

                        170
                 ....*....|....*...
gi 116089333 713 PDAFQCAVV-DNLIYCVG 729
Cdd:COG3055  159 RDHLAAAVLpDGKILVIG 176
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 578-619 3.97e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 3.97e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 116089333  578 ARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLP 619
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
PHA03098 PHA03098
kelch-like protein; Provisional
 510-620 1.47e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 54.77  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 510 CYDDEQDVWRPLARMPpEAVSRGCAIcSLFNYLFVVSGCQ-GPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALD 588
Cdd:PHA03098 410 CFSLNTNKWSKGSPLP-ISHYGGCAI-YHDGKIYVIGGISyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFN 487

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 116089333 589 GHLYAIGGECLNS----VERYDPRLDRWDFAPPLPS 620
Cdd:PHA03098 488 NKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFPK 523
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 430-522 2.88e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 49.38  E-value: 2.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116089333 430 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAeRELILQRRLRGRQYLVV----ADVCPKEDS 505
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPSSL-KQQLRERRLRGTPALVAlgdfLGTPLDPYQ 79

                         90       100
                 ....*....|....*....|
gi 116089333 506 GGLCC---YDDEQDVWRPLA 522
Cdd:cd18478   80 DEPWSmlrYDEVEQRWLPLA 99
Kelch smart00612
Kelch domain;
590-620 2.17e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 2.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 116089333   590 HLYAIGG----ECLNSVERYDPRLDRWDFAPPLPS 620
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPT 35
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 431-470 3.42e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 41.88  E-value: 3.42e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 116089333 431 DLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPD 470
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEE 40
Kelch_6 pfam13964
Kelch motif;
584-619 1.12e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 1.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 116089333  584 LVALDGHLYAIGGEC-----LNSVERYDPRLDRWDFAPPLP 619
Cdd:pfam13964   7 VVSVGGYIYVFGGYTnaspaLNKLEVYNPLTKSWEELPPLP 47
Kelch smart00612
Kelch domain;
542-589 4.50e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.69  E-value: 4.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 116089333   542 LFVVSGCqgPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDG 589
Cdd:smart00612   2 IYVVGGF--DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 531-572 8.60e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.59  E-value: 8.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 116089333  531 RGCAICSLFNYLFVVSGCQGpgHQPSSRVFCYNPLTGIWSEV 572
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDG--NQSLNSVEVYDPETNTWSKL 42
Kelch_6 pfam13964
Kelch motif;
540-579 6.19e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 6.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 116089333  540 NYLFVVSGcQGPGHQPSSRVFCYNPLTGIWSEVCPLNQAR 579
Cdd:pfam13964  12 GYIYVFGG-YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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