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Conserved domains on  [gi|22748883|ref|NP_689630|]
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DGAT1/2-independent enzyme synthesizing storage lipids isoform 2 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168420)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0006644|GO:0008654
PubMed:  18718904|18931347|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 103-229 3.58e-49

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


:

Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 160.92  E-value: 3.58e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883 103 HAAVWHGYEVHGMEKIPEDGPALIIFYHGAIPIDFYYFMAKIF-IHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPRE 181
Cdd:cd07987   1 HRKYFRVYEVRGLENIPDEGPALLVHPHGGLPIDGALLAAAFLlLFPGRLPRALADHFLFPLPGLRDLLRRLGAVPGSRE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22748883 182 KCVEILRSGHLLAISPGGVREALIS-DETYNIVWGHRRGFAQVAIDAKV 229
Cdd:cd07987  81 NCVRLLREGELVLIFPGGAREALKSkREEYYLLWKKRKGFARLALRAGA 129
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 103-229 3.58e-49

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 160.92  E-value: 3.58e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883 103 HAAVWHGYEVHGMEKIPEDGPALIIFYHGAIPIDFYYFMAKIF-IHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPRE 181
Cdd:cd07987   1 HRKYFRVYEVRGLENIPDEGPALLVHPHGGLPIDGALLAAAFLlLFPGRLPRALADHFLFPLPGLRDLLRRLGAVPGSRE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22748883 182 KCVEILRSGHLLAISPGGVREALIS-DETYNIVWGHRRGFAQVAIDAKV 229
Cdd:cd07987  81 NCVRLLREGELVLIFPGGAREALKSkREEYYLLWKKRKGFARLALRAGA 129
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 111-230 2.26e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 62.30  E-value: 2.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883   111 EVHGMEKIPEDGPALIIFYHgAIPIDfYYFMAKIFIHKGRTCRVVADHFVFKIPGFSLLLD----VFC------ALHGPR 180
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANH-QSYLD-VLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRllgcIFIdrknrkDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 22748883   181 EKCVEILRSGHLLAISPGGVRealiSDETYniVWGHRRGFAQVAIDAKVT 230
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTR----SREGE--LLPFKKGAFRLAIEAGVP 124
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 110-229 9.37e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 45.39  E-value: 9.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883 110 YEVHGMEKIPEDGPALIIFYHgAIPIDFYYFMAkifiHKGRTCRVVADHFVFKIPGFSLLLDVF----------CALHGP 179
Cdd:COG0204  31 VRVEGLENLPADGPVLIVANH-QSWLDILLLLA----ALPRPVRFVAKKELFKIPLLGWLLRALgaipvdrskrRAALRA 105

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22748883 180 REKCVEILRSGHLLAISPggvrEALISDEtyNIVWGHRRGFAQVAIDAKV 229
Cdd:COG0204 106 LRQAVEALKAGESLVIFP----EGTRSPD--GRLLPFKTGAARLALEAGV 149
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 103-229 3.58e-49

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 160.92  E-value: 3.58e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883 103 HAAVWHGYEVHGMEKIPEDGPALIIFYHGAIPIDFYYFMAKIF-IHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPRE 181
Cdd:cd07987   1 HRKYFRVYEVRGLENIPDEGPALLVHPHGGLPIDGALLAAAFLlLFPGRLPRALADHFLFPLPGLRDLLRRLGAVPGSRE 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22748883 182 KCVEILRSGHLLAISPGGVREALIS-DETYNIVWGHRRGFAQVAIDAKV 229
Cdd:cd07987  81 NCVRLLREGELVLIFPGGAREALKSkREEYYLLWKKRKGFARLALRAGA 129
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 111-230 2.26e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 62.30  E-value: 2.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883   111 EVHGMEKIPEDGPALIIFYHgAIPIDfYYFMAKIFIHKGRTCRVVADHFVFKIPGFSLLLD----VFC------ALHGPR 180
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANH-QSYLD-VLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRllgcIFIdrknrkDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 22748883   181 EKCVEILRSGHLLAISPGGVRealiSDETYniVWGHRRGFAQVAIDAKVT 230
Cdd:pfam01553  81 EYLVELLREGKLVVIFPEGTR----SREGE--LLPFKKGAFRLAIEAGVP 124
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 110-229 9.37e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 45.39  E-value: 9.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883 110 YEVHGMEKIPEDGPALIIFYHgAIPIDFYYFMAkifiHKGRTCRVVADHFVFKIPGFSLLLDVF----------CALHGP 179
Cdd:COG0204  31 VRVEGLENLPADGPVLIVANH-QSWLDILLLLA----ALPRPVRFVAKKELFKIPLLGWLLRALgaipvdrskrRAALRA 105

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22748883 180 REKCVEILRSGHLLAISPggvrEALISDEtyNIVWGHRRGFAQVAIDAKV 229
Cdd:COG0204 106 LRQAVEALKAGESLVIFP----EGTRSPD--GRLLPFKTGAARLALEAGV 149
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 104-229 3.48e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 40.33  E-value: 3.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883 104 AAVWHGYEVHGMEKIPEDGPALIIFYHGAIpIDFYYFMAkifiHKGRTCRVVADHFVFKIPGFSLLLDVF---------- 173
Cdd:cd07989   6 RLLGVRVRVEGLENLPPKGPVIIVANHQSY-LDPLVLGA----ALPRPIRFVAKKELFKIPFLGWLLRLLgaipidrgng 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22748883 174 CALHGPREKCVEILRSGHLLAISP-------GGVREAlisdetynivwghRRGFAQVAIDAKV 229
Cdd:cd07989  81 RSAREALREAIEALKEGESVVIFPegtrsrdGELLPF-------------KSGAFRLAKEAGV 130
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 110-199 1.13e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 39.15  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22748883 110 YEVHGMEKIPEDGPALIIFYH--GAI-PIDFYYFMAKIfihkGRTCRVVADHFVFKIPGfslLLDVFCAL---------- 176
Cdd:cd07986  10 VDVSGLENIPKDGPVVIVANHpfGILdGLILADLLGSV----RPDVRILANQLLSKIPE---LRDLFIPVdplegraala 82

                        90       100
                ....*....|....*....|....*
gi 22748883 177 --HGPREKCVEILRSGHLLAISPGG 199
Cdd:cd07986  83 knRESLREALRHLKNGGALIIFPAG 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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