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Conserved domains on  [gi|281427267|ref|NP_689836|]
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cell division cycle protein 20 homolog B isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
274-513 2.72e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 2.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRvAQHHVGT 351
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLA-TGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 352 LR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVIT-QSTAVKAMDWCPwQSGVLAIGGGmkDGRLH 429
Cdd:COG2319  242 LTgHSGSVRSVAFSPDGRLLASGSADGTVRLW--DL---ATGELLRTLTgHSGGVNSVAFSP-DGKLLASGSD--DGTVR 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 430 ILDINAGKSIQTPSTNS-QICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSR----SGHRGRVLHLSLSPDQTRVFS 502
Cdd:COG2319  314 LWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGsdDGT----VRLWDLATGELlrtlTGHTGAVTSVAFSPDGRTLAS 389

                        250
                 ....*....|.
gi 281427267 503 AAADGTASVWN 513
Cdd:COG2319  390 GSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
274-513 2.72e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 2.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRvAQHHVGT 351
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLA-TGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 352 LR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVIT-QSTAVKAMDWCPwQSGVLAIGGGmkDGRLH 429
Cdd:COG2319  242 LTgHSGSVRSVAFSPDGRLLASGSADGTVRLW--DL---ATGELLRTLTgHSGGVNSVAFSP-DGKLLASGSD--DGTVR 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 430 ILDINAGKSIQTPSTNS-QICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSR----SGHRGRVLHLSLSPDQTRVFS 502
Cdd:COG2319  314 LWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGsdDGT----VRLWDLATGELlrtlTGHTGAVTSVAFSPDGRTLAS 389

                        250
                 ....*....|.
gi 281427267 503 AAADGTASVWN 513
Cdd:COG2319  390 GSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-513 1.98e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRVAQhHVGTLR 353
Cdd:cd00200   54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGK-CLTTLR 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 354 -HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQST-AVKAMDWCPwQSGVLAIGGGmkDGRLHIL 431
Cdd:cd00200  133 gHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DL---RTGKCVATLTGHTgEVNSVAFSP-DGEKLLSSSS--DGTIKLW 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 432 DINAGKSIQT-PSTNSQICSLIWLPKTKEIATgqGTPKNDVTVW---TCPTVSR-SGHRGRVLHLSLSPDQTRVFSAAAD 506
Cdd:cd00200  205 DLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS--GSEDGTIRVWdlrTGECVQTlSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*..
gi 281427267 507 GTASVWN 513
Cdd:cd00200  283 GTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 4.12e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.12e-05
                           10        20
                   ....*....|....*....|....*....
gi 281427267   354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 2.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....*....
gi 281427267  354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
274-513 2.72e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 2.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRvAQHHVGT 351
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLA-TGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 352 LR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVIT-QSTAVKAMDWCPwQSGVLAIGGGmkDGRLH 429
Cdd:COG2319  242 LTgHSGSVRSVAFSPDGRLLASGSADGTVRLW--DL---ATGELLRTLTgHSGGVNSVAFSP-DGKLLASGSD--DGTVR 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 430 ILDINAGKSIQTPSTNS-QICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSR----SGHRGRVLHLSLSPDQTRVFS 502
Cdd:COG2319  314 LWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGsdDGT----VRLWDLATGELlrtlTGHTGAVTSVAFSPDGRTLAS 389

                        250
                 ....*....|.
gi 281427267 503 AAADGTASVWN 513
Cdd:COG2319  390 GSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
244-513 6.30e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 6.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 244 LVAIALGSAVYIWNGENhnGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 324 NH--FILSSGSRLGRVYHHDVRVAQhHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVIT- 399
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DL---ATGKLLRTLTg 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 400 QSTAVKAMDWCPwQSGVLAIGGGmkDGRLHILDINAGKSIQTPST-NSQICSLIWLPKTKEIATG--QGTpkndVTVWTC 476
Cdd:COG2319  245 HSGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLASGsdDGT----VRLWDL 317

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 281427267 477 PT----VSRSGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 513
Cdd:COG2319  318 ATgkllRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
237-513 1.24e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 1.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 237 LDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLS 316
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 317 VVGALSW--NHFILSSGSRLGRVYHHDVRVAQhHVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWphdpgASAQGQ 393
Cdd:COG2319  122 AVRSVAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLW-----DLATGK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 394 PLKVITQST-AVKAMDWCPwQSGVLAIGGGmkDGRLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEIATgqGTPKNDV 471
Cdd:COG2319  196 LLRTLTGHTgAVRSVAFSP-DGKLLASGSA--DGTVRLWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLAS--GSADGTV 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 281427267 472 TVWTCPT----VSRSGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 513
Cdd:COG2319  271 RLWDLATgellRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-513 1.98e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW--NHFILSSGSRLGRVYHHDVRVAQhHVGTLR 353
Cdd:cd00200   54 VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGK-CLTTLR 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 354 -HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVITQST-AVKAMDWCPwQSGVLAIGGGmkDGRLHIL 431
Cdd:cd00200  133 gHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DL---RTGKCVATLTGHTgEVNSVAFSP-DGEKLLSSSS--DGTIKLW 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 432 DINAGKSIQT-PSTNSQICSLIWLPKTKEIATgqGTPKNDVTVW---TCPTVSR-SGHRGRVLHLSLSPDQTRVFSAAAD 506
Cdd:cd00200  205 DLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS--GSEDGTIRVWdlrTGECVQTlSGHTNSVTSLAWSPDGKRLASGSAD 282


                 ....*..
gi 281427267 507 GTASVWN 513
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
276-513 2.24e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 2.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 276 ISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVG--ALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLR 353
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 354 HKQAVCALKWSPDGRLLSSGCSDGLLTIWphDPgasAQGQPLKVIT-QSTAVKAMDWCPwQSGVLAIGGGmkDGRLHILD 432
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLW--DL---ATGKLLRTLTgHSGAVTSVAFSP-DGKLLASGSD--DGTVRLWD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 433 INAGKSIQT-PSTNSQICSLIWLPKTKEIATG--QGTpkndVTVWTCPT----VSRSGHRGRVLHLSLSPDQTRVFSAAA 505
Cdd:COG2319  191 LATGKLLRTlTGHTGAVRSVAFSPDGKLLASGsaDGT----VRLWDLATgkllRTLTGHSGSVRSVAFSPDGRLLASGSA 266


                 ....*...
gi 281427267 506 DGTASVWN 513
Cdd:COG2319  267 DGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-513 1.34e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 274 NYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSW---NHFILSSGS-RLGRVYhhDVRvAQHHV 349
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsadGTYLASGSSdKTIRLW--DLE-TGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 350 GTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPhdpgaSAQGQPLKVIT-QSTAVKAMDWCPwQSGVLAigGGMKDGR 427
Cdd:cd00200   87 RTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-----VETGKCLTTLRgHTDWVNSVAFSP-DGTFVA--SSSQDGT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 428 LHILDINAGKSIQT-PSTNSQICSLIWLPKTKEIATgqGTPKNDVTVWTCPT----VSRSGHRGRVLHLSLSPDQTRVFS 502
Cdd:cd00200  159 IKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTgkclGTLRGHENGVNSVAFSPDGYLLAS 236

                        250
                 ....*....|.
gi 281427267 503 AAADGTASVWN 513
Cdd:cd00200  237 GSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
288-513 5.64e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 5.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 288 LAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHF--ILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSP 365
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 366 DGRLLSSGCSDGLLTIWphdpgASAQGQPLKVITQST-AVKAMDWCPwQSGVLAIGGGmkDGRLHILDINAGKSIQTPST 444
Cdd:COG2319   89 DGRLLASASADGTVRLW-----DLATGLLLRTLTGHTgAVRSVAFSP-DGKTLASGSA--DGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281427267 445 NSQ-ICSLIWLPKTKEIATG--QGTpkndVTVWTCPTVSR----SGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 513
Cdd:COG2319  161 HSGaVTSVAFSPDGKLLASGsdDGT----VRLWDLATGKLlrtlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 348-513 1.04e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 348 HVGTLR-HKQAVCALKWSPDGRLLSSGCSDGLLTIWPhdpgaSAQGQPLKVITQST-AVKAMDWCPWqSGVLAIGGgmKD 425
Cdd:cd00200    1 LRRTLKgHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-----LETGELLRTLKGHTgPVRDVAASAD-GTYLASGS--SD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 426 GRLHILDINAGKSIQT-PSTNSQICSLIWLPKTKEIATG--QGTpkndVTVWTCPT----VSRSGHRGRVLHLSLSPDQT 498
Cdd:cd00200   73 KTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSsrDKT----IKVWDVETgkclTTLRGHTDWVNSVAFSPDGT 148

                        170
                 ....*....|....*
gi 281427267 499 RVFSAAADGTASVWN 513
Cdd:cd00200  149 FVASSSQDGTIKLWD 163
WD40 COG2319
WD40 repeat [General function prediction only];
364-513 1.01e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427267 364 SPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDwcpwqsGVLAIGGGMKDGRLHILDINAGKSIQTPS 443
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPD------GARLAAGAGDLTLLLLDAAAGALLATLLG 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281427267 444 TNSQICSLIWLPKTKEIATGQGTpkNDVTVWTCPT----VSRSGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 513
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASAD--GTVRLWDLATglllRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 4.12e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.12e-05
                           10        20
                   ....*....|....*....|....*....
gi 281427267   354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 2.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....*....
gi 281427267  354 HKQAVCALKWSPDGRLLSSGCSDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 482-513 5.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.64e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 281427267   482 SGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 513
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
482-513 1.32e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 281427267  482 SGHRGRVLHLSLSPDQTRVFSAAADGTASVWN 513
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 354-410 2.04e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 2.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 281427267  354 HKQAVCALKWSPDGRLLSSGCSDGLLTIwpHDpgaSAQGQPL-KVITQSTAVKAMDWC 410
Cdd:pfam12894  37 EDLEVTSLAWRPDGKLLAVGYSDGTVRL--LD---AENGKIVhHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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