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Conserved domains on  [gi|164663805|ref|NP_689850|]
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thiol S-methyltransferase TMT1B precursor [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 55-190 5.66e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.83  E-value: 5.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  55 KRELFSQIKGLTGASgkvaLLELGCGTGAN-FQFYPPGCRVTCLDPNPhfeKFLTKSMAENRHLQYE-RFVVAPGEDMrQ 132
Cdd:COG2226   11 REALLAALGLRPGAR----VLDLGCGTGRLaLALAERGARVTGVDISP---EMLELARERAAEAGLNvEFVVGDAEDL-P 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 164663805 133 LADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQV 190
Cdd:COG2226   83 FPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA 140
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 55-190 5.66e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.83  E-value: 5.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  55 KRELFSQIKGLTGASgkvaLLELGCGTGAN-FQFYPPGCRVTCLDPNPhfeKFLTKSMAENRHLQYE-RFVVAPGEDMrQ 132
Cdd:COG2226   11 REALLAALGLRPGAR----VLDLGCGTGRLaLALAERGARVTGVDISP---EMLELARERAAEAGLNvEFVVGDAEDL-P 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 164663805 133 LADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQV 190
Cdd:COG2226   83 FPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA 140
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-172 3.82e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 92.34  E-value: 3.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   75 LELGCGTGANFQ-FYPPGCRVTCLDPNPhfeKFLTKSMAENRHLQYErFVVAPGEDMrQLADGSMDVVVCTLVLCSVQSP 153
Cdd:pfam08241   1 LDVGCGTGLLTElLARLGARVTGVDISP---EMLELAREKAPREGLT-FVVGDAEDL-PFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
gi 164663805  154 RKVLQEVRRVLRPGGVLFF 172
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 74-173 2.94e-20

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 82.48  E-value: 2.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  74 LLELGCGTGANFQFY--PPGCRVTCLDPNPHFEKFLTKSMAENRHlQYERFVVAPGEDMRQLADGSMDVVVCTLVL-CSV 150
Cdd:cd02440    2 VLDLGCGTGALALALasGPGARVTGVDISPVALELARKAAAALLA-DNVEVLKGDAEELPPEADESFDVIISDPPLhHLV 80

                         90       100
                 ....*....|....*....|...
gi 164663805 151 QSPRKVLQEVRRVLRPGGVLFFW 173
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLT 103
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 73-229 2.30e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 58.84  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   73 ALLELGCGTG----ANFQFYPPGcRVTCLDPNPHFEKFLTKSMAENRHlqyerFVVApgeDMRQL--ADGSMDVVVCTLV 146
Cdd:TIGR02072  37 SVLDIGCGTGyltrALLKRFPQA-EFIALDISAGMLAQAKTKLSENVQ-----FICG---DAEKLplEDSSFDLIVSNLA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  147 LCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTwkhigdgccLTRETWKDLENAQFSEIQMERQP 226
Cdd:TIGR02072 108 LQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQHGLRY---------LSLDELKALLKNSFELLTLEEEL 178


                  ...
gi 164663805  227 PPL 229
Cdd:TIGR02072 179 ITL 181
PRK08317 PRK08317
hypothetical protein; Provisional
 75-168 6.69e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 57.64  E-value: 6.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTG------ANfQFYPPGcRVTCLDPNphfEKFLTksMAENR---HLQYERFVVAPGEDMrQLADGSMDVVVCTL 145
Cdd:PRK08317  24 LDVGCGPGndarelAR-RVGPEG-RVVGIDRS---EAMLA--LAKERaagLGPNVEFVRGDADGL-PFPDGSFDAVRSDR 95

                         90       100
                 ....*....|....*....|...
gi 164663805 146 VLCSVQSPRKVLQEVRRVLRPGG 168
Cdd:PRK08317  96 VLQHLEDPARALAEIARVLRPGG 118
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 55-190 5.66e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.83  E-value: 5.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  55 KRELFSQIKGLTGASgkvaLLELGCGTGAN-FQFYPPGCRVTCLDPNPhfeKFLTKSMAENRHLQYE-RFVVAPGEDMrQ 132
Cdd:COG2226   11 REALLAALGLRPGAR----VLDLGCGTGRLaLALAERGARVTGVDISP---EMLELARERAAEAGLNvEFVVGDAEDL-P 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 164663805 133 LADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQV 190
Cdd:COG2226   83 FPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA 140
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-172 3.82e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 92.34  E-value: 3.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   75 LELGCGTGANFQ-FYPPGCRVTCLDPNPhfeKFLTKSMAENRHLQYErFVVAPGEDMrQLADGSMDVVVCTLVLCSVQSP 153
Cdd:pfam08241   1 LDVGCGTGLLTElLARLGARVTGVDISP---EMLELAREKAPREGLT-FVVGDAEDL-PFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
gi 164663805  154 RKVLQEVRRVLRPGGVLFF 172
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 74-173 2.94e-20

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 82.48  E-value: 2.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  74 LLELGCGTGANFQFY--PPGCRVTCLDPNPHFEKFLTKSMAENRHlQYERFVVAPGEDMRQLADGSMDVVVCTLVL-CSV 150
Cdd:cd02440    2 VLDLGCGTGALALALasGPGARVTGVDISPVALELARKAAAALLA-DNVEVLKGDAEELPPEADESFDVIISDPPLhHLV 80

                         90       100
                 ....*....|....*....|...
gi 164663805 151 QSPRKVLQEVRRVLRPGGVLFFW 173
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLT 103
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 56-172 3.01e-19

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 80.45  E-value: 3.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  56 RELFSQIKGLTGASGKValLELGCGTGAN-FQFYPPGCRVTCLDPNPHFEKFLtKSMAENRHLqyeRFVVAPGEDMrQLA 134
Cdd:COG2227   12 RRLAALLARLLPAGGRV--LDVGCGTGRLaLALARRGADVTGVDISPEALEIA-RERAAELNV---DFVQGDLEDL-PLE 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 164663805 135 DGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFF 172
Cdd:COG2227   85 DGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 75-168 9.13e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 75.68  E-value: 9.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   75 LELGCGTGANFQFYPP--GCRVTCLDPNPHF-EKFLTKSMAENRHLqyeRFVVAPGEDMrQLADGSMDVVVCTLVL--CS 149
Cdd:pfam13649   2 LDLGCGTGRLTLALARrgGARVTGVDLSPEMlERARERAAEAGLNV---EFVQGDAEDL-PFPDGSFDLVVSSGVLhhLP 77

                          90
                  ....*....|....*....
gi 164663805  150 VQSPRKVLQEVRRVLRPGG 168
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 75-170 3.20e-17

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 74.33  E-value: 3.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   75 LELGCGTGANFQF---YPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERfVVAPGEDMRQLADGSMDVVVCTLVLCSVQ 151
Cdd:pfam08242   1 LEIGCGTGTLLRAlleALPGLEYTGLDISPAALEAARERLAALGLLNAVR-VELFQLDLGELDPGSFDVVVASNVLHHLA 79

                          90
                  ....*....|....*....
gi 164663805  152 SPRKVLQEVRRVLRPGGVL 170
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGGVL 98
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
75-174 7.20e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 67.93  E-value: 7.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTGAN---FQFYPPGCRVTCLDPNPhfekfltkSMAE--NRHLQYERFVVApgeDMRQLA-DGSMDVVVCTLVLC 148
Cdd:COG4106    6 LDLGCGTGRLtalLAERFPGARVTGVDLSP--------EMLAraRARLPNVRFVVA---DLRDLDpPEPFDLVVSNAALH 74

                         90       100
                 ....*....|....*....|....*.
gi 164663805 149 SVQSPRKVLQEVRRVLRPGGVLFFWE 174
Cdd:COG4106   75 WLPDHAALLARLAAALAPGGVLAVQV 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
75-181 8.06e-15

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 70.03  E-value: 8.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTGANFQFYPP-GCRVTCLDPNPhfeKFLtkSMAENRHLqYERFVVApgeDMRQLA--DGSMDVVVCTLVLCSVQ 151
Cdd:COG4976   51 LDLGCGTGLLGEALRPrGYRLTGVDLSE---EML--AKAREKGV-YDRLLVA---DLADLAepDGRFDLIVAADVLTYLG 121

                         90       100       110
                 ....*....|....*....|....*....|
gi 164663805 152 SPRKVLQEVRRVLRPGGVLFFWEHVAEPYG 181
Cdd:COG4976  122 DLAAVFAGVARALKPGGLFIFSVEDADGSG 151
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-217 5.46e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 64.76  E-value: 5.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   48 NRKMESKKRELFSQIKGLTGASGKValLELGCGTGANFQ-FYPPGCRVTCLDPNPhfekfltksMAENRHLQYERFVVAP 126
Cdd:pfam13489   2 AHQRERLLADLLLRLLPKLPSPGRV--LDFGCGTGIFLRlLRAQGFSVTGVDPSP---------IAIERALLNVRFDQFD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  127 GEDMRQLAdGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFweHVAEPYGSWAFMWQQVfePTWKHIGDGCCL-T 205
Cdd:pfam13489  71 EQEAAVPA-GKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLL--STPLASDEADRLLLEW--PYLRPRNGHISLfS 145

                         170
                  ....*....|...
gi 164663805  206 RETWKD-LENAQF 217
Cdd:pfam13489 146 ARSLKRlLEEAGF 158
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 75-172 4.98e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 63.01  E-value: 4.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTGANFQFY--PPGCRVTCLDPNPHFEKFLTKsMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSV-- 150
Cdd:COG0500   31 LDLGCGTGRNLLALaaRFGGRVIGIDLSPEAIALARA-RAAKAGLGNVEFLVADLAELDPLPAESFDLVVAFGVLHHLpp 109

                         90       100
                 ....*....|....*....|..
gi 164663805 151 QSPRKVLQEVRRVLRPGGVLFF 172
Cdd:COG0500  110 EEREALLRELARALKPGGVLLL 131
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 69-170 2.22e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.12  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   69 SGKVALLELGCGTGA-NFQFYP---PGCRVTCLDpnphFEKFLTKSMAEN-RHLQYER--FVVAPGEDM-RQLADGSMDV 140
Cdd:pfam13847   2 DKGMRVLDLGCGTGHlSFELAEelgPNAEVVGID----ISEEAIEKARENaQKLGFDNveFEQGDIEELpELLEDDKFDV 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 164663805  141 VVCTLVLCSVQSPRKVLQEVRRVLRPGGVL 170
Cdd:pfam13847  78 VISNCVLNHIPDPDKVLQEILRVLKPGGRL 107
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 73-229 2.30e-10

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 58.84  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   73 ALLELGCGTG----ANFQFYPPGcRVTCLDPNPHFEKFLTKSMAENRHlqyerFVVApgeDMRQL--ADGSMDVVVCTLV 146
Cdd:TIGR02072  37 SVLDIGCGTGyltrALLKRFPQA-EFIALDISAGMLAQAKTKLSENVQ-----FICG---DAEKLplEDSSFDLIVSNLA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  147 LCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTwkhigdgccLTRETWKDLENAQFSEIQMERQP 226
Cdd:TIGR02072 108 LQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQSFGQHGLRY---------LSLDELKALLKNSFELLTLEEEL 178


                  ...
gi 164663805  227 PPL 229
Cdd:TIGR02072 179 ITL 181
PRK08317 PRK08317
hypothetical protein; Provisional
 75-168 6.69e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 57.64  E-value: 6.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTG------ANfQFYPPGcRVTCLDPNphfEKFLTksMAENR---HLQYERFVVAPGEDMrQLADGSMDVVVCTL 145
Cdd:PRK08317  24 LDVGCGPGndarelAR-RVGPEG-RVVGIDRS---EAMLA--LAKERaagLGPNVEFVRGDADGL-PFPDGSFDAVRSDR 95

                         90       100
                 ....*....|....*....|...
gi 164663805 146 VLCSVQSPRKVLQEVRRVLRPGG 168
Cdd:PRK08317  96 VLQHLEDPARALAEIARVLRPGG 118
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 74-172 1.52e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 55.32  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  74 LLELGCGTGANF----QFYppGCRVTCLDPNPHFEKFLtKSMAENRHLQYE-RFVVApgeDMRQL-ADGSMDVVVCTLVL 147
Cdd:COG2230   55 VLDIGCGWGGLAlylaRRY--GVRVTGVTLSPEQLEYA-RERAAEAGLADRvEVRLA---DYRDLpADGQFDAIVSIGMF 128

                         90       100
                 ....*....|....*....|....*..
gi 164663805 148 CSVQSP--RKVLQEVRRVLRPGGVLFF 172
Cdd:COG2230  129 EHVGPEnyPAYFAKVARLLKPGGRLLL 155
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
75-185 1.15e-08

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 52.95  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTganfqFYPPGCRVTCLDPNPhfekfltksmaenrhlqyERFVVAPGEDMRQLADGSMDVVVCTLVL--CSVQS 152
Cdd:COG4627    7 LNIGCGP-----KRLPGWLNVDIVPAP------------------GVDIVGDLTDPLPFPDNSVDAIYSSHVLehLDYEE 63

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 164663805 153 PRKVLQEVRRVLRPGGVLFF----WEHVAEPYGSWAF 185
Cdd:COG4627   64 APLALKECYRVLKPGGILRIvvpdLEHVARLYLAEYD 100
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 74-174 1.03e-07

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 51.11  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   74 LLELGCGTG---ANFQFYPPGC-RVTCLDPNPhfeKFLtkSMAENRHLQYER--FVVAPGEDMrQLADGSMDVVVCTLVL 147
Cdd:TIGR01934  43 VLDVACGTGdlaIELAKSAPDRgKVTGVDFSS---EML--EVAKKKSELPLNieFIQADAEAL-PFEDNSFDAVTIAFGL 116

                          90       100
                  ....*....|....*....|....*..
gi 164663805  148 CSVQSPRKVLQEVRRVLRPGGVLFFWE 174
Cdd:TIGR01934 117 RNVTDIQKALREMYRVLKPGGRLVILE 143
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 65-172 6.66e-07

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 48.99  E-value: 6.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  65 LTGASGKVALLELGCGTGANFQFY-PPGCRVTCLDPNPHFekfltksMAENRHLQY-ERFVVAPGEDMrQLADGSMDVVV 142
Cdd:PRK10258  37 MLPQRKFTHVLDAGCGPGWMSRYWrERGSQVTALDLSPPM-------LAQARQKDAaDHYLAGDIESL-PLATATFDLAW 108

                         90       100       110
                 ....*....|....*....|....*....|
gi 164663805 143 CTLVLCSVQSPRKVLQEVRRVLRPGGVLFF 172
Cdd:PRK10258 109 SNLAVQWCGNLSTALRELYRVVRPGGVVAF 138
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
75-170 1.20e-05

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 44.43  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTGAnFQFY-----PPGCRVTCLDPNPHFEKFLTKsmaenrhlQYERFVVAPG--EDMRQLA----DGSMDVVVC 143
Cdd:COG3963   50 VELGPGTGV-FTRAilargVPDARLLAVEINPEFAEHLRR--------RFPRVTVVNGdaEDLAELLaehgIGKVDAVVS 120

                         90       100       110
                 ....*....|....*....|....*....|.
gi 164663805 144 TLVLCS----VQspRKVLQEVRRVLRPGGVL 170
Cdd:COG3963  121 GLPLLSfppeLR--RAILDAAFRVLAPGGVF 149
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 75-172 9.08e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 41.71  E-value: 9.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  75 LELGCGTGanfqfY---------PPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGED-MRQLADGSMDVVVC- 143
Cdd:COG4122   21 LEIGTGTG-----YstlwlaralPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEvLPRLADGPFDLVFId 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 164663805 144 ---TLVLcsvqsprKVLQEVRRVLRPGGVLFF 172
Cdd:COG4122   96 adkSNYP-------DYLELALPLLRPGGLIVA 120
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 74-170 1.92e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.29  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805  74 LLELGCGTG--ANF--QFYPPGCRVTCLDPNphfekfltKSM---AENRHLQYER-----FVVAPGEDMrQLADGSMDVV 141
Cdd:PRK00216  55 VLDLACGTGdlAIAlaKAVGKTGEVVGLDFS--------EGMlavGREKLRDLGLsgnveFVQGDAEAL-PFPDNSFDAV 125

                         90       100
                 ....*....|....*....|....*....
gi 164663805 142 VCTLVLCSVQSPRKVLQEVRRVLRPGGVL 170
Cdd:PRK00216 126 TIAFGLRNVPDIDKALREMYRVLKPGGRL 154
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
64-193 2.75e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 40.89  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   64 GLTGASgkvaLLELGCGTGA-NFQFYP---PGCRVTCLDPNPHFEKFLTKSMAENRHLQYErFVVAPGEDMrQLADGSMD 139
Cdd:pfam01209  40 VKRGNK----FLDVAGGTGDwTFGLSDsagSSGKVVGLDINENMLKEGEKKAKEEGKYNIE-FLQGNAEEL-PFEDDSFD 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 164663805  140 VVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWE--HVAEPYGSWAF-MWQQVFEP 193
Cdd:pfam01209 114 IVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEfsKPENPLLSQAYeLYFKYVMP 170
arsM PRK11873
arsenite methyltransferase;
133-168 2.73e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 38.01  E-value: 2.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 164663805 133 LADGSMDVVV--CTLVLcsvqSPRK--VLQEVRRVLRPGG 168
Cdd:PRK11873 142 VADNSVDVIIsnCVINL----SPDKerVFKEAFRVLKPGG 177
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 75-172 5.94e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 35.36  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663805   75 LELGCGTGANFQFYPPGCR------VTCLDPNPHFEKFLtKSMAENRHLQYERFVVAPGED-MRQLADGSMDvvvctLVL 147
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRdnglgrLTAVDPDPGAEEAG-ALLRKAGLDDRVRLIVGDSREaLPSLADGPID-----LLF 74

                          90       100
                  ....*....|....*....|....*....
gi 164663805  148 C----SVQSPRKVLQEVRRVLRPGGVLFF 172
Cdd:pfam13578  75 IdgdhTYEAVLNDLELWLPRLAPGGVILF 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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