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Conserved domains on  [gi|189217919|ref|NP_689929|]
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protein PAT1 homolog 1 [Homo sapiens]

Protein Classification

PAT1 family protein( domain architecture ID 1001013)

PAT1 family protein similar to Saccharomyces cerevisiae DNA topoisomerase 2-associated protein PAT1, an activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation

Gene Ontology:  GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 16-613 9.21e-08

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 55.81  E-value: 9.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919   16 EDAFQGLGEE-DEEIDQFNDDTFG---------SGAVDDDW----QEAHERLAELEEKL------PVAVNEQTGNGERDE 75
Cdd:pfam09770  42 EDTYDGLGDQlDETGDAFNDDTFGgggggddvsAGPVGKDFdffgQTAKVSDAIEEEQVrfnrqqPAARAAQSSAQPPAS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919   76 MDLLGDHEENLAERLSKMV---IENELEDPAImravqtrPVLQPqpgslNSSIWDGSEvlrriRGPLLAQEMPTVSvley 152
Cdd:pfam09770 122 SLPQYQYASQQSQQPSKPVrtgYEKYKEPEPI-------PDLQV-----DASLWGVAP-----KKAAAPAPAPQPA---- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  153 ALPQRPPQGPEDDRDLSE-----RALPRRSTSPIIGSPPVraVPIGTPPKQMavPSFTQQILCPKPVHVRPPMPPRYPAP 227
Cdd:pfam09770 181 AQPASLPAPSRKMMSLEEveaamRAQAKKPAQQPAPAPAQ--PPAAPPAQQA--QQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  228 YGERMSPnqlcsvpnsSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGfvgsplaaMNPKLLQGRVGQ 307
Cdd:pfam09770 257 PGQGHPV---------TILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPN--------RLSAARVGYPQN 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  308 MLPPAPGFRAFfsappsatpppqqhppgpgphlQNLRSQAPMFRPDTTHLHPQHrrLLHQRQQQnrsqhRNLNGAGDRGS 387
Cdd:pfam09770 320 PQPGVQPAPAH----------------------QAHRQQGSFGRQAPIITHPQQ--LAQLSEEE-----KAAYLDEEAKR 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  388 HRSSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQNYfekleklsaaEEIQGdGPKK 456
Cdd:pfam09770 371 AKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQVY----------SQIRG-GPRQ 437

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  457 E---------RTKL-----------------------ITPQV------AKLEHAYKPVQFEGSLGKLTVSSVNNPRKMI- 497
Cdd:pfam09770 438 HpsqplsnfaQTYLfqtgsrqggmrrqgrgaenhmqrMEQQVqraveaAKNKPKNKQLVIEGSLGKISFSNAKTPKPLLn 517

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  498 --------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDDRKHKICSMYDNL 569
Cdd:pfam09770 518 ikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDPELIEKHMEWRSTLQAL 597

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....
gi 189217919  570 RGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 613
Cdd:pfam09770 598 NAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 16-613 9.21e-08

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 55.81  E-value: 9.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919   16 EDAFQGLGEE-DEEIDQFNDDTFG---------SGAVDDDW----QEAHERLAELEEKL------PVAVNEQTGNGERDE 75
Cdd:pfam09770  42 EDTYDGLGDQlDETGDAFNDDTFGgggggddvsAGPVGKDFdffgQTAKVSDAIEEEQVrfnrqqPAARAAQSSAQPPAS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919   76 MDLLGDHEENLAERLSKMV---IENELEDPAImravqtrPVLQPqpgslNSSIWDGSEvlrriRGPLLAQEMPTVSvley 152
Cdd:pfam09770 122 SLPQYQYASQQSQQPSKPVrtgYEKYKEPEPI-------PDLQV-----DASLWGVAP-----KKAAAPAPAPQPA---- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  153 ALPQRPPQGPEDDRDLSE-----RALPRRSTSPIIGSPPVraVPIGTPPKQMavPSFTQQILCPKPVHVRPPMPPRYPAP 227
Cdd:pfam09770 181 AQPASLPAPSRKMMSLEEveaamRAQAKKPAQQPAPAPAQ--PPAAPPAQQA--QQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  228 YGERMSPnqlcsvpnsSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGfvgsplaaMNPKLLQGRVGQ 307
Cdd:pfam09770 257 PGQGHPV---------TILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPN--------RLSAARVGYPQN 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  308 MLPPAPGFRAFfsappsatpppqqhppgpgphlQNLRSQAPMFRPDTTHLHPQHrrLLHQRQQQnrsqhRNLNGAGDRGS 387
Cdd:pfam09770 320 PQPGVQPAPAH----------------------QAHRQQGSFGRQAPIITHPQQ--LAQLSEEE-----KAAYLDEEAKR 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  388 HRSSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQNYfekleklsaaEEIQGdGPKK 456
Cdd:pfam09770 371 AKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQVY----------SQIRG-GPRQ 437

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  457 E---------RTKL-----------------------ITPQV------AKLEHAYKPVQFEGSLGKLTVSSVNNPRKMI- 497
Cdd:pfam09770 438 HpsqplsnfaQTYLfqtgsrqggmrrqgrgaenhmqrMEQQVqraveaAKNKPKNKQLVIEGSLGKISFSNAKTPKPLLn 517

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  498 --------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDDRKHKICSMYDNL 569
Cdd:pfam09770 518 ikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDPELIEKHMEWRSTLQAL 597

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....
gi 189217919  570 RGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 613
Cdd:pfam09770 598 NAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 16-613 9.21e-08

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 55.81  E-value: 9.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919   16 EDAFQGLGEE-DEEIDQFNDDTFG---------SGAVDDDW----QEAHERLAELEEKL------PVAVNEQTGNGERDE 75
Cdd:pfam09770  42 EDTYDGLGDQlDETGDAFNDDTFGgggggddvsAGPVGKDFdffgQTAKVSDAIEEEQVrfnrqqPAARAAQSSAQPPAS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919   76 MDLLGDHEENLAERLSKMV---IENELEDPAImravqtrPVLQPqpgslNSSIWDGSEvlrriRGPLLAQEMPTVSvley 152
Cdd:pfam09770 122 SLPQYQYASQQSQQPSKPVrtgYEKYKEPEPI-------PDLQV-----DASLWGVAP-----KKAAAPAPAPQPA---- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  153 ALPQRPPQGPEDDRDLSE-----RALPRRSTSPIIGSPPVraVPIGTPPKQMavPSFTQQILCPKPVHVRPPMPPRYPAP 227
Cdd:pfam09770 181 AQPASLPAPSRKMMSLEEveaamRAQAKKPAQQPAPAPAQ--PPAAPPAQQA--QQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  228 YGERMSPnqlcsvpnsSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGfvgsplaaMNPKLLQGRVGQ 307
Cdd:pfam09770 257 PGQGHPV---------TILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPN--------RLSAARVGYPQN 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  308 MLPPAPGFRAFfsappsatpppqqhppgpgphlQNLRSQAPMFRPDTTHLHPQHrrLLHQRQQQnrsqhRNLNGAGDRGS 387
Cdd:pfam09770 320 PQPGVQPAPAH----------------------QAHRQQGSFGRQAPIITHPQQ--LAQLSEEE-----KAAYLDEEAKR 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  388 HRSSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQNYfekleklsaaEEIQGdGPKK 456
Cdd:pfam09770 371 AKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQVY----------SQIRG-GPRQ 437

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  457 E---------RTKL-----------------------ITPQV------AKLEHAYKPVQFEGSLGKLTVSSVNNPRKMI- 497
Cdd:pfam09770 438 HpsqplsnfaQTYLfqtgsrqggmrrqgrgaenhmqrMEQQVqraveaAKNKPKNKQLVIEGSLGKISFSNAKTPKPLLn 517

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217919  498 --------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDDRKHKICSMYDNL 569
Cdd:pfam09770 518 ikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDPELIEKHMEWRSTLQAL 597

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....
gi 189217919  570 RGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 613
Cdd:pfam09770 598 NAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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