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Conserved domains on  [gi|23346457|ref|NP_694702|]
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glucose-6-phosphate exchanger SLC37A1 [Mus musculus]

Protein Classification

glucose-6-phosphate exchanger SLC37A1/SLC37A2( domain architecture ID 13023824)

glucose-6-phosphate exchanger SLC37A1/SLC37A2 is an inorganic phosphate and glucose-6-phosphate antiporter that may transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
21-514 0e+00

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 679.42  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKQCtagdgpespfsdpssSTRHGPTHWLLNNETDCGWAPFDKNNYQQLLG 100
Cdd:cd17344   1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNC---------------SALIPPPNIVLNNTTWCGWAPFDGKNGTELLG 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCL 180
Cdd:cd17344  66 ALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 181 SNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpthpra 260
Cdd:cd17344 146 GNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 261 senginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLV 340
Cdd:cd17344 211 ----------------------------------------------------------------PGVIEFSLCLFFAKLV 226
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 341 SYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEAT 420
Cdd:cd17344 227 SYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTN 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 421 IAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFAD 500
Cdd:cd17344 307 IVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAAD 386
                       490
                ....*....|....
gi 23346457 501 ACALLFLVRLIHKE 514
Cdd:cd17344 387 VCAGLLLTRLVYKE 400
 
Name Accession Description Interval E-value
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
21-514 0e+00

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 679.42  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKQCtagdgpespfsdpssSTRHGPTHWLLNNETDCGWAPFDKNNYQQLLG 100
Cdd:cd17344   1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNC---------------SALIPPPNIVLNNTTWCGWAPFDGKNGTELLG 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCL 180
Cdd:cd17344  66 ALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 181 SNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpthpra 260
Cdd:cd17344 146 GNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 261 senginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLV 340
Cdd:cd17344 211 ----------------------------------------------------------------PGVIEFSLCLFFAKLV 226
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 341 SYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEAT 420
Cdd:cd17344 227 SYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTN 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 421 IAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFAD 500
Cdd:cd17344 307 IVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAAD 386
                       490
                ....*....|....
gi 23346457 501 ACALLFLVRLIHKE 514
Cdd:cd17344 387 VCAGLLLTRLVYKE 400
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
105-513 5.57e-33

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 129.22  E-value: 5.57e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:COG2271  53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcsstlpthprasen 263
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLLA--------------------- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 ginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalripgviefsLCLLFAKLVSYT 343
Cdd:COG2271 187 --------------------------------------------------------------------LAYFLVYFALYG 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 344 FLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYVFSSVSrmGLEATIA 422
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLP--SPALAIA 276
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 423 MLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAG-LISPSGWSNVFYMLMFADA 501
Cdd:COG2271 277 LLFLAGFGLGGAFGLLWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALAL 348
                       410
                ....*....|..
gi 23346457 502 CALLFLVRLIHK 513
Cdd:COG2271 349 LAALLALLLLRE 360
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
99-493 2.01e-27

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 113.62  E-value: 2.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457    99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgyFYNihSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:TIGR00881  32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWV--STCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPT 256
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEM 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   257 HPRASEnginrfrlQKQTTYSEKNGPLDPELQCLLLSdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLF 336
Cdd:TIGR00881 187 PNEEPD--------GDAEKKEEELTKKQIFLQYVLLN-------------------------------KVLWYISLGYVF 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   337 AKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR-------ASTCGLMLLLAAPTLYVF 409
Cdd:TIGR00881 228 VYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGrrgplavFFMALIIVSLLVYWLNPA 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   410 SSVSRMgleatIAMLLLSGALVSGPYALIttavsadlGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPL-LAGLISPSG 488
Cdd:TIGR00881 308 ANPLMD-----LICLFALGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADGFG 374

                  ....*
gi 23346457   489 WSNVF 493
Cdd:TIGR00881 375 WAGAF 379
MFS_1 pfam07690
Major Facilitator Superfamily;
98-478 1.63e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.09  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457    98 LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVV 177
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   178 TCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVS-TCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKcsstlpt 256
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   257 hprasenginrfrlqkqttysekngpldpelqclllsdgknplhpshivVLPADGNMAAISFTGALRIPGVIEFSLCLLF 336
Cdd:pfam07690 181 -------------------------------------------------KPAEEARLSLIVAWKALLRDPVLWLLLALLL 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   337 AKLVSYTFLFWLPLYITsVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMG 416
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLS 290
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23346457   417 LEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnshalSTVTAIIDGTGSVGAALGP 478
Cdd:pfam07690 291 SLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER--------GTASGLYNTAGSLGGALGP 344
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
99-507 5.53e-16

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 80.14  E-value: 5.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:PRK11663  60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAK 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVST-CWGLSFIVPGAIvaamGIVCFLFLIEHPKDVKCSSTLPTh 257
Cdd:PRK11663 135 LLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHyGWRYGMMIAGII----AIVVGLFLCWRLRDKPQAMGLPS- 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  258 prasengINRFRLQKQTTYSEKNGPLDPELQCLLLSDGKNPlhpsHIVVLpadgnmaaisftgalripgviefSLCLLFA 337
Cdd:PRK11663 210 -------VGEWRHDALELAQQQEGAGLSRKEILTKYVLLNP----YIWLL-----------------------SFSYVLV 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  338 KLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAptLYVFSSVSRMGL 417
Cdd:PRK11663 256 YVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFN--GNRGPMNLIFA--AGILLSVGSLWL 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  418 EATIAMLLLSGAL------VSGPYALITTAvsADLGTHKSLKGnshalsTVTAIIDGTGSVGAAL-GPLLAGLISPSGWS 490
Cdd:PRK11663 332 MPFASYVMQAACFftigffVFGPQMLIGMA--AAECSHKEAAG------AATGFVGLFAYLGAALsGYPLAKVLEIWHWT 403
                        410
                 ....*....|....*..
gi 23346457  491 NVFYMLMFADACALLFL 507
Cdd:PRK11663 404 GFFVVISIAAGISALLL 420
 
Name Accession Description Interval E-value
MFS_SLC37A1_2 cd17344
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ...
21-514 0e+00

Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340902 [Multi-domain]  Cd Length: 400  Bit Score: 679.42  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKQCtagdgpespfsdpssSTRHGPTHWLLNNETDCGWAPFDKNNYQQLLG 100
Cdd:cd17344   1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNC---------------SALIPPPNIVLNNTTWCGWAPFDGKNGTELLG 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCL 180
Cdd:cd17344  66 ALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACV 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 181 SNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpthpra 260
Cdd:cd17344 146 GNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 261 senginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLV 340
Cdd:cd17344 211 ----------------------------------------------------------------PGVIEFSLCLFFAKLV 226
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 341 SYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEAT 420
Cdd:cd17344 227 SYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTN 306
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 421 IAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFAD 500
Cdd:cd17344 307 IVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAAD 386
                       490
                ....*....|....
gi 23346457 501 ACALLFLVRLIHKE 514
Cdd:cd17344 387 VCAGLLLTRLVYKE 400
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
21-511 3.41e-101

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 310.40  E-value: 3.41e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKQCTagdgpesPFSDPSSSTRHGPThWLLNNETDcgwapfDKNNYQQLLG 100
Cdd:cd17342   1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWT-------PSNSNTSIELHEET-WNANPLFP------SQDDAALFLG 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGL----GYFYNIHslgFYVVTQIINGLVQTTGWPSV 176
Cdd:cd17342  67 VLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVltewLHFYNKY---LYCILWVLNGLLQSTGWPCV 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 177 VTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpt 256
Cdd:cd17342 144 VAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP----------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 257 hprasenginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLF 336
Cdd:cd17342 213 --------------------------------------------------------------------PGVIPYSLAYAC 224
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 337 AKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSV-SRM 415
Cdd:cd17342 225 LKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSpSDK 304
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 416 GLEATIamLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPS-GWSNVFY 494
Cdd:cd17342 305 VLNAFV--MTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRlGWMWVFY 382
                       490
                ....*....|....*..
gi 23346457 495 MLMFADACALLFLVRLI 511
Cdd:cd17342 383 FFIIMTILTIVCILPLL 399
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
21-511 1.44e-79

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 253.35  E-value: 1.44e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKqctagdgpespfsdpssstrhgpthwllnnetdcgwapfDKNNYQQLLG 100
Cdd:cd17312   1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE---------------------------------------EIGLSKDDLG 41
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCL 180
Cdd:cd17312  42 IIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLL 116
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 181 SNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpthpr 259
Cdd:cd17312 117 GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYgWRAAFLVPGIVGLVVAIILFFFLRDSP-------------- 182
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 260 asenginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKL 339
Cdd:cd17312 183 -----------------------------------------------------------------PYVWVLSLAYAFVYI 197
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 340 VSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL--EKRASTCGLMLLLAAPTLYVFSSVSRmGL 417
Cdd:cd17312 198 VRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPH-NK 276
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 418 EATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshALSTVTAIIDGTGSVGAALGPLLAGLISPS-GWSNVFYML 496
Cdd:cd17312 277 LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKE-------AAGTATGFVGLFGYLGASLAGLPLGYIIDHyGWSTVFYFL 349
                       490
                ....*....|....*
gi 23346457 497 MFADACALLFLVRLI 511
Cdd:cd17312 350 ISAALLSVLLLLSLW 364
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
105-513 5.57e-33

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 129.22  E-value: 5.57e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:COG2271  53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcsstlpthprasen 263
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLLA--------------------- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 ginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalripgviefsLCLLFAKLVSYT 343
Cdd:COG2271 187 --------------------------------------------------------------------LAYFLVYFALYG 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 344 FLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYVFSSVSrmGLEATIA 422
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLP--SPALAIA 276
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 423 MLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAG-LISPSGWSNVFYMLMFADA 501
Cdd:COG2271 277 LLFLAGFGLGGAFGLLWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALAL 348
                       410
                ....*....|..
gi 23346457 502 CALLFLVRLIHK 513
Cdd:COG2271 349 LAALLALLLLRE 360
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
99-508 3.31e-29

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 119.27  E-value: 3.31e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYnIHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:cd17345  40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA-TSSVGLMFILLFLNGWFQGMGWPPSGR 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWN-SHTSVGNILGSLI---AGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVkcsstl 254
Cdd:cd17345 119 TMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESE------ 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 255 pthprasenGINRFRLQKQTTYSEKNGPLDPElqclllsdgknplhpshivvlpadgNMAA--ISFTGALRIPGVIEFSL 332
Cdd:cd17345 193 ---------GLPPIEEYKGDYPEEADGEEEEQ-------------------------ELSAweIFVKYVLKNKLLWYIAI 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 333 CLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGLMLLLAAPTLYVFS 410
Cdd:cd17345 239 ANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYW 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 411 SVSRMGLEATIAMLLlsGALVSGPYALIttAVSADLGTHKSLKGNSHALSTVTAIIdgtgsVGAALGPLLAGLISP-SGW 489
Cdd:cd17345 319 LAPNVLVDLIALIAL--GFLIYGPVMLI--GLQALELVPKKAAGTAAGLTGLFGYL-----GGSVLATALIGIIVDhFGW 389
                       410
                ....*....|....*....
gi 23346457 490 SNVFYMLMFADACALLFLV 508
Cdd:cd17345 390 NGGFIVLLASCILAIIFLA 408
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
99-493 2.01e-27

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 113.62  E-value: 2.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457    99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgyFYNihSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:TIGR00881  32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWV--STCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPT 256
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEM 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   257 HPRASEnginrfrlQKQTTYSEKNGPLDPELQCLLLSdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLF 336
Cdd:TIGR00881 187 PNEEPD--------GDAEKKEEELTKKQIFLQYVLLN-------------------------------KVLWYISLGYVF 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   337 AKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR-------ASTCGLMLLLAAPTLYVF 409
Cdd:TIGR00881 228 VYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGrrgplavFFMALIIVSLLVYWLNPA 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   410 SSVSRMgleatIAMLLLSGALVSGPYALIttavsadlGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPL-LAGLISPSG 488
Cdd:TIGR00881 308 ANPLMD-----LICLFALGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADGFG 374

                  ....*
gi 23346457   489 WSNVF 493
Cdd:TIGR00881 375 WAGAF 379
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
105-510 1.69e-25

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 107.66  E-value: 1.69e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17319  46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLiehpkdvkcsstlpthprasen 263
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFgWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 ginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLVSYT 343
Cdd:cd17319 179 -------------------------------------------------------------RQVWGLALGYFGINYALYG 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 344 FLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEATIAM 423
Cdd:cd17319 198 LLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 424 LLLSGALVSGPYALITTaVSADLgthkslkGNSHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFADA 501
Cdd:cd17319 278 LSLAGFGIGAASPVFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLIGYLvdATGSYTAAFLFLAAVAL 349

                ....*....
gi 23346457 502 CALLFLVRL 510
Cdd:cd17319 350 LAALLVLLL 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
109-514 2.29e-21

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 96.10  E-value: 2.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:COG2223  52 VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPTHprasenginr 267
Cdd:COG2223 127 RGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------- 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 268 frlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaiSFTGALRIPGVIEFSLCLLFAKLVSYTFLFW 347
Cdd:COG2223 197 -------------------------------------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSW 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLeATIAMLLLs 427
Cdd:COG2223 228 LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL-FLVLFLLL- 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 428 GALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFADACALL 505
Cdd:COG2223 306 GLALGGGNGAVFALVPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALldATGSYTAAFLVFAVLALVALV 377

                ....*....
gi 23346457 506 FLVRLIHKE 514
Cdd:COG2223 378 LTLLLYRRP 386
MFS_1 pfam07690
Major Facilitator Superfamily;
98-478 1.63e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.09  E-value: 1.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457    98 LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVV 177
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   178 TCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVS-TCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKcsstlpt 256
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   257 hprasenginrfrlqkqttysekngpldpelqclllsdgknplhpshivVLPADGNMAAISFTGALRIPGVIEFSLCLLF 336
Cdd:pfam07690 181 -------------------------------------------------KPAEEARLSLIVAWKALLRDPVLWLLLALLL 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   337 AKLVSYTFLFWLPLYITsVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMG 416
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLS 290
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23346457   417 LEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnshalSTVTAIIDGTGSVGAALGP 478
Cdd:pfam07690 291 SLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER--------GTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
105-508 1.92e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 87.10  E-value: 1.92e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd06174  39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVStCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPTHPRASEng 264
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILAS-SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK-- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 265 inrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnMAAISFTGALRIPGVIEFSLCLLFAKLVSYTF 344
Cdd:cd06174 191 ------------------------------------------------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 345 LFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFssVSRMGLEATIAML 424
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL--LLAPSLLLLLLLL 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 425 LLSGALVSGPYALITTAVSADLgthkslkgNSHALSTVTAIIDGTGSVGAALGPLLAGLISPS--GWSNVFYMLMFADAC 502
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELF--------PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtfGLTGAFLVLAVLLLL 372

                ....*.
gi 23346457 503 ALLFLV 508
Cdd:cd06174 373 AAILLL 378
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
109-510 6.08e-18

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 85.85  E-value: 6.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgYFyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:cd17343  50 AYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS--GS---SSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGYWV-STCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVkcsstlpthprasenGINR 267
Cdd:cd17343 125 FGTWWSVLSTSMNLAGSLGPILATLLAlSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDV---------------GLNN 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 268 FRLQKQTTYSEKNGPLDPELQCLLLSdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLVSYTFLFW 347
Cdd:cd17343 190 IEEEESKGKKKKSPRGESTLKELLLS-------------------------------PFLWLLSLGYLVVFGVKTAVTDW 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCG----------LMLLLAAPTLYVFS-SVSRMG 416
Cdd:cd17343 239 GQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSrgnprmplalVFMAGLTVSLHLFRvHITSDS 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 417 LEATIAML-LLSGALVSGPYALIttAVSADLGTHKSLKGNSHALSTVTAiidgtgSVGAALGPLLAGLISPS-GWSNVFY 494
Cdd:cd17343 319 SELFILLLgFLIGFSLYGPIAIF--GVIANESAPSHLCGTSHAIVALAA------NVGGVLAGLPFSYIAKHyDWRTAFL 390
                       410
                ....*....|....*.
gi 23346457 495 MLMFADACALLFLVRL 510
Cdd:cd17343 391 LLEILCAITVVILFLL 406
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
99-507 5.53e-16

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 80.14  E-value: 5.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:PRK11663  60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAK 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVST-CWGLSFIVPGAIvaamGIVCFLFLIEHPKDVKCSSTLPTh 257
Cdd:PRK11663 135 LLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHyGWRYGMMIAGII----AIVVGLFLCWRLRDKPQAMGLPS- 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  258 prasengINRFRLQKQTTYSEKNGPLDPELQCLLLSDGKNPlhpsHIVVLpadgnmaaisftgalripgviefSLCLLFA 337
Cdd:PRK11663 210 -------VGEWRHDALELAQQQEGAGLSRKEILTKYVLLNP----YIWLL-----------------------SFSYVLV 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  338 KLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAptLYVFSSVSRMGL 417
Cdd:PRK11663 256 YVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFN--GNRGPMNLIFA--AGILLSVGSLWL 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  418 EATIAMLLLSGAL------VSGPYALITTAvsADLGTHKSLKGnshalsTVTAIIDGTGSVGAAL-GPLLAGLISPSGWS 490
Cdd:PRK11663 332 MPFASYVMQAACFftigffVFGPQMLIGMA--AAECSHKEAAG------AATGFVGLFAYLGAALsGYPLAKVLEIWHWT 403
                        410
                 ....*....|....*..
gi 23346457  491 NVFYMLMFADACALLFL 507
Cdd:PRK11663 404 GFFVVISIAAGISALLL 420
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
105-476 6.05e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 79.25  E-value: 6.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:COG2814  53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEhpkdvkcsstlpTHPRASEN 263
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWVFLVNAVLALLALLLLLRLLPE------------SRPAARAR 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 GINRFRLqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgALRIPGVIEFSLCLLFAKLVSYT 343
Cdd:COG2814 196 LRGSLRE--------------------------------------------------LLRRPRLLLLLLLAFLLGFGFFA 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 344 FLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYVFSSvsrmGLEATIA 422
Cdd:COG2814 226 LFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFgRRRLLLIGLLLLALGLLLLALAG----SLWLLLL 301
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 23346457 423 MLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAAL 476
Cdd:COG2814 302 ALFLLGFGFGLLFPLLQALVAELAPP--------EARGRASGLYNSAFFLGGPL 347
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
109-511 4.79e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.85  E-value: 4.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:cd17325  43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGYwVSTCWGLSFivPGAIVAAMGIVCFLfliehpkdvkcsstlpthprasenginrf 268
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRA--PFLVCAALALLALV----------------------------- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 269 rlqkqttysekngpldpeLQCLLLSDGKNPLHPSHIVVLPADGNMAAISFTGALRIPGVIEFSLCLLFAKLVSYtflfwL 348
Cdd:cd17325 166 ------------------LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF-----L 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 349 PLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRaSTCGLMLLLAAPTLYVFSSVSrmgleaTIAMLLLSG 428
Cdd:cd17325 223 PLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT------SFWLLLLLL 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 429 ALVSGPYALITTAVSADLG--THKSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPS-GWSNVFYMLMFADACALL 505
Cdd:cd17325 296 ALLGLGLGLVFPATLALLAdiVPPEGRG------TAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAAAALLLLAAV 369

                ....*.
gi 23346457 506 FLVRLI 511
Cdd:cd17325 370 LFLLLR 375
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
99-511 7.93e-15

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 75.91  E-value: 7.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:cd17488  40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPPCAR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVST-CWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpth 257
Cdd:cd17488 115 LLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTyGWRAGMYVPGIIAILMGIVLCWRLRDRP------------ 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 258 prasenginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFA 337
Cdd:cd17488 183 -------------------------------------------------------------------PYIWLLAFCYVLV 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 338 KLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAPTLYV------FSS 411
Cdd:cd17488 196 YVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK--GNRGPMNLIFALGLLVsvgalwLVP 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 412 VSRMGLEATiaMLLLSGALVSGPYALIttAVSADLGTHKSLKGnshalsTVTAIIDGTGSVGAAL-GPLLAGLISPSGWS 490
Cdd:cd17488 274 VHSYWLLAT--CFFTIGFFVFGPQMLI--GMAAAECSHKDAAG------SATGFVGLFAYLGAALaGYPLAKVIESWGWS 343
                       410       420
                ....*....|....*....|.
gi 23346457 491 NVFYMLMFADACALLFLVRLI 511
Cdd:cd17488 344 GFFIVISIAAAISGLLLLPLL 364
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
99-513 1.71e-13

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 72.19  E-value: 1.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTqIINGLVQTTGWPSVVT 178
Cdd:COG0738  45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLG-LGLGLLDVAANPYVAA 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 ClsnwfGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcsstlpthp 258
Cdd:COG0738 124 L-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL---------------- 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 259 rasenginRFRLQKQTTYSEKNGPldpelqclllsdgknplhpshivvlpadgnmAAISFTGALRIPGVIEFSLCLLFAK 338
Cdd:COG0738 183 --------RSKLPEIEEEEEEAAG-------------------------------SAASLKSLLKNPRLLLGGLAIFLYV 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 339 LVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYVFSSVSrmGLE 418
Cdd:COG0738 224 GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAP--GPW 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 419 ATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshalSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMF 498
Cdd:COG0738 301 LALIGLALVGLGLSLMFPTIFSLALDGLGKRT---------AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPL 371
                       410
                ....*....|....*
gi 23346457 499 ADACALLFLVRLIHK 513
Cdd:COG0738 372 VCYLLILLLALALKR 386
uhpT PRK09556
hexose-6-phosphate:phosphate antiporter;
99-508 1.76e-12

hexose-6-phosphate:phosphate antiporter;


Pssm-ID: 236564 [Multi-domain]  Cd Length: 467  Bit Score: 69.31  E-value: 1.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:PRK09556  66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYS 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLS----FIVPGAIVAAMGIVCFLFLIEHPKdvkcsstl 254
Cdd:PRK09556 146 TITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHvigmFIFPSIIALIIGFIGLRYGSDSPE-------- 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  255 pthprasENGINRfrlqKQTTYSEKNGPLDPELQCLLLSDGKnplhpshivvlpadgnmaaISFTGALRIPGVieFSLCL 334
Cdd:PRK09556 218 -------ELGWGK----AEEIFGEPISEEDKETESTDMTKWQ-------------------IFVEYVLKNPVI--WLLCF 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  335 --LFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE-KRASTCGLMLLLAAPTLYVFSS 411
Cdd:PRK09556 266 anIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANgRRALVACIALALIIFTLGVYQH 345
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  412 VSRMGLeaTIAMLLLSGALVSGPYALI------------TTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPL 479
Cdd:PRK09556 346 ATSEYM--YLASLFALGFLVFGPQLLIgvaavgfvpkkaIGVANGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFGYT 423
                        410       420
                 ....*....|....*....|....*....
gi 23346457  480 LaglispSGWSNVFYMLMFADACALLFLV 508
Cdd:PRK09556 424 L------TGWAGTFAALDIAAIGCICLMA 446
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
87-507 4.03e-12

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 67.65  E-value: 4.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  87 WAPFDKNNYQ----QLLGALDYAFLcAYAIGMYLSGIIGERLPIRYYLTFGMLASGAftALFGLGYFYNIHSLG-FYVVT 161
Cdd:cd17475  18 LAPFLQEDLHlslaQVGLLLSALNL-GVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLvLLFLV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 162 QIINGLVQTTGWPSVVTclsnWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLF 240
Cdd:cd17475  95 GAGYGSVQPGGGRAIMR----WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYgWRAAFVVAGLVSILAAVLFWLF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 241 LIEHPkdvkcsstlpthprasenginrfrlqkqttysekNGPLDPELQCLLLSDGKNPLHpshivvlpaDGNMAAISFTG 320
Cdd:cd17475 171 YREPP----------------------------------AASAATESASTLLRSLKEVLR---------NRDVWLIAIAG 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 321 ALRIpgviefslcllfakLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE--KRASTCGLM 398
Cdd:cd17475 208 ALLV--------------APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggRRRPVLVIT 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 399 LLLAAPTLYVFSSVSRMGLEATIAMLL-LSGALVSGPYALITTAVSADLGTHKSlkgnSHALSTVTAIIdgtgSVGAALG 477
Cdd:cd17475 274 AAIAAAALLVLSLLSPGTPLWLLVLLLiLLGLFAIGWNGLYLTLVAESAGPEQA----GTALGLANTIN----FIGIAIG 345
                       410       420       430
                ....*....|....*....|....*....|..
gi 23346457 478 PLLAGLISP--SGWSNVFYMLMFADACALLFL 507
Cdd:cd17475 346 PPLFGLLVDatHSYAPAWLALALLLVLAALLL 377
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
97-507 1.52e-11

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 66.11  E-value: 1.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  97 QLLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSV 176
Cdd:cd17328  34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF-----APNFWQLLLFRALVGIGEASYSPIA 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 177 VTCLSNWFGKGRRGLIMGIWNSHTSVGNILG----SLIAGYWVStcWGLSFIVPGAIVAAMGIVCFLFLIEHPKdvkcss 252
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGyvvgGLVAQATGG--WRWAFRVTGVLGVLLAILLLLFVREPPR------ 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 253 tlpthpRASENGinrfrlqkqttysekngpldpelqclllsdgknPLHPSHIVVLPADgnMAAIsftgaLRIPGVIEFSL 332
Cdd:cd17328 181 ------GAAEGG---------------------------------VMAKSTATSFLAD--LKAL-----AKNPSFILSTL 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 333 CLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFD----VGGIFGGILAGVISDRLEKRAST-----CGLMLLLAA 403
Cdd:cd17328 215 GFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKTPRadplvCAVGLLAAA 294
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 404 PTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSAD-LGTHKSLkgnSHALSTVTaiidgTGSVGAALGPLLAG 482
Cdd:cd17328 295 PFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVvIPTRRST---ASAIQILL-----SHLLGDAGSPYLIG 366
                       410       420
                ....*....|....*....|....*
gi 23346457 483 LISPSGWSNVFYMLMFADACALLFL 507
Cdd:cd17328 367 LISDLLRQNKDSPLAEAASLQYALL 391
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
109-510 7.70e-11

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 64.12  E-value: 7.70e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTG---WPSVVtclSNWFG 185
Cdd:COG2807  65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGnvlLPGLI---KRWFP 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 186 KgRRGLIMGIWNSHTSVGNILGSLIAGYWV-STCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlPTHPRASeng 264
Cdd:COG2807 137 D-RVGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAVWALLALLALLLWLPLLRRRP---------AAAAAAP--- 203
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 265 inrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmAAISFTGALRIPGVIEFSLCLLFAKLVSYTF 344
Cdd:COG2807 204 -------------------------------------------------AAASLRSLWRSPLAWLLTLFFGLQSLLYYAV 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 345 LFWLPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcGLMLLLAAPTLYVFSSVSRMGLEATIAML 424
Cdd:COG2807 235 VAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRR---PLLLLLGLLGLAGLLGLLLAPGSLPWLWA 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 425 LLSGALVSGPYALITTAVSADLGTHkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFADAC 502
Cdd:COG2807 311 VLLGLGQGGLFPLALTLIGLRARTP-------AEAAALSGMAQSVGYLLAALGPLLVGALhdATGSWTAALLLLAALAVL 383

                ....*...
gi 23346457 503 ALLFLVRL 510
Cdd:COG2807 384 MLVAGLLA 391
glpT PRK11273
glycerol-3-phosphate transporter;
109-438 8.97e-11

glycerol-3-phosphate transporter;


Pssm-ID: 236889 [Multi-domain]  Cd Length: 452  Bit Score: 63.96  E-value: 8.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:PRK11273  75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKE 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  189 RGLIMGIWN-SHTSVGNILGSL-IAGYWVSTCWGLSFIVPGAivAAMGIVCFLFLIEhpKDVKCSSTLPThprasengIN 266
Cdd:PRK11273 154 RGGIVSVWNcAHNVGGGLPPLLfLLGMAWFNDWHAALYMPAF--AAILVALFAFAMM--RDTPQSCGLPP--------IE 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  267 RFRLQKQTTYSEKNgplDPELqclllsdgknplhpshivvlpadgNMAAISFTGALRIPGVIEFSLCLLFAKLVSYTFLF 346
Cdd:PRK11273 222 EYKNDYPDDYNEKH---EQEL------------------------TAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILD 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  347 WLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGL-MLLLAAPTL-YVFSSVSRMGLEatIA 422
Cdd:PRK11273 275 WSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgnRGATGVFfMTLVTIATIvYWLNPAGNPTVD--MA 352
                        330
                 ....*....|....*.
gi 23346457  423 MLLLSGALVSGPYALI 438
Cdd:PRK11273 353 CMIVIGFLIYGPVMLI 368
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
90-506 1.24e-09

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 60.53  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457    90 FDKNNYQQ--LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfynihslGFYVVTQIINGL 167
Cdd:TIGR00894  67 KNPNFKWSgaLQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA-------GGGIALVVFCRV 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   168 VQTTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGY------WVSTCWGLSFIVPGAIVAAMGIVCFLFL 241
Cdd:TIGR00894 140 IQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPisgwlcESWGGWPMIFYVFGIVGCAWSLLWFVFP 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   242 IEHPKDVKCSStlpthpRASENGINRfRLQKQTTYSEKNGPLDPELQCLllsdgknplhpshivvlpadgNMAAISFTga 321
Cdd:TIGR00894 220 ADDPSIHPCIS------KFEKKYINS-SLQGQKGSTRQSLPIKAIPKSL---------------------PVWAIWFA-- 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   322 lripgviefslclLFAKLVSYTFLF-WLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR--------- 391
Cdd:TIGR00894 270 -------------IFGHFWLYTILPtYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSktlsltaar 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   392 ---ASTCGLMLLLAAPTLYVFSSvsrmGLEATIAMLLLSGALVSGPYALITTAvsadlgthkSLKGNSHALSTVTAIIDG 468
Cdd:TIGR00894 337 kifNGIGGLGPGIFAYALPYLSA----AFYLTIIILTLANAVSSGPLAGVLIN---------SLDLAPRFLGFIKGITGL 403
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 23346457   469 TGSVGAALGPLLAGLI----SPSGWSNVFYMLMFADACALLF 506
Cdd:TIGR00894 404 PGFIGGLIASTLAGNIlsqdSKNVWLIVFLIMAFVNILCVIF 445
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
109-506 3.69e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 58.71  E-value: 3.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:cd17324  46 GYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGyWVSTCWGLSFIVpgAIVAAMGIVCFLFLIehpkdvkcsSTLPTHPrasenginrf 268
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAF--LAIAVLALLAALLLW---------RLLPSLP---------- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 269 rlqkqttysekngpldpelqclllsdgknplhPSHIVVLPADGNMAAISFTGALRIPGVIEFslCLLFAKLVSYTFLfwl 348
Cdd:cd17324 179 --------------------------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITF--LLFGGFFALYTYL--- 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 349 PLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAptLYVFSSVSRMGLEATIAMLLLSG 428
Cdd:cd17324 222 APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA--LLLLTLLGPSPLLLLVGLVLWGL 299
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23346457 429 ALVSGPYALITTAVSAdlgthkslkgNSHALSTVTAIIDGTGSVGAALGPLLAGL-ISPSGWSNVFYMLMFADACALLF 506
Cdd:cd17324 300 GFFAAHSALQTRVLRL----------APEARGLASSLYLAAYNLGGALGAALGGLvLDHGGWAGVGWVGAALLLLALLL 368
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
99-507 1.29e-08

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 56.95  E-value: 1.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGL----VQTTGWP 174
Cdd:cd17333  33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT-----PSIYLFVVLMFLAGLgagiLDTGANT 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 175 SVVTCLSNwfgkgRRGLIMGIWNSHTSVGNILGSLIAGY--WVSTCWGLSFIVPGAIVAAMGIVCFLFLiehpkdvkcss 252
Cdd:cd17333 108 FVGALFEE-----SSATRLNVLHGFFGLGALIGPLIATSllTSELSWSWAYLIIGLIYLLLAILILLTL----------- 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 253 tLPTHPRASENginrfrLQKQTTYSEkngpldpelqclllsdgknplhpshivvlpadgnmaaiSFTGALRIPGVIEFSL 332
Cdd:cd17333 172 -FPELPSARNP------QQSVGAFSA--------------------------------------SASRLLRNPSIILGAL 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 333 CLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLekrASTCGLMLLLAAPTLYVFSSV 412
Cdd:cd17333 207 ALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI---KPHTLLVLSGSGALLGLLILL 283
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 413 SRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshalSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNV 492
Cdd:cd17333 284 LAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK---------GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQT 354
                       410
                ....*....|....*
gi 23346457 493 FyMLMFADACALLFL 507
Cdd:cd17333 355 A-MLLITILYAIIFV 368
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
99-482 1.65e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 56.60  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457    99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHSLGFYvvtQIINGLVQTTGWPSVVT 178
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLIL---RFLAGLGLGGLMPNLNA 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLiehpkdvkcsstlpth 257
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFgWRSLFYVGGIAPLLLLLLLMRFL---------------- 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   258 PRASENGINRFRLQKQTTYSEKNGPLDPELQCLLLSDGKNPLHPSHIVVLPADGNMAAISFtgalripgvieFSLCLLFA 337
Cdd:TIGR00895 193 PESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITV-----------LLWLLYFM 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   338 KLVSYTFLF-WLPlYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAStcGLMLLLAAPTLY-VFSSVSRM 415
Cdd:TIGR00895 262 LLVGVYFLTnWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT--ALLLLLGAVFAVlVGSTLFSP 338
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23346457   416 GLEATiaMLLLSGALVSGPYALittavsadLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAG 482
Cdd:TIGR00895 339 TLLLL--LGAIAGFFVNGGQSG--------LYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
67-508 2.24e-08

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 56.09  E-value: 2.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  67 SSSTRHGPTHWLLNNETDCGWAPFDKNNYQQllGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgL 146
Cdd:cd17318  28 STATHDNNNTSTDKDTLPVEAPEFDWSEKTQ--GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLL--T 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 147 GYFYNIHsLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIV 225
Cdd:cd17318 104 PLAARGG-YGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLgWPSIFYI 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 226 PGAIvaamGIVCFLFLIehpkdvkcsstlpthprasenginrfrlqkqttysekngpldpelqclllsdgknplhpshIV 305
Cdd:cd17318 183 FGGL----GLLWCLLWF-------------------------------------------------------------FL 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 306 VLPADGNMAAiSFTGALripgviefslcllfaklVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVIS 385
Cdd:cd17318 198 VLPVWAIVVA-HFGHNW-----------------GFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLA 259
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 386 DRLEKRastcGLMLLLAapTLYVFSSvsrmgleatIAMLLLSGALVSGPY---------ALITTAVSADLGTHKSLKGNS 456
Cdd:cd17318 260 DWLRSR----GILSTTT--VRKLFTS---------IGFLGPGVFLIALGYlgsnatlavVFLTLSVGLSGACYSGFLVNH 324
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23346457 457 HALS-----TVTAIIDGTGSVGAALGPLLAGLI-----SPSGWSNVFYMLMFADA-CALLFLV 508
Cdd:cd17318 325 LDLApnyagTLMGITNTAATIAGIISPLIVGAIvkndqTIGQWRIVFFISAAIYIlGAIFYLI 387
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
331-508 4.42e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.30  E-value: 4.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 331 SLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAsTCGLMLLLAAPTLYVFS 410
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK-TLVIGLILSGILALPLF 261
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 411 SVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWS 490
Cdd:cd17316 262 YLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT--------EVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
                       170
                ....*....|....*...
gi 23346457 491 NVFYMLMFADACALLFLV 508
Cdd:cd17316 334 TGVPALILALLAIVALIV 351
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
105-247 3.04e-07

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 52.64  E-value: 3.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17327  49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAgYWVSTC--------WGLSFIVPGAIVAAMGIVCFLFLIEHPKD 247
Cdd:cd17327 124 KREEQAKRIAFFYAAAGLGSIFGGLLA-YGVFKIlgvgglagWRWLFIIEGLITIIIGLVIFFWLPDNPSK 193
MFS_1 pfam07690
Major Facilitator Superfamily;
330-528 4.96e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.65  E-value: 4.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   330 FSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYV 408
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFgRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   409 FSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSAdlgthkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLISPS- 487
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP------------EERGRALGLVSAGFGLGAALGPLLGGLLASLf 148
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 23346457   488 GWSNVFYMLM-FADACALLFLVRLIHKELSCPGPAAGIQAPL 528
Cdd:pfam07690 149 GWRAAFLILAiLSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
105-243 5.56e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 51.35  E-value: 5.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:COG0477  57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELF 131
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVpGAIVAAMGIVCFLFLIE 243
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALgWRWIFLI-NAPLGLLALVLRLRLPE 190
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
348-514 2.13e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.88  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYVFSSvsrmgleaTIAMLLL 426
Cdd:cd17325  19 LPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFgRKRLLLLGLLLLAVSTLLFAFAT--------SYWQLLL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 427 S---GALVSGPYALITTAVSADLGTHKSLkgnSHALSTVTAIIdgtgSVGAALGPLLAGLISP-SGWSNVFYMLMFADAC 502
Cdd:cd17325  90 ArflQGLASAAVWPAAMALIADIAPPEER---GRAMGIFSSAI----GLGFLIGPLLGGLLADaLGYRAPFLVCAALALL 162
                       170
                ....*....|..
gi 23346457 503 ALLFLVRLIHKE 514
Cdd:cd17325 163 ALVLALLLLPEP 174
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
339-512 3.02e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.51  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 339 LVSYTFLFWLPLYITSVDhLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVfsSVSRMGLE 418
Cdd:cd17365 185 LLVYLLNSWLPKLMVEAG-YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALL--GVSPASLV 261
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 419 ATIAMLLLSGALVSGPYALItTAVSADLGThkslkgnSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMF 498
Cdd:cd17365 262 LLYVLVFLAGACVNGAQVGL-YALAARFYP-------TEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLAL 333
                       170
                ....*....|....
gi 23346457 499 ADACALLFLVRLIH 512
Cdd:cd17365 334 AIPAALGALAVLLL 347
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
319-512 1.05e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.66  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 319 TGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcglm 398
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR------ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 399 LLLAAPTLYVFSSVSrMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnSHALSTVTAIIDGTGSVGAALGP 478
Cdd:COG2814  77 VLLLGLLLFALGSLL-CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP----PERRGRALGLLGAGLGLGPALGP 151
                       170       180       190
                ....*....|....*....|....*....|....*
gi 23346457 479 LLAGLISPS-GWSNVFYMLMFADACALLFLVRLIH 512
Cdd:COG2814 152 LLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLP 186
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
313-488 1.15e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.55  E-value: 1.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 313 MAAISFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRA 392
Cdd:cd17321 156 NVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL 235
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 393 STCGLMLLLAAPTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnshalSTVTAIIDGTGSV 472
Cdd:cd17321 236 VLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA--------GAASGILNTARQL 307
                       170
                ....*....|....*.
gi 23346457 473 GAALGPLLAGLISPSG 488
Cdd:cd17321 308 GGALGVALLGALLTAG 323
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
116-484 2.13e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.78  E-value: 2.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 116 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVvTCLSNWFGKGRRGLIMGI 195
Cdd:cd17478  50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEG-ARLASQAAGGRRGLAMSI 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 196 WNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcSSTLPTHPRASENGINRFRLQKqtt 275
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR--------PLKKPEAKKAAAKSSARSTLKG--- 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 276 ysekngpldpelqclllsdgknplhpshivVLPADGNMAAISFTGALRIPGVIEFSLCLLFAKLVSYTFlfwlplyitsv 355
Cdd:cd17478 193 ------------------------------VWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF----------- 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 356 dhldakkAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMlLLAAPTLYVFSSVSrmgLEATIAMLLLSGALVSGPY 435
Cdd:cd17478 232 -------AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL-LLAAPFLLLFLLTP---GIWSYILLVLAGFLLFASF 300
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 23346457 436 ALITTAVsadlgtHKSLKGNshaLSTVTAIIDGTGSVGAALGPLLAGLI 484
Cdd:cd17478 301 PVTVVLA------QELLPGN---VGLASGLMMGLSFGLGGIGAPVLGAL 340
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
98-510 2.33e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.84  E-value: 2.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  98 LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVV 177
Cdd:cd06173  35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQ 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 178 TCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTcWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPTH 257
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL-LGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 258 PRASENGINRFRlqkqttysekngpldpelqclllsdgknplhpSHIVVLPADGNMAAISFTGALripgviefslcllfa 337
Cdd:cd06173 194 LRDLREGLRYLR--------------------------------RSPLLRLLLLALALFALLGGA--------------- 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 338 klvsytFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYVFSSVSRMGL 417
Cdd:cd06173 227 ------LTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR-RRGRLLLIGALLLGLALLVLGLSPSLWL 299
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 418 eaTIAMLLLSGalVSGPYALITTAVSADLGTHKSLKGnsHALSTVTAIIDGTGSVGAALGPLLAGLIspsGWSNVFYMLM 497
Cdd:cd06173 300 --LLAALFLLG--LAGGLFNVPLNTLLQLRVPDELRG--RVFSVYNALNSGAMPLGALLAGLLADAL---GLSAVFLLAG 370
                       410
                ....*....|...
gi 23346457 498 FADACALLFLVRL 510
Cdd:cd06173 371 ALLLLAALLLLLL 383
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
330-511 3.59e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.27  E-value: 3.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 330 FSLCLLFAKLVSYTFLFWLPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVF 409
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 410 SSVSrmgleatIAMLLLSGALVSGPYALITTAVSADLGTHkslkGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGW 489
Cdd:cd06174  80 FAPS-------FWLLLLGRFLLGLGSGLIDPAVLALIADL----FPERERGRALGLLQAFGSVGGILGPLLGGILASSLG 148
                       170       180
                ....*....|....*....|..
gi 23346457 490 SNVFYMLMFADACALLFLVRLI 511
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLL 170
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
111-240 6.25e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 45.25  E-value: 6.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 111 AIGMYLSG-IIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGRR 189
Cdd:cd17474 248 ALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGF-----VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER 322
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 23346457 190 GLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLF 240
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFgLSAPFLVGAAIALAAAVLLALL 374
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
332-482 1.15e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  332 LCLLFAKLVSYTFLFWLPLYITSvDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLM--LLLAAPTLYVF 409
Cdd:PRK11551 227 ISYFFTLIVLYFLLNWLPSLLVG-QGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYagILASLAALAAA 305
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23346457  410 SSVSRMGLEATIAMLLLSGALvSGPYALITTAVSADL-GThkslkgnshALSTVTAIidgtGSVGAALGPLLAG 482
Cdd:PRK11551 306 PSFAGMLLAGFAAGLFVVGGQ-SVLYALAPLFYPTQVrGT---------GVGAAVAV----GRLGSMAGPLLAG 365
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
317-484 1.42e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.51  E-value: 1.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 317 SFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCG 396
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 397 LMLLLAAPTLyVFSSVSRMGLEATIAMLLLSGALVSGPYALItTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAAL 476
Cdd:COG2211 300 GLLLAALGLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLP-WAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQAL 377

                ....*...
gi 23346457 477 GPLLAGLI 484
Cdd:COG2211 378 AGALAGLL 385
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
348-508 1.65e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.09  E-value: 1.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS--TCGLMLLLAAPTLYVFSSVSrmglEATIAMLL 425
Cdd:cd17477 211 LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVllGCALLGALAALLLPLVPGLP----LALLVLLF 285
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 426 LSGALVSGPYALITTAVSADLGthkslkgnSHALSTVTAIIDGTGSVGAALGPLLAGLIspSGWSNVFYMLMFADACALL 505
Cdd:cd17477 286 LWGGAAGPLYTLALALAGDRLP--------GDELVAANAALLLLYGLGSVIGPLLAGAL--MDAFGPHGLFLFLAAVALL 355

                ...
gi 23346457 506 FLV 508
Cdd:cd17477 356 FLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
94-208 2.08e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457    94 NYQQLLGALDYAFLCA-YAIGMYLSGIIGERLPIRYYLTFGMLasGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTG 172
Cdd:pfam07690 231 GLSALLAGLLLGLGGLlGAIGRLLLGRLSDRLGRRRRLLLALL--LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 23346457   173 WPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGS 208
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
335-508 2.19e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.76  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 335 LFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYVFSsvs 413
Cdd:cd17329   9 FLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVmLAGLLLRALGFALLGFA--- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 414 rMGLEATIAMLLLSGALvsgpYALITTAVSADLGTHKSLKGNSHALSTVTAIIdgtgSVGAALGPLLAGLISPSGWSNVF 493
Cdd:cd17329  86 -HSPWLFAIALVLTGFG----GGLFEPASEAMIADVTTPENRTRAFSLLYWAI----NLGVAIGPLLGGLLLLYSFRLLF 156
                       170
                ....*....|....*
gi 23346457 494 ymlmFADACALLFLV 508
Cdd:cd17329 157 ----LAAAVLFLLAA 167
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
363-512 2.72e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.41  E-value: 2.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 363 AGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSsvsrmgLEATIAMLLLSGALVSGPYALITTAV 442
Cdd:cd17355 247 AAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLL------LPFPPLALLLFAALFGLGWGATVPLT 320
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23346457 443 SADLGThkslKGNSHALSTVTAIIDGTGSVGAALGPLLAGLI-SPSGwsnvFYMLMFADACALLFLVRLIH 512
Cdd:cd17355 321 AALAAR----YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLyDRTG----SYTAAWALAVALGLIAALLV 383
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
105-511 2.77e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 2.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17474  42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAmGIVCFLFLIEHPKDVKcsstlpthPRASENG 264
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPV-AFLAILFLLPEPKEKA--------KSSSATK 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 265 INRFRLQKqttysekngpldpelqclllsdgknplhpshivvlpaDGNMAAISFTGAlripgvieFSLCLLFaklvsYTF 344
Cdd:cd17474 188 LRDLKKAL-------------------------------------RGRGLLTFLVSA--------FLYFFLY-----FAF 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 345 LFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISD-RLEKRASTCGLMLLLAApTLYVFSSVSRMGLeaTIAM 423
Cdd:cd17474 218 LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYAL-SLLLLGFVPSLAL--LLIA 294
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 424 LLLSGALVSGPYALITTAVSAdlGTHKSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFADACA 503
Cdd:cd17474 295 IVLFGLGLGLNLPLLTTLVTE--LAPEEERG------TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366

                ....*...
gi 23346457 504 LLFLVRLI 511
Cdd:cd17474 367 AAVLLALL 374
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
106-476 3.65e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 43.14  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   106 FLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfyNIHSLGFYVVTQ-IINGLVQttgwPSVVTCLSNWF 184
Cdd:TIGR00711  46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP--NLELMIIFRVIQgFGGGPLI----PLSFSTLLNIY 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEHpkdvkcsstlptHPRASEN 263
Cdd:TIGR00711 120 PPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYhWRWIFLINVPIGIIVVVVAFFILPRD------------KPAASEN 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   264 gINRFRLQKqttysekngpLDPELQCLL--LSDGKNP--LHPSHIVVLPADGNMAAISFTGA----------LRIPGVIE 329
Cdd:TIGR00711 188 -FDFLGLLL----------LSVGLGSLLygLSEGPERgwFDSNEILILSITGLVAIIAFVVWeltddnplvdLRLFKYRN 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457   330 FS---LCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTlfdVGGIFGGI---LAGVISDRL-EKRASTCGLMLLLA 402
Cdd:TIGR00711 257 FTigcVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHIL---PVGLAPMLsspIAGRMGDKIdPRKLVTIGLILYAV 333
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23346457   403 APTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgNSHALSTVTAIIDGTGSVGAAL 476
Cdd:TIGR00711 334 GFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHK----IARGSSLSNFTRQLGGSIGTAL 403
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
357-509 3.85e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.95  E-value: 3.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 357 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLeatIAMLLLSGALVSGPYA 436
Cdd:COG2223  36 GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL---LLLGLLLGIGGGGSFA 112
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23346457 437 LITTAVSAdlGTHKSLKGnshalsTVTAIIDGTGSVGAALGPLLAG-LISPSGWSNVFYM---LMFADACALLFLVR 509
Cdd:COG2223 113 VGIALVSK--WFPPDRRG------LALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLIlgiLLLVVAVLAWLFLR 181
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
331-512 6.30e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.29  E-value: 6.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 331 SLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcgLMLLLAAPTLYVFS 410
Cdd:cd17371 215 SLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN----NFALFALGSAISIL 290
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 411 SVSRMGLEATIAMLLLS--GALVSGPYALITTAVSADLGThkSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPSG 488
Cdd:cd17371 291 LYFFLPLSPTLILILGFplGFFASGPFSGMGAYLTELFPT--AVRA------TAQGFCYNVGRIIGALFPFLVGFLATSG 362
                       170       180
                ....*....|....*....|....*
gi 23346457 489 -WSNVFYMLMFADACALLFLVRLIH 512
Cdd:cd17371 363 sLGTAIAVFAAVYYIAGLVLALLLP 387
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
357-511 1.11e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 357 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSrmgleatIAMLLLSGALVSGPYA 436
Cdd:cd17324  30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-------FALLLLARALAGLAHG 102
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23346457 437 L---ITTAVSADLgTHKSLKGnsHALSTVTAIIdgtgSVGAALGPLLAGLISPS-GWSNVFYMLMFADACALLFLVRLI 511
Cdd:cd17324 103 GfwaIAAAYAADL-VPPEKRG--RAIGLVFSGL----TLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLL 174
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
116-510 1.37e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 116 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLvqttGWPSVVTCLSNW----FGKGRRGL 191
Cdd:cd17489  50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLL-----ATSVALLLVLRLIHGI----GWGAFTTAAATLvadiIPPSRRGE 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 192 IMGIWNSHTSVGNILGSLIaGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcsstlPTHPRASENGINRFRLQ 271
Cdd:cd17489 121 GIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLFIVAAVLALLALLLVFLV------------KDPPPVAAEEAEAGTRA 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 272 KqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLY 351
Cdd:cd17489 188 F-----------------------------------------------RRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 352 itsVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLyvfssvsrMGLEATIAMLLLSGAL 430
Cdd:cd17489 221 ---AAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKgPKTVIIPGLLLLALGLLL--------LSFAGSPWMLLLAAVL 289
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 431 VSGPYALITTAVSADLG--THKSLKGnsHALSTVTAIIDgtgsVGAALGPLLAGLISPS-GWSNVFYMLMFADACALLFL 507
Cdd:cd17489 290 YGLGFGLLFPALQALAVdlVPPHRRG--AANGTFFIFFD----LGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALVLY 363

                ...
gi 23346457 508 VRL 510
Cdd:cd17489 364 IFL 366
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
105-229 1.51e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.00  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLgfyVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17380  42 SFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLL---ILSRILLGLGEGVHFPSMTSLFSRWV 118
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAI 229
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYgWPSVFYFFGLL 164
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
313-484 3.53e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.84  E-value: 3.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 313 MAAISFTGALRIPGVIEFSLCL--------------------LFAKLVSYTFLFWLPLYITSVDhLDAKKAGELSTLFDV 372
Cdd:cd17352 151 LDNYGWRGALLILGGLCLNLCVcglllrllkdptfvllalgvSFAMLGFFVPFVYLPSYAKSLG-IDESDAAFLLSIIGI 229
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 373 GGIFGGILAGVISDRLEKRASTCGLMLLLAApTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKsl 452
Cdd:cd17352 230 SDIVGRILLGLLADKPRIGRLYLYIFTLLIL-GLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEK-- 306
                       170       180       190
                ....*....|....*....|....*....|..
gi 23346457 453 kgnshaLSTVTAIIDGTGSVGAALGPLLAGLI 484
Cdd:cd17352 307 ------LSNAYGLVLLFQGLAALVGPPIAGLL 332
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
105-242 3.83e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 3.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFglgYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSN-- 182
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADvv 348
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23346457 183 -----WFGKGRRGLIMGIWNSHTSVGNILGSLIAGyWVSTCWGLSFIVPGAIVAAMGIVCFLFLI 242
Cdd:COG2211 349 dydewKTGRRREGLYFGIFTFAIKLGQALAGALAG-LLLALFGYVAGAAQSPSALTGIRLLFFLL 412
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
368-531 5.12e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.18  E-value: 5.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 368 TLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEATIAmLLLSGALVSGPYALITTAVSADLG 447
Cdd:cd17355  45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWG-LLGGGGAGTLAAVAFATVAAWWFE 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 448 THKSLkgnshALSTVTAiidGTGSVGAALGPLLAGLISPSGWSNVFYMLMFADACALLFLVRLIHKELSCPGPAAGIQAP 527
Cdd:cd17355 124 RRRGL-----ALGILTA---GGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDAS 195

                ....
gi 23346457 528 LKEH 531
Cdd:cd17355 196 PASP 199
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
97-239 6.00e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.06  E-value: 6.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  97 QLLGALDYA-FLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGL---VQTTG 172
Cdd:cd17370 233 AALIPLLYAlFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG-----SSLWLLLLGFILWGLymgAQESI 307
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23346457 173 WPSVVTCLSnwfGKGRRGLIMGIWNSHTSVGNILGSLIAGY-WVSTCWGLSFIVpGAIVAAMGIVCFL 239
Cdd:cd17370 308 ERAAVADLV---PAELRGTAYGLFNTVVGIGWLLASLIAGYlWDLISPSAAFLF-SAVLALIALLLLL 371
PRK03699 PRK03699
putative transporter; Provisional
325-509 9.04e-03

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 38.37  E-value: 9.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  325 PGVIEFSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMlLLAAP 404
Cdd:PRK03699 205 IGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLA-GLALV 283
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457  405 TLYVFSSVSRMGLEATIAMLLlsGALVSGPYALITTavsadLGTHKSlkgnSHALSTVTAIIDGTGSVGAALGPLLAGLI 484
Cdd:PRK03699 284 LMYLFVNTDDPSHLLYAILGL--GFFSSAIYTTIIT-----LGSQQT----KVASPKLVNFILTCGTIGTMLTFVVTSPI 352
                        170       180       190
                 ....*....|....*....|....*....|..
gi 23346457  485 -SPSGW------SNVFYMLMFADACALLFLVR 509
Cdd:PRK03699 353 vAHFGLqaalltANGLYAVVFVMCILLGFVSK 384
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
357-516 9.91e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 9.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 357 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcglMLLLAAPTLYVFSSVSrmGLEATIAMLLLSGA---LVSG 433
Cdd:cd17474  30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKK-----VLLPGLLLFGIGGLLC--GLSDSFALLLAGRAlqgIGAA 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 434 PYALITTAVSADLGTHKSLkgnSHALSTVTAIIdgtgSVGAALGPLLAGLISPSGWSNVFYMLMFADACALLFLVRLIHK 513
Cdd:cd17474 103 GLGPLALTLIGDLFEGGER---AKAMGLYEAAL----GLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPE 175

                ...
gi 23346457 514 ELS 516
Cdd:cd17474 176 PKE 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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