|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
21-514 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 679.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKQCtagdgpespfsdpssSTRHGPTHWLLNNETDCGWAPFDKNNYQQLLG 100
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNC---------------SALIPPPNIVLNNTTWCGWAPFDGKNGTELLG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCL 180
Cdd:cd17344 66 ALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 181 SNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpthpra 260
Cdd:cd17344 146 GNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 261 senginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLV 340
Cdd:cd17344 211 ----------------------------------------------------------------PGVIEFSLCLFFAKLV 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 341 SYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEAT 420
Cdd:cd17344 227 SYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTN 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 421 IAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFAD 500
Cdd:cd17344 307 IVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAAD 386
|
490
....*....|....
gi 23346457 501 ACALLFLVRLIHKE 514
Cdd:cd17344 387 VCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
21-511 |
3.41e-101 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 310.40 E-value: 3.41e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKQCTagdgpesPFSDPSSSTRHGPThWLLNNETDcgwapfDKNNYQQLLG 100
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWT-------PSNSNTSIELHEET-WNANPLFP------SQDDAALFLG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGL----GYFYNIHslgFYVVTQIINGLVQTTGWPSV 176
Cdd:cd17342 67 VLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVltewLHFYNKY---LYCILWVLNGLLQSTGWPCV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 177 VTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpt 256
Cdd:cd17342 144 VAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP----------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 257 hprasenginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLF 336
Cdd:cd17342 213 --------------------------------------------------------------------PGVIPYSLAYAC 224
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 337 AKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSV-SRM 415
Cdd:cd17342 225 LKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSpSDK 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 416 GLEATIamLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPS-GWSNVFY 494
Cdd:cd17342 305 VLNAFV--MTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRlGWMWVFY 382
|
490
....*....|....*..
gi 23346457 495 MLMFADACALLFLVRLI 511
Cdd:cd17342 383 FFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-511 |
1.44e-79 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 253.35 E-value: 1.44e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKqctagdgpespfsdpssstrhgpthwllnnetdcgwapfDKNNYQQLLG 100
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE---------------------------------------EIGLSKDDLG 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 101 ALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCL 180
Cdd:cd17312 42 IIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLL 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 181 SNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpthpr 259
Cdd:cd17312 117 GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYgWRAAFLVPGIVGLVVAIILFFFLRDSP-------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 260 asenginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKL 339
Cdd:cd17312 183 -----------------------------------------------------------------PYVWVLSLAYAFVYI 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 340 VSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL--EKRASTCGLMLLLAAPTLYVFSSVSRmGL 417
Cdd:cd17312 198 VRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPH-NK 276
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 418 EATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshALSTVTAIIDGTGSVGAALGPLLAGLISPS-GWSNVFYML 496
Cdd:cd17312 277 LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKE-------AAGTATGFVGLFGYLGASLAGLPLGYIIDHyGWSTVFYFL 349
|
490
....*....|....*
gi 23346457 497 MFADACALLFLVRLI 511
Cdd:cd17312 350 ISAALLSVLLLLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
105-513 |
5.57e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.22 E-value: 5.57e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcsstlpthprasen 263
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLLA--------------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 ginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalripgviefsLCLLFAKLVSYT 343
Cdd:COG2271 187 --------------------------------------------------------------------LAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 344 FLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYVFSSVSrmGLEATIA 422
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLP--SPALAIA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 423 MLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAG-LISPSGWSNVFYMLMFADA 501
Cdd:COG2271 277 LLFLAGFGLGGAFGLLWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALAL 348
|
410
....*....|..
gi 23346457 502 CALLFLVRLIHK 513
Cdd:COG2271 349 LAALLALLLLRE 360
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
99-508 |
3.31e-29 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 119.27 E-value: 3.31e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYnIHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA-TSSVGLMFILLFLNGWFQGMGWPPSGR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWN-SHTSVGNILGSLI---AGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVkcsstl 254
Cdd:cd17345 119 TMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESE------ 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 255 pthprasenGINRFRLQKQTTYSEKNGPLDPElqclllsdgknplhpshivvlpadgNMAA--ISFTGALRIPGVIEFSL 332
Cdd:cd17345 193 ---------GLPPIEEYKGDYPEEADGEEEEQ-------------------------ELSAweIFVKYVLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 333 CLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGLMLLLAAPTLYVFS 410
Cdd:cd17345 239 ANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 411 SVSRMGLEATIAMLLlsGALVSGPYALIttAVSADLGTHKSLKGNSHALSTVTAIIdgtgsVGAALGPLLAGLISP-SGW 489
Cdd:cd17345 319 LAPNVLVDLIALIAL--GFLIYGPVMLI--GLQALELVPKKAAGTAAGLTGLFGYL-----GGSVLATALIGIIVDhFGW 389
|
410
....*....|....*....
gi 23346457 490 SNVFYMLMFADACALLFLV 508
Cdd:cd17345 390 NGGFIVLLASCILAIIFLA 408
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
99-493 |
2.01e-27 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 113.62 E-value: 2.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgyFYNihSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWV--STCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPT 256
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEM 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 257 HPRASEnginrfrlQKQTTYSEKNGPLDPELQCLLLSdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLF 336
Cdd:TIGR00881 187 PNEEPD--------GDAEKKEEELTKKQIFLQYVLLN-------------------------------KVLWYISLGYVF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 337 AKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR-------ASTCGLMLLLAAPTLYVF 409
Cdd:TIGR00881 228 VYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGrrgplavFFMALIIVSLLVYWLNPA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 410 SSVSRMgleatIAMLLLSGALVSGPYALIttavsadlGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPL-LAGLISPSG 488
Cdd:TIGR00881 308 ANPLMD-----LICLFALGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADGFG 374
|
....*
gi 23346457 489 WSNVF 493
Cdd:TIGR00881 375 WAGAF 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
105-510 |
1.69e-25 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 107.66 E-value: 1.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLiehpkdvkcsstlpthprasen 263
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFgWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 ginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLVSYT 343
Cdd:cd17319 179 -------------------------------------------------------------RQVWGLALGYFGINYALYG 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 344 FLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEATIAM 423
Cdd:cd17319 198 LLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 424 LLLSGALVSGPYALITTaVSADLgthkslkGNSHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFADA 501
Cdd:cd17319 278 LSLAGFGIGAASPVFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLIGYLvdATGSYTAAFLFLAAVAL 349
|
....*....
gi 23346457 502 CALLFLVRL 510
Cdd:cd17319 350 LAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
109-514 |
2.29e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 96.10 E-value: 2.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:COG2223 52 VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPTHprasenginr 267
Cdd:COG2223 127 RGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 268 frlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaiSFTGALRIPGVIEFSLCLLFAKLVSYTFLFW 347
Cdd:COG2223 197 -------------------------------------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSW 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLeATIAMLLLs 427
Cdd:COG2223 228 LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL-FLVLFLLL- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 428 GALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFADACALL 505
Cdd:COG2223 306 GLALGGGNGAVFALVPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALldATGSYTAAFLVFAVLALVALV 377
|
....*....
gi 23346457 506 FLVRLIHKE 514
Cdd:COG2223 378 LTLLLYRRP 386
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-478 |
1.63e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.09 E-value: 1.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 98 LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVV 177
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 178 TCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVS-TCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKcsstlpt 256
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 257 hprasenginrfrlqkqttysekngpldpelqclllsdgknplhpshivVLPADGNMAAISFTGALRIPGVIEFSLCLLF 336
Cdd:pfam07690 181 -------------------------------------------------KPAEEARLSLIVAWKALLRDPVLWLLLALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 337 AKLVSYTFLFWLPLYITsVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMG 416
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLS 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23346457 417 LEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnshalSTVTAIIDGTGSVGAALGP 478
Cdd:pfam07690 291 SLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER--------GTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
105-508 |
1.92e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.10 E-value: 1.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVStCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPTHPRASEng 264
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILAS-SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK-- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 265 inrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnMAAISFTGALRIPGVIEFSLCLLFAKLVSYTF 344
Cdd:cd06174 191 ------------------------------------------------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 345 LFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFssVSRMGLEATIAML 424
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL--LLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 425 LLSGALVSGPYALITTAVSADLgthkslkgNSHALSTVTAIIDGTGSVGAALGPLLAGLISPS--GWSNVFYMLMFADAC 502
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELF--------PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtfGLTGAFLVLAVLLLL 372
|
....*.
gi 23346457 503 ALLFLV 508
Cdd:cd06174 373 AAILLL 378
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
109-510 |
6.08e-18 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 85.85 E-value: 6.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgYFyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:cd17343 50 AYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS--GS---SSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGYWV-STCWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVkcsstlpthprasenGINR 267
Cdd:cd17343 125 FGTWWSVLSTSMNLAGSLGPILATLLAlSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDV---------------GLNN 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 268 FRLQKQTTYSEKNGPLDPELQCLLLSdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFAKLVSYTFLFW 347
Cdd:cd17343 190 IEEEESKGKKKKSPRGESTLKELLLS-------------------------------PFLWLLSLGYLVVFGVKTAVTDW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCG----------LMLLLAAPTLYVFS-SVSRMG 416
Cdd:cd17343 239 GQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSrgnprmplalVFMAGLTVSLHLFRvHITSDS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 417 LEATIAML-LLSGALVSGPYALIttAVSADLGTHKSLKGNSHALSTVTAiidgtgSVGAALGPLLAGLISPS-GWSNVFY 494
Cdd:cd17343 319 SELFILLLgFLIGFSLYGPIAIF--GVIANESAPSHLCGTSHAIVALAA------NVGGVLAGLPFSYIAKHyDWRTAFL 390
|
410
....*....|....*.
gi 23346457 495 MLMFADACALLFLVRL 510
Cdd:cd17343 391 LLEILCAITVVILFLL 406
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
99-507 |
5.53e-16 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 80.14 E-value: 5.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:PRK11663 60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVST-CWGLSFIVPGAIvaamGIVCFLFLIEHPKDVKCSSTLPTh 257
Cdd:PRK11663 135 LLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHyGWRYGMMIAGII----AIVVGLFLCWRLRDKPQAMGLPS- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 258 prasengINRFRLQKQTTYSEKNGPLDPELQCLLLSDGKNPlhpsHIVVLpadgnmaaisftgalripgviefSLCLLFA 337
Cdd:PRK11663 210 -------VGEWRHDALELAQQQEGAGLSRKEILTKYVLLNP----YIWLL-----------------------SFSYVLV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 338 KLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAptLYVFSSVSRMGL 417
Cdd:PRK11663 256 YVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFN--GNRGPMNLIFA--AGILLSVGSLWL 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 418 EATIAMLLLSGAL------VSGPYALITTAvsADLGTHKSLKGnshalsTVTAIIDGTGSVGAAL-GPLLAGLISPSGWS 490
Cdd:PRK11663 332 MPFASYVMQAACFftigffVFGPQMLIGMA--AAECSHKEAAG------AATGFVGLFAYLGAALsGYPLAKVLEIWHWT 403
|
410
....*....|....*..
gi 23346457 491 NVFYMLMFADACALLFL 507
Cdd:PRK11663 404 GFFVVISIAAGISALLL 420
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
105-476 |
6.05e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 79.25 E-value: 6.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEhpkdvkcsstlpTHPRASEN 263
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWVFLVNAVLALLALLLLLRLLPE------------SRPAARAR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 GINRFRLqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgALRIPGVIEFSLCLLFAKLVSYT 343
Cdd:COG2814 196 LRGSLRE--------------------------------------------------LLRRPRLLLLLLLAFLLGFGFFA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 344 FLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYVFSSvsrmGLEATIA 422
Cdd:COG2814 226 LFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFgRRRLLLIGLLLLALGLLLLALAG----SLWLLLL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 23346457 423 MLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAAL 476
Cdd:COG2814 302 ALFLLGFGFGLLFPLLQALVAELAPP--------EARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-511 |
4.79e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 4.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:cd17325 43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGYwVSTCWGLSFivPGAIVAAMGIVCFLfliehpkdvkcsstlpthprasenginrf 268
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRA--PFLVCAALALLALV----------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 269 rlqkqttysekngpldpeLQCLLLSDGKNPLHPSHIVVLPADGNMAAISFTGALRIPGVIEFSLCLLFAKLVSYtflfwL 348
Cdd:cd17325 166 ------------------LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF-----L 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 349 PLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRaSTCGLMLLLAAPTLYVFSSVSrmgleaTIAMLLLSG 428
Cdd:cd17325 223 PLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT------SFWLLLLLL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 429 ALVSGPYALITTAVSADLG--THKSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPS-GWSNVFYMLMFADACALL 505
Cdd:cd17325 296 ALLGLGLGLVFPATLALLAdiVPPEGRG------TAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAAAALLLLAAV 369
|
....*.
gi 23346457 506 FLVRLI 511
Cdd:cd17325 370 LFLLLR 375
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
99-511 |
7.93e-15 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 75.91 E-value: 7.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:cd17488 40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPPCAR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVST-CWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlpth 257
Cdd:cd17488 115 LLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTyGWRAGMYVPGIIAILMGIVLCWRLRDRP------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 258 prasenginrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftgalriPGVIEFSLCLLFA 337
Cdd:cd17488 183 -------------------------------------------------------------------PYIWLLAFCYVLV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 338 KLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAPTLYV------FSS 411
Cdd:cd17488 196 YVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK--GNRGPMNLIFALGLLVsvgalwLVP 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 412 VSRMGLEATiaMLLLSGALVSGPYALIttAVSADLGTHKSLKGnshalsTVTAIIDGTGSVGAAL-GPLLAGLISPSGWS 490
Cdd:cd17488 274 VHSYWLLAT--CFFTIGFFVFGPQMLI--GMAAAECSHKDAAG------SATGFVGLFAYLGAALaGYPLAKVIESWGWS 343
|
410 420
....*....|....*....|.
gi 23346457 491 NVFYMLMFADACALLFLVRLI 511
Cdd:cd17488 344 GFFIVISIAAAISGLLLLPLL 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
99-513 |
1.71e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.19 E-value: 1.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTqIINGLVQTTGWPSVVT 178
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLG-LGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 ClsnwfGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcsstlpthp 258
Cdd:COG0738 124 L-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL---------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 259 rasenginRFRLQKQTTYSEKNGPldpelqclllsdgknplhpshivvlpadgnmAAISFTGALRIPGVIEFSLCLLFAK 338
Cdd:COG0738 183 --------RSKLPEIEEEEEEAAG-------------------------------SAASLKSLLKNPRLLLGGLAIFLYV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 339 LVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYVFSSVSrmGLE 418
Cdd:COG0738 224 GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAP--GPW 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 419 ATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshalSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMF 498
Cdd:COG0738 301 LALIGLALVGLGLSLMFPTIFSLALDGLGKRT---------AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPL 371
|
410
....*....|....*
gi 23346457 499 ADACALLFLVRLIHK 513
Cdd:COG0738 372 VCYLLILLLALALKR 386
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
99-508 |
1.76e-12 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 69.31 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVVT 178
Cdd:PRK09556 66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLS----FIVPGAIVAAMGIVCFLFLIEHPKdvkcsstl 254
Cdd:PRK09556 146 TITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHvigmFIFPSIIALIIGFIGLRYGSDSPE-------- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 255 pthprasENGINRfrlqKQTTYSEKNGPLDPELQCLLLSDGKnplhpshivvlpadgnmaaISFTGALRIPGVieFSLCL 334
Cdd:PRK09556 218 -------ELGWGK----AEEIFGEPISEEDKETESTDMTKWQ-------------------IFVEYVLKNPVI--WLLCF 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 335 --LFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE-KRASTCGLMLLLAAPTLYVFSS 411
Cdd:PRK09556 266 anIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANgRRALVACIALALIIFTLGVYQH 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 412 VSRMGLeaTIAMLLLSGALVSGPYALI------------TTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPL 479
Cdd:PRK09556 346 ATSEYM--YLASLFALGFLVFGPQLLIgvaavgfvpkkaIGVANGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFGYT 423
|
410 420
....*....|....*....|....*....
gi 23346457 480 LaglispSGWSNVFYMLMFADACALLFLV 508
Cdd:PRK09556 424 L------TGWAGTFAALDIAAIGCICLMA 446
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
87-507 |
4.03e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.65 E-value: 4.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 87 WAPFDKNNYQ----QLLGALDYAFLcAYAIGMYLSGIIGERLPIRYYLTFGMLASGAftALFGLGYFYNIHSLG-FYVVT 161
Cdd:cd17475 18 LAPFLQEDLHlslaQVGLLLSALNL-GVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLvLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 162 QIINGLVQTTGWPSVVTclsnWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLF 240
Cdd:cd17475 95 GAGYGSVQPGGGRAIMR----WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYgWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 241 LIEHPkdvkcsstlpthprasenginrfrlqkqttysekNGPLDPELQCLLLSDGKNPLHpshivvlpaDGNMAAISFTG 320
Cdd:cd17475 171 YREPP----------------------------------AASAATESASTLLRSLKEVLR---------NRDVWLIAIAG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 321 ALRIpgviefslcllfakLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE--KRASTCGLM 398
Cdd:cd17475 208 ALLV--------------APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggRRRPVLVIT 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 399 LLLAAPTLYVFSSVSRMGLEATIAMLL-LSGALVSGPYALITTAVSADLGTHKSlkgnSHALSTVTAIIdgtgSVGAALG 477
Cdd:cd17475 274 AAIAAAALLVLSLLSPGTPLWLLVLLLiLLGLFAIGWNGLYLTLVAESAGPEQA----GTALGLANTIN----FIGIAIG 345
|
410 420 430
....*....|....*....|....*....|..
gi 23346457 478 PLLAGLISP--SGWSNVFYMLMFADACALLFL 507
Cdd:cd17475 346 PPLFGLLVDatHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
97-507 |
1.52e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.11 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 97 QLLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSV 176
Cdd:cd17328 34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF-----APNFWQLLLFRALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 177 VTCLSNWFGKGRRGLIMGIWNSHTSVGNILG----SLIAGYWVStcWGLSFIVPGAIVAAMGIVCFLFLIEHPKdvkcss 252
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGyvvgGLVAQATGG--WRWAFRVTGVLGVLLAILLLLFVREPPR------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 253 tlpthpRASENGinrfrlqkqttysekngpldpelqclllsdgknPLHPSHIVVLPADgnMAAIsftgaLRIPGVIEFSL 332
Cdd:cd17328 181 ------GAAEGG---------------------------------VMAKSTATSFLAD--LKAL-----AKNPSFILSTL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 333 CLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFD----VGGIFGGILAGVISDRLEKRAST-----CGLMLLLAA 403
Cdd:cd17328 215 GFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKTPRadplvCAVGLLAAA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 404 PTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSAD-LGTHKSLkgnSHALSTVTaiidgTGSVGAALGPLLAG 482
Cdd:cd17328 295 PFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVvIPTRRST---ASAIQILL-----SHLLGDAGSPYLIG 366
|
410 420
....*....|....*....|....*
gi 23346457 483 LISPSGWSNVFYMLMFADACALLFL 507
Cdd:cd17328 367 LISDLLRQNKDSPLAEAASLQYALL 391
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
109-510 |
7.70e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.12 E-value: 7.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTG---WPSVVtclSNWFG 185
Cdd:COG2807 65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGnvlLPGLI---KRWFP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 186 KgRRGLIMGIWNSHTSVGNILGSLIAGYWV-STCWGLSFIVPGAIVAAMGIVCFLFLIEHPkdvkcsstlPTHPRASeng 264
Cdd:COG2807 137 D-RVGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAVWALLALLALLLWLPLLRRRP---------AAAAAAP--- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 265 inrfrlqkqttysekngpldpelqclllsdgknplhpshivvlpadgnmAAISFTGALRIPGVIEFSLCLLFAKLVSYTF 344
Cdd:COG2807 204 -------------------------------------------------AAASLRSLWRSPLAWLLTLFFGLQSLLYYAV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 345 LFWLPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcGLMLLLAAPTLYVFSSVSRMGLEATIAML 424
Cdd:COG2807 235 VAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRR---PLLLLLGLLGLAGLLGLLLAPGSLPWLWA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 425 LLSGALVSGPYALITTAVSADLGTHkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFADAC 502
Cdd:COG2807 311 VLLGLGQGGLFPLALTLIGLRARTP-------AEAAALSGMAQSVGYLLAALGPLLVGALhdATGSWTAALLLLAALAVL 383
|
....*...
gi 23346457 503 ALLFLVRL 510
Cdd:COG2807 384 MLVAGLLA 391
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
109-438 |
8.97e-11 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 63.96 E-value: 8.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:PRK11273 75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWN-SHTSVGNILGSL-IAGYWVSTCWGLSFIVPGAivAAMGIVCFLFLIEhpKDVKCSSTLPThprasengIN 266
Cdd:PRK11273 154 RGGIVSVWNcAHNVGGGLPPLLfLLGMAWFNDWHAALYMPAF--AAILVALFAFAMM--RDTPQSCGLPP--------IE 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 267 RFRLQKQTTYSEKNgplDPELqclllsdgknplhpshivvlpadgNMAAISFTGALRIPGVIEFSLCLLFAKLVSYTFLF 346
Cdd:PRK11273 222 EYKNDYPDDYNEKH---EQEL------------------------TAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 347 WLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGL-MLLLAAPTL-YVFSSVSRMGLEatIA 422
Cdd:PRK11273 275 WSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgnRGATGVFfMTLVTIATIvYWLNPAGNPTVD--MA 352
|
330
....*....|....*.
gi 23346457 423 MLLLSGALVSGPYALI 438
Cdd:PRK11273 353 CMIVIGFLIYGPVMLI 368
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
90-506 |
1.24e-09 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 60.53 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 90 FDKNNYQQ--LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfynihslGFYVVTQIINGL 167
Cdd:TIGR00894 67 KNPNFKWSgaLQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA-------GGGIALVVFCRV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 168 VQTTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGY------WVSTCWGLSFIVPGAIVAAMGIVCFLFL 241
Cdd:TIGR00894 140 IQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPisgwlcESWGGWPMIFYVFGIVGCAWSLLWFVFP 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 242 IEHPKDVKCSStlpthpRASENGINRfRLQKQTTYSEKNGPLDPELQCLllsdgknplhpshivvlpadgNMAAISFTga 321
Cdd:TIGR00894 220 ADDPSIHPCIS------KFEKKYINS-SLQGQKGSTRQSLPIKAIPKSL---------------------PVWAIWFA-- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 322 lripgviefslclLFAKLVSYTFLF-WLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR--------- 391
Cdd:TIGR00894 270 -------------IFGHFWLYTILPtYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSktlsltaar 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 392 ---ASTCGLMLLLAAPTLYVFSSvsrmGLEATIAMLLLSGALVSGPYALITTAvsadlgthkSLKGNSHALSTVTAIIDG 468
Cdd:TIGR00894 337 kifNGIGGLGPGIFAYALPYLSA----AFYLTIIILTLANAVSSGPLAGVLIN---------SLDLAPRFLGFIKGITGL 403
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 23346457 469 TGSVGAALGPLLAGLI----SPSGWSNVFYMLMFADACALLF 506
Cdd:TIGR00894 404 PGFIGGLIASTLAGNIlsqdSKNVWLIVFLIMAFVNILCVIF 445
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-506 |
3.69e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.71 E-value: 3.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 109 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 188
Cdd:cd17324 46 GYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 189 RGLIMGIWNSHTSVGNILGSLIAGyWVSTCWGLSFIVpgAIVAAMGIVCFLFLIehpkdvkcsSTLPTHPrasenginrf 268
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAF--LAIAVLALLAALLLW---------RLLPSLP---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 269 rlqkqttysekngpldpelqclllsdgknplhPSHIVVLPADGNMAAISFTGALRIPGVIEFslCLLFAKLVSYTFLfwl 348
Cdd:cd17324 179 --------------------------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITF--LLFGGFFALYTYL--- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 349 PLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAptLYVFSSVSRMGLEATIAMLLLSG 428
Cdd:cd17324 222 APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA--LLLLTLLGPSPLLLLVGLVLWGL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23346457 429 ALVSGPYALITTAVSAdlgthkslkgNSHALSTVTAIIDGTGSVGAALGPLLAGL-ISPSGWSNVFYMLMFADACALLF 506
Cdd:cd17324 300 GFFAAHSALQTRVLRL----------APEARGLASSLYLAAYNLGGALGAALGGLvLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
99-507 |
1.29e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.95 E-value: 1.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGL----VQTTGWP 174
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT-----PSIYLFVVLMFLAGLgagiLDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 175 SVVTCLSNwfgkgRRGLIMGIWNSHTSVGNILGSLIAGY--WVSTCWGLSFIVPGAIVAAMGIVCFLFLiehpkdvkcss 252
Cdd:cd17333 108 FVGALFEE-----SSATRLNVLHGFFGLGALIGPLIATSllTSELSWSWAYLIIGLIYLLLAILILLTL----------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 253 tLPTHPRASENginrfrLQKQTTYSEkngpldpelqclllsdgknplhpshivvlpadgnmaaiSFTGALRIPGVIEFSL 332
Cdd:cd17333 172 -FPELPSARNP------QQSVGAFSA--------------------------------------SASRLLRNPSIILGAL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 333 CLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLekrASTCGLMLLLAAPTLYVFSSV 412
Cdd:cd17333 207 ALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI---KPHTLLVLSGSGALLGLLILL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 413 SRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshalSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNV 492
Cdd:cd17333 284 LAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK---------GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQT 354
|
410
....*....|....*
gi 23346457 493 FyMLMFADACALLFL 507
Cdd:cd17333 355 A-MLLITILYAIIFV 368
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
99-482 |
1.65e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.60 E-value: 1.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 99 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHSLGFYvvtQIINGLVQTTGWPSVVT 178
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLIL---RFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 179 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLiehpkdvkcsstlpth 257
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFgWRSLFYVGGIAPLLLLLLLMRFL---------------- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 258 PRASENGINRFRLQKQTTYSEKNGPLDPELQCLLLSDGKNPLHPSHIVVLPADGNMAAISFtgalripgvieFSLCLLFA 337
Cdd:TIGR00895 193 PESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITV-----------LLWLLYFM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 338 KLVSYTFLF-WLPlYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAStcGLMLLLAAPTLY-VFSSVSRM 415
Cdd:TIGR00895 262 LLVGVYFLTnWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT--ALLLLLGAVFAVlVGSTLFSP 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23346457 416 GLEATiaMLLLSGALVSGPYALittavsadLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAG 482
Cdd:TIGR00895 339 TLLLL--LGAIAGFFVNGGQSG--------LYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
67-508 |
2.24e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 56.09 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 67 SSSTRHGPTHWLLNNETDCGWAPFDKNNYQQllGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgL 146
Cdd:cd17318 28 STATHDNNNTSTDKDTLPVEAPEFDWSEKTQ--GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLL--T 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 147 GYFYNIHsLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIV 225
Cdd:cd17318 104 PLAARGG-YGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLgWPSIFYI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 226 PGAIvaamGIVCFLFLIehpkdvkcsstlpthprasenginrfrlqkqttysekngpldpelqclllsdgknplhpshIV 305
Cdd:cd17318 183 FGGL----GLLWCLLWF-------------------------------------------------------------FL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 306 VLPADGNMAAiSFTGALripgviefslcllfaklVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVIS 385
Cdd:cd17318 198 VLPVWAIVVA-HFGHNW-----------------GFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLA 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 386 DRLEKRastcGLMLLLAapTLYVFSSvsrmgleatIAMLLLSGALVSGPY---------ALITTAVSADLGTHKSLKGNS 456
Cdd:cd17318 260 DWLRSR----GILSTTT--VRKLFTS---------IGFLGPGVFLIALGYlgsnatlavVFLTLSVGLSGACYSGFLVNH 324
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23346457 457 HALS-----TVTAIIDGTGSVGAALGPLLAGLI-----SPSGWSNVFYMLMFADA-CALLFLV 508
Cdd:cd17318 325 LDLApnyagTLMGITNTAATIAGIISPLIVGAIvkndqTIGQWRIVFFISAAIYIlGAIFYLI 387
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
331-508 |
4.42e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.30 E-value: 4.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 331 SLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAsTCGLMLLLAAPTLYVFS 410
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK-TLVIGLILSGILALPLF 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 411 SVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWS 490
Cdd:cd17316 262 YLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT--------EVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170
....*....|....*...
gi 23346457 491 NVFYMLMFADACALLFLV 508
Cdd:cd17316 334 TGVPALILALLAIVALIV 351
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
105-247 |
3.04e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 52.64 E-value: 3.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17327 49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAgYWVSTC--------WGLSFIVPGAIVAAMGIVCFLFLIEHPKD 247
Cdd:cd17327 124 KREEQAKRIAFFYAAAGLGSIFGGLLA-YGVFKIlgvgglagWRWLFIIEGLITIIIGLVIFFWLPDNPSK 193
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
330-528 |
4.96e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 330 FSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYV 408
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFgRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 409 FSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSAdlgthkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLISPS- 487
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP------------EERGRALGLVSAGFGLGAALGPLLGGLLASLf 148
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 23346457 488 GWSNVFYMLM-FADACALLFLVRLIHKELSCPGPAAGIQAPL 528
Cdd:pfam07690 149 GWRAAFLILAiLSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
105-243 |
5.56e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.35 E-value: 5.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELF 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVpGAIVAAMGIVCFLFLIE 243
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALgWRWIFLI-NAPLGLLALVLRLRLPE 190
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
348-514 |
2.13e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.88 E-value: 2.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYVFSSvsrmgleaTIAMLLL 426
Cdd:cd17325 19 LPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFgRKRLLLLGLLLLAVSTLLFAFAT--------SYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 427 S---GALVSGPYALITTAVSADLGTHKSLkgnSHALSTVTAIIdgtgSVGAALGPLLAGLISP-SGWSNVFYMLMFADAC 502
Cdd:cd17325 90 ArflQGLASAAVWPAAMALIADIAPPEER---GRAMGIFSSAI----GLGFLIGPLLGGLLADaLGYRAPFLVCAALALL 162
|
170
....*....|..
gi 23346457 503 ALLFLVRLIHKE 514
Cdd:cd17325 163 ALVLALLLLPEP 174
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
339-512 |
3.02e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.51 E-value: 3.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 339 LVSYTFLFWLPLYITSVDhLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVfsSVSRMGLE 418
Cdd:cd17365 185 LLVYLLNSWLPKLMVEAG-YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALL--GVSPASLV 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 419 ATIAMLLLSGALVSGPYALItTAVSADLGThkslkgnSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMF 498
Cdd:cd17365 262 LLYVLVFLAGACVNGAQVGL-YALAARFYP-------TEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLAL 333
|
170
....*....|....
gi 23346457 499 ADACALLFLVRLIH 512
Cdd:cd17365 334 AIPAALGALAVLLL 347
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
319-512 |
1.05e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 319 TGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcglm 398
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 399 LLLAAPTLYVFSSVSrMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnSHALSTVTAIIDGTGSVGAALGP 478
Cdd:COG2814 77 VLLLGLLLFALGSLL-CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP----PERRGRALGLLGAGLGLGPALGP 151
|
170 180 190
....*....|....*....|....*....|....*
gi 23346457 479 LLAGLISPS-GWSNVFYMLMFADACALLFLVRLIH 512
Cdd:COG2814 152 LLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
313-488 |
1.15e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.55 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 313 MAAISFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRA 392
Cdd:cd17321 156 NVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 393 STCGLMLLLAAPTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnshalSTVTAIIDGTGSV 472
Cdd:cd17321 236 VLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA--------GAASGILNTARQL 307
|
170
....*....|....*.
gi 23346457 473 GAALGPLLAGLISPSG 488
Cdd:cd17321 308 GGALGVALLGALLTAG 323
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
116-484 |
2.13e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.78 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 116 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVvTCLSNWFGKGRRGLIMGI 195
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEG-ARLASQAAGGRRGLAMSI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 196 WNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcSSTLPTHPRASENGINRFRLQKqtt 275
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR--------PLKKPEAKKAAAKSSARSTLKG--- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 276 ysekngpldpelqclllsdgknplhpshivVLPADGNMAAISFTGALRIPGVIEFSLCLLFAKLVSYTFlfwlplyitsv 355
Cdd:cd17478 193 ------------------------------VWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF----------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 356 dhldakkAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMlLLAAPTLYVFSSVSrmgLEATIAMLLLSGALVSGPY 435
Cdd:cd17478 232 -------AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL-LLAAPFLLLFLLTP---GIWSYILLVLAGFLLFASF 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 23346457 436 ALITTAVsadlgtHKSLKGNshaLSTVTAIIDGTGSVGAALGPLLAGLI 484
Cdd:cd17478 301 PVTVVLA------QELLPGN---VGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
98-510 |
2.33e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 98 LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVV 177
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 178 TCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTcWGLSFIVPGAIVAAMGIVCFLFLIEHPKDVKCSSTLPTH 257
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL-LGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 258 PRASENGINRFRlqkqttysekngpldpelqclllsdgknplhpSHIVVLPADGNMAAISFTGALripgviefslcllfa 337
Cdd:cd06173 194 LRDLREGLRYLR--------------------------------RSPLLRLLLLALALFALLGGA--------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 338 klvsytFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYVFSSVSRMGL 417
Cdd:cd06173 227 ------LTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR-RRGRLLLIGALLLGLALLVLGLSPSLWL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 418 eaTIAMLLLSGalVSGPYALITTAVSADLGTHKSLKGnsHALSTVTAIIDGTGSVGAALGPLLAGLIspsGWSNVFYMLM 497
Cdd:cd06173 300 --LLAALFLLG--LAGGLFNVPLNTLLQLRVPDELRG--RVFSVYNALNSGAMPLGALLAGLLADAL---GLSAVFLLAG 370
|
410
....*....|...
gi 23346457 498 FADACALLFLVRL 510
Cdd:cd06173 371 ALLLLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
330-511 |
3.59e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.27 E-value: 3.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 330 FSLCLLFAKLVSYTFLFWLPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVF 409
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 410 SSVSrmgleatIAMLLLSGALVSGPYALITTAVSADLGTHkslkGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGW 489
Cdd:cd06174 80 FAPS-------FWLLLLGRFLLGLGSGLIDPAVLALIADL----FPERERGRALGLLQAFGSVGGILGPLLGGILASSLG 148
|
170 180
....*....|....*....|..
gi 23346457 490 SNVFYMLMFADACALLFLVRLI 511
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLL 170
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
111-240 |
6.25e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 6.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 111 AIGMYLSG-IIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGRR 189
Cdd:cd17474 248 ALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGF-----VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 23346457 190 GLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLF 240
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFgLSAPFLVGAAIALAAAVLLALL 374
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
332-482 |
1.15e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.57 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 332 LCLLFAKLVSYTFLFWLPLYITSvDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLM--LLLAAPTLYVF 409
Cdd:PRK11551 227 ISYFFTLIVLYFLLNWLPSLLVG-QGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYagILASLAALAAA 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23346457 410 SSVSRMGLEATIAMLLLSGALvSGPYALITTAVSADL-GThkslkgnshALSTVTAIidgtGSVGAALGPLLAG 482
Cdd:PRK11551 306 PSFAGMLLAGFAAGLFVVGGQ-SVLYALAPLFYPTQVrGT---------GVGAAVAV----GRLGSMAGPLLAG 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
317-484 |
1.42e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 317 SFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCG 396
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 397 LMLLLAAPTLyVFSSVSRMGLEATIAMLLLSGALVSGPYALItTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAAL 476
Cdd:COG2211 300 GLLLAALGLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLP-WAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQAL 377
|
....*...
gi 23346457 477 GPLLAGLI 484
Cdd:COG2211 378 AGALAGLL 385
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
348-508 |
1.65e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 348 LPLYITSVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS--TCGLMLLLAAPTLYVFSSVSrmglEATIAMLL 425
Cdd:cd17477 211 LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVllGCALLGALAALLLPLVPGLP----LALLVLLF 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 426 LSGALVSGPYALITTAVSADLGthkslkgnSHALSTVTAIIDGTGSVGAALGPLLAGLIspSGWSNVFYMLMFADACALL 505
Cdd:cd17477 286 LWGGAAGPLYTLALALAGDRLP--------GDELVAANAALLLLYGLGSVIGPLLAGAL--MDAFGPHGLFLFLAAVALL 355
|
...
gi 23346457 506 FLV 508
Cdd:cd17477 356 FLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
94-208 |
2.08e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 94 NYQQLLGALDYAFLCA-YAIGMYLSGIIGERLPIRYYLTFGMLasGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTG 172
Cdd:pfam07690 231 GLSALLAGLLLGLGGLlGAIGRLLLGRLSDRLGRRRRLLLALL--LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
|
90 100 110
....*....|....*....|....*....|....*.
gi 23346457 173 WPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGS 208
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
335-508 |
2.19e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 335 LFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYVFSsvs 413
Cdd:cd17329 9 FLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVmLAGLLLRALGFALLGFA--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 414 rMGLEATIAMLLLSGALvsgpYALITTAVSADLGTHKSLKGNSHALSTVTAIIdgtgSVGAALGPLLAGLISPSGWSNVF 493
Cdd:cd17329 86 -HSPWLFAIALVLTGFG----GGLFEPASEAMIADVTTPENRTRAFSLLYWAI----NLGVAIGPLLGGLLLLYSFRLLF 156
|
170
....*....|....*
gi 23346457 494 ymlmFADACALLFLV 508
Cdd:cd17329 157 ----LAAAVLFLLAA 167
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
363-512 |
2.72e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 363 AGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSsvsrmgLEATIAMLLLSGALVSGPYALITTAV 442
Cdd:cd17355 247 AAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLL------LPFPPLALLLFAALFGLGWGATVPLT 320
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23346457 443 SADLGThkslKGNSHALSTVTAIIDGTGSVGAALGPLLAGLI-SPSGwsnvFYMLMFADACALLFLVRLIH 512
Cdd:cd17355 321 AALAAR----YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLyDRTG----SYTAAWALAVALGLIAALLV 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
105-511 |
2.77e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAmGIVCFLFLIEHPKDVKcsstlpthPRASENG 264
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPV-AFLAILFLLPEPKEKA--------KSSSATK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 265 INRFRLQKqttysekngpldpelqclllsdgknplhpshivvlpaDGNMAAISFTGAlripgvieFSLCLLFaklvsYTF 344
Cdd:cd17474 188 LRDLKKAL-------------------------------------RGRGLLTFLVSA--------FLYFFLY-----FAF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 345 LFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISD-RLEKRASTCGLMLLLAApTLYVFSSVSRMGLeaTIAM 423
Cdd:cd17474 218 LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYAL-SLLLLGFVPSLAL--LLIA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 424 LLLSGALVSGPYALITTAVSAdlGTHKSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFADACA 503
Cdd:cd17474 295 IVLFGLGLGLNLPLLTTLVTE--LAPEEERG------TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
|
....*...
gi 23346457 504 LLFLVRLI 511
Cdd:cd17474 367 AAVLLALL 374
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
106-476 |
3.65e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 43.14 E-value: 3.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 106 FLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfyNIHSLGFYVVTQ-IINGLVQttgwPSVVTCLSNWF 184
Cdd:TIGR00711 46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP--NLELMIIFRVIQgFGGGPLI----PLSFSTLLNIY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVAAMGIVCFLFLIEHpkdvkcsstlptHPRASEN 263
Cdd:TIGR00711 120 PPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYhWRWIFLINVPIGIIVVVVAFFILPRD------------KPAASEN 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 264 gINRFRLQKqttysekngpLDPELQCLL--LSDGKNP--LHPSHIVVLPADGNMAAISFTGA----------LRIPGVIE 329
Cdd:TIGR00711 188 -FDFLGLLL----------LSVGLGSLLygLSEGPERgwFDSNEILILSITGLVAIIAFVVWeltddnplvdLRLFKYRN 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 330 FS---LCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTlfdVGGIFGGI---LAGVISDRL-EKRASTCGLMLLLA 402
Cdd:TIGR00711 257 FTigcVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHIL---PVGLAPMLsspIAGRMGDKIdPRKLVTIGLILYAV 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23346457 403 APTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgNSHALSTVTAIIDGTGSVGAAL 476
Cdd:TIGR00711 334 GFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHK----IARGSSLSNFTRQLGGSIGTAL 403
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
357-509 |
3.85e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.95 E-value: 3.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 357 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLeatIAMLLLSGALVSGPYA 436
Cdd:COG2223 36 GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL---LLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23346457 437 LITTAVSAdlGTHKSLKGnshalsTVTAIIDGTGSVGAALGPLLAG-LISPSGWSNVFYM---LMFADACALLFLVR 509
Cdd:COG2223 113 VGIALVSK--WFPPDRRG------LALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLIlgiLLLVVAVLAWLFLR 181
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
331-512 |
6.30e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.29 E-value: 6.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 331 SLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcgLMLLLAAPTLYVFS 410
Cdd:cd17371 215 SLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN----NFALFALGSAISIL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 411 SVSRMGLEATIAMLLLS--GALVSGPYALITTAVSADLGThkSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPSG 488
Cdd:cd17371 291 LYFFLPLSPTLILILGFplGFFASGPFSGMGAYLTELFPT--AVRA------TAQGFCYNVGRIIGALFPFLVGFLATSG 362
|
170 180
....*....|....*....|....*
gi 23346457 489 -WSNVFYMLMFADACALLFLVRLIH 512
Cdd:cd17371 363 sLGTAIAVFAAVYYIAGLVLALLLP 387
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
357-511 |
1.11e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.38 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 357 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSrmgleatIAMLLLSGALVSGPYA 436
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-------FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23346457 437 L---ITTAVSADLgTHKSLKGnsHALSTVTAIIdgtgSVGAALGPLLAGLISPS-GWSNVFYMLMFADACALLFLVRLI 511
Cdd:cd17324 103 GfwaIAAAYAADL-VPPEKRG--RAIGLVFSGL----TLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLL 174
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
116-510 |
1.37e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.04 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 116 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLvqttGWPSVVTCLSNW----FGKGRRGL 191
Cdd:cd17489 50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLL-----ATSVALLLVLRLIHGI----GWGAFTTAAATLvadiIPPSRRGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 192 IMGIWNSHTSVGNILGSLIaGYWVSTCWGLSFIVPGAIVAAMGIVCFLFLIehpkdvkcsstlPTHPRASENGINRFRLQ 271
Cdd:cd17489 121 GIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLFIVAAVLALLALLLVFLV------------KDPPPVAAEEAEAGTRA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 272 KqttysekngpldpelqclllsdgknplhpshivvlpadgnmaaisftGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLY 351
Cdd:cd17489 188 F-----------------------------------------------RRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 352 itsVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLyvfssvsrMGLEATIAMLLLSGAL 430
Cdd:cd17489 221 ---AAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKgPKTVIIPGLLLLALGLLL--------LSFAGSPWMLLLAAVL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 431 VSGPYALITTAVSADLG--THKSLKGnsHALSTVTAIIDgtgsVGAALGPLLAGLISPS-GWSNVFYMLMFADACALLFL 507
Cdd:cd17489 290 YGLGFGLLFPALQALAVdlVPPHRRG--AANGTFFIFFD----LGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALVLY 363
|
...
gi 23346457 508 VRL 510
Cdd:cd17489 364 IFL 366
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
105-229 |
1.51e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLgfyVVTQIINGLVQTTGWPSVVTCLSNWF 184
Cdd:cd17380 42 SFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLL---ILSRILLGLGEGVHFPSMTSLFSRWV 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 23346457 185 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAI 229
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYgWPSVFYFFGLL 164
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
313-484 |
3.53e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 313 MAAISFTGALRIPGVIEFSLCL--------------------LFAKLVSYTFLFWLPLYITSVDhLDAKKAGELSTLFDV 372
Cdd:cd17352 151 LDNYGWRGALLILGGLCLNLCVcglllrllkdptfvllalgvSFAMLGFFVPFVYLPSYAKSLG-IDESDAAFLLSIIGI 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 373 GGIFGGILAGVISDRLEKRASTCGLMLLLAApTLYVFSSVSRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKsl 452
Cdd:cd17352 230 SDIVGRILLGLLADKPRIGRLYLYIFTLLIL-GLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEK-- 306
|
170 180 190
....*....|....*....|....*....|..
gi 23346457 453 kgnshaLSTVTAIIDGTGSVGAALGPLLAGLI 484
Cdd:cd17352 307 ------LSNAYGLVLLFQGLAALVGPPIAGLL 332
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
105-242 |
3.83e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 105 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFglgYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSN-- 182
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADvv 348
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23346457 183 -----WFGKGRRGLIMGIWNSHTSVGNILGSLIAGyWVSTCWGLSFIVPGAIVAAMGIVCFLFLI 242
Cdd:COG2211 349 dydewKTGRRREGLYFGIFTFAIKLGQALAGALAG-LLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
368-531 |
5.12e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 5.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 368 TLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSRMGLEATIAmLLLSGALVSGPYALITTAVSADLG 447
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWG-LLGGGGAGTLAAVAFATVAAWWFE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 448 THKSLkgnshALSTVTAiidGTGSVGAALGPLLAGLISPSGWSNVFYMLMFADACALLFLVRLIHKELSCPGPAAGIQAP 527
Cdd:cd17355 124 RRRGL-----ALGILTA---GGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDAS 195
|
....
gi 23346457 528 LKEH 531
Cdd:cd17355 196 PASP 199
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
97-239 |
6.00e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 6.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 97 QLLGALDYA-FLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGL---VQTTG 172
Cdd:cd17370 233 AALIPLLYAlFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG-----SSLWLLLLGFILWGLymgAQESI 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23346457 173 WPSVVTCLSnwfGKGRRGLIMGIWNSHTSVGNILGSLIAGY-WVSTCWGLSFIVpGAIVAAMGIVCFL 239
Cdd:cd17370 308 ERAAVADLV---PAELRGTAYGLFNTVVGIGWLLASLIAGYlWDLISPSAAFLF-SAVLALIALLLLL 371
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
325-509 |
9.04e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 38.37 E-value: 9.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 325 PGVIEFSLCLLFAKLVSYTFLFWLPLYITSVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMlLLAAP 404
Cdd:PRK03699 205 IGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLA-GLALV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 405 TLYVFSSVSRMGLEATIAMLLlsGALVSGPYALITTavsadLGTHKSlkgnSHALSTVTAIIDGTGSVGAALGPLLAGLI 484
Cdd:PRK03699 284 LMYLFVNTDDPSHLLYAILGL--GFFSSAIYTTIIT-----LGSQQT----KVASPKLVNFILTCGTIGTMLTFVVTSPI 352
|
170 180 190
....*....|....*....|....*....|..
gi 23346457 485 -SPSGW------SNVFYMLMFADACALLFLVR 509
Cdd:PRK03699 353 vAHFGLqaalltANGLYAVVFVMCILLGFVSK 384
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
357-516 |
9.91e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 9.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 357 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcglMLLLAAPTLYVFSSVSrmGLEATIAMLLLSGA---LVSG 433
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKK-----VLLPGLLLFGIGGLLC--GLSDSFALLLAGRAlqgIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346457 434 PYALITTAVSADLGTHKSLkgnSHALSTVTAIIdgtgSVGAALGPLLAGLISPSGWSNVFYMLMFADACALLFLVRLIHK 513
Cdd:cd17474 103 GLGPLALTLIGDLFEGGER---AKAMGLYEAAL----GLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
...
gi 23346457 514 ELS 516
Cdd:cd17474 176 PKE 178
|
|
| |
