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Conserved domains on  [gi|30795123|ref|NP_699179|]
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F-box/WD repeat-containing protein 8 isoform 1 [Homo sapiens]

Protein Classification

F-box/WD repeat-containing protein 8( domain architecture ID 17778640)

F-box/WD repeat-containing protein 8 (FBXW8) is a substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.130.10.10
Gene Ontology:  GO:0019005|GO:0005515|GO:0007030|GO:0060271|GO:0016567|GO:0008283
PubMed:  31898225|11178263|30069656|29026209
SCOP:  4001927|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 113-160 1.77e-28

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438906  Cd Length: 48  Bit Score: 107.46  E-value: 1.77e-28
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30795123 113 PFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22134   1 PFFDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
WD40 COG2319
WD40 repeat [General function prediction only];
191-530 5.35e-20

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 5.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 191 LRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIA-GYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRI-- 267
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAsASADGTVRLWDLATGLLLRTLTGHTGA---------VRSVAFsp 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 268 NSSLAVAAYEDGFLNIWDLRTGKyPVHRFE-HDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVPKL-- 344
Cdd:COG2319 131 DGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRL-------WDLATGKLLRTLtg 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 345 ----VQYLEIVPETRRypVAVAAAGDLMYLLKAED-SARTLLYAHGPPVTCLDVSAN--QVAFGvqglgwvYEGSKILVY 417
Cdd:COG2319 203 htgaVRSVAFSPDGKL--LASGSADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDgrLLASG-------SADGTVRLW 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 418 SLEAGRRLLKLGNVLRDFTCVNLS-DSppNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQM--DDWKIVSGGEE 494
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSpDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDD 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 30795123 495 GLVSVWDYRmNQKLWEVYSGH--PVQHISFSSHS--LITA 530
Cdd:COG2319 352 GTVRLWDLA-TGELLRTLTGHtgAVTSVAFSPDGrtLASG 390
 
Name Accession Description Interval E-value
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 113-160 1.77e-28

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 107.46  E-value: 1.77e-28
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30795123 113 PFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22134   1 PFFDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
WD40 COG2319
WD40 repeat [General function prediction only];
191-530 5.35e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 5.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 191 LRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIA-GYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRI-- 267
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAsASADGTVRLWDLATGLLLRTLTGHTGA---------VRSVAFsp 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 268 NSSLAVAAYEDGFLNIWDLRTGKyPVHRFE-HDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVPKL-- 344
Cdd:COG2319 131 DGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRL-------WDLATGKLLRTLtg 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 345 ----VQYLEIVPETRRypVAVAAAGDLMYLLKAED-SARTLLYAHGPPVTCLDVSAN--QVAFGvqglgwvYEGSKILVY 417
Cdd:COG2319 203 htgaVRSVAFSPDGKL--LASGSADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDgrLLASG-------SADGTVRLW 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 418 SLEAGRRLLKLGNVLRDFTCVNLS-DSppNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQM--DDWKIVSGGEE 494
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSpDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDD 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 30795123 495 GLVSVWDYRmNQKLWEVYSGH--PVQHISFSSHS--LITA 530
Cdd:COG2319 352 GTVRLWDLA-TGELLRTLTGHtgAVTSVAFSPDGrtLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-501 4.73e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 4.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 195 WKNRKGA-VSELEHVPDTVLC-DVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRI--NSS 270
Cdd:cd00200  78 WDLETGEcVRTLTGHTSYVSSvAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---------VNSVAFspDGT 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 271 LAVAAYEDGFLNIWDLRTGKyPVHRFE-HDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVpklvqyle 349
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGK-CVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKL-------WDLSTGKCL-------- 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 350 ivpetrrypvavaaagdlmyllkaedsarTLLYAHGPPVTCLDVSANQvafgvqglgwvyegskilvysleagrrllklg 429
Cdd:cd00200 213 -----------------------------GTLRGHENGVNSVAFSPDG-------------------------------- 231

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30795123 430 nvlrdftcvnlsdsppNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWK--IVSGGEEGLVSVWD 501
Cdd:cd00200 232 ----------------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkrLASGSADGTIRIWD 289
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 118-160 2.53e-14

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 67.12  E-value: 2.53e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 30795123   118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:pfam12937   3 SLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
119-159 1.58e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.74  E-value: 1.58e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 30795123    119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 113-160 1.77e-28

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 107.46  E-value: 1.77e-28
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30795123 113 PFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22134   1 PFFDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48
WD40 COG2319
WD40 repeat [General function prediction only];
191-530 5.35e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 5.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 191 LRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIA-GYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRI-- 267
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAsASADGTVRLWDLATGLLLRTLTGHTGA---------VRSVAFsp 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 268 NSSLAVAAYEDGFLNIWDLRTGKyPVHRFE-HDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVPKL-- 344
Cdd:COG2319 131 DGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRL-------WDLATGKLLRTLtg 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 345 ----VQYLEIVPETRRypVAVAAAGDLMYLLKAED-SARTLLYAHGPPVTCLDVSAN--QVAFGvqglgwvYEGSKILVY 417
Cdd:COG2319 203 htgaVRSVAFSPDGKL--LASGSADGTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDgrLLASG-------SADGTVRLW 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 418 SLEAGRRLLKLGNVLRDFTCVNLS-DSppNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQM--DDWKIVSGGEE 494
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSpDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDD 351

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 30795123 495 GLVSVWDYRmNQKLWEVYSGH--PVQHISFSSHS--LITA 530
Cdd:COG2319 352 GTVRLWDLA-TGELLRTLTGHtgAVTSVAFSPDGrtLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
191-523 4.44e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 4.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 191 LRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDeedepgmQPNVSFVRINSS 270
Cdd:COG2319  19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-------AVLSVAFSPDGR 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 271 LAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVPKL------ 344
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL-------WDLATGKLLRTLtghsga 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 345 VQYLEIVPETRRypVAVAAAGDLMYLLKAEDSARTL-LYAHGPPVTCLDVSAN--QVAFGVqglgwvyEGSKILVYSLEA 421
Cdd:COG2319 165 VTSVAFSPDGKL--LASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSVAFSPDgkLLASGS-------ADGTVRLWDLAT 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 422 GRRLLKLGNVLRDFTCVNLSdspPN--LMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQM--DDWKIVSGGEEGLV 497
Cdd:COG2319 236 GKLLRTLTGHSGSVRSVAFS---PDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTV 312

                       330       340
                ....*....|....*....|....*...
gi 30795123 498 SVWDYRMNQKLWeVYSGH--PVQHISFS 523
Cdd:COG2319 313 RLWDLATGKLLR-TLTGHtgAVRSVAFS 339
WD40 COG2319
WD40 repeat [General function prediction only];
218-501 6.97e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 6.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 218 SHDGVVIA-GYTSGDVRVWDTRTWDYVAPFlesedeedePGMQPNVSFVRI--NSSLAVAAYEDGFLNIWDLRTGKyPVH 294
Cdd:COG2319 129 SPDGKTLAsGSADGTVRLWDLATGKLLRTL---------TGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGK-LLR 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 295 RFE-HDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVPKL------VQYLEIVPETRRypVAVAAAGDL 367
Cdd:COG2319 199 TLTgHTGAVRSVAFSPDGKLLASGSADGTVRL-------WDLATGKLLRTLtghsgsVRSVAFSPDGRL--LASGSADGT 269

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 368 MYLLKAED-SARTLLYAHGPPVTCLDVSAN--QVAFGvqglgwvYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdsp 444
Cdd:COG2319 270 VRLWDLATgELLRTLTGHSGGVNSVAFSPDgkLLASG-------SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS--- 339

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30795123 445 PN--LMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMD-DWK-IVSGGEEGLVSVWD 501
Cdd:COG2319 340 PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpDGRtLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-501 4.73e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 4.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 195 WKNRKGA-VSELEHVPDTVLC-DVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRI--NSS 270
Cdd:cd00200  78 WDLETGEcVRTLTGHTSYVSSvAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---------VNSVAFspDGT 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 271 LAVAAYEDGFLNIWDLRTGKyPVHRFE-HDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVpklvqyle 349
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGK-CVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKL-------WDLSTGKCL-------- 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 350 ivpetrrypvavaaagdlmyllkaedsarTLLYAHGPPVTCLDVSANQvafgvqglgwvyegskilvysleagrrllklg 429
Cdd:cd00200 213 -----------------------------GTLRGHENGVNSVAFSPDG-------------------------------- 231

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30795123 430 nvlrdftcvnlsdsppNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWK--IVSGGEEGLVSVWD 501
Cdd:cd00200 232 ----------------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkrLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 214-530 9.86e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 9.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 214 CDVHSHDGVVIAGYTSGDVRVWDTRTWDyvapfLESEDEEDEPGMQpNVSFVRINSSLAVAAYeDGFLNIWDLRTGKyPV 293
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVR-DVAASADGTYLASGSS-DKTIRLWDLETGE-CV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 294 HRFE-HDARIQALALSQDDaTVATASAFD-VVMLspneegyWqiaaEFEVPKLVQyleivpetrrypvavaaagdlmyll 371
Cdd:cd00200  87 RTLTgHTSYVSSVAFSPDG-RILSSSSRDkTIKV-------W----DVETGKCLT------------------------- 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 372 kaedsartLLYAHGPPVTCLDVS-ANQVAFGVQGLGwvyegsKILVYSLEAGRRLLKL----GNVlrdfTCVNLSDSPPN 446
Cdd:cd00200 130 --------TLRGHTDWVNSVAFSpDGTFVASSSQDG------TIKLWDLRTGKCVATLtghtGEV----NSVAFSPDGEK 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 447 LMVSGNmDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDWK--IVSGGEEGLVSVWDYRmNQKLWEVYSGH--PVQHISF 522
Cdd:cd00200 192 LLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLR-TGECVQTLSGHtnSVTSLAW 269

                       330
                ....*....|
gi 30795123 523 SSHS--LITA 530
Cdd:cd00200 270 SPDGkrLASG 279
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 118-160 2.53e-14

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 67.12  E-value: 2.53e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 30795123   118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:pfam12937   3 SLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 118-160 3.86e-13

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 63.87  E-value: 3.86e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22147   4 ALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
WD40 COG2319
WD40 repeat [General function prediction only];
218-464 1.77e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 1.77e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 218 SHDGVVIA-GYTSGDVRVWDTRTWDYVAPFlesedeedePGMQPNVSFVRI--NSSLAVAAYEDGFLNIWDLRTGKyPVH 294
Cdd:COG2319 171 SPDGKLLAsGSDDGTVRLWDLATGKLLRTL---------TGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGK-LLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 295 RFE-HDARIQALALSQDDATVATASAFDVVMLspneegyWQIAAEFEVPKL------VQYLEIVPETRRypVAVAAAGDL 367
Cdd:COG2319 241 TLTgHSGSVRSVAFSPDGRLLASGSADGTVRL-------WDLATGELLRTLtghsggVNSVAFSPDGKL--LASGSDDGT 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 368 MYLLKAEDSAR-TLLYAHGPPVTCLDVSAN--QVAFGvqglgwvYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLS-DS 443
Cdd:COG2319 312 VRLWDLATGKLlRTLTGHTGAVRSVAFSPDgkTLASG-------SDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpDG 384

                       250       260
                ....*....|....*....|.
gi 30795123 444 ppNLMVSGNMDGRVRIHDLRS 464
Cdd:COG2319 385 --RTLASGSADGTVRLWDLAT 403
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
 118-156 2.03e-11

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 58.89  E-value: 2.03e-11
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22124   3 LLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 118-156 9.24e-09

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 51.39  E-value: 9.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30795123   118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLW 41
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 118-156 9.51e-09

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 51.26  E-value: 9.51e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22115   6 KLPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNW 44
WD40 COG2319
WD40 repeat [General function prediction only];
202-319 1.25e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 1.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 202 VSELEHVPDTVLCDVHSHDG-VVIAGYTSGDVRVWDTRTWDYVAPFlesedeEDEPGMQPNVSFVRINSSLAVAAyEDGF 280
Cdd:COG2319 281 LRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTL------TGHTGAVRSVAFSPDGKTLASGS-DDGT 353

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 30795123 281 LNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASA 319
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 436-528 1.45e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30795123 436 TCVNLSDSPpNLMVSGNMDGRVRIHDLRSGNIALSLSAHQLRVSAVQMDDW--KIVSGGEEGLVSVWDYRMNQKLWEvYS 513
Cdd:cd00200  13 TCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADgtYLASGSSDKTIRLWDLETGECVRT-LT 90

                        90
                ....*....|....*..
gi 30795123 514 GH--PVQHISFSSHSLI 528
Cdd:cd00200  91 GHtsYVSSVAFSPDGRI 107
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 117-160 1.56e-08

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 50.84  E-value: 1.56e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 30795123 117 IQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22137   1 IQLPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRNLC 44
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 118-160 2.26e-08

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 50.40  E-value: 2.26e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22151   2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWENAC 44
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 115-162 2.40e-08

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 50.52  E-value: 2.40e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30795123 115 FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ 162
Cdd:cd22094   2 FTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWLPKCLR 49
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 118-156 3.04e-08

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 49.64  E-value: 3.04e-08
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22118   3 SLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 115-164 3.38e-08

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 50.10  E-value: 3.38e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 30795123 115 FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEG 164
Cdd:cd22173   2 FTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQDCLWMPKCVKFG 51
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 119-156 5.56e-08

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 49.20  E-value: 5.56e-08
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22148   5 LPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELW 42
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 118-151 7.58e-08

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 48.59  E-value: 7.58e-08
                        10        20        30
                ....*....|....*....|....*....|....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAE 151
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 122-158 9.46e-08

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 48.52  E-value: 9.46e-08
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 30795123 122 ELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYR 158
Cdd:cd22149   7 EIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWRR 43
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 119-162 2.43e-07

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 47.64  E-value: 2.43e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQ 162
Cdd:cd22084   4 LPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKK 47
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 118-159 3.60e-07

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 47.03  E-value: 3.60e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
Cdd:cd22091   3 ELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 127-160 3.90e-07

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 46.94  E-value: 3.90e-07
                        10        20        30
                ....*....|....*....|....*....|....
gi 30795123 127 IFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22109  14 VFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 119-160 7.24e-07

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 46.09  E-value: 7.24e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22093   4 LPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLY 45
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 115-160 8.82e-07

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 46.12  E-value: 8.82e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 30795123 115 FDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22172   5 FTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKC 50
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 119-159 1.39e-06

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 45.30  E-value: 1.39e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
Cdd:cd22132   4 LPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKEL 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
119-159 1.58e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.74  E-value: 1.58e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 30795123    119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 118-149 1.89e-06

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 44.63  E-value: 1.89e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTW-KVI 149
Cdd:cd22131   5 LLPLELSFYLLSFLDPESLLTCCLVSKQWnKVI 37
F-box_FBXO10 cd22090
F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called ...
 119-160 8.99e-06

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438862  Cd Length: 50  Bit Score: 43.11  E-value: 8.99e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWK--VIAEDEVLWYRLC 160
Cdd:cd22090   5 LPLELWRLILAYLPVRDLCRCCQVCRAWYelILSLDSTRWKQLY 48
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 119-160 1.01e-05

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 42.69  E-value: 1.01e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTW-KVIAEDEVLWYRLC 160
Cdd:cd22113   4 LPPEMSLRIFSQLDVQSLCRASQTCKTWnDLIENSDYLWRPHC 46
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 119-156 1.02e-05

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 43.18  E-value: 1.02e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22133  21 LPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLW 58
F-box_JHDM cd22122
F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; ...
 119-156 1.05e-05

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438894  Cd Length: 43  Bit Score: 42.65  E-value: 1.05e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22122   4 LPREVWLPVFQYLSPKDLCVCMRVCKTWNRWCCDPSLW 41
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 115-159 1.29e-05

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 42.61  E-value: 1.29e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 30795123 115 FDIqLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
Cdd:cd22117   1 FDL-LPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKEL 44
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 118-155 1.86e-05

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 41.85  E-value: 1.86e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEdEVL 155
Cdd:cd22136   4 CLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTE-EVK 40
F-box_ScCDC4-like cd22141
F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and ...
 119-160 1.91e-05

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438913  Cd Length: 47  Bit Score: 42.17  E-value: 1.91e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22141   4 LPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLL 45
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 119-160 2.19e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 41.84  E-value: 2.19e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22139   4 LPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 118-156 3.12e-05

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 41.24  E-value: 3.12e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22114   3 SLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
F-box_FBXO8 cd22088
F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called ...
 114-160 9.33e-05

F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438860  Cd Length: 46  Bit Score: 40.00  E-value: 9.33e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 30795123 114 FFDI-QLPYELAINIFQYLDRKELGRCAQVsktWKVIAEDEVLWYRLC 160
Cdd:cd22088   1 FPDLeELPPELSLTVLSHLNATDLCLASCV---WQDLANDELLWQGLC 45
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
 115-156 1.18e-04

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 39.68  E-value: 1.18e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 30795123 115 FDIqLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22120   1 FDR-LPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLW 41
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 117-163 1.34e-04

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 39.72  E-value: 1.34e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 30795123 117 IQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQE 163
Cdd:cd22102   2 LDLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQRRCKEE 48
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 118-156 1.70e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 39.26  E-value: 1.70e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22123   3 QLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLW 41
F-box_FBXO32 cd22103
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ...
 119-160 2.20e-04

F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438875  Cd Length: 48  Bit Score: 39.07  E-value: 2.20e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 30795123 119 LPYELAINIFQYL-DRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22103   6 LPLCLQLNIMQRLsDGRDIVSLGQVSPDLQVLSEDRLLWKKLC 48
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
 118-156 6.94e-04

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 37.74  E-value: 6.94e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22156   4 QLPEDVLMQILRLLGPKDAAKLCLVCKSWRYLVSDNRLW 42
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 118-156 1.26e-03

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 36.92  E-value: 1.26e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22138   3 SLPVECQLKIFSFLSEVDKCLAATVCRSWSELIRSPRLW 41
F-box_FBXL11 cd22181
F-box domain found in F-box/LRR-repeat protein 11 (FBXL11) and similar proteins; FBXL11, also ...
 116-158 1.55e-03

F-box domain found in F-box/LRR-repeat protein 11 (FBXL11) and similar proteins; FBXL11, also called lysine-specific demethylase 2A (KDM2A), CXXC-type zinc finger protein (CXXC8), F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438952  Cd Length: 47  Bit Score: 36.79  E-value: 1.55e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 30795123 116 DIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYR 158
Cdd:cd22181   5 ESWMQKDVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTK 47
F-box_AtSKIP31-like cd22166
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar ...
 119-159 4.60e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438937  Cd Length: 46  Bit Score: 35.51  E-value: 4.60e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
Cdd:cd22166   4 LPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWRRL 44
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 118-146 5.04e-03

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 34.95  E-value: 5.04e-03
                        10        20
                ....*....|....*....|....*....
gi 30795123 118 QLPYELAINIFQYLDRKELGRCAQVSKTW 146
Cdd:cd22111   3 RLPSRVLEVIFSYLDLPDLRNCSLVCKSW 31
F-box_FBXO2 cd22167
F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called ...
 119-181 5.28e-03

F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438938 [Multi-domain]  Cd Length: 72  Bit Score: 35.87  E-value: 5.28e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30795123 119 LPYELAINIFQYLDRKELGR-CAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIF 181
Cdd:cd22167   4 LPEAVLVRILAYLPAEELVLvCRLVCSQWKELVDGAALWILKCQQEGFSPTELEEEPDNWQTFY 67
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 119-160 5.87e-03

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 34.97  E-value: 5.87e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLC 160
Cdd:cd22087   4 LPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 119-159 7.81e-03

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 34.86  E-value: 7.81e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 30795123 119 LPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 159
Cdd:cd22106   4 LPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKI 44
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
 123-156 9.01e-03

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 34.76  E-value: 9.01e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 30795123 123 LAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLW 156
Cdd:cd22130  16 IAENILSYLDAKSLCAAELVCKEWYRVIADGMLW 49
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
 127-149 9.74e-03

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 34.39  E-value: 9.74e-03
                        10        20
                ....*....|....*....|...
gi 30795123 127 IFQYLDRKELGRCAQVSKTWKVI 149
Cdd:cd22086  15 ILSYLSPEDLCRVSCVSKTWRQI 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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