sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| LamG super family | cl22861 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1424-1622 | 7.10e-69 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. The actual alignment was detected with superfamily member cd00152: Pssm-ID: 473984 Cd Length: 201 Bit Score: 231.39 E-value: 7.10e-69
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| VWA | pfam00092 | von Willebrand factor type A domain; |
83-258 | 5.75e-41 | |||||
von Willebrand factor type A domain; : Pssm-ID: 459670 [Multi-domain] Cd Length: 174 Bit Score: 150.12 E-value: 5.75e-41
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| PHA02927 super family | cl33700 | secreted complement-binding protein; Provisional |
1789-2017 | 1.12e-28 | |||||
secreted complement-binding protein; Provisional The actual alignment was detected with superfamily member PHA02927: Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 117.83 E-value: 1.12e-28
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| PHA02927 super family | cl33700 | secreted complement-binding protein; Provisional |
2401-2609 | 2.97e-28 | |||||
secreted complement-binding protein; Provisional The actual alignment was detected with superfamily member PHA02927: Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 116.68 E-value: 2.97e-28
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| PHA02927 super family | cl33700 | secreted complement-binding protein; Provisional |
2094-2319 | 8.11e-25 | |||||
secreted complement-binding protein; Provisional The actual alignment was detected with superfamily member PHA02927: Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 106.66 E-value: 8.11e-25
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| PHA02639 super family | cl31493 | EEV host range protein; Provisional |
2714-2887 | 8.12e-22 | |||||
EEV host range protein; Provisional The actual alignment was detected with superfamily member PHA02639: Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 98.97 E-value: 8.12e-22
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| PHA02927 super family | cl33700 | secreted complement-binding protein; Provisional |
3195-3411 | 8.61e-21 | |||||
secreted complement-binding protein; Provisional The actual alignment was detected with superfamily member PHA02927: Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 95.10 E-value: 8.61e-21
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| PHA02639 super family | cl31493 | EEV host range protein; Provisional |
2833-3003 | 3.48e-19 | |||||
EEV host range protein; Provisional The actual alignment was detected with superfamily member PHA02639: Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 91.26 E-value: 3.48e-19
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| PHA02927 super family | cl33700 | secreted complement-binding protein; Provisional |
3015-3229 | 1.08e-15 | |||||
secreted complement-binding protein; Provisional The actual alignment was detected with superfamily member PHA02927: Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 80.08 E-value: 1.08e-15
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| HYR super family | cl47740 | HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ... |
560-642 | 1.09e-15 | |||||
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion. The actual alignment was detected with superfamily member pfam02494: Pssm-ID: 460572 [Multi-domain] Cd Length: 81 Bit Score: 74.35 E-value: 1.09e-15
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1005-1052 | 2.13e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. : Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 72.38 E-value: 2.13e-15
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1113-1160 | 4.98e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. : Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 71.61 E-value: 4.98e-15
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1059-1106 | 6.24e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. : Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 71.23 E-value: 6.24e-15
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
438-494 | 1.10e-12 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. : Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 65.18 E-value: 1.10e-12
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| HYR super family | cl47740 | HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ... |
644-722 | 8.73e-12 | |||||
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion. The actual alignment was detected with superfamily member pfam02494: Pssm-ID: 460572 [Multi-domain] Cd Length: 81 Bit Score: 63.18 E-value: 8.73e-12
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
310-360 | 1.07e-11 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. : Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 61.98 E-value: 1.07e-11
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1690-1743 | 1.34e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. : Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 62.10 E-value: 1.34e-11
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| PHA02831 super family | cl31511 | EEV host range protein; Provisional |
2280-2436 | 3.20e-10 | |||||
EEV host range protein; Provisional The actual alignment was detected with superfamily member PHA02831: Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 63.86 E-value: 3.20e-10
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2670-2713 | 1.40e-09 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. : Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 56.32 E-value: 1.40e-09
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1383-1419 | 1.43e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 55.72 E-value: 1.43e-09
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1231-1267 | 6.13e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.79 E-value: 6.13e-09
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3416-3469 | 1.02e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. : Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 54.01 E-value: 1.02e-08
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1628-1685 | 1.07e-08 | |||||
Sushi repeat (SCR repeat); : Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 53.66 E-value: 1.07e-08
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1345-1381 | 1.70e-08 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 52.64 E-value: 1.70e-08
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
378-434 | 2.22e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. : Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 52.85 E-value: 2.22e-08
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1308-1342 | 6.42e-08 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 51.10 E-value: 6.42e-08
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1269-1305 | 1.54e-07 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 49.94 E-value: 1.54e-07
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| PHA02817 super family | cl31508 | EEV Host range protein; Provisional |
1958-2079 | 1.56e-07 | |||||
EEV Host range protein; Provisional The actual alignment was detected with superfamily member PHA02817: Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 54.95 E-value: 1.56e-07
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1745-1783 | 4.49e-07 | |||||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 48.78 E-value: 4.49e-07
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1196-1229 | 1.12e-04 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 1.12e-04
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| Name | Accession | Description | Interval | E-value | |||||
| PTX | cd00152 | Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ... |
1424-1622 | 7.10e-69 | |||||
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers. Pssm-ID: 238086 Cd Length: 201 Bit Score: 231.39 E-value: 7.10e-69
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| PTX | smart00159 | Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ... |
1446-1621 | 1.85e-42 | |||||
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding. Pssm-ID: 128463 Cd Length: 206 Bit Score: 155.50 E-value: 1.85e-42
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| VWA | pfam00092 | von Willebrand factor type A domain; |
83-258 | 5.75e-41 | |||||
von Willebrand factor type A domain; Pssm-ID: 459670 [Multi-domain] Cd Length: 174 Bit Score: 150.12 E-value: 5.75e-41
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| vWFA_subfamily_ECM | cd01450 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
82-244 | 3.37e-39 | |||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains Pssm-ID: 238727 [Multi-domain] Cd Length: 161 Bit Score: 144.74 E-value: 3.37e-39
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| VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
84-258 | 1.36e-29 | |||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 117.56 E-value: 1.36e-29
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
1789-2017 | 1.12e-28 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 117.83 E-value: 1.12e-28
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2401-2609 | 2.97e-28 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 116.68 E-value: 2.97e-28
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| Pentaxin | pfam00354 | Pentaxin family; Pentaxins are also known as pentraxins. |
1448-1608 | 7.88e-25 | |||||
Pentaxin family; Pentaxins are also known as pentraxins. Pssm-ID: 278768 Cd Length: 194 Bit Score: 104.43 E-value: 7.88e-25
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2094-2319 | 8.11e-25 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 106.66 E-value: 8.11e-25
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2714-2887 | 8.12e-22 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 98.97 E-value: 8.12e-22
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
3195-3411 | 8.61e-21 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 95.10 E-value: 8.61e-21
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2279-2493 | 2.20e-20 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 93.95 E-value: 2.20e-20
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2833-3003 | 3.48e-19 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 91.26 E-value: 3.48e-19
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| ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
10-235 | 8.96e-16 | |||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 80.37 E-value: 8.96e-16
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
3015-3229 | 1.08e-15 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 80.08 E-value: 1.08e-15
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| HYR | pfam02494 | HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ... |
560-642 | 1.09e-15 | |||||
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion. Pssm-ID: 460572 [Multi-domain] Cd Length: 81 Bit Score: 74.35 E-value: 1.09e-15
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1005-1052 | 2.13e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 72.38 E-value: 2.13e-15
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1113-1160 | 4.98e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 71.61 E-value: 4.98e-15
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1059-1106 | 6.24e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 71.23 E-value: 6.24e-15
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
438-494 | 1.10e-12 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 65.18 E-value: 1.10e-12
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2146-2199 | 5.66e-12 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 63.25 E-value: 5.66e-12
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| HYR | pfam02494 | HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ... |
644-722 | 8.73e-12 | |||||
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion. Pssm-ID: 460572 [Multi-domain] Cd Length: 81 Bit Score: 63.18 E-value: 8.73e-12
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
310-360 | 1.07e-11 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 61.98 E-value: 1.07e-11
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2146-2199 | 1.21e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 62.16 E-value: 1.21e-11
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1690-1743 | 1.34e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 62.10 E-value: 1.34e-11
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1690-1743 | 1.35e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 62.16 E-value: 1.35e-11
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
438-493 | 2.40e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 61.39 E-value: 2.40e-11
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1789-1843 | 2.43e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 61.32 E-value: 2.43e-11
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3241-3295 | 3.19e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 60.94 E-value: 3.19e-11
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1789-1842 | 4.53e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 60.62 E-value: 4.53e-11
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2833-2887 | 1.45e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 59.01 E-value: 1.45e-10
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
438-493 | 1.85e-10 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 58.66 E-value: 1.85e-10
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2381-2436 | 2.32e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 58.63 E-value: 2.32e-10
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2775-2828 | 2.61e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 58.31 E-value: 2.61e-10
|
|||||||||
| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2280-2436 | 3.20e-10 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 63.86 E-value: 3.20e-10
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2146-2199 | 3.46e-10 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 57.89 E-value: 3.46e-10
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3241-3294 | 3.78e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 57.92 E-value: 3.78e-10
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2949-3002 | 6.10e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 57.15 E-value: 6.10e-10
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1690-1743 | 6.34e-10 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 57.12 E-value: 6.34e-10
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2498-2551 | 6.80e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 57.15 E-value: 6.80e-10
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2949-3002 | 6.94e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 57.09 E-value: 6.94e-10
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3241-3294 | 1.25e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 56.35 E-value: 1.25e-09
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2670-2713 | 1.40e-09 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 56.32 E-value: 1.40e-09
|
|||||||||
| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1383-1419 | 1.43e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 55.72 E-value: 1.43e-09
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2381-2435 | 1.75e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 55.97 E-value: 1.75e-09
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1789-1842 | 3.22e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 55.20 E-value: 3.22e-09
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2670-2712 | 4.24e-09 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 54.84 E-value: 4.24e-09
|
|||||||||
| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1231-1267 | 6.13e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.79 E-value: 6.13e-09
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2674-2712 | 8.07e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 54.04 E-value: 8.07e-09
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3416-3469 | 1.02e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 54.01 E-value: 1.02e-08
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1628-1685 | 1.07e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 53.66 E-value: 1.07e-08
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3416-3468 | 1.37e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 53.30 E-value: 1.37e-08
|
|||||||||
| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1345-1381 | 1.70e-08 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 52.64 E-value: 1.70e-08
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
378-434 | 2.22e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 52.85 E-value: 2.22e-08
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2775-2828 | 2.28e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 52.89 E-value: 2.28e-08
|
|||||||||
| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1651-1747 | 3.23e-08 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 57.26 E-value: 3.23e-08
|
|||||||||
| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1383-1419 | 3.25e-08 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 51.86 E-value: 3.25e-08
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3064-3118 | 4.15e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 52.08 E-value: 4.15e-08
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2323-2377 | 5.20e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 51.69 E-value: 5.20e-08
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
378-433 | 6.26e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 51.76 E-value: 6.26e-08
|
|||||||||
| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1308-1342 | 6.42e-08 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 51.10 E-value: 6.42e-08
|
|||||||||
| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1269-1305 | 1.54e-07 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 49.94 E-value: 1.54e-07
|
|||||||||
| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1958-2079 | 1.56e-07 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 54.95 E-value: 1.56e-07
|
|||||||||
| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1231-1267 | 2.24e-07 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 49.55 E-value: 2.24e-07
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3064-3117 | 2.83e-07 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 49.83 E-value: 2.83e-07
|
|||||||||
| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1345-1381 | 3.65e-07 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 48.78 E-value: 3.65e-07
|
|||||||||
| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1745-1783 | 4.49e-07 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 48.78 E-value: 4.49e-07
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2323-2376 | 6.32e-07 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 48.68 E-value: 6.32e-07
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
378-433 | 1.01e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 48.26 E-value: 1.01e-06
|
|||||||||
| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1307-1342 | 1.07e-06 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 47.63 E-value: 1.07e-06
|
|||||||||
| EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
1749-1783 | 1.68e-06 | |||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 46.82 E-value: 1.68e-06
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3416-3468 | 2.19e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 47.11 E-value: 2.19e-06
|
|||||||||
| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1745-1783 | 2.46e-06 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 46.48 E-value: 2.46e-06
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2323-2376 | 4.62e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 46.34 E-value: 4.62e-06
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1640-1686 | 4.97e-06 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 46.30 E-value: 4.97e-06
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2949-3002 | 6.21e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 45.95 E-value: 6.21e-06
|
|||||||||
| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1269-1305 | 6.21e-06 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 6.21e-06
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1631-1685 | 9.57e-06 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 45.60 E-value: 9.57e-06
|
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1387-1417 | 1.53e-05 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 44.30 E-value: 1.53e-05
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3064-3117 | 3.71e-05 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 43.64 E-value: 3.71e-05
|
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1235-1265 | 4.04e-05 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 42.76 E-value: 4.04e-05
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2021-2078 | 7.16e-05 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 42.87 E-value: 7.16e-05
|
|||||||||
| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1196-1229 | 1.12e-04 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 1.12e-04
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2021-2079 | 2.29e-04 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 41.68 E-value: 2.29e-04
|
|||||||||
| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1197-1225 | 2.44e-04 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.83 E-value: 2.44e-04
|
|||||||||
| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1349-1379 | 4.94e-04 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 39.67 E-value: 4.94e-04
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2021-2078 | 1.03e-03 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 39.82 E-value: 1.03e-03
|
|||||||||
| PHA02831 | PHA02831 | EEV host range protein; Provisional |
401-495 | 2.20e-03 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 43.06 E-value: 2.20e-03
|
|||||||||
| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1311-1337 | 3.49e-03 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 37.36 E-value: 3.49e-03
|
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| Name | Accession | Description | Interval | E-value | |||||
| PTX | cd00152 | Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ... |
1424-1622 | 7.10e-69 | |||||
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers. Pssm-ID: 238086 Cd Length: 201 Bit Score: 231.39 E-value: 7.10e-69
|
|||||||||
| PTX | smart00159 | Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ... |
1446-1621 | 1.85e-42 | |||||
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding. Pssm-ID: 128463 Cd Length: 206 Bit Score: 155.50 E-value: 1.85e-42
|
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| VWA | pfam00092 | von Willebrand factor type A domain; |
83-258 | 5.75e-41 | |||||
von Willebrand factor type A domain; Pssm-ID: 459670 [Multi-domain] Cd Length: 174 Bit Score: 150.12 E-value: 5.75e-41
|
|||||||||
| vWFA_subfamily_ECM | cd01450 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
82-244 | 3.37e-39 | |||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains Pssm-ID: 238727 [Multi-domain] Cd Length: 161 Bit Score: 144.74 E-value: 3.37e-39
|
|||||||||
| VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
84-258 | 1.36e-29 | |||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 117.56 E-value: 1.36e-29
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
1789-2017 | 1.12e-28 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 117.83 E-value: 1.12e-28
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2401-2609 | 2.97e-28 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 116.68 E-value: 2.97e-28
|
|||||||||
| vWFA | cd00198 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
84-242 | 2.93e-25 | |||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 104.57 E-value: 2.93e-25
|
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| vWA_collagen | cd01472 | von Willebrand factor (vWF) type A domain; equivalent to the I-domain of integrins. This ... |
84-252 | 5.20e-25 | |||||
von Willebrand factor (vWF) type A domain; equivalent to the I-domain of integrins. This domain has a variety of functions including: intermolecular adhesion, cell migration, signalling, transcription, and DNA repair. In integrins these domains form heterodimers while in vWF it forms homodimers and multimers. There are different interaction surfaces of this domain as seen by its complexes with collagen with either integrin or human vWFA. In integrins collagen binding occurs via the metal ion-dependent adhesion site (MIDAS) and involves three surface loops located on the upper surface of the molecule. In human vWFA, collagen binding is thought to occur on the bottom of the molecule and does not involve the vestigial MIDAS motif. Pssm-ID: 238749 [Multi-domain] Cd Length: 164 Bit Score: 104.23 E-value: 5.20e-25
|
|||||||||
| Pentaxin | pfam00354 | Pentaxin family; Pentaxins are also known as pentraxins. |
1448-1608 | 7.88e-25 | |||||
Pentaxin family; Pentaxins are also known as pentraxins. Pssm-ID: 278768 Cd Length: 194 Bit Score: 104.43 E-value: 7.88e-25
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2094-2319 | 8.11e-25 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 106.66 E-value: 8.11e-25
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2137-2376 | 3.10e-23 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 102.04 E-value: 3.10e-23
|
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| vWA_collagen_alphaI-XII-like | cd01482 | Collagen: The extracellular matrix represents a complex alloy of variable members of diverse ... |
83-249 | 5.42e-23 | |||||
Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions. Pssm-ID: 238759 [Multi-domain] Cd Length: 164 Bit Score: 98.13 E-value: 5.42e-23
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
1644-1900 | 6.88e-23 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 101.27 E-value: 6.88e-23
|
|||||||||
| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2714-2887 | 8.12e-22 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 98.97 E-value: 8.12e-22
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2660-2887 | 3.18e-21 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 96.26 E-value: 3.18e-21
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
3195-3411 | 8.61e-21 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 95.10 E-value: 8.61e-21
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2770-3003 | 1.13e-20 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 94.72 E-value: 1.13e-20
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2279-2493 | 2.20e-20 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 93.95 E-value: 2.20e-20
|
|||||||||
| vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
81-311 | 6.36e-20 | |||||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 91.29 E-value: 6.36e-20
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2498-2770 | 3.42e-19 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 90.48 E-value: 3.42e-19
|
|||||||||
| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2833-3003 | 3.48e-19 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 91.26 E-value: 3.48e-19
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
3255-3462 | 2.55e-18 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 87.79 E-value: 2.55e-18
|
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| Laminin_G_3 | pfam13385 | Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ... |
1434-1590 | 2.71e-18 | |||||
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily. Pssm-ID: 463865 [Multi-domain] Cd Length: 151 Bit Score: 84.36 E-value: 2.71e-18
|
|||||||||
| PHA02639 | PHA02639 | EEV host range protein; Provisional |
3241-3411 | 9.74e-18 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 87.03 E-value: 9.74e-18
|
|||||||||
| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2264-2436 | 1.07e-17 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 86.64 E-value: 1.07e-17
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
2847-3117 | 1.39e-17 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 85.47 E-value: 1.39e-17
|
|||||||||
| PHA02639 | PHA02639 | EEV host range protein; Provisional |
1843-2017 | 2.82e-17 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 85.49 E-value: 2.82e-17
|
|||||||||
| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2440-2612 | 3.10e-17 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 85.49 E-value: 3.10e-17
|
|||||||||
| vWA_integrins_alpha_subunit | cd01469 | Integrins are a class of adhesion receptors that link the extracellular matrix to the ... |
82-255 | 3.66e-17 | |||||
Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta sub-unit. Each sub-unit has a large extracellular portion, a single transmembrane segment and a short cytoplasmic domain. The N-terminal domains of the alpha and beta subunits associate to form the integrin headpiece, which contains the ligand binding site, whereas the C-terminal segments traverse the plasma membrane and mediate interaction with the cytoskeleton and with signalling proteins.The VWA domains present in the alpha subunits of integrins seem to be a chordate specific radiation of the gene family being found only in vertebrates. They mediate protein-protein interactions. Pssm-ID: 238746 [Multi-domain] Cd Length: 177 Bit Score: 82.02 E-value: 3.66e-17
|
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2146-2322 | 1.69e-16 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 83.17 E-value: 1.69e-16
|
|||||||||
| PHA02639 | PHA02639 | EEV host range protein; Provisional |
1690-1900 | 2.50e-16 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 82.79 E-value: 2.50e-16
|
|||||||||
| VWA_integrin_invertebrates | cd01476 | VWA_integrin (invertebrates): Integrins are a family of cell surface receptors that have ... |
82-221 | 2.89e-16 | |||||
VWA_integrin (invertebrates): Integrins are a family of cell surface receptors that have diverse functions in cell-cell and cell-extracellular matrix interactions. Because of their involvement in many biologically important adhesion processes, integrins are conserved across a wide range of multicellular animals. Integrins from invertebrates have been identified from six phyla. There are no data to date to suggest any immunological functions for the invertebrate integrins. The members of this sub-group have the conserved MIDAS motif that is charateristic of this domain suggesting the involvement of the integrins in the recognition and binding of multi-ligands. Pssm-ID: 238753 [Multi-domain] Cd Length: 163 Bit Score: 78.98 E-value: 2.89e-16
|
|||||||||
| ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
10-235 | 8.96e-16 | |||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 80.37 E-value: 8.96e-16
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
3015-3229 | 1.08e-15 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 80.08 E-value: 1.08e-15
|
|||||||||
| HYR | pfam02494 | HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ... |
560-642 | 1.09e-15 | |||||
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion. Pssm-ID: 460572 [Multi-domain] Cd Length: 81 Bit Score: 74.35 E-value: 1.09e-15
|
|||||||||
| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1005-1052 | 2.13e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 72.38 E-value: 2.13e-15
|
|||||||||
| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
1842-2134 | 4.28e-15 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 78.16 E-value: 4.28e-15
|
|||||||||
| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1113-1160 | 4.98e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 71.61 E-value: 4.98e-15
|
|||||||||
| vWA_micronemal_protein | cd01471 | Micronemal proteins: The Toxoplasma lytic cycle begins when the parasite actively invades a ... |
82-251 | 6.14e-15 | |||||
Micronemal proteins: The Toxoplasma lytic cycle begins when the parasite actively invades a target cell. In association with invasion, T. gondii sequentially discharges three sets of secretory organelles beginning with the micronemes, which contain adhesive proteins involved in parasite attachment to a host cell. Deployed as protein complexes, several micronemal proteins possess vertebrate-derived adhesive sequences that function in binding receptors. The VWA domain likely mediates the protein-protein interactions of these with their interacting partners. Pssm-ID: 238748 [Multi-domain] Cd Length: 186 Bit Score: 75.88 E-value: 6.14e-15
|
|||||||||
| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
1059-1106 | 6.24e-15 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 71.23 E-value: 6.24e-15
|
|||||||||
| vWA_collagen_alpha_1-VI-type | cd01480 | VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable ... |
82-242 | 7.51e-15 | |||||
VWA_collagen alpha(VI) type: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions. Pssm-ID: 238757 [Multi-domain] Cd Length: 186 Bit Score: 75.50 E-value: 7.51e-15
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
1789-1958 | 9.72e-15 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 77.78 E-value: 9.72e-15
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1788-1900 | 1.71e-14 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 75.75 E-value: 1.71e-14
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2678-2832 | 1.13e-13 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 74.70 E-value: 1.13e-13
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
438-494 | 1.10e-12 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 65.18 E-value: 1.10e-12
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
1783-1943 | 1.64e-12 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 70.79 E-value: 1.64e-12
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2711-2849 | 2.74e-12 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 69.20 E-value: 2.74e-12
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
3295-3468 | 3.38e-12 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 70.46 E-value: 3.38e-12
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2146-2199 | 5.66e-12 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 63.25 E-value: 5.66e-12
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2553-2770 | 7.18e-12 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 69.31 E-value: 7.18e-12
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| HYR | pfam02494 | HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ... |
644-722 | 8.73e-12 | |||||
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion. Pssm-ID: 460572 [Multi-domain] Cd Length: 81 Bit Score: 63.18 E-value: 8.73e-12
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| Ephrin_rec_like | pfam07699 | Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region ... |
310-360 | 1.07e-11 | |||||
Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity. Pssm-ID: 429604 [Multi-domain] Cd Length: 48 Bit Score: 61.98 E-value: 1.07e-11
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2141-2257 | 1.15e-11 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 67.27 E-value: 1.15e-11
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2146-2199 | 1.21e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 62.16 E-value: 1.21e-11
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1690-1743 | 1.34e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 62.10 E-value: 1.34e-11
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1690-1743 | 1.35e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 62.16 E-value: 1.35e-11
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
438-493 | 2.40e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 61.39 E-value: 2.40e-11
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1789-1843 | 2.43e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 61.32 E-value: 2.43e-11
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2259-2376 | 2.55e-11 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 66.12 E-value: 2.55e-11
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3241-3295 | 3.19e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 60.94 E-value: 3.19e-11
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1847-1901 | 4.45e-11 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 60.55 E-value: 4.45e-11
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1789-1842 | 4.53e-11 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 60.62 E-value: 4.53e-11
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2945-3117 | 5.10e-11 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 66.61 E-value: 5.10e-11
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| VWA_2 | pfam13519 | von Willebrand factor type A domain; |
84-194 | 5.23e-11 | |||||
von Willebrand factor type A domain; Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 61.92 E-value: 5.23e-11
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
3265-3413 | 6.19e-11 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 66.17 E-value: 6.19e-11
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2377-2551 | 7.03e-11 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 66.23 E-value: 7.03e-11
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2464-2609 | 7.72e-11 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 65.78 E-value: 7.72e-11
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2833-2887 | 1.45e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 59.01 E-value: 1.45e-10
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
2492-2645 | 1.75e-10 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 65.49 E-value: 1.75e-10
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
1905-2079 | 1.77e-10 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 65.07 E-value: 1.77e-10
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
438-493 | 1.85e-10 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 58.66 E-value: 1.85e-10
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2381-2436 | 2.32e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 58.63 E-value: 2.32e-10
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2849-3003 | 2.49e-10 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 64.24 E-value: 2.49e-10
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2775-2828 | 2.61e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 58.31 E-value: 2.61e-10
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1905-1958 | 2.80e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 58.24 E-value: 2.80e-10
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2678-2770 | 3.19e-10 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 63.04 E-value: 3.19e-10
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2280-2436 | 3.20e-10 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 63.86 E-value: 3.20e-10
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2770-2887 | 3.28e-10 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 63.04 E-value: 3.28e-10
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2146-2199 | 3.46e-10 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 57.89 E-value: 3.46e-10
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3241-3294 | 3.78e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 57.92 E-value: 3.78e-10
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2264-2318 | 4.06e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 57.86 E-value: 4.06e-10
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2891-3059 | 4.56e-10 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 63.91 E-value: 4.56e-10
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| vWA_complement_factors | cd01470 | Complement factors B and C2 are two critical proteases for complement activation. They both ... |
87-253 | 4.66e-10 | |||||
Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred commonly as the MIDAS motif. Orthologues of these molecules are found from echinoderms to chordates. During complement activation, the CCP domains are cleaved off, resulting in the formation of an active protease that cleaves and activates complement C3. Complement C2 is in the classical pathway and complement B is in the alternative pathway. The interaction of C2 with C4 and of factor B with C3b are both dependent on Mg2+ binding sites within the VWA domains and the VWA domain of factor B has been shown to mediate the binding of C3. This is consistent with the common inferred function of VWA domains as magnesium-dependent protein interaction domains. Pssm-ID: 238747 [Multi-domain] Cd Length: 198 Bit Score: 61.92 E-value: 4.66e-10
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
2710-2954 | 4.76e-10 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 63.95 E-value: 4.76e-10
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2886-3021 | 5.98e-10 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 62.27 E-value: 5.98e-10
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2949-3002 | 6.10e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 57.15 E-value: 6.10e-10
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1690-1743 | 6.34e-10 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 57.12 E-value: 6.34e-10
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2498-2551 | 6.80e-10 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 57.15 E-value: 6.80e-10
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2949-3002 | 6.94e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 57.09 E-value: 6.94e-10
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2404-2551 | 7.67e-10 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 62.70 E-value: 7.67e-10
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2775-2829 | 8.04e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 57.09 E-value: 8.04e-10
|
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
2040-2199 | 9.11e-10 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 62.76 E-value: 9.11e-10
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2498-2551 | 9.41e-10 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 56.70 E-value: 9.41e-10
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1847-1900 | 1.18e-09 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 56.38 E-value: 1.18e-09
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3241-3294 | 1.25e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 56.35 E-value: 1.25e-09
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2670-2713 | 1.40e-09 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 56.32 E-value: 1.40e-09
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1383-1419 | 1.43e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 55.72 E-value: 1.43e-09
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1905-1958 | 1.46e-09 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 56.38 E-value: 1.46e-09
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2264-2318 | 1.64e-09 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 56.00 E-value: 1.64e-09
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2493-2612 | 1.69e-09 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 61.11 E-value: 1.69e-09
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2381-2435 | 1.75e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 55.97 E-value: 1.75e-09
|
|||||||||
| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2264-2318 | 1.95e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 55.97 E-value: 1.95e-09
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2381-2435 | 2.57e-09 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 55.61 E-value: 2.57e-09
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1963-2016 | 2.68e-09 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 55.55 E-value: 2.68e-09
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2370-2493 | 2.88e-09 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 60.34 E-value: 2.88e-09
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1789-1842 | 3.22e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 55.20 E-value: 3.22e-09
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2828-2944 | 4.19e-09 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 59.57 E-value: 4.19e-09
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2670-2712 | 4.24e-09 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 54.84 E-value: 4.24e-09
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
3294-3413 | 4.31e-09 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 59.57 E-value: 4.31e-09
|
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| YfbK | COG2304 | Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ... |
13-223 | 5.66e-09 | |||||
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only]; Pssm-ID: 441879 [Multi-domain] Cd Length: 289 Bit Score: 60.50 E-value: 5.66e-09
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1231-1267 | 6.13e-09 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 53.79 E-value: 6.13e-09
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2674-2712 | 8.07e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 54.04 E-value: 8.07e-09
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1963-2016 | 9.44e-09 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 54.04 E-value: 9.44e-09
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2833-2886 | 9.64e-09 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 54.07 E-value: 9.64e-09
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2891-2945 | 9.94e-09 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 54.01 E-value: 9.94e-09
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3416-3469 | 1.02e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 54.01 E-value: 1.02e-08
|
|||||||||
| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1963-2016 | 1.05e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 53.68 E-value: 1.05e-08
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1628-1685 | 1.07e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 53.66 E-value: 1.07e-08
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
3352-3468 | 1.35e-08 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 58.41 E-value: 1.35e-08
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3416-3468 | 1.37e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 53.30 E-value: 1.37e-08
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2440-2494 | 1.58e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 53.24 E-value: 1.58e-08
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2498-2551 | 1.59e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 53.27 E-value: 1.59e-08
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1345-1381 | 1.70e-08 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 52.64 E-value: 1.70e-08
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2078-2199 | 1.72e-08 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 58.03 E-value: 1.72e-08
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2440-2493 | 2.22e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 52.91 E-value: 2.22e-08
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
378-434 | 2.22e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 52.85 E-value: 2.22e-08
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3299-3353 | 2.26e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 52.85 E-value: 2.26e-08
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2775-2828 | 2.28e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 52.89 E-value: 2.28e-08
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3299-3352 | 2.37e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 52.91 E-value: 2.37e-08
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2717-2771 | 2.50e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 52.85 E-value: 2.50e-08
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1905-1958 | 2.67e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 52.50 E-value: 2.67e-08
|
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2929-3059 | 2.69e-08 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 58.08 E-value: 2.69e-08
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1651-1747 | 3.23e-08 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 57.26 E-value: 3.23e-08
|
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1383-1419 | 3.25e-08 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 51.86 E-value: 3.25e-08
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
3169-3294 | 3.75e-08 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 56.87 E-value: 3.75e-08
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2717-2770 | 3.76e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 52.14 E-value: 3.76e-08
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3064-3118 | 4.15e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 52.08 E-value: 4.15e-08
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2323-2377 | 5.20e-08 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 51.69 E-value: 5.20e-08
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1900-2009 | 5.44e-08 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 56.49 E-value: 5.44e-08
|
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| vWA_collagen_alpha3-VI-like | cd01481 | VWA_collagen alpha 3(VI) like: The extracellular matrix represents a complex alloy of variable ... |
83-238 | 5.51e-08 | |||||
VWA_collagen alpha 3(VI) like: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified thus far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. Some collagens have about 15-18 vWA domains in them. The VWA domains present in these collagens mediate protein-protein interactions. Pssm-ID: 238758 Cd Length: 165 Bit Score: 55.02 E-value: 5.51e-08
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2833-2886 | 5.84e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 51.73 E-value: 5.84e-08
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
378-433 | 6.26e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 51.76 E-value: 6.26e-08
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1308-1342 | 6.42e-08 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 51.10 E-value: 6.42e-08
|
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| vWA_subgroup | cd01465 | VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
82-223 | 6.61e-08 | |||||
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known. Pssm-ID: 238742 [Multi-domain] Cd Length: 170 Bit Score: 54.97 E-value: 6.61e-08
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2891-2944 | 6.90e-08 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 51.37 E-value: 6.90e-08
|
|||||||||
| TerY | COG4245 | Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown]; |
81-223 | 7.13e-08 | |||||
Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown]; Pssm-ID: 443387 [Multi-domain] Cd Length: 196 Bit Score: 55.32 E-value: 7.13e-08
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3181-3231 | 7.31e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 51.35 E-value: 7.31e-08
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3299-3352 | 7.83e-08 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 51.35 E-value: 7.83e-08
|
|||||||||
| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2204-2260 | 1.03e-07 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 50.92 E-value: 1.03e-07
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
1847-1900 | 1.16e-07 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 50.96 E-value: 1.16e-07
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
1646-1842 | 1.49e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 56.21 E-value: 1.49e-07
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1269-1305 | 1.54e-07 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 49.94 E-value: 1.54e-07
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
1810-2034 | 1.54e-07 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 56.25 E-value: 1.54e-07
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1958-2079 | 1.56e-07 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 54.95 E-value: 1.56e-07
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2556-2608 | 1.57e-07 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 50.54 E-value: 1.57e-07
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
3070-3229 | 1.64e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 55.83 E-value: 1.64e-07
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2556-2608 | 1.68e-07 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 50.22 E-value: 1.68e-07
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2204-2256 | 1.82e-07 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 50.19 E-value: 1.82e-07
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2797-2944 | 1.90e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 55.38 E-value: 1.90e-07
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2440-2493 | 2.05e-07 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 50.19 E-value: 2.05e-07
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1231-1267 | 2.24e-07 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 49.55 E-value: 2.24e-07
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
1803-1900 | 2.61e-07 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 55.48 E-value: 2.61e-07
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2204-2256 | 2.69e-07 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 49.83 E-value: 2.69e-07
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
3036-3117 | 2.79e-07 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 54.18 E-value: 2.79e-07
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3064-3117 | 2.83e-07 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 49.83 E-value: 2.83e-07
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2556-2608 | 2.85e-07 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 49.81 E-value: 2.85e-07
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
1662-1744 | 2.99e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 55.00 E-value: 2.99e-07
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
3181-3355 | 3.08e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 55.06 E-value: 3.08e-07
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
1928-2079 | 3.24e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 54.61 E-value: 3.24e-07
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1345-1381 | 3.65e-07 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 48.78 E-value: 3.65e-07
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2400-2493 | 3.79e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 54.61 E-value: 3.79e-07
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1745-1783 | 4.49e-07 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 48.78 E-value: 4.49e-07
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2717-2770 | 4.71e-07 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 49.03 E-value: 4.71e-07
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
373-494 | 5.46e-07 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 53.89 E-value: 5.46e-07
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2760-2887 | 5.49e-07 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 54.23 E-value: 5.49e-07
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1836-1958 | 5.65e-07 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 53.41 E-value: 5.65e-07
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2323-2376 | 6.32e-07 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 48.68 E-value: 6.32e-07
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2083-2136 | 6.39e-07 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 48.61 E-value: 6.39e-07
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| ViaA | COG2425 | Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ... |
10-223 | 9.85e-07 | |||||
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown]; Pssm-ID: 441973 [Multi-domain] Cd Length: 263 Bit Score: 53.15 E-value: 9.85e-07
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
378-433 | 1.01e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 48.26 E-value: 1.01e-06
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1307-1342 | 1.07e-06 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 47.63 E-value: 1.07e-06
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
1967-2199 | 1.39e-06 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 53.17 E-value: 1.39e-06
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
1803-1958 | 1.46e-06 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 52.69 E-value: 1.46e-06
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2675-2770 | 1.52e-06 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 52.69 E-value: 1.52e-06
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| EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
1749-1783 | 1.68e-06 | |||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 46.82 E-value: 1.68e-06
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
3235-3355 | 1.88e-06 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 51.87 E-value: 1.88e-06
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2170-2322 | 2.08e-06 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 52.30 E-value: 2.08e-06
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3416-3468 | 2.19e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 47.11 E-value: 2.19e-06
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3181-3231 | 2.40e-06 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 47.14 E-value: 2.40e-06
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1745-1783 | 2.46e-06 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 46.48 E-value: 2.46e-06
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2435-2551 | 3.43e-06 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 51.09 E-value: 3.43e-06
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2323-2376 | 4.62e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 46.34 E-value: 4.62e-06
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| vWA_BatA_type | cd01467 | VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
83-241 | 4.76e-06 | |||||
VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif. Pssm-ID: 238744 [Multi-domain] Cd Length: 180 Bit Score: 49.64 E-value: 4.76e-06
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
1640-1686 | 4.97e-06 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 46.30 E-value: 4.97e-06
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2949-3002 | 6.21e-06 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 45.95 E-value: 6.21e-06
|
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| EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1269-1305 | 6.21e-06 | |||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 6.21e-06
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
1631-1685 | 9.57e-06 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 45.60 E-value: 9.57e-06
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
2893-3117 | 9.74e-06 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 50.86 E-value: 9.74e-06
|
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
1651-1744 | 9.76e-06 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 50.04 E-value: 9.76e-06
|
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2083-2136 | 1.09e-05 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 45.21 E-value: 1.09e-05
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3181-3230 | 1.22e-05 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 45.15 E-value: 1.22e-05
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2891-2944 | 1.42e-05 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 44.80 E-value: 1.42e-05
|
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2045-2199 | 1.52e-05 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 49.61 E-value: 1.52e-05
|
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
3022-3180 | 1.52e-05 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 50.05 E-value: 1.52e-05
|
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1387-1417 | 1.53e-05 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 44.30 E-value: 1.53e-05
|
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| vWA_F09G8-8_type | cd01477 | VWA F09G8.8 type: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
82-220 | 1.58e-05 | |||||
VWA F09G8.8 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. The members of this subgroup lack the MIDAS motif. This subgroup is found only in C. elegans and the members identified thus far are always found fused to a C-Lectin type domain. Biochemical function thus far has not be attributed to any of the members of this subgroup. Pssm-ID: 238754 [Multi-domain] Cd Length: 193 Bit Score: 48.57 E-value: 1.58e-05
|
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3357-3412 | 1.73e-05 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 44.76 E-value: 1.73e-05
|
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| vWA_ATR | cd01474 | ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, ... |
83-255 | 1.97e-05 | |||||
ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ATR contains the toxin binding site and mediates interaction with protective antigen. The binding is mediated by divalent cations that binds to the MIDAS motif. These proteins are a family of vertebrate ECM receptors expressed by endothelial cells. Pssm-ID: 238751 [Multi-domain] Cd Length: 185 Bit Score: 48.28 E-value: 1.97e-05
|
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
2944-3063 | 2.18e-05 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 49.70 E-value: 2.18e-05
|
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| PHA02639 | PHA02639 | EEV host range protein; Provisional |
1628-1744 | 2.31e-05 | |||||
EEV host range protein; Provisional Pssm-ID: 165022 [Multi-domain] Cd Length: 295 Bit Score: 49.28 E-value: 2.31e-05
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
3114-3229 | 3.55e-05 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 48.01 E-value: 3.55e-05
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3064-3117 | 3.71e-05 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 43.64 E-value: 3.71e-05
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
3007-3060 | 3.71e-05 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 43.61 E-value: 3.71e-05
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2971-3117 | 4.01e-05 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 48.45 E-value: 4.01e-05
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1235-1265 | 4.04e-05 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 42.76 E-value: 4.04e-05
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
3059-3197 | 4.81e-05 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 47.63 E-value: 4.81e-05
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
1685-1842 | 4.86e-05 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 47.63 E-value: 4.86e-05
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2083-2136 | 6.24e-05 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 43.26 E-value: 6.24e-05
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3007-3059 | 6.49e-05 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 43.26 E-value: 6.49e-05
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
2021-2078 | 7.16e-05 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 42.87 E-value: 7.16e-05
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
3313-3462 | 8.60e-05 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 47.29 E-value: 8.60e-05
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
2150-2376 | 8.84e-05 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 47.77 E-value: 8.84e-05
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1196-1229 | 1.12e-04 | |||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 1.12e-04
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3357-3411 | 1.23e-04 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 42.13 E-value: 1.23e-04
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1386-1419 | 1.34e-04 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 41.69 E-value: 1.34e-04
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2550-2713 | 1.58e-04 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 46.09 E-value: 1.58e-04
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| CCP | cd00033 | Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
2021-2079 | 2.29e-04 | |||||
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function. Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 41.68 E-value: 2.29e-04
|
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1197-1225 | 2.44e-04 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 40.83 E-value: 2.44e-04
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
3007-3059 | 2.45e-04 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 41.36 E-value: 2.45e-04
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
2510-2750 | 3.07e-04 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 45.75 E-value: 3.07e-04
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
1651-1748 | 3.60e-04 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 45.85 E-value: 3.60e-04
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| vWA_CTRP | cd01473 | CTRP for CS protein-TRAP-related protein: Adhesion of Plasmodium to host cells is an ... |
84-231 | 4.59e-04 | |||||
CTRP for CS protein-TRAP-related protein: Adhesion of Plasmodium to host cells is an important phenomenon in parasite invasion and in malaria associated pathology.CTRP encodes a protein containing a putative signal sequence followed by a long extracellular region of 1990 amino acids, a transmembrane domain, and a short cytoplasmic segment. The extracellular region of CTRP contains two separated adhesive domains. The first domain contains six 210-amino acid-long homologous VWA domain repeats. The second domain contains seven repeats of 87-60 amino acids in length, which share similarities with the thrombospondin type 1 domain found in a variety of adhesive molecules. Finally, CTRP also contains consensus motifs found in the superfamily of haematopoietin receptors. The VWA domains in these proteins likely mediate protein-protein interactions. Pssm-ID: 238750 [Multi-domain] Cd Length: 192 Bit Score: 44.23 E-value: 4.59e-04
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1349-1379 | 4.94e-04 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 39.67 E-value: 4.94e-04
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
2687-2856 | 5.79e-04 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 45.08 E-value: 5.79e-04
|
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1310-1341 | 7.96e-04 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 39.38 E-value: 7.96e-04
|
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1348-1381 | 8.28e-04 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 39.38 E-value: 8.28e-04
|
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1234-1267 | 9.50e-04 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 39.38 E-value: 9.50e-04
|
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1748-1780 | 1.03e-03 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 39.00 E-value: 1.03e-03
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| CCP | smart00032 | Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
2021-2078 | 1.03e-03 | |||||
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 39.82 E-value: 1.03e-03
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
1709-1842 | 1.26e-03 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 43.92 E-value: 1.26e-03
|
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| Sushi | pfam00084 | Sushi repeat (SCR repeat); |
3357-3411 | 1.34e-03 | |||||
Sushi repeat (SCR repeat); Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 39.40 E-value: 1.34e-03
|
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| EGF_CA | pfam07645 | Calcium-binding EGF domain; |
1745-1774 | 1.37e-03 | |||||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 38.76 E-value: 1.37e-03
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| LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1495-1580 | 1.60e-03 | |||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 41.63 E-value: 1.60e-03
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| PHA02927 | PHA02927 | secreted complement-binding protein; Provisional |
370-566 | 2.04e-03 | |||||
secreted complement-binding protein; Provisional Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 43.10 E-value: 2.04e-03
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| PHA02831 | PHA02831 | EEV host range protein; Provisional |
401-495 | 2.20e-03 | |||||
EEV host range protein; Provisional Pssm-ID: 165176 [Multi-domain] Cd Length: 268 Bit Score: 43.06 E-value: 2.20e-03
|
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1272-1305 | 2.89e-03 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 37.84 E-value: 2.89e-03
|
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| EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1311-1337 | 3.49e-03 | |||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 37.36 E-value: 3.49e-03
|
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| Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1471-1579 | 4.97e-03 | |||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 39.71 E-value: 4.97e-03
|
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| EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1200-1229 | 5.01e-03 | |||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 37.07 E-value: 5.01e-03
|
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| PHA02817 | PHA02817 | EEV Host range protein; Provisional |
2944-3059 | 6.37e-03 | |||||
EEV Host range protein; Provisional Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 41.08 E-value: 6.37e-03
|
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| vWA_interalpha_trypsin_inhibitor | cd01461 | vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- ... |
83-223 | 8.15e-03 | |||||
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to the extracellular matrix by binding to hyaluronic acid. The heavy chains carry the VWA domain with a conserved MIDAS motif. Although the exact role of the VWA domains remains unknown, it has been speculated to be involved in mediating protein-protein interactions with the components of the extracellular matrix. Pssm-ID: 238738 [Multi-domain] Cd Length: 171 Bit Score: 39.89 E-value: 8.15e-03
|
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| PHA02954 | PHA02954 | EEV membrane glycoprotein; Provisional |
2506-2713 | 9.02e-03 | |||||
EEV membrane glycoprotein; Provisional Pssm-ID: 165263 [Multi-domain] Cd Length: 317 Bit Score: 41.23 E-value: 9.02e-03
|
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| hEGF | pfam12661 | Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
1316-1337 | 9.27e-03 | |||||
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue. Pssm-ID: 463660 Cd Length: 22 Bit Score: 36.16 E-value: 9.27e-03
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| Blast search parameters | ||||
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