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Conserved domains on  [gi|223633947|ref|NP_699198|]
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zinc finger CCHC domain-containing protein 24 [Homo sapiens]

Protein Classification

zinc finger CCHC domain-containing protein; RING-HC finger protein( domain architecture ID 13423497)

zinc finger CCHC (ZCCHC) domain-containing protein contains a zinc knuckle or a zinc binding motif, CX2CX4HX4C, where X can be any amino acid, and may bind single-stranded RNA; similar to Feline leukemia virus virion core structural peptide p10; RING-HC finger protein may function as an E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-3CxxC_2 pfam17180
Zinc-binding domain;
164-230 4.60e-38

Zinc-binding domain;


:

Pssm-ID: 407306  Cd Length: 74  Bit Score: 127.53  E-value: 4.60e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223633947  164 KRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDV------SDQSKEHPQHLCEKC 230
Cdd:pfam17180   2 KRLFGKFTCTKCAREWSSGNSWANMGQECKKCKIPVYPWVQRPLLKKEDYDEdlmrggSIGDRAHETHLCEKC 74
zf-CCHC_2 pfam13696
Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of ...
 129-149 1.10e-07

Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.


:

Pssm-ID: 463959 [Multi-domain]  Cd Length: 21  Bit Score: 46.74  E-value: 1.10e-07
                          10        20
                  ....*....|....*....|.
gi 223633947  129 PPNYLCHLCFNKGHYIKDCPQ 149
Cdd:pfam13696   1 PPGYVCHICGKKGHYIQDCPT 21
COG5222 super family cl34947
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
33-157 1.35e-07

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5222:

Pssm-ID: 227547 [Multi-domain]  Cd Length: 427  Bit Score: 51.67  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633947  33 QASAFDAFRPEPTAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASpyGSLNNIADGLSSLTEHF 112
Cdd:COG5222   80 WKSKGTAARYKGGAPKTTGARGYNVKRPRMLQKKAPITSGELNSQSSSEDAAIQQMFQVSS--DQWRETQDKMSSATPIY 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223633947 113 SDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCP-QARPKGEGL 157
Cdd:COG5222  158 KPNQHRIGAQKHNKPPPPGYVCYRCGQKGHWIQNCPtNQDPNFDGK 203
 
Name Accession Description Interval E-value
zf-3CxxC_2 pfam17180
Zinc-binding domain;
164-230 4.60e-38

Zinc-binding domain;


Pssm-ID: 407306  Cd Length: 74  Bit Score: 127.53  E-value: 4.60e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223633947  164 KRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDV------SDQSKEHPQHLCEKC 230
Cdd:pfam17180   2 KRLFGKFTCTKCAREWSSGNSWANMGQECKKCKIPVYPWVQRPLLKKEDYDEdlmrggSIGDRAHETHLCEKC 74
zf-CCHC_2 pfam13696
Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of ...
 129-149 1.10e-07

Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.


Pssm-ID: 463959 [Multi-domain]  Cd Length: 21  Bit Score: 46.74  E-value: 1.10e-07
                          10        20
                  ....*....|....*....|.
gi 223633947  129 PPNYLCHLCFNKGHYIKDCPQ 149
Cdd:pfam13696   1 PPGYVCHICGKKGHYIQDCPT 21
COG5222 COG5222
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
33-157 1.35e-07

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227547 [Multi-domain]  Cd Length: 427  Bit Score: 51.67  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633947  33 QASAFDAFRPEPTAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASpyGSLNNIADGLSSLTEHF 112
Cdd:COG5222   80 WKSKGTAARYKGGAPKTTGARGYNVKRPRMLQKKAPITSGELNSQSSSEDAAIQQMFQVSS--DQWRETQDKMSSATPIY 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223633947 113 SDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCP-QARPKGEGL 157
Cdd:COG5222  158 KPNQHRIGAQKHNKPPPPGYVCYRCGQKGHWIQNCPtNQDPNFDGK 203
 
Name Accession Description Interval E-value
zf-3CxxC_2 pfam17180
Zinc-binding domain;
164-230 4.60e-38

Zinc-binding domain;


Pssm-ID: 407306  Cd Length: 74  Bit Score: 127.53  E-value: 4.60e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223633947  164 KRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDV------SDQSKEHPQHLCEKC 230
Cdd:pfam17180   2 KRLFGKFTCTKCAREWSSGNSWANMGQECKKCKIPVYPWVQRPLLKKEDYDEdlmrggSIGDRAHETHLCEKC 74
zf-CCHC_2 pfam13696
Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of ...
 129-149 1.10e-07

Zinc knuckle; This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.


Pssm-ID: 463959 [Multi-domain]  Cd Length: 21  Bit Score: 46.74  E-value: 1.10e-07
                          10        20
                  ....*....|....*....|.
gi 223633947  129 PPNYLCHLCFNKGHYIKDCPQ 149
Cdd:pfam13696   1 PPGYVCHICGKKGHYIQDCPT 21
COG5222 COG5222
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
33-157 1.35e-07

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227547 [Multi-domain]  Cd Length: 427  Bit Score: 51.67  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633947  33 QASAFDAFRPEPTAGAAPPELAFGKGRPEQLGSPLHSSYLNSFFQLQRGEALSNSVYKGASpyGSLNNIADGLSSLTEHF 112
Cdd:COG5222   80 WKSKGTAARYKGGAPKTTGARGYNVKRPRMLQKKAPITSGELNSQSSSEDAAIQQMFQVSS--DQWRETQDKMSSATPIY 157

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223633947 113 SDLTLTSEARKPSKRPPPNYLCHLCFNKGHYIKDCP-QARPKGEGL 157
Cdd:COG5222  158 KPNQHRIGAQKHNKPPPPGYVCYRCGQKGHWIQNCPtNQDPNFDGK 203
zf-3CxxC pfam13695
Zinc-binding domain; This is a family with several pairs of CxxC motifs possibly representing ...
 165-231 3.07e-06

Zinc-binding domain; This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.


Pssm-ID: 463958  Cd Length: 96  Bit Score: 44.33  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633947  165 RCFGEYKCPKCKRKWMSGNSWA--------------NM---GQECIKCHINVYPH-------------KQRPLEKPDGLD 214
Cdd:pfam13695   1 KVYGRFRCSSCSRKWTSAKVWItirmyldppgngtyNArvyGQRCKKCKRLERPEldeeevervlyrlKKKIEKPCYGEK 80

                          90
                  ....*....|....*..
gi 223633947  215 VsdqSKEHPQHLCEKCK 231
Cdd:pfam13695  81 T---TGPHERDLCEGCK 94
UPF0515 pfam15135
Uncharacterized protein UPF0515; This family of proteins is functionally uncharacterized. This ...
 168-230 1.63e-03

Uncharacterized protein UPF0515; This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. There are two conserved sequence motifs: PLT and HSC.


Pssm-ID: 464521  Cd Length: 271  Bit Score: 38.63  E-value: 1.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223633947  168 GEYKCPKCKRKWmsgNSWANMG--QECIKCHINVYPHKQRPLEKPDGldvsdQSKEHpQHLC--EKC 230
Cdd:pfam15135 152 AEFHCPKCKRTF---RGFGQMEvsSPCYGCGNPVLPSRILPPRRSQG-----PRSRN-QHSCfaEDC 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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