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Conserved domains on  [gi|23957692|ref|NP_705832|]
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myocardin isoform 2 [Homo sapiens]

Protein Classification

SAP domain-containing protein( domain architecture ID 10653801)

SAP (SAF-A/B, Acinus and PIAS) domain-containing protein may bind DNA or RNA and act as a transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 371-404 1.67e-08

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 50.86  E-value: 1.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 23957692   371 LDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPF 404
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
106-131 4.18e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 4.18e-05
                           10        20
                   ....*....|....*....|....*.
gi 23957692    106 DDLNEKIALRPGPLELVEKNILPVDS 131
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 371-404 1.67e-08

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 50.86  E-value: 1.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 23957692   371 LDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPF 404
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
371-402 2.05e-08

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 50.56  E-value: 2.05e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 23957692    371 LDDLKVSELRQQLRIRGLPVSGTKTALMDRLR 402
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
106-131 4.18e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 4.18e-05
                           10        20
                   ....*....|....*....|....*.
gi 23957692    106 DDLNEKIALRPGPLELVEKNILPVDS 131
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 107-130 7.17e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 40.33  E-value: 7.17e-05
                          10        20
                  ....*....|....*....|....
gi 23957692   107 DLNEKIALRPGPLELVEKNILPVD 130
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPED 24
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 371-404 1.67e-08

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 50.86  E-value: 1.67e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 23957692   371 LDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPF 404
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
371-402 2.05e-08

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 50.56  E-value: 2.05e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 23957692    371 LDDLKVSELRQQLRIRGLPVSGTKTALMDRLR 402
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
106-131 4.18e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 4.18e-05
                           10        20
                   ....*....|....*....|....*.
gi 23957692    106 DDLNEKIALRPGPLELVEKNILPVDS 131
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 107-130 7.17e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 40.33  E-value: 7.17e-05
                          10        20
                  ....*....|....*....|....
gi 23957692   107 DLNEKIALRPGPLELVEKNILPVD 130
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPED 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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