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Conserved domains on  [gi|24234744|ref|NP_705872|]
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semaphorin-6D isoform 5 precursor [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 10181432)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
49-513 0e+00

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


:

Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 1037.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  49 SGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128
Cdd:cd11269   1 SGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEVPKTEVTPSRKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSAL 208
Cdd:cd11269  81 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG 288
Cdd:cd11269 161 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 289 DSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPG 368
Cdd:cd11269 241 DSFFYFDVLQSITDIIEINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 369 CCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMV 448
Cdd:cd11269 321 CCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYRLTAIAVDHAAGPHQNYTVIFVGSEAGVV 400
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24234744 449 LKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11269 401 LKILAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDRRVISLQLDRDHHALFVAFSSCVVRIPLS 465
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
514-569 6.58e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 46.55  E-value: 6.58e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234744   514 RCERYGSCKkSCIASRDPYCGWLS-QGSCgrvTPGMLAEGYEQDTEFGNTAHLGdCH 569
Cdd:pfam01437   1 RCSQYTSCS-SCLAARDPYCGWCSsEGRC---VRRSACGAPEGNCEEWEQASSK-CP 52
 
Name Accession Description Interval E-value
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
49-513 0e+00

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 1037.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  49 SGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128
Cdd:cd11269   1 SGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEVPKTEVTPSRKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSAL 208
Cdd:cd11269  81 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG 288
Cdd:cd11269 161 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 289 DSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPG 368
Cdd:cd11269 241 DSFFYFDVLQSITDIIEINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 369 CCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMV 448
Cdd:cd11269 321 CCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYRLTAIAVDHAAGPHQNYTVIFVGSEAGVV 400
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24234744 449 LKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11269 401 LKILAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDRRVISLQLDRDHHALFVAFSSCVVRIPLS 465
Sema smart00630
semaphorin domain;
57-470 1.42e-145

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 426.01  E-value: 1.42e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744     57 LDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVipnkKLTWRSRQQDRENCAMKGKHK-DECHNFIKVFVPRNDEMVFV 135
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAEL----KTGPVLSSPDCEECVSKGKDPpTDCVNYIRLLLDYNEDRLLV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    136 CGTNAFNPMCRYYRLstleydgeeisglarcpfdarqtnvalfadGKLYSATVADFLASDAVIYRSMG-------DGSAL 208
Cdd:smart00630  77 CGTNAFQPVCRLRNL------------------------------GELYVGTVADFSGSDPAIPRSLSvrrlkgtSGVSL 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPG 288
Cdd:smart00630 127 RTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGG-PRSLDKKWTSFLKARLECSVPG 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    289 DSFFYFDVLQSITDIIQINGIPTVV-GVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367
Cdd:smart00630 206 EDPFYFNELQAAFLLPPGSESDDVLyGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRP 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    368 GCCAKHGLaeaykTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYqNYTVIFVGSEAGM 447
Cdd:smart00630 286 GTCPNKPP-----SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYLLTSIAVDRVATDG-NYTVLFLGTSDGR 359
                          410       420
                   ....*....|....*....|...
gi 24234744    448 VLKVLAKTSPfSLNDSVLLEEIE 470
Cdd:smart00630 360 ILKVVLSESS-SSSESVVLEEIS 381
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
297-474 1.96e-55

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 185.55  E-value: 1.96e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744   297 LQSITDIIQINGIP--TVV-GVFTTQL-NSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPeDKVPKPRPGCCAK 372
Cdd:pfam01403   1 LQDVFVLKPGAGDAldTVLyGVFTTQWsNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYT-GKVPYPRPGTCIN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744   373 HGLaeayktSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYrlTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL 452
Cdd:pfam01403  80 DPL------RLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRL--TSIAVDRVQALDGNYTVLFLGTDDGRLHKVV 151
                         170       180
                  ....*....|....*....|..
gi 24234744   453 AKTSpfslNDSVLLEEIEAYNH 474
Cdd:pfam01403 152 LVGS----EESHIIEEIQVFPE 169
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
514-569 6.58e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 46.55  E-value: 6.58e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234744   514 RCERYGSCKkSCIASRDPYCGWLS-QGSCgrvTPGMLAEGYEQDTEFGNTAHLGdCH 569
Cdd:pfam01437   1 RCSQYTSCS-SCLAARDPYCGWCSsEGRC---VRRSACGAPEGNCEEWEQASSK-CP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
514-543 6.54e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 40.61  E-value: 6.54e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24234744    514 RCERYGSCKkSCIASRDPYCGW-LSQGSCGR 543
Cdd:smart00423   1 RCSKYTSCS-ECLLARDPYCAWcSSQGRCTS 30
 
Name Accession Description Interval E-value
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
49-513 0e+00

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 1037.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  49 SGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128
Cdd:cd11269   1 SGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEVPKTEVTPSRKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSAL 208
Cdd:cd11269  81 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG 288
Cdd:cd11269 161 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 289 DSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPG 368
Cdd:cd11269 241 DSFFYFDVLQSITDIIEINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 369 CCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMV 448
Cdd:cd11269 321 CCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYRLTAIAVDHAAGPHQNYTVIFVGSEAGVV 400
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24234744 449 LKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11269 401 LKILAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDRRVISLQLDRDHHALFVAFSSCVVRIPLS 465
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
49-513 0e+00

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 963.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  49 SGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPR 128
Cdd:cd11242   1 DNTTARHRLDFQRMLRINRTLYIAARDHVYTVDLDASHTEEIVPSKKLTWRSRQADVENCRMKGKHKDECHNFIKVLVPR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 129 NDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSAL 208
Cdd:cd11242  81 NDETLFVCGTNAFNPVCRNYRIDTLEQDGEEISGMARCPFDAKQANVALFADGKLYSATVTDFLASDAVIYRSLGDSPTL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPG 288
Cdd:cd11242 161 RTVKYDSKWLKEPHFVHAVEYGDYVYFFFREIAVEYNTLGKVVFSRVARVCKNDMGGSPRVLEKQWTSFLKARLNCSVPG 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 289 DSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPG 368
Cdd:cd11242 241 DSHFYFDVLQAVTDVIRINGRPVVLGVFTTQYNSIPGSAVCAFDMDDIEKVFEGRFKEQKSPDSAWTPVPEDRVPKPRPG 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 369 CCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMV 448
Cdd:cd11242 321 CCAGSGSAEKYKTSNDFPDDTLNFIKTHPLMDEAVPSIINRPWFTRTMVRYRLTQIAVDNAAGPYQNYTVVFLGSEAGTV 400
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24234744 449 LKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11242 401 LKFLARIGPSGSNGSVFLEEIDVYNPAKCSYDGEEDRRIIGLELDRASHALFVAFSGCVIRVPLS 465
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
51-512 0e+00

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 732.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  51 NESQ-HRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRN 129
Cdd:cd11266   2 NTTQrHRLDIQMIMIMNRTLYIAARDHIYTVDIDTSHTEEIYFSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKRN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 130 DEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALR 209
Cdd:cd11266  82 DDTLFVCGTNAFNPSCRNYKMDTLEFFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 210 TIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Cdd:cd11266 162 TVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGD 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 290 SFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGC 369
Cdd:cd11266 242 SHFYFNILQAVTDVIHINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGC 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 370 CAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVL 449
Cdd:cd11266 322 CAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDNAAGPYQNHTVVFLGSEKGIIL 401
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24234744 450 KVLAKT--SPFsLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPL 512
Cdd:cd11266 402 KFLARTgnSGF-LNDSLFLEEMNVYNSEKCSYDGVEDKRIMGMQLDKASSALYVAFSTCVIKVPL 465
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
52-513 0e+00

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 672.31  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  52 ESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE 131
Cdd:cd11267   4 RGRDRLNIQRVLRVNRTLYIGDRDNLYRVELDPTAGTEMRYHKKLTWRSNKNDINVCRMKGKHEGECRNFIKVLLLRDYG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 132 MVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTI 211
Cdd:cd11267  84 TLFVCGTNAFNPVCANYSIDTLEPVGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSLGDSPALRTV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 212 KYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291
Cdd:cd11267 164 KHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSH 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 292 FYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCA 371
Cdd:cd11267 244 FYFNVLQAVSDILNLGGRPVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEELVPRPRPGCCA 323
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 372 KHGLaeAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKV 451
Cdd:cd11267 324 APGM--RYNSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTMTRYQLTHMVVDTEAGPHGNHTVVFLGSTRGTVLKF 401
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24234744 452 L----AKTSPFSlNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11267 402 LiipnASSSEIS-NQSVFLEELETYNPERCGWDSPQAQKLLSLELDKGSGGLLLAFPSCVVRVPVA 466
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
57-513 0e+00

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 672.20  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  57 LDFQLMLKIRDTLYIAGRDQVYTVNLNEmPKTEVIPNKKLTWRSrqQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVC 136
Cdd:cd11270   9 LDFQRMLRINHMVYIAARDHVFAINLSA-SLERIVPQQKLTWKT--KDVEKCTVRGKNSDECYNYIKVLVPRNDETLFAC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 137 GTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGS-ALRTIKYDS 215
Cdd:cd11270  86 GTNAFNPTCRNYKMSSLEQDGEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGESSpVLRTVKYDS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 216 KWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFD 295
Cdd:cd11270 166 KWLREPHFLHAIEYGNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSPRVLERYWTSFLKARLNCSVPGDSFFYFD 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 296 VLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGL 375
Cdd:cd11270 246 VLQSLTNVMQINHRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVPDEAVPKPRPGSCAGDGP 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 376 AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKT 455
Cdd:cd11270 326 AAGYKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFKLTQIAVDTAAGPYKNYTVVFLGSENGHVLKVLASM 405
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24234744 456 SPFSLNDSVLLEEIEAYNHAKCSAEnEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11270 406 HPNSSYSTQVLEDIDVYNPNKCNVR-GEDRRILGLELDKDHHALFVAFTGCVIRVPLS 462
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
57-513 0e+00

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 565.48  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  57 LDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTE-VIPNKKLTWRSrqQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFV 135
Cdd:cd11268   9 LDFQRFLTLNRTLLVAARDHVFSFDLQAEEEGEgLVPNKYLTWRS--QDVENCAVRGKLTDECYNYIRVLVPWDSQTLLA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 136 CGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDS 215
Cdd:cd11268  87 CGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 216 KWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFD 295
Cdd:cd11268 167 KWLREPHFVQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFD 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 296 VLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGL 375
Cdd:cd11268 247 VLQALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSEDRVPSPRPGSCAGVGG 326
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 376 AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRvRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKT 455
Cdd:cd11268 327 AALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLTLTS-RALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLPPG 405
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 456 SPFSLNDSVLLEEIEAYNHAKCSAEN--EEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11268 406 GRSGGPEPILLEEIDAYSPARCSGKRtaQTARRIIGLELDTEGHRLFVAFSGCIVYLPLS 465
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
61-512 0e+00

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 545.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  61 LMLKIRDTLYIAGRDQVYTVNLNEMPKtevipNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNA 140
Cdd:cd11235   7 LLHEDRSTLYVGARDRVYLVDLDSLYT-----EQKVAWPSSPDDVDTCYLKGKSKDDCRNFIKVLEKNSDDSLLVCGTNA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 141 FNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKE 220
Cdd:cd11235  82 FNPSCRNYNVETFELVGKEESGRGKCPYDPDHNSTALFADGELYSGTSADFLGTDPVIYRTLGHNPPLRTEYHDSKWLNE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 221 PHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRvLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI 300
Cdd:cd11235 162 PQFVGAFDIGDYVYFFFREIAVEYINCGKAVYSRVARVCKNDQGGSRS-LEKKWTTFLKARLNCSVPGEFPFYFNELQDV 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 301 TDIIQINGIPTVV-GVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCakhglaeaY 379
Cdd:cd11235 241 FDLPSPSNKEKIFyAVFTTPYNSIPGSAVCAYSLSDIEAVFNGPFKEQHSSNSAWLPVPDERVPEPRPGTC--------V 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 380 KTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSpF 458
Cdd:cd11235 313 DDSSPLPDDTLNFIKSHPLMDEAVTPILNRPLFIKTDVNYRFTKIAVDRVqAKLGQTYDVLFVGTDRGIILKVVSLPE-Q 391
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 24234744 459 SLNDSVLLEEIEAYNhakcsaeneEDKKVISLQLDKDHHALYVAFSSCIIRIPL 512
Cdd:cd11235 392 GLQASNILEEMPVGP---------PPEPIQTMQLSRKRRSLYVGSETGVLQVPL 436
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
50-515 1.87e-173

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 499.55  E-value: 1.87e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  50 GNESQHrldFQLMLKIRDTLYIAGRDQVYTVNLNEMpkTEvipNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRN 129
Cdd:cd11237   1 ETHSDH---FKLLDQDGNSLLVGARNAVYNISLSDL--TE---NQRIEWPSSDAHREMCLLKGKSEDDCQNYIRVLAKKS 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 130 DEMVFVCGTNAFNPMCRYYRLSTLEYDGE-EISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSmgdgsAL 208
Cdd:cd11237  73 AGRLLVCGTNAYKPLCREYTVKDGGYRVErEFDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYRE-----PL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRvLEKHWTSFLKARLNCSVPG 288
Cdd:cd11237 148 RTERYDLKQLNAPNFVSSFAYGDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGGPHP-FRDRWTSFLKARLNCSVPG 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 289 DSFFYFDVLQSITDII--QINGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPK 364
Cdd:cd11237 227 EYPFYFNEIQSTSDIVegGYGGKsaKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQDINSNWLPVPSNKVPE 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 365 PRPGCCAkhglaeayKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDH--SAGPYQNYTVIFVG 442
Cdd:cd11237 307 PRPGQCV--------NDSRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQYRFTQIAVDPqvKALDGKYYDVLFIG 378
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24234744 443 SEAGMVLKVL--AKTSPFSLNDSVLLEEIEAYNHAkcsaeneedKKVISLQL--DKDHHALYVAFSSCIIRIPLSRC 515
Cdd:cd11237 379 TDDGKVLKAVniASADTVDKVSPVVIEETQVFPRG---------VPIRNLLIvrGKDDGRLVVVSDDEIVSIPLHRC 446
Sema smart00630
semaphorin domain;
57-470 1.42e-145

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 426.01  E-value: 1.42e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744     57 LDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVipnkKLTWRSRQQDRENCAMKGKHK-DECHNFIKVFVPRNDEMVFV 135
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAEL----KTGPVLSSPDCEECVSKGKDPpTDCVNYIRLLLDYNEDRLLV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    136 CGTNAFNPMCRYYRLstleydgeeisglarcpfdarqtnvalfadGKLYSATVADFLASDAVIYRSMG-------DGSAL 208
Cdd:smart00630  77 CGTNAFQPVCRLRNL------------------------------GELYVGTVADFSGSDPAIPRSLSvrrlkgtSGVSL 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPG 288
Cdd:smart00630 127 RTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGG-PRSLDKKWTSFLKARLECSVPG 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    289 DSFFYFDVLQSITDIIQINGIPTVV-GVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367
Cdd:smart00630 206 EDPFYFNELQAAFLLPPGSESDDVLyGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSRGKVPYPRP 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744    368 GCCAKHGLaeaykTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYqNYTVIFVGSEAGM 447
Cdd:smart00630 286 GTCPNKPP-----SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYLLTSIAVDRVATDG-NYTVLFLGTSDGR 359
                          410       420
                   ....*....|....*....|...
gi 24234744    448 VLKVLAKTSPfSLNDSVLLEEIE 470
Cdd:smart00630 360 ILKVVLSESS-SSSESVVLEEIS 381
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
51-515 1.00e-131

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 393.65  E-value: 1.00e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  51 NESQHRLDFQLMLK--IRDTLYIAGRDQVYTVNLNEMPKteviPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVP 127
Cdd:cd11239   2 LGSMNSLDYRSLLLdeDRDRLYVGGKDHILSLSLDNINQ----DPKKIYWPASPERIEECKMAGKDPNtECANFVRVLQP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 128 RNDEMVFVCGTNAFNPMCRYYRLST---------LEYDGEeiSGLARCPFDARQTNVALFADGKLYSATVADFLASDAVI 198
Cdd:cd11239  78 YNRTHLYACGTGAFHPICAFINVGRrledpifklDDSSLE--SGRGKCPFDPNQPFASVLIDGELYSGTAIDFMGRDAAI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 199 YRSMGDGSALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLE 271
Cdd:cd11239 156 FRSLGHRHYIRTEQYDSRWLNEPKFVGAYlipdsdnPDDDKVYFFFREKAVEAEGSGKAIYSRVGRICKNDVGG-QRSLV 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 272 KHWTSFLKARLNCSVPG----DSffYFDVLQSITdIIQINGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFK 345
Cdd:cd11239 235 NKWSTFLKARLVCSVPGpdgiDT--YFDELEDVF-LLPTRDPknPLIYGVFTTSSNVFKGSAVCVYSMADIRAAFNGPFA 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 346 EQKTPDSVWTAVpEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIS 425
Cdd:cd11239 312 HKEGPNYQWVEY-QGKVPYPRPGTCPSKTYGPLYKSTKDFPDDVISFARSHPLMYNPVYPLHGRPLLIRTNVPYRLTQIA 390
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 426 VDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHakcsaeneeDKKVISLQLDKDHHALYVAFSS 505
Cdd:cd11239 391 VDRVEAEDGQYDVLFIGTDSGTVLKVVSLPKENWEMEEVILEELQVFKH---------PSPITSMEISSKRQQLYVGSAE 461
                       490
                ....*....|
gi 24234744 506 CIIRIPLSRC 515
Cdd:cd11239 462 GVVQLPLHRC 471
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
67-513 5.38e-123

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 370.97  E-value: 5.38e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  67 DTLYIAGRDQVYTVNLNEmpkTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPMC 145
Cdd:cd11240  19 GTLYVGAREALFALNVSD---ISTELKDKIKWEASEDKKKECANKGKDNQtDCFNFIRILQFYNSTHLYVCGTFAFSPRC 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 146 RYYRLSTLEYDGEEI-SGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTiKYDSKWIKEPHFL 224
Cdd:cd11240  96 TYINLSDFSLSSIKFeDGKGRCPFDPAQRYTAIMVDGELYSATVNNFLGSEPVISRNHSEGNVLKT-ENTLRWLNEPAFV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 225 HA----------IEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPGDSFfYF 294
Cdd:cd11240 175 GSahiresidspDGDDDKIYFFFTETAVEYDFYEKVTVSRVARVCKGDLGG-QRTLQKKWTTFLKAQLVCSQPDSGL-PF 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 295 DVLQsitDIIQING----IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVpEDKVPKPRPGCC 370
Cdd:cd11240 253 NVLR---DVFVLSPdswdATIFYGVFTSQWNVSGLSAVCAYSLEDIKKVFSGKYKEFNRETSKWSRY-TGPVPDPRPGAC 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 371 AKHGLAEA-YKTSIDFPDETLSFIKSHPLMDSAVPPIaDEPWFTKTRVRYrlTAISVDHSAGPY-QNYTVIFVGSEAGMV 448
Cdd:cd11240 329 ITNSARSQgITSSLNLPDNVLTFVKDHPLMDEQVHPI-NRPLLVKSGVNY--TRIAVHRVQALDgQTYTVLFLGTEDGFL 405
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24234744 449 LKVLaktspfSLNDSV-LLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11240 406 HKAV------SLDGGMhIIEEIQLF---------DQPQPVKNLLLSSSKGVLYVGSSSGVVQVPLS 456
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
58-515 2.43e-107

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 331.02  E-value: 2.43e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  58 DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIpnkkLTWRSRQQDRENCAMKGK-HKDECHNFIKVFVPRNDEMVF 134
Cdd:cd11254   9 DYRILLKDEDhdRMYVGSKDYVLSLDLHDINREPLI----IHWPASPQRIEECILSGKgSNGECGNFIRLIQPWNRTHLY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 135 VCGTNAFNPMCRY-YR-------LSTLEYDGEEiSGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGS 206
Cdd:cd11254  85 VCGTGAYNPVCAYiNRgrraedyMFRLEPDKLE-SGKGKCPYDPKQDSVSALINGELYAGVYIDFMGTDAAIFRTMGKQP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 207 ALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNlGKAVYSRVARICKNDMGGsQRVLEKHWTSFLK 279
Cdd:cd11254 164 AMRTDQYNSRWLNDPAFVHAHlipdsseKNDDKLYFFFREKSLEAPQ-SPAVLSRIGRVCLNDDGG-HCCLVNKWSTFLK 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 280 ARLNCSVPGDSFF--YFDVLQSI-TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTA 356
Cdd:cd11254 242 ARLVCSVPGADGIetHFDELRDVfIQPTQDTKNPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 357 VpEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNY 436
Cdd:cd11254 322 Y-TGKIPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNYRFTTIAVDQVDAADGRY 400
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24234744 437 TVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC 515
Cdd:cd11254 401 EVLFLGTDRGTVQKVIVLPKDDLETEELTLEEVEVF---------KVPAPIKTMKISSKRQQLYVSSAVGVTHLSLHRC 470
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
53-515 4.52e-107

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 330.33  E-value: 4.52e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEvipnKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVPRN 129
Cdd:cd11252   4 SSEGLDFQTLLldEERGRLLLGAKDHIYLLDLVDLNKNP----KKIYWPAAKERVELCKLAGKDANtECANFIRVLHPYN 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 130 DEMVFVCGTNAFNPMCRYYRLST------LEYDGEEI-SGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSM 202
Cdd:cd11252  80 RTHVYVCGTGAFHPTCGYIELGThkedriFLLDTQNLeSGRLKCPFDPQQPFASVMTDEYLYAGTASDFLGKDTTFTRSL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 203 G---DGSALRTIKYDSKWIKEPHFL--HAIE--YG---NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEK 272
Cdd:cd11252 160 GptpDHHYIRTDISEHYWLNGAKFIgtFPIPdtYNpddDKIYFFFREASQDGSTSDKSVLSRVGRVCKNDVGG-QRSLIN 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 273 HWTSFLKARLNCSVPG----DSffYFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347
Cdd:cd11252 239 KWTTFLKARLVCSIPGpdgaDT--HFDELQDIFLLpTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHK 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 348 KTPDSVWTAVpEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVD 427
Cdd:cd11252 317 ESPDHRWVQY-EGRIPYPRPGTCPSKTYDPLIKSTKDFPDEVISFIKRHPLMYKSVYPLTGGPVFTRINVDYRLTQIVVD 395
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 428 HSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCsaeneedkkVISLQLDKDHHALYVAFSSCI 507
Cdd:cd11252 396 HVAAEDGQYDVMFLGTDIGTVLKVVSITKEKWTMEEVVLEELQIFKHPSP---------ILNMELSLKQQQLYIGSRDGL 466

                ....*...
gi 24234744 508 IRIPLSRC 515
Cdd:cd11252 467 VQLSLHRC 474
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
44-512 1.00e-106

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 328.36  E-value: 1.00e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  44 FRGRPSGNESQHRLDfqlmlKIRDTLYIAGRDQVYTVNLNEMPKTEVIPnkkltWRSRQQDRENCAMKGKHKDECHNFIK 123
Cdd:cd11241   1 FEIEYVSDFSRLVLD-----PTHDQLIVGARNYLFRLRLQSLSLLQAVP-----WNSDEDTKRQCQSKGKSVEECQNYVR 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 124 VFVPrNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSATVADFLASDAVIYRSM 202
Cdd:cd11241  71 VLLV-VGKNLFTCGTYAFSPVCTIRKLSNLTQILDTISGVARCPYSPAHNSTALIsASGELYAGTVYDFSGRDPAIYRSL 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 203 GDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARL 282
Cdd:cd11241 150 GGKPPLRTAQYNSKWLNEPNFVGSYEIGNHTYFFFRENAVEHQDCGKTVYSRIARVCKNDIGG-RFLLEDTWTTFMKARL 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 283 NCSVPGDSFFYFDVLQsitDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPedkV 362
Cdd:cd11241 229 NCSLPGEFPFYYNEIQ---GTFYLPETDLIYAVFTTNVNGIAGSAICAFNLSAINQAFNGPFKYQENNGSAWLPTP---N 302
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 363 PKPRPGCC-----------AKHGLAEAYKtsidfpdetlsfiksHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAG 431
Cdd:cd11241 303 PHPNFQCTtsidrgqpantTERDLQDAQK---------------YQLMAEVVQPVTKIPLVTMDDVRFSKLAVDVVQGRG 367
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 432 pYQNYTVIFVGSEAGMVLKVLaktSPFSLNDSVLLEEIEAYNHAKCSaeneedkKVISLQLDKDHHALYVAFSSCIIRIP 511
Cdd:cd11241 368 -TQLVHIFYVGTDYGTILKMY---QPHRSQKSCTLEEIKILPAMKGE-------PITSLQFLKSEKSLFVGLETGVLRIP 436

                .
gi 24234744 512 L 512
Cdd:cd11241 437 L 437
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
66-512 3.30e-106

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 325.31  E-value: 3.30e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDE-MVFVCGTNAFNPM 144
Cdd:cd09295  11 KDTIYVGAIARIYKVDGGGTRLLLSCISPELNFGFNEDQKAFCPLRRGKWTECINYIKVLQQKGDLdILAVCGSNAAQPS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 145 CRYYRLSTLEYDGEE--ISGLARCPFDARQTNVALFADGKLYSATVADFL-ASDAVIYRSMGDGSALRTIKYDSKWIKEP 221
Cdd:cd09295  91 CGSYRLDVLVELGKVrwPSGRPRCPIDNKHSNMGVNVDSKLYSATDHDFKdGDRPALSRRSSNVHYLRIVVDSSTGLDEI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 222 HFLHAIEYG---NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRvLEKHWTSFLKARLNCSVPGDSfFYFDVLQ 298
Cdd:cd09295 171 TFVYAFVSGdddDEVYFFFRQEPVEYLKKGMVYVPRIARVCKLDVGGCHR-LKKKLTSFLKADLNCSRPQSG-FAFNLLQ 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 299 SITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFkgrfkeqktpdsvwtavpedkvpkprpgccakhglaea 378
Cdd:cd09295 249 DATGDTKNLIQDVKFAIFSSCLNKSVESAVCAYLFTDINNVF-------------------------------------- 290
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 379 yktsidfpdetlsfikshplmDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKtspF 458
Cdd:cd09295 291 ---------------------DDPVEAINNRPLYAHQNQRSRLTSIAVDATKQKSVGYQVVFLGLKLGSLGKALAF---F 346
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 24234744 459 SLNDSVLLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPL 512
Cdd:cd09295 347 FLYKGHIIEEWKVF---------KDSSRITNLDLSRPPLYLYVGSESGVLGVPV 391
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
58-513 8.58e-105

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 323.47  E-value: 8.58e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  58 DF-QLMLKI-RDTLYIAGRDQVYTVNLNEMPKTEVIpnkklTWRSRQQDRENCAMKGKHKDECHNFIKVFVPrNDEMVFV 135
Cdd:cd11264   8 DFsQLALDLnRNQLIVGARNYLFRLSLHNVSLIQAT-----EWGSDEDTRRSCQSKGKTEEECQNYVRVLIV-YGKKVFT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 136 CGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD-GKLYSATVADFLASDAVIYRSMGDGSALRTIKYD 214
Cdd:cd11264  82 CGTNAFSPVCTSRQVGNLSKVIERINGVARCPYDPRHNSTAVITSrGELYAATVIDFSGRDPAIYRSLGSVPPLRTAQYN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 215 SKWIKEPHFLHAIEYGNYVYFFFREIAVEHnNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPGDSFFYF 294
Cdd:cd11264 162 SKWLNEPNFIAAYDIGLFTYFFFRENAVEH-DCGKTVYSRVARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEIPFYY 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 295 DVLQSITDIIQINgipTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPeDKVPKPRPGCCAKHG 374
Cdd:cd11264 240 NELQSTFYLPEQD---LIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWLPTA-NPIPNFQCGTLSDDS 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 375 LAEayktsiDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYrlTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAK 454
Cdd:cd11264 316 PNE------NLTERSLQDAQRLFLMNDVVQPVTVDPLVTQDSVRF--SKLVVDIVQGKDTLYHVMYIGTEYGTILKALST 387
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24234744 455 TSPfSLNdSVLLEEIEAYNHAKcsaeneeDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11264 388 TNR-SLR-SCYLEEMQILPPGQ-------REPIRSLQILHSDRSLFVGLNNGVLKIPLE 437
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
66-451 2.09e-104

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 322.84  E-value: 2.09e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  66 RDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQqDRENCAMKGKHKD-ECHNFIKVFVPRND-EMVFVCGTNAFNP 143
Cdd:cd11238  12 RNALYVGAMDRVFRLNLYNINDTGNNCARDELTLSPS-DVSECVSKGKDEEyECRNHVRVIQPMGDgQTLYVCSTNAMNP 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 144 MCR--YYRLSTLEYDGEEI-SGLARCPFDARQTNVALFADG-------KLYSATVADFLASDAVIYRS----MGDG---S 206
Cdd:cd11238  91 KDRvlDANLLHLPEYVPGPgNGIGKCPYDPDDNSTAVWVEWgnpgdlpALYSGTRTEFTKANTVIYRPplynNTKGrheS 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 207 ALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSV 286
Cdd:cd11238 171 FMRTLKYDSKWLDEPNFVGSFDIGDYVYFFFRETAVEYINCGKVVYSRVARVCKKDTGG-KNVLRQNWTTFLKARLNCSI 249
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 287 PGDSFFYFDVLQSITdiiQINGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVF-KGRFKEQKTPDSVWTAVPEDKVP 363
Cdd:cd11238 250 SGEFPFYFNEIQSVY---KVPGRddTLFYATFTTSENGFTGSAVCVFTLSDINAAFdTGKFKEQASSSSAWLPVLSSEVP 326
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 364 KPRPGCCAkhglaeayKTSIDFPDETLSFIKSHPLMDSAVPpiADEPWFTKTRVryRLTAISVDHSAGPYQNYTVIFVGS 443
Cdd:cd11238 327 EPRPGTCV--------NDSATLSDTVLHFARTHPLMDDAVS--HGPPLLYLRDV--VFTHLVVDKLRIDDQEYVVFYAGS 394

                ....*...
gi 24234744 444 EAGMVLKV 451
Cdd:cd11238 395 NDGKVYKI 402
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
53-511 6.78e-104

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 320.96  E-value: 6.78e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  53 SQHRLDFQlmlkiRDTLYIAGRDQVYTVNLNEMPKTEVIPnkkltWRSRQQDRENCAMKGKHKDECHNFIKVFVPrNDEM 132
Cdd:cd11265  10 SQMLFDVA-----RNQVIVGARDNLYRLSLDGLELLERAS-----WPAAESKVALCQNKGQSEEDCHNYVKVLLS-YGKQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 133 VFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA-DGKLYSATVADFLASDAVIYRSMG--DGSALR 209
Cdd:cd11265  79 LFACGTNAFSPRCSWREMENLTSVTEWDSGVAKCPYSPHANITALLSsSGQLFVGSPTDFSGSDSAIYRTLGtsNKSFLR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 210 TIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Cdd:cd11265 159 TKQYNSKWLNEPQFVGSFETGNFVYFLFRESAVEYMNCGKVIYSRIARVCKNDVGGGTMLLKDNWTTFLKARLNCSLPGE 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 290 SFFYFDVLQSITdIIQINGIptVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKvpKPRPGC 369
Cdd:cd11265 239 YPFYFDEIQGMT-YLPDEGI--LYATFTTPENSIAGSAVCAFNLSSINAAFDGPFKHQESSGAAWERVNVNH--RDHFNQ 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 370 C---AKHGLAEAYKtsidfpdetlsfiksHPLMDSAVPPIADEPWFTKTrvRYRLTAISVD-HSAGPYQNYTVIFVGSEA 445
Cdd:cd11265 314 CsssSSSHLLESSR---------------YQLMDEAVQPITLEPLHHAK--LERFSHIAVDvIPTKIHQSVHVLYVATTG 376
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24234744 446 GMVLK--VLAKTSpfslnDSVLLEEIEaynhakcsAENEEDKKVISLQLDKDHHALYVAFSSCIIRIP 511
Cdd:cd11265 377 GLIKKisVLPRTQ-----ETCLVEIWQ--------PLPTPDSPIKTMQYLKVTDSLYVGTELALMRIP 431
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
66-515 4.44e-103

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 319.94  E-value: 4.44e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  66 RDTLYIAGRDQVYTVNLNEMPKTEvipnKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPM 144
Cdd:cd11250  19 RGRLFVGAKNYLASLSLDNISKQE----KKIYWPAPVEWREECNWAGKDINtDCMNYVKILHHYNRTHLYACGTGAFHPT 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 145 CRYYRL------STLEYDGEEIS-GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKW 217
Cdd:cd11250  95 CAFVEVgqrmedHVFRLDPSRVEdGKGKSPYDPRHTAASVLVGDELYSGVATDLMGRDFTIFRSLGQRPSLRTEQHDSRW 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 218 IKEPHFLHAI---EYGN----YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPGD- 289
Cdd:cd11250 175 LNEPKFVKVFwipESENpdddKIYFFFRETAVEAAGLGKQSYSRIGQICRNDMGG-QRSLVNKWTTFLKARLVCSVPGNe 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 290 -SFFYFDVLQSITdIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVpEDKVPKPR 366
Cdd:cd11250 254 gGDTHFDELRDVF-LLQTRDkrNPLIYAVFSTSSSVFQGSAVCVYTMNDVRRAFLGPFAHKEGPNYQWVSY-QGKVPYPR 331
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 367 PGCCAKHGLAeAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAG 446
Cdd:cd11250 332 PGMCPSKTFG-SFESTKDFPDDVIQFARNHPLMFNPVLPLGGRPLFLRTGIPYTFTQIAVDRVAAADGHYDVMFIGTDVG 410
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24234744 447 MVLKVLA--KTSPFSlNDSVLLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC 515
Cdd:cd11250 411 SVLKVISvpKGSWPS-NEELLLEELHVF---------KDSSPITSMQISSKRQQLYVGSRSGVSQLPLHRC 471
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
66-516 1.39e-102

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 319.64  E-value: 1.39e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  66 RDTLYIAGRDQVYTVNLnempkTEVIPNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKVFVPRNDEMVFVCGTNAFNPM 144
Cdd:cd11249  41 RGRLYVGAKDHIFSFNL-----VNIKDFQKIVWPVSPSRRDECKWAGKDiLKECANFIKVLKAYNQTHLYACGTGAFHPV 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 145 CRY-----------YRLSTLEYDgeeiSGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKY 213
Cdd:cd11249 116 CTYievghhpedniFRLEDSHFE----NGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQH 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 214 DSKWIKEPHFL--HAI-EYGN----YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKhWTSFLKARLNCSV 286
Cdd:cd11249 192 DSRWLNDPRFIsaHLIpESDNpeddKIYFFFRENAIDGEHTGKATHARIGQLCKNDFGGHRSLVNK-WTTFLKARLICSV 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 287 PGDSFF--YFDVLQsitDIIQINGI----PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWtaVP-E 359
Cdd:cd11249 271 PGPNGIdtHFDELQ---DVFLMNSKdpknPIVYAVFTTSSNIFKGSAVCMYSMTDIRRVFLGPYAHRDGPNYQW--VPfQ 345
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 360 DKVPKPRPGCCAKHGLAeAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVI 439
Cdd:cd11249 346 GRVPYPRPGTCPSKTFG-GFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIIIKTDVDYQFTQIVVDRVEAEDGQYDVM 424
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24234744 440 FVGSEAGMVLKVLA--KTSPFSLnDSVLLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCE 516
Cdd:cd11249 425 FIGTDMGTVLKVVSipKETWHDL-EEVLLEEMTVF---------REPTAISAMELSTKQQQLYIGSAIGVSQLPLHRCD 493
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
52-512 4.68e-101

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 313.50  E-value: 4.68e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  52 ESQHRLDF-QLMLKIRDTLYIAG-RDQVYTVNLNEMPKTEVIpnkklTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRN 129
Cdd:cd11263   2 RAENAVDFsQLTFDPGQKELIVGaRNYLFRLQLEDLSLIQAV-----EWECDEATKKACYSKGKSKEECQNYIRVLLVGG 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 130 DEMvFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSATVADFLASDAVIYRSMGDGSAL 208
Cdd:cd11263  77 DRL-FTCGTNAFTPICTNRTLNNLTEIHDQISGMARCPYSPQHNSTALLtSSGELYAATAMDFPGRDPAIYRSLGILPPL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 209 RTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHnNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPG 288
Cdd:cd11263 156 RTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPG 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 289 DSFFYFDVLQSITDIIQINgipTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEdkvPKPRPG 368
Cdd:cd11263 234 EIPFYYNELQSTFFLPELD---LIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPN---PNPNFQ 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 369 C-CAKHGLaeayktSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYrlTAISVDHSAGPYQNYTVIFVGSEAGM 447
Cdd:cd11263 308 CgTMDQGL------YVNLTERNLQDAQKFILMHEVVQPVTPVPYFMEDNSRF--SHVAVDVVQGKDMLFHIIYLATDYGT 379
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24234744 448 VLKVLAKTSPFSlnDSVLLEEIEAYNHAKcsaeneeDKKVISLQLDKDHHALYVAFSSCIIRIPL 512
Cdd:cd11263 380 IKKVLAPLNQSS--SSCLLEEIELFPKRQ-------REPIRSLQILHSQSVLFVGLQEHVIKIPL 435
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
56-515 7.08e-97

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 304.08  E-value: 7.08e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  56 RLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKteviPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMV 133
Cdd:cd11253   7 FLDLHTMLldEYQERLFVGGRDLLYSLSLERISA----NYKEIHWPSTQLQVEDCIMKGRDKPECANYIRVLHHYNRTHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 134 FVCGTNAFNPMCRYYRLS--------TLEYDGEEiSGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDG 205
Cdd:cd11253  83 LACGTGAFDPVCAFIRVGrgsedhlfQLESDKFE-RGRGRCPFDPNSSFISTLIGGELFVGLYSDYWGRDAAIFRTMNHL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 206 SALRTIKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFL 278
Cdd:cd11253 162 AHIRTEHDDERLLKEPKFVGSYmipdnedPDDNKVYFFFTEKALEAEGGNHAIYTRVGRVCANDQGG-QRMLVNKWSTFL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 279 KARLNCSVPGDSFF--YFDVLQSITDI-IQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWt 355
Cdd:cd11253 241 KTRLICSVPGPNGIdtHFDELEDVFLLrTRDNKNPEIFGLFSTTSNIFKGYAICVYHMASIRAAFNGPFAHKEGPEYHW- 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 356 AVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQN 435
Cdd:cd11253 320 SVYEGKVPYPRPGSCASKVNGGHYGTTKDYPDEALRFARSHPLMYQAVKPVHKRPILVKTDGKYNLKQIAVDRVEAEDGQ 399
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 436 YTVIFVGSEAGMVLKVLA-KTSPFSLNDSVLLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSR 514
Cdd:cd11253 400 YDVLFIGTDNGIVLKVITiYNQETETMEEVILEELQVF---------KVPVPIISMEISSKRQQLYIGSESGVAQIRFHQ 470

                .
gi 24234744 515 C 515
Cdd:cd11253 471 C 471
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
57-515 6.09e-96

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 301.83  E-value: 6.09e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  57 LDFQLML--KIRDTLYIAGRDQVYTVNLNEmpkTEVIPnKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVPRNDEMV 133
Cdd:cd11255   8 LHLSAVYldEYRDRLFLGGKDVLYSLRLDQ---THPDA-KEIHWPPLPGQREECIRKGKDPEtECANFVRVLQPFNRTHL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 134 FVCGTNAFNPMCRYYrlsTLEYDGEEI---------SGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGD 204
Cdd:cd11255  84 LACGTGAFQPVCALI---NVGHRGEHVfsldpttveSGRGRCPHEPKRPFASTFTGGELYTGLTADFLGRDSVIFRGFGT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 205 GSALRTiKYDSKWIKEPHFLHAI-------EYGNYVYFFFREIAVE-HNNLGKAVYSRVARICKNDMGGsQRVLEKHWTS 276
Cdd:cd11255 161 RSPLRT-ETDQRLLHEPRFVAAHlipdnadRDNDKVYFFFTERATEtAEDDDGAIHSRVGRLCANDAGG-QRVLVNKWST 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 277 FLKARLNCSVPGDSFF--YFDVLQSITDIIQINGI-PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSV 353
Cdd:cd11255 239 FIKARLVCSVPGPHGIqtHFDQLEDVFLLRTKDGKsPEIYALFSTISNVFQGFAVCVYSMADIWEVFNGPFAHKDGPDHQ 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 354 WTAVpEDKVPKPRPGCCAKHGLAE---AYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSA 430
Cdd:cd11255 319 WGPY-EGKVPYPRPGVCPSKITAQpgrAFRSTKDYPDEVLQFARAHPLMWRPVYPSHRRPVLVKTGLPYRLTQIVVDRVE 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 431 GPYQNYTVIFVGSEAGMVLKVLA-KTSPFSLNDSVLLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIR 509
Cdd:cd11255 398 AEDGYYDVMFIGTDSGSVLKVIVlQKGNSAAGEEVTLEELQVF---------KVPTPITEMEISVKRQMLYVGSRTGVAQ 468

                ....*.
gi 24234744 510 IPLSRC 515
Cdd:cd11255 469 VPLHRC 474
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
66-513 1.38e-93

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 295.23  E-value: 1.38e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  66 RDTLYIAGRDQVYTVNLNEMpkteVIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGTNAFNPM 144
Cdd:cd11259  29 KDVLYVGAREAVFALNALNI----SEKQHELYWKVSEDKRTKCAVKGKSKQtECRNYIRVLQPLNDTFLYVCGTNAFQPT 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 145 CRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDgSALRTiKYDSKWIKEPHFL 224
Cdd:cd11259 105 CDYLNLTSFRLLGKNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLGSEPIISRNSSQ-SPLRT-EYAIPWLNEPSFV 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 225 HA--IEYG--------NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPgDSFFYF 294
Cdd:cd11259 183 FAdvIRADpdspdgedDKIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSIP-DKNLVF 260
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 295 DVLQSITdIIQINGI--PTVVGVFTTQLNSIPGSAVCAFSMDDIEKVF-KGRFKEQKTPDSVWTAVPE--DKVPKPRPGC 369
Cdd:cd11259 261 NVVNDVF-ILKSPTLkePVIYGVFTPQLNNVGLSAVCAYNLSTVEEVFsKGKYMQSATVEQSHTKWVRynGEVPKPRPGA 339
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 370 CAKH-GLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYrlTAISVDHSAGPYQN-YTVIFVGSEAGM 447
Cdd:cd11259 340 CINNeARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNY--TQIVVDRVQALDGTiYDVMFISTDRGA 417
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24234744 448 VLKVLAKTspfslNDSVLLEEIEAYNHAkcsaeneEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11259 418 LHKAISLE-----NEVHIIEETQLFPDF-------EPVQTLLLSSKKGRRFLYAGSNSGVVQSPLA 471
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
53-515 1.68e-92

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 292.56  E-value: 1.68e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  53 SQHRLDFQLML--KIRDTLYIAGRDQVYTVNLNEMPKTEVipnkKLTWRSRQQDRENCAMKGKHKDE-CHNFIKVFVPRN 129
Cdd:cd11251   4 SERPLDYRILFmdEDQDRIYVGSKDHILSLNINNISQDAL----SIFWPASASKVEECKMAGKDPTHgCGNFVRVIQPYN 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 130 DEMVFVCGTNAFNPMCRYY--------RLSTLEYDGEeiSGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRS 201
Cdd:cd11251  80 RTHLYVCGSGAFSPVCVYVnrgrrseeQVFHIDSKAE--SGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 202 MGDGSALRTIKYDSKWIKEPHFL--HAIEYGNY-----VYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHW 274
Cdd:cd11251 158 LTKRNAVRTDQHNSKWLSEPIFVdaHLIPDGTDpndakLYFFLKERLTDNSGSTKQIHSMIARVCPNDTGG-QRSLVNKW 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 275 TSFLKARLNCSVPGD--SFFYFDVLQSITDIIQINGIPTVV-GVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPD 351
Cdd:cd11251 237 TTFLKARLVCSVMDEdgTETHFDELEDVFLLETDNPRTTLVyGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEGPN 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 352 SVWTAVpEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAG 431
Cdd:cd11251 317 HQLIAY-QGRIPYPRPGTCPGGAFTPNMQSTKEFPDDVVTFIRNHPLMFNPIYPIGRRPLLVRTGTDYKYTKIAVDRVNA 395
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 432 PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAY-NHAkcsaeneedkKVISLQLDKDHHALYVAFSSCIIRI 510
Cdd:cd11251 396 ADGRYHVLFLGTDKGTVQKVVVLPTNGSLSGELILEELEVFkNHA----------PITNMKISSKKQQLYVSSEEGISQV 465

                ....*
gi 24234744 511 PLSRC 515
Cdd:cd11251 466 SLHRC 470
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
61-513 2.69e-89

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 284.06  E-value: 2.69e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVipNKKLTWRSRQQDRENCAMKGKH-KDECHNFIKVFVPRNDEMVFVCGTN 139
Cdd:cd11257  14 LLSKDGNMLYVGARETLFALSSNDISPTGE--QQELTWSADEEKKQECSFKGKDpQRDCQNYIKILLRLNSTHLFTCGTY 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 140 AFNPMCRYYRLS--TLEYD--GEEI--SGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTiKY 213
Cdd:cd11257  92 AFSPICTYIVMTnfSLERDekGEPLleDGKGRCPFDPEYKSTAIMVDGELYTGTVSNFQGNDPIIYRSLGSGTPLKT-EN 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 214 DSKWIKEPHFL----------HAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLN 283
Cdd:cd11257 171 SLNWLQDPAFVgsayiqeslpKLVGDDDKIYFFFSETGKEFDFFENTIVSRIARVCKGDEGG-ERVLQKRWTTFLKAQLL 249
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 284 CSVPGDSfFYFDVLQsitDIIQINGIPT------VVGVFTTQLN--SIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWT 355
Cdd:cd11257 250 CSLPDDG-FPFNVLQ---DVFVLTPSPEdwkdtlFYGVFTSQWHkgTAGSSAVCVFTMDQVQRAFNGLYKEVNRETQQWY 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 356 AVPEdKVPKPRPGCC----AKHglaEAYKTSIDFPDETLSFIKSHPLMDSavpPIADEPWFTKTRVRYrlTAISVDHSAG 431
Cdd:cd11257 326 TYTH-PVPEPRPGACitnsARE---RKINSSLHMPDRVLNFVKDHFLMDG---QVRSQPLLLQPQVRY--TQIAVHRVKG 396
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 432 PYQNYTVIFVGSEAGMVLKVLaktspfSLNDSV-LLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRI 510
Cdd:cd11257 397 LHKTYDVLFLGTDDGRLHKAV------SVGPMVhIIEELQIF---------SEGQPVQNLLLDTHKGLLYASSHSGVVQV 461

                ...
gi 24234744 511 PLS 513
Cdd:cd11257 462 PVA 464
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
58-513 5.33e-88

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 280.25  E-value: 5.33e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  58 DFQLMLKIRDT--LYIAGRDQVYTVNLNEMPktevIPNKKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVPRNDEMVF 134
Cdd:cd11260   8 NYSTMLLREDLglLVLGAREAVFALDLNDIS----VKRAKVLWEVTEEKQKDCTNKGKHADiDCHNYIRILHKMNDSRMY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 135 VCGTNAFNPMCRY--YRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSmgDGSALRTiK 212
Cdd:cd11260  84 VCGTNAFSPTCDYisYDDGQLTLEGKQEDGKGKCPFDPFQRYSSVMVDQDLYSATSMNFLGSEPVIMRS--SPITIRT-E 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 213 YDSKWIKEPHFLH--AIEYG--------NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARL 282
Cdd:cd11260 161 FKSSWLNEPNFIYmaAVPESedspegddDKIYLFFSETAVEYDFYNKLVVSRVARVCKGDLGG-QRTLQKKWTSFLKARL 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 283 NCSVPGDSFFYfdVLQSITDIIQINGIPTVV-GVFTTQLNSIPGSAVCAFSMDDIEKVF-KGRFKEQ---KTPDSVWTAV 357
Cdd:cd11260 240 DCSVPEPSLPY--VIQDVFHVCHQDWRKCVFyAVFTSQSDSSQSSAVCAYNVTDISNVFsRGKFKTPvavETSFVKWVMY 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 358 PEDkVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVryRLTAISVDH-SAGPYQN 435
Cdd:cd11260 318 SGE-LPVPRPGACInNAARTSGIKKSLNLPDKTLQFVKDKPLMDQAVHPITGKPLLVKRGA--LFTRIVVDMvTAADGQS 394
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24234744 436 YTVIFVGSEAGMVLKVLAKTSpfslnDSVLLEEIEAYnhakcsaENEEDKKVISLQldkdHHALYVAFSSCIIRIPLS 513
Cdd:cd11260 395 YPVMFIGTANGYVLKAVNYDG-----EMHIIEEVQLF-------EPEEPIDILRLS----QNQLYAGSASGVVQMPVS 456
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
68-513 2.48e-82

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 265.60  E-value: 2.48e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  68 TLYIAGRDQVYTVNLnemPKTEVIPnKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRY 147
Cdd:cd11261  25 TLYVGARDAIFALTL---PFSGERP-RRIDWMVPEAHRQNCRKKGKKEAECHNFIRILAIANASHLLTCGTFAFDPKCGV 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 148 YRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI 227
Cdd:cd11261 101 IDVSSFQQVERLESGRGKCPFEPAQRSAAIMAGGVLYAATVKNFLGTEPIISRAVGRAEEWIRTETLPSWLNAPAFVAAV 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 228 -----EYG-----NYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPgDSFFYFDVL 297
Cdd:cd11261 181 flspaEWGdedgdDEIYFFFTETAREYDSYERIKVPRVARVCAGDLGG-RKTLQQRWTTFLKADLLCPGP-EHGRASSIL 258
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 298 QSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGL 375
Cdd:cd11261 259 QDVTTLRPLPGagTPIFYGIFSSQWEGASISAVCAFRPQDIRRVMNGPFREFKHDCNRGLPVMDSDVPQPRPGECITNNM 338
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 376 A-EAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRY-RLTAISVDHSAGpyQNYTVIFVGSEAGMVLKVLA 453
Cdd:cd11261 339 KlLGFGSSLSLPDRVLTFVRDHPLMDRPVFPADGHPLLVTTDTAYlRVAAHRVTSLSG--KEYDVLYLGTEDGHLHRAVR 416
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24234744 454 KTSPFSlndsvLLEEIEAYnhakcsaenEEDKKVISLQLdkdHHA-LYVAFSSCIIRIPLS 513
Cdd:cd11261 417 IGAQLS-----VLEDLALF---------PEPQPVENLQL---HHNwLLVGSDTEVTQINTS 460
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
52-513 9.08e-80

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 258.69  E-value: 9.08e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  52 ESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEmPKTEVIPNKkLTWRSRQQDRENCAMKGK-HKDECHNFIKVFVPRND 130
Cdd:cd11256   5 ENVHNYDQLLLSPDETTLYVGARDNILALGIRT-PGPIRLKHQ-IPWPANDSKISECAFKKKsNETECFNFIRVLVPVNG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 131 EMVFVCGTNAFNPMCRYYRL--STLEYDGEEI---SGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDG 205
Cdd:cd11256  83 THLYTCGTYAFSPACTYIELdhFSLPPPNGTIitmDGKGQSPFDPQHNYTAILVDGELYTGTMNNFRGNEPIIFRNLGTK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 206 SALRTIKYdSKWIK-EPHFLHAI--EYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARL 282
Cdd:cd11256 163 VSLKTDGF-LRWLNaDAVFVASFnpQGDSKVYFFFEETAREFDFFEKLTVARVARVCKNDVGG-EKLLQKKWTTFLKAQL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 283 NCSVPGDsfFYFDVLQSITDIIQ-INGIPTVVGVFTT--QLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTaVPE 359
Cdd:cd11256 241 TCSQQGH--FPFNVIHHVALLNQpDPNNSVFYAVFTSqwQLGGRRSSAVCAYKLNDIEKVFNGKYKELNKESSRWT-RYM 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 360 DKVPKPRPGCCAKHGlaeayktsidFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYrlTAISVDHSAGPY-QNYTV 438
Cdd:cd11256 318 GPVSDPRPGSCSGGK----------SSDKALNFMKDHFLMDEVVLPGAGRPLLVKSNVQY--TRIAVDSVQGVSgHNYTV 385
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24234744 439 IFVGSEAGMVLKVLAktspfsLNDSV--LLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11256 386 MFLGTDKGFLHKAVL------MGGSEshIIEEIELL---------TPPEPVENLLLAANEGVVYIGYSAGVWRVPLA 447
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
66-473 2.37e-77

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 252.42  E-value: 2.37e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  66 RDTLYIAGRDQVYTVNLNEMpktEVIPnkKLTWRSRQQDRENCAMKGK-HKDECHNFIKVFVPRNDEMVFVCGTNAFNPM 144
Cdd:cd11258  21 RGLLYVGAREAIFALSLSNI---ELQP--PISWEAPAEKKTECAQKGKsNQTECFNYIRFLQPYNQSHLYTCGTYAFQPK 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 145 CRYYRLSTLEYDGEEIS-GLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTiKYDSKWIKEPHF 223
Cdd:cd11258  96 CAYINMLTFTLDRAEFEdGKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRNLGQHYSMKT-EYLAFWLNEPHF 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 224 L---HAIEYGNY-------VYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSqRVLEKHWTSFLKARLNCSVPgDSFFY 293
Cdd:cd11258 175 VgsaFVPESVGSftgdddkIYFFFSERAVEYDCDSEQVVARVARVCKGDLGGA-RTLQKKWTTFLKARLLCSIP-EWQLY 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 294 FDVLQSitdIIQINGIP----TVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPeDKVPKPRPGC 369
Cdd:cd11258 253 FNQLKA---VFTLEGASwrntTFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKWGRYT-DPVPSPRPGS 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 370 CAKHGLAE-AYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPwFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMV 448
Cdd:cd11258 329 CINNWHRDhGYTSSLELPDNTLNFVKKHPLMEDRVKPRLGRP-LLVPCNSNFTHVVWTRVLGLDGETYSVLFIGTLDGWL 407
                       410       420
                ....*....|....*....|....*.
gi 24234744 449 LKVLaktspfSLNDSV-LLEEIEAYN 473
Cdd:cd11258 408 IKAV------SLGSWVhMIEELQVFD 427
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
66-513 7.78e-74

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 243.13  E-value: 7.78e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  66 RDTLYIAGRDQVYTVNLNEMPKTEvipNKKLTWRSRQQDRENCAMKGK-HKDECHNFIKVFVPRNDEMVFVCGTNAFNPM 144
Cdd:cd11262  19 SGRLYVGARGAIFSLNASDISDSS---ALTIDWEASPEQKHQCLKKGKnNQTECFNHVRFLQRFNSTHLYTCGTHAFRPL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 145 CRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFlASDAVIYRSMGDGSaLRTIKYDSKWIKEPHFL 224
Cdd:cd11262  96 CAYIDAERFTLSSQFEEGKEKCPYDPAKGYTGLIVDGQLYTASQYEF-RSFPDIRRNSPQPT-LRTEEAPTRWLNDADFV 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 225 HAI--------EYG--NYVYFFFREIAVEHNN--LGKAVySRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPgDSFF 292
Cdd:cd11262 174 GSVlvresmnsSVGddDKIYFFFTERSQEETAyfSQSRV-ARVARVCKGDRGG-KKTLQRKWTSFLKARLVCYIP-EYEF 250
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 293 YFDVLQSITDIIQINGIPTVV-GVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVpEDKVPKPRPGCCA 371
Cdd:cd11262 251 LFNVLRSVFVLWGSTPQDTVFyGIFGLEWKNVKASAICRYSLSDIQTAFEGPYMEYQDSSSKWSRY-TGKVPEPRPGSCI 329
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 372 KHGL-AEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYrlTAISVDHSAGPYQN-YTVIFVGSEAGMVL 449
Cdd:cd11262 330 TDEHrSQGINSSQDLPDNVLDFVRRHPLMAEQVLPVEGRPLLFKRNVIY--TKIAVQTVRGLDGRvYDVLFLGTDEGWLH 407
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24234744 450 KvlaktsPFSLNDSV-LLEEIEAYnhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIPLS 513
Cdd:cd11262 408 K------AVVIGSAVhIIEELQVF---------REPQPVENLVISKKQNSLYVGARSGVVQVPLS 457
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
297-474 1.96e-55

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 185.55  E-value: 1.96e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744   297 LQSITDIIQINGIP--TVV-GVFTTQL-NSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPeDKVPKPRPGCCAK 372
Cdd:pfam01403   1 LQDVFVLKPGAGDAldTVLyGVFTTQWsNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYT-GKVPYPRPGTCIN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744   373 HGLaeayktSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYrlTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL 452
Cdd:pfam01403  80 DPL------RLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRL--TSIAVDRVQALDGNYTVLFLGTDDGRLHKVV 151
                         170       180
                  ....*....|....*....|..
gi 24234744   453 AKTSpfslNDSVLLEEIEAYNH 474
Cdd:pfam01403 152 LVGS----EESHIIEEIQVFPE 169
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
67-512 8.52e-44

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 161.55  E-value: 8.52e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  67 DTLYIAGRDQVYTVNLnemPKTEVIpNKKLTWRSRQQDRENCAMKgkhkDECHNFIKVfVPRNDEMVFVCGTNAFNPMCR 146
Cdd:cd11243  14 SSVYVGGQGALYLLDF---TGSAVI-VKKIPDEKTEKDCKKRATL----DDCENYITL-IKKLDYRLLVCGTNAGSPKCW 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 147 YYRLSTLEYDGEEiSGLArcPFDARQTNVALFADGKLYSATVADflASDAVIYRSMGDGSALRTikyDSKWIKEPHFLHA 226
Cdd:cd11243  85 FLVNQTLVTLSAD-RGVA--PFLPDENSLVLIEGNNVYSTISGK--KGNIPRFRRYGGKKELYT---SDTVMQKPQFVKA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 227 I------EYGNYVYFFFREIAvEHNNLGKAVY-SRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSfFYFDVLQS 299
Cdd:cd11243 157 TllpedeQYQDKIYYFFREDN-EDKGPEAEPNiSRVARLCKEDQGGTSSLSTSKWSTFLKARLVCGDPATP-MNFNRLQD 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 300 ITDIIQINGIPTVV-GVFTTQLNSipgSAVCAFSMDDIEKVFKgrfkeqktPDSVWTAvpEDKVPKPRPGCCAKHGLAEa 378
Cdd:cd11243 235 VFLLPKEEWREAVVyGVFSNTWGS---SAVCSYSLGDIDKVFR--------TSSLKGY--SGSLPNPRPGTCVPPEQTH- 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 379 yktsidfPDETLSFIKSHPLMDSAVPPiaDEPwfTKTRV---RYRLTAISVDH-SAGPYQNYTVIFVGSEAGMVLKVLAk 454
Cdd:cd11243 301 -------PSETFSFADEHPELDDRIEP--DEP--RKLPVfqnKDHYQKVVVDEvRASDGVSYDVLYLATDKGKIHKVVE- 368
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24234744 455 tspfSLNDSVLLEEIEAYNhakcsaeneEDKKVISLQLDKDHHALYVAFSSCIIRIPL 512
Cdd:cd11243 369 ----SKGQTHNIMEIQPFK---------EQEPIQSMILDAERSHLYVGTKAEVTRLPL 413
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
195-511 7.83e-16

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 80.21  E-value: 7.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 195 DAVIYRSMGDGSALRTiKYDSKWIKEphFLHAIEYGNYVYFFFREiavehnNLGKAVYSR--VARICKNDmggsqrvleK 272
Cdd:cd11276 167 DREVFENYIDAATVKS-AYVSRYTQQ--FRYAFEDNNYVYFLFNQ------QLGHPDKNRtlIARLCEND---------H 228
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 273 HWTSFLKARLNCSVPGDSF-----FYF-----DVLQSITDIIQINGIptVVGVFTTQLNSIPGSAVCAFSMDDIEKvfkg 342
Cdd:cd11276 229 HYYSYTEMDLNCRDGANAYnkcqaAYVstpgkELAQNYGNSILSDKV--LFAVFSRDEKDSGESALCMFPLKSINA---- 302
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 343 rfKEQKTPDSVWTAVPEDK--VPKP----RPGCCAKH--GLAEAYKTSIDF-PdetlSFIKSHPLMDSAVPPIadepwft 413
Cdd:cd11276 303 --KMEANREACYTGTIDDRdvFYKPfhsqKDIICGSHqqKNSKSFPCGSEHlP----YPLGSRDELALTAPVL------- 369
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 414 kTRVRYRLTAISVDHSagpyQNYTVIFVGSEAGMVLKVLAKTSPfslndsvlleeiEAYNhakcSAENEEDKKV-ISLQL 492
Cdd:cd11276 370 -QRGGLNLTAVTVAVE----NGHTVAFLGTSDGRILKVHLSPDP------------EEYN----SILIEKNKPVnKDLVL 428
                       330
                ....*....|....*....
gi 24234744 493 DKDHHALYVAFSSCIIRIP 511
Cdd:cd11276 429 DKTLEHLYIMTEDKVFRLP 447
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
64-513 3.84e-13

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 71.59  E-value: 3.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744  64 KIRDTLYIAGRDQVYTVNLNEMPKTEVI--PnkkltwrsrQQDRENCAMKG-----KHKDECHNFIKVFVP-RNDEMVFV 135
Cdd:cd11236   9 NSTGRVYVGAVNRLYQLDSSLLLEAEVStgP---------VLDSPLCLPPGccscdHPRSPTDNYNKILLIdYSSGRLIT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 136 CGTnAFNPMCRYYRLSTLEYDGEEISgLARCPFDARQTNVALFADG------KLYSATVADFLASD----AVIYRSM--- 202
Cdd:cd11236  80 CGS-LYQGVCQLRNLSNISVVVERSS-TPVAANDPNASTVGFVGPGpynnenVLYVGATYTNNGYRdyrpAVSSRSLppd 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 203 -----GDGSALRTIKYDSKWIKE--PHFLHAIEYGNYVYFFFREiaVEHNNLGKAVYSRVARICKNDmggsqrvleKHWT 275
Cdd:cd11236 158 ddfnaGSLTGGSAISIDDEYRDRysIKYVYGFSSGGFSYFVTVQ--RKSVDDESPYISRLVRVCQSD---------SNYY 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 276 SFLKARLNCSVPGDSFFyfDVLQSI------TDIIQINGIPT----VVGVFTTQLNS--IPG--SAVCAFSMDDIEKvfk 341
Cdd:cd11236 227 SYTEVPLQCTGGDGTNY--NLLQAAyvgkagSDLARSLGISTdddvLFGVFSKSKGPsaEPSskSALCVFSMKDIEA--- 301
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 342 grfkeqktpdsvwtavpedkvpkprpgccakhglaeayktsidfpdetlSFIKSHPLmdSAVPPIADEPWFTKTrvryRL 421
Cdd:cd11236 302 -------------------------------------------------AFNDNCPL--GGGVPITTSAVLSDS----LL 326
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 422 TAISVDHsagpYQNYTVIFVGSEAGMVLKVLAKTSpfslndsvlleeieaynhakCSAENEEDKKVIS-------LQLDK 494
Cdd:cd11236 327 TSVAVTT----TRNHTVAFLGTSDGQLKKVVLESS--------------------SSATQYETLLVDSgspilpdMVFDP 382
                       490
                ....*....|....*....
gi 24234744 495 DHHALYVAFSSCIIRIPLS 513
Cdd:cd11236 383 DGEHLYVMTPKKVTKVPVE 401
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
221-543 5.00e-11

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 65.34  E-value: 5.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 221 PHF----LHAIEYGNYVYFFFREI----AVEHNNLGKAVY-SRVARICKNDmggsqrvleKHWTSFLKARLNCSVPGDSF 291
Cdd:cd11272 200 SHFdifyIYGFASGNFVYFLTVQPetpeGVSINSAGDLFYtSRIVRLCKDD---------PKFHSYVSLPFGCVRGGVEY 270
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 292 FYF---------DVLQSITDIIQINGIptVVGVFTT---QLNSIPG-SAVCAFSMDDIEKVFKGR----FKEQKTPDSVW 354
Cdd:cd11272 271 RLLqaaylskpgEVLARSLNITAQEDV--LFAIFSKgqkQYHHPPDdSALCAFPIRAINAQIKERlqscYQGEGNLELNW 348
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 355 ---TAVPEDKVPKPrpgccakhglaeayktsIDfpDETLSFIKSHPLMDSAvpPIADEPWFTKTRvrYRLTAISvdhsAG 431
Cdd:cd11272 349 llgKDVQCTKAPVP-----------------ID--DNFCGLDINQPLGGST--PVEGVTLYTSSR--DRLTSVA----SY 401
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 432 PYQNYTVIFVGSEAGMVLKVLAKTSPfslNDSVLLEEIEAYNhakcsaenEEDKKVISLQLDKDHHALYVAFSSCIIRIP 511
Cdd:cd11272 402 VYNGYSVVFVGTKSGKLKKIRADGPP---HGGVQYEMVSVFK--------DGSPILRDMAFSIDHKYLYVMSERQVSRVP 470
                       330       340       350
                ....*....|....*....|....*....|...
gi 24234744 512 LSRCERYGSCKKsCIASRDPYCGWLS-QGSCGR 543
Cdd:cd11272 471 VESCEQYTTCGE-CLSSGDPHCGWCAlHNMCSR 502
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
514-569 6.58e-07

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 46.55  E-value: 6.58e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24234744   514 RCERYGSCKkSCIASRDPYCGWLS-QGSCgrvTPGMLAEGYEQDTEFGNTAHLGdCH 569
Cdd:pfam01437   1 RCSQYTSCS-SCLAARDPYCGWCSsEGRC---VRRSACGAPEGNCEEWEQASSK-CP 52
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
222-451 3.01e-06

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 49.93  E-value: 3.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 222 HFLHAIEYGNYVYFFFREIAVEHNnlgKAVYSRVARICKNDmggsqrvleKHWTSFLKARLNCSVPGDSFFyfDVLQSI- 300
Cdd:cd11245 185 DFVYAFADNGYIYFLFSRRPGTAD---STKRTYISRLCEND---------HHYYSYVELPLNCTVNQENTY--NLVQAAy 250
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 301 --TDIIQINGiPTVVGVFTTQLNSIPG----SAVCAFSMDDIEKVFkgrfkeQKTPDSVWT-AVPEDKVPKprpgccakh 373
Cdd:cd11245 251 laKPGKVLNG-KVLFGVFSADEASTAApdgrSALCMYPLSSVDARF------ERTRESCYTgEGLEDDKPE--------- 314
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24234744 374 glaEAY----KTSI--DFPDETLsfiKSHPLMDSAVP-PIADEPWFTKTRVRYR---LTAISVDHSAGpyqnYTVIFVGS 443
Cdd:cd11245 315 ---TAYieynVKSIckTLPDKNV---KAYPCGAEHTPsPLASRYPLAAKPILTRndmLTAVAVAVENG----HTIAFLGD 384

                ....*...
gi 24234744 444 EAGMVLKV 451
Cdd:cd11245 385 SGGQLHKV 392
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
514-543 6.54e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 40.61  E-value: 6.54e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24234744    514 RCERYGSCKkSCIASRDPYCGW-LSQGSCGR 543
Cdd:smart00423   1 RCSKYTSCS-ECLLARDPYCAWcSSQGRCTS 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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