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Conserved domains on  [gi|444299649|ref|NP_733468|]
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kinetochore scaffold 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRWD-C_Knl1 cd22892
C-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore ...
 2238-2336 4.39e-50

C-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore scaffold 1 (KNL1 or Knl1, also known as Spc105, Spc7, and Blinkin) coordinates the spindle assembly checkpoint (SAC), a signaling pathway that delays chromosome segregation until all sister chromatids are properly attached to spindle microtubules (MTs). Knl1 is part of the KMN network, a conserved kinetochore protein complex that connects kinetochores to MTs. Knl1 has been shown to play an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach for colorectal cancer patients. Knl1 contains tandem RWD domains, also known as a double-RWD domain, DRWD, which has been shown to bind the Mis12 complex, consisting of Dsn1 and Nsl1, that tethers directly onto the underlying chromatin layer and mediates kinetochore targeting of Knl1. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


:

Pssm-ID: 467644  Cd Length: 99  Bit Score: 172.57  E-value: 4.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2238 LLGEEIEYLKRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEITLFLSAYYPSVPLPSTIQNHVGNTSQDDIATILSKVP 2317
Cdd:cd22892     1 LLGEEIEYLKRWGGKYNILKIDINDTNVHLLFSSSAAFAKFEITLSLTSGYPSVPLPFTFENHIGNTSQDQIEEVISKVP 80

                          90
                  ....*....|....*....
gi 444299649 2318 LENNYLKNVVKQIYQDLFQ 2336
Cdd:cd22892    81 PGKNYLKRVVKKIHQDLLQ 99
DRWD-N_Knl1 cd22817
N-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore ...
 2124-2231 3.75e-45

N-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore scaffold 1 (KNL1 or Knl1, also known as Spc105, Spc7, and Blinkin) coordinates the spindle assembly checkpoint (SAC), a signaling pathway that delays chromosome segregation until all sister chromatids are properly attached to spindle microtubules (MTs). Knl1 is part of the KMN network, a conserved kinetochore protein complex that connects kinetochores to MTs. Knl1 has been shown to play an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach for colorectal cancer patients. Knl1 contains tandem RWD domains, also known as a double-RWD domain, DRWD, which has been shown to bind the Mis12 complex, consisting of Dsn1 and Nsl1, that tethers directly onto the underlying chromatin layer and mediates kinetochore targeting of Knl1. The model corresponds to N-terminal double-RWD domain (DRWD-N).


:

Pssm-ID: 467642  Cd Length: 112  Bit Score: 158.98  E-value: 3.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2124 EELLDQL-SLSEWDVVEWSDDQAVFTFVYDTIQLTITFEESVVGFPFlDKRYRKIVDVNFQSLLDEDQAPPSSLLVHKLI 2202
Cdd:cd22817     5 ESHLELLnSLSEWRLEEWDENQAVFTFLYDSLELEVKFEDSKDGTAF-EKPERKIVDISFQSLLDEEKAPPSARLVHKLI 83

                          90       100
                  ....*....|....*....|....*....
gi 444299649 2203 FQYVEEKESWKKTCTTQHQLPKMLEEFSL 2231
Cdd:cd22817    84 FQFIESKESWKETYPTQRDLPKLLHDVSL 112
KNL1_NTD cd21853
N-terminal domain found in kinetochore scaffold 1 (KNL1) and similar proteins; Kinetochore ...
 20-75 3.09e-20

N-terminal domain found in kinetochore scaffold 1 (KNL1) and similar proteins; Kinetochore scaffold 1 (KNL1), also called ALL1-fused gene from chromosome 15q14 protein (AF15q14), Bub-linking kinetochore protein (Blinkin), cancer susceptibility candidate gene 5 protein (CASC5), cancer/testis antigen 29 (CT29), kinetochore-null protein 1, or protein D40/AF15q14, plays crucial roles during mitosis. It is essential for spindle-assembly checkpoint (SAC) signaling and for correct chromosome alignment. It is required for attachment of the kinetochores to the spindle microtubules. KNL1 directly links BUB1 and BUB1B to kinetochores. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. KNL1 also acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. This model corresponds to a small conserved region at the N-terminus of KNL1, which is responsible for the binding of protein phosphatase 1 (PP1). PP1 regulates SAC silencing and mitotic exit, and is targeted to kinetochores, in part, by KNL1.


:

Pssm-ID: 439316  Cd Length: 56  Bit Score: 85.86  E-value: 3.09e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 444299649   20 RRRHSSILKPPRSPLQDLRGGNERVQESNALRNKKNSRRVSFADTIKVFQTESHMK 75
Cdd:cd21853     1 KRRRSSILKPPRSPLLDLDEGNEQNQDLNKKKKRRSSRRVSFADTIQVKEFEKDAK 56
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2025-2134 5.63e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2025 QSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDE--EKNNPVEEWDSEMRAAEKELEQLKTEEEELQRnllEL 2102
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiaALARRIRALEQELAALEAELAELEKEIAELRA---EL 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 444299649 2103 EVQKEQTLAQIDFMQK--QRNRTEELLDQLSLSE 2134
Cdd:COG4942   100 EAQKEELAELLRALYRlgRQPPLALLLSPEDFLD 133
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 883-908 6.51e-06

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 44.35  E-value: 6.51e-06
                           10        20
                   ....*....|....*....|....*.
gi 444299649   883 KIDKTIVFSEDDkNDMDITKSYTIEI 908
Cdd:pfam19221    1 PGDKTVVFSSDA-NDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 774-798 7.76e-06

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 44.35  E-value: 7.76e-06
                           10        20
                   ....*....|....*....|....*
gi 444299649   774 CHDKMIICSEEEQNMDLTKSHTVVI 798
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1097-1122 1.68e-05

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 43.19  E-value: 1.68e-05
                           10        20
                   ....*....|....*....|....*.
gi 444299649  1097 KNDKTIVFSENHkNDMDITQSCMVEI 1122
Cdd:pfam19221    1 PGDKTVVFSSDA-NDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 964-988 6.50e-05

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 41.65  E-value: 6.50e-05
                           10        20
                   ....*....|....*....|....*
gi 444299649   964 PMDKTVVFVDNHVELEMTESHTVFI 988
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 165-187 5.10e-04

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.96  E-value: 5.10e-04
                           10        20
                   ....*....|....*....|....
gi 444299649   165 NDQTVIF-SDENQMDLTSSHTVMI 187
Cdd:pfam19221    2 GDKTVVFsSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 500-520 1.03e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.19  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|...
gi 444299649   500 EKTIY--SGEENMDITKSHTVAI 520
Cdd:pfam19221    3 DKTVVfsSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1176-1200 1.26e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.19  E-value: 1.26e-03
                           10        20
                   ....*....|....*....|....*
gi 444299649  1176 PMDKTVLFTDNYSDLEVTDSHTVFI 1200
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1141-1162 2.63e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


:

Pssm-ID: 466004  Cd Length: 25  Bit Score: 37.03  E-value: 2.63e-03
                           10        20
                   ....*....|....*....|..
gi 444299649  1141 KTILYSCGQDDMEITRSHTTAL 1162
Cdd:pfam19221    4 KTVVFSSDANDMDITKSHTVNI 25
 
Name Accession Description Interval E-value
DRWD-C_Knl1 cd22892
C-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore ...
 2238-2336 4.39e-50

C-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore scaffold 1 (KNL1 or Knl1, also known as Spc105, Spc7, and Blinkin) coordinates the spindle assembly checkpoint (SAC), a signaling pathway that delays chromosome segregation until all sister chromatids are properly attached to spindle microtubules (MTs). Knl1 is part of the KMN network, a conserved kinetochore protein complex that connects kinetochores to MTs. Knl1 has been shown to play an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach for colorectal cancer patients. Knl1 contains tandem RWD domains, also known as a double-RWD domain, DRWD, which has been shown to bind the Mis12 complex, consisting of Dsn1 and Nsl1, that tethers directly onto the underlying chromatin layer and mediates kinetochore targeting of Knl1. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


Pssm-ID: 467644  Cd Length: 99  Bit Score: 172.57  E-value: 4.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2238 LLGEEIEYLKRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEITLFLSAYYPSVPLPSTIQNHVGNTSQDDIATILSKVP 2317
Cdd:cd22892     1 LLGEEIEYLKRWGGKYNILKIDINDTNVHLLFSSSAAFAKFEITLSLTSGYPSVPLPFTFENHIGNTSQDQIEEVISKVP 80

                          90
                  ....*....|....*....
gi 444299649 2318 LENNYLKNVVKQIYQDLFQ 2336
Cdd:cd22892    81 PGKNYLKRVVKKIHQDLLQ 99
DRWD-N_Knl1 cd22817
N-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore ...
 2124-2231 3.75e-45

N-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore scaffold 1 (KNL1 or Knl1, also known as Spc105, Spc7, and Blinkin) coordinates the spindle assembly checkpoint (SAC), a signaling pathway that delays chromosome segregation until all sister chromatids are properly attached to spindle microtubules (MTs). Knl1 is part of the KMN network, a conserved kinetochore protein complex that connects kinetochores to MTs. Knl1 has been shown to play an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach for colorectal cancer patients. Knl1 contains tandem RWD domains, also known as a double-RWD domain, DRWD, which has been shown to bind the Mis12 complex, consisting of Dsn1 and Nsl1, that tethers directly onto the underlying chromatin layer and mediates kinetochore targeting of Knl1. The model corresponds to N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467642  Cd Length: 112  Bit Score: 158.98  E-value: 3.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2124 EELLDQL-SLSEWDVVEWSDDQAVFTFVYDTIQLTITFEESVVGFPFlDKRYRKIVDVNFQSLLDEDQAPPSSLLVHKLI 2202
Cdd:cd22817     5 ESHLELLnSLSEWRLEEWDENQAVFTFLYDSLELEVKFEDSKDGTAF-EKPERKIVDISFQSLLDEEKAPPSARLVHKLI 83

                          90       100
                  ....*....|....*....|....*....
gi 444299649 2203 FQYVEEKESWKKTCTTQHQLPKMLEEFSL 2231
Cdd:cd22817    84 FQFIESKESWKETYPTQRDLPKLLHDVSL 112
Knl1_RWD_C pfam18210
Knl1 RWD C-terminal domain; This domain is found in Knl1, a sub-unit of the KMN network, ...
 2087-2240 2.66e-37

Knl1 RWD C-terminal domain; This domain is found in Knl1, a sub-unit of the KMN network, present in Homo sapiens. The KMN network is the core of the outer kinetochore which is responsible for microtubule binding/stabilization and controls the spindle assembly checkpoint. This domain is the second of two RING finger, WD repeat, DEAD-like helicase (RWD) domains. The tandem RWD domains mediate kinetochore targeting of the microtubule-binding subunits by interacting with the Mis12 complex. The Mis12 complex is a KMN sub-complex that tethers directly onto the underlying chromatin layer.


Pssm-ID: 465680 [Multi-domain]  Cd Length: 152  Bit Score: 138.35  E-value: 2.66e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2087 QLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRN---------RTEELLDQL-SLSEWDVVEWSDDQAVFTFVYDtIQL 2156
Cdd:pfam18210    1 ELKEELEELEEKLEELEERKQELLAAIGEAERIREecwtseevlRLKEELEALeSLHGWRITEVSDDTLVFTYLSD-IEL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2157 TITFEESvvgfpfldkryRKIVDVNFQSLLDEDQAPPSSLLVHKLIFQYVEEKESWKKTCTTQHQLPKMLEEFSLVVHHC 2236
Cdd:pfam18210   80 TFDFGAS-----------PKISSIDLESYLDDEKAPPSSLLVHRLAFFFLQSARDWVRKYPTQTSLPKLLQDVSLVWSRC 148


                   ....
gi 444299649  2237 RLLG 2240
Cdd:pfam18210  149 RLLG 152
KNL1_NTD cd21853
N-terminal domain found in kinetochore scaffold 1 (KNL1) and similar proteins; Kinetochore ...
 20-75 3.09e-20

N-terminal domain found in kinetochore scaffold 1 (KNL1) and similar proteins; Kinetochore scaffold 1 (KNL1), also called ALL1-fused gene from chromosome 15q14 protein (AF15q14), Bub-linking kinetochore protein (Blinkin), cancer susceptibility candidate gene 5 protein (CASC5), cancer/testis antigen 29 (CT29), kinetochore-null protein 1, or protein D40/AF15q14, plays crucial roles during mitosis. It is essential for spindle-assembly checkpoint (SAC) signaling and for correct chromosome alignment. It is required for attachment of the kinetochores to the spindle microtubules. KNL1 directly links BUB1 and BUB1B to kinetochores. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. KNL1 also acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. This model corresponds to a small conserved region at the N-terminus of KNL1, which is responsible for the binding of protein phosphatase 1 (PP1). PP1 regulates SAC silencing and mitotic exit, and is targeted to kinetochores, in part, by KNL1.


Pssm-ID: 439316  Cd Length: 56  Bit Score: 85.86  E-value: 3.09e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 444299649   20 RRRHSSILKPPRSPLQDLRGGNERVQESNALRNKKNSRRVSFADTIKVFQTESHMK 75
Cdd:cd21853     1 KRRRSSILKPPRSPLLDLDEGNEQNQDLNKKKKRRSSRRVSFADTIQVKEFEKDAK 56
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2025-2134 5.63e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2025 QSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDE--EKNNPVEEWDSEMRAAEKELEQLKTEEEELQRnllEL 2102
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiaALARRIRALEQELAALEAELAELEKEIAELRA---EL 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 444299649 2103 EVQKEQTLAQIDFMQK--QRNRTEELLDQLSLSE 2134
Cdd:COG4942   100 EAQKEELAELLRALYRlgRQPPLALLLSPEDFLD 133
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 883-908 6.51e-06

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 44.35  E-value: 6.51e-06
                           10        20
                   ....*....|....*....|....*.
gi 444299649   883 KIDKTIVFSEDDkNDMDITKSYTIEI 908
Cdd:pfam19221    1 PGDKTVVFSSDA-NDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 774-798 7.76e-06

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 44.35  E-value: 7.76e-06
                           10        20
                   ....*....|....*....|....*
gi 444299649   774 CHDKMIICSEEEQNMDLTKSHTVVI 798
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1097-1122 1.68e-05

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 43.19  E-value: 1.68e-05
                           10        20
                   ....*....|....*....|....*.
gi 444299649  1097 KNDKTIVFSENHkNDMDITQSCMVEI 1122
Cdd:pfam19221    1 PGDKTVVFSSDA-NDMDITKSHTVNI 25
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 2049-2135 3.43e-05

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 45.28  E-value: 3.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2049 DNCLTEMETETKNLEDEEK------NNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQrnr 2122
Cdd:pfam17675    8 DLLLEELDKQLEDAEKERDayisflKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEALEEE--- 84

                           90
                   ....*....|...
gi 444299649  2123 tEELLDQLSLSEW 2135
Cdd:pfam17675   85 -LEALDEEEEEFW 96
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 964-988 6.50e-05

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 41.65  E-value: 6.50e-05
                           10        20
                   ....*....|....*....|....*
gi 444299649   964 PMDKTVVFVDNHVELEMTESHTVFI 988
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2016-2130 7.47e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 7.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2016 KVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETEtknledeeknnpVEEWDSEMRAAEKELEQLKTEEEEL 2095
Cdd:TIGR02168  226 ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------------LEELRLEVSELEEEIEELQKELYAL 293

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 444299649  2096 QRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEELEAQLEEL 328
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2022-2126 4.46e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.83  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2022 KLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLE 2101
Cdd:PRK03918  619 KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEK 698

                          90       100
                  ....*....|....*....|....*...
gi 444299649 2102 LEVQKE---QTLAQIDFMQKQRNRTEEL 2126
Cdd:PRK03918  699 LKEELEereKAKKELEKLEKALERVEEL 726
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 165-187 5.10e-04

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.96  E-value: 5.10e-04
                           10        20
                   ....*....|....*....|....
gi 444299649   165 NDQTVIF-SDENQMDLTSSHTVMI 187
Cdd:pfam19221    2 GDKTVVFsSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 500-520 1.03e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.19  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|...
gi 444299649   500 EKTIY--SGEENMDITKSHTVAI 520
Cdd:pfam19221    3 DKTVVfsSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1176-1200 1.26e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.19  E-value: 1.26e-03
                           10        20
                   ....*....|....*....|....*
gi 444299649  1176 PMDKTVLFTDNYSDLEVTDSHTVFI 1200
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1141-1162 2.63e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 37.03  E-value: 2.63e-03
                           10        20
                   ....*....|....*....|..
gi 444299649  1141 KTILYSCGQDDMEITRSHTTAL 1162
Cdd:pfam19221    4 KTVVFSSDANDMDITKSHTVNI 25
 
Name Accession Description Interval E-value
DRWD-C_Knl1 cd22892
C-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore ...
 2238-2336 4.39e-50

C-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore scaffold 1 (KNL1 or Knl1, also known as Spc105, Spc7, and Blinkin) coordinates the spindle assembly checkpoint (SAC), a signaling pathway that delays chromosome segregation until all sister chromatids are properly attached to spindle microtubules (MTs). Knl1 is part of the KMN network, a conserved kinetochore protein complex that connects kinetochores to MTs. Knl1 has been shown to play an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach for colorectal cancer patients. Knl1 contains tandem RWD domains, also known as a double-RWD domain, DRWD, which has been shown to bind the Mis12 complex, consisting of Dsn1 and Nsl1, that tethers directly onto the underlying chromatin layer and mediates kinetochore targeting of Knl1. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


Pssm-ID: 467644  Cd Length: 99  Bit Score: 172.57  E-value: 4.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2238 LLGEEIEYLKRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEITLFLSAYYPSVPLPSTIQNHVGNTSQDDIATILSKVP 2317
Cdd:cd22892     1 LLGEEIEYLKRWGGKYNILKIDINDTNVHLLFSSSAAFAKFEITLSLTSGYPSVPLPFTFENHIGNTSQDQIEEVISKVP 80

                          90
                  ....*....|....*....
gi 444299649 2318 LENNYLKNVVKQIYQDLFQ 2336
Cdd:cd22892    81 PGKNYLKRVVKKIHQDLLQ 99
DRWD-N_Knl1 cd22817
N-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore ...
 2124-2231 3.75e-45

N-terminal double-RWD domain of kinetochore scaffold 1 and related proteins; Kinetochore scaffold 1 (KNL1 or Knl1, also known as Spc105, Spc7, and Blinkin) coordinates the spindle assembly checkpoint (SAC), a signaling pathway that delays chromosome segregation until all sister chromatids are properly attached to spindle microtubules (MTs). Knl1 is part of the KMN network, a conserved kinetochore protein complex that connects kinetochores to MTs. Knl1 has been shown to play an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach for colorectal cancer patients. Knl1 contains tandem RWD domains, also known as a double-RWD domain, DRWD, which has been shown to bind the Mis12 complex, consisting of Dsn1 and Nsl1, that tethers directly onto the underlying chromatin layer and mediates kinetochore targeting of Knl1. The model corresponds to N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467642  Cd Length: 112  Bit Score: 158.98  E-value: 3.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2124 EELLDQL-SLSEWDVVEWSDDQAVFTFVYDTIQLTITFEESVVGFPFlDKRYRKIVDVNFQSLLDEDQAPPSSLLVHKLI 2202
Cdd:cd22817     5 ESHLELLnSLSEWRLEEWDENQAVFTFLYDSLELEVKFEDSKDGTAF-EKPERKIVDISFQSLLDEEKAPPSARLVHKLI 83

                          90       100
                  ....*....|....*....|....*....
gi 444299649 2203 FQYVEEKESWKKTCTTQHQLPKMLEEFSL 2231
Cdd:cd22817    84 FQFIESKESWKETYPTQRDLPKLLHDVSL 112
Knl1_RWD_C pfam18210
Knl1 RWD C-terminal domain; This domain is found in Knl1, a sub-unit of the KMN network, ...
 2087-2240 2.66e-37

Knl1 RWD C-terminal domain; This domain is found in Knl1, a sub-unit of the KMN network, present in Homo sapiens. The KMN network is the core of the outer kinetochore which is responsible for microtubule binding/stabilization and controls the spindle assembly checkpoint. This domain is the second of two RING finger, WD repeat, DEAD-like helicase (RWD) domains. The tandem RWD domains mediate kinetochore targeting of the microtubule-binding subunits by interacting with the Mis12 complex. The Mis12 complex is a KMN sub-complex that tethers directly onto the underlying chromatin layer.


Pssm-ID: 465680 [Multi-domain]  Cd Length: 152  Bit Score: 138.35  E-value: 2.66e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2087 QLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRN---------RTEELLDQL-SLSEWDVVEWSDDQAVFTFVYDtIQL 2156
Cdd:pfam18210    1 ELKEELEELEEKLEELEERKQELLAAIGEAERIREecwtseevlRLKEELEALeSLHGWRITEVSDDTLVFTYLSD-IEL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2157 TITFEESvvgfpfldkryRKIVDVNFQSLLDEDQAPPSSLLVHKLIFQYVEEKESWKKTCTTQHQLPKMLEEFSLVVHHC 2236
Cdd:pfam18210   80 TFDFGAS-----------PKISSIDLESYLDDEKAPPSSLLVHRLAFFFLQSARDWVRKYPTQTSLPKLLQDVSLVWSRC 148


                   ....
gi 444299649  2237 RLLG 2240
Cdd:pfam18210  149 RLLG 152
KNL1_NTD cd21853
N-terminal domain found in kinetochore scaffold 1 (KNL1) and similar proteins; Kinetochore ...
 20-75 3.09e-20

N-terminal domain found in kinetochore scaffold 1 (KNL1) and similar proteins; Kinetochore scaffold 1 (KNL1), also called ALL1-fused gene from chromosome 15q14 protein (AF15q14), Bub-linking kinetochore protein (Blinkin), cancer susceptibility candidate gene 5 protein (CASC5), cancer/testis antigen 29 (CT29), kinetochore-null protein 1, or protein D40/AF15q14, plays crucial roles during mitosis. It is essential for spindle-assembly checkpoint (SAC) signaling and for correct chromosome alignment. It is required for attachment of the kinetochores to the spindle microtubules. KNL1 directly links BUB1 and BUB1B to kinetochores. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. KNL1 also acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. This model corresponds to a small conserved region at the N-terminus of KNL1, which is responsible for the binding of protein phosphatase 1 (PP1). PP1 regulates SAC silencing and mitotic exit, and is targeted to kinetochores, in part, by KNL1.


Pssm-ID: 439316  Cd Length: 56  Bit Score: 85.86  E-value: 3.09e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 444299649   20 RRRHSSILKPPRSPLQDLRGGNERVQESNALRNKKNSRRVSFADTIKVFQTESHMK 75
Cdd:cd21853     1 KRRRSSILKPPRSPLLDLDEGNEQNQDLNKKKKRRSSRRVSFADTIQVKEFEKDAK 56
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2025-2134 5.63e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2025 QSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDE--EKNNPVEEWDSEMRAAEKELEQLKTEEEELQRnllEL 2102
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiaALARRIRALEQELAALEAELAELEKEIAELRA---EL 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 444299649 2103 EVQKEQTLAQIDFMQK--QRNRTEELLDQLSLSE 2134
Cdd:COG4942   100 EAQKEELAELLRALYRlgRQPPLALLLSPEDFLD 133
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 883-908 6.51e-06

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 44.35  E-value: 6.51e-06
                           10        20
                   ....*....|....*....|....*.
gi 444299649   883 KIDKTIVFSEDDkNDMDITKSYTIEI 908
Cdd:pfam19221    1 PGDKTVVFSSDA-NDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 774-798 7.76e-06

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 44.35  E-value: 7.76e-06
                           10        20
                   ....*....|....*....|....*
gi 444299649   774 CHDKMIICSEEEQNMDLTKSHTVVI 798
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1097-1122 1.68e-05

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 43.19  E-value: 1.68e-05
                           10        20
                   ....*....|....*....|....*.
gi 444299649  1097 KNDKTIVFSENHkNDMDITQSCMVEI 1122
Cdd:pfam19221    1 PGDKTVVFSSDA-NDMDITKSHTVNI 25
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 2049-2135 3.43e-05

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 45.28  E-value: 3.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2049 DNCLTEMETETKNLEDEEK------NNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQrnr 2122
Cdd:pfam17675    8 DLLLEELDKQLEDAEKERDayisflKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEALEEE--- 84

                           90
                   ....*....|...
gi 444299649  2123 tEELLDQLSLSEW 2135
Cdd:pfam17675   85 -LEALDEEEEEFW 96
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 2022-2130 4.69e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 47.23  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2022 KLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLED---EEKNNpveewdSEMRAAEKELEQLKTEEEELQRN 2098
Cdd:COG1579    38 DELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgNVRNN------KEYEALQKEIESLKRRISDLEDE 111

                          90       100       110
                  ....*....|....*....|....*....|..
gi 444299649 2099 LLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG1579   112 ILELMERIEELEEELAELEAELAELEAELEEK 143
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2025-2130 5.46e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.97  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2025 QSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEknnpvEEWDSEMRAAEKELEQLKTEEEELQRNLLELEV 2104
Cdd:COG4372    69 EQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEA-----EELQEELEELQKERQDLEQQRKQLEAQIAELQS 143

                          90       100
                  ....*....|....*....|....*.
gi 444299649 2105 QKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG4372   144 EIAEREEELKELEEQLESLQEELAAL 169
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 964-988 6.50e-05

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 41.65  E-value: 6.50e-05
                           10        20
                   ....*....|....*....|....*
gi 444299649   964 PMDKTVVFVDNHVELEMTESHTVFI 988
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2016-2130 7.47e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 7.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2016 KVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETEtknledeeknnpVEEWDSEMRAAEKELEQLKTEEEEL 2095
Cdd:TIGR02168  226 ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEK------------LEELRLEVSELEEEIEELQKELYAL 293

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 444299649  2096 QRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEELEAQLEEL 328
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2016-2130 7.94e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 7.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2016 KVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETE---------TKNLEDEEKNNPVEEWDSEMRAAEKELE 2086
Cdd:COG1196   226 EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAEleelrleleELELELEEAQAEEYELLAELARLEQDIA 305

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 444299649 2087 QLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG1196   306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2032-2130 2.15e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.05  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2032 EKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEknnpveewdSEMRAAEKELEQLKTEEEELQRNLLELEVQKEQTLA 2111
Cdd:COG4372    31 EQLRKALFELDKLQEELEQLREELEQAREELEQLE---------EELEQARSELEQLEEELEELNEQLQAAQAELAQAQE 101

                          90
                  ....*....|....*....
gi 444299649 2112 QIDFMQKQRNRTEELLDQL 2130
Cdd:COG4372   102 ELESLQEEAEELQEELEEL 120
Nuf2_DHR10-like pfam18595
Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This ...
 2027-2125 2.50e-04

Nuf2, DHR10-like domain; This domain is found at the C-terminal region of Nuf2 proteins. This domain was identified as MazG related domain also designated as Designed helical repeat protein 10 (DHR10) that actually adopts a coiled-coil structure. Nuf2 is part of the Ndc80 complex, which binds to the spindle and is required for chromosome segregation and spindle checkpoint activity.


Pssm-ID: 465814 [Multi-domain]  Cd Length: 117  Bit Score: 42.57  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2027 AQNERE--KLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKnnpveewdsemraAEKELEQLKTEEEELQRNLLELEV 2104
Cdd:pfam18595   12 AELERKarELQAKIDALQVVEKDLRSCIKLLEEIEAELAKLEE-------------AKKKLKELRDALEEKEIELRELER 78

                           90       100
                   ....*....|....*....|.
gi 444299649  2105 QKEQTLAQIDFMQKQRNRTEE 2125
Cdd:pfam18595   79 REERLQRQLENAQEKLERLRE 99
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2024-2130 2.56e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.66  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2024 VQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETE--TKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLE 2101
Cdd:COG4372    54 LEQAREELEQLEEELEQARSELEQLEEELEELNEQlqAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ 133

                          90       100
                  ....*....|....*....|....*....
gi 444299649 2102 LEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG4372   134 LEAQIAELQSEIAEREEELKELEEQLESL 162
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1942-2131 2.62e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.60  E-value: 2.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  1942 KIQIYREDCEARRQKIEELKLsasnqdklLVDINKNLWEKMRHCSDKELKAFGIYLNKIKSCFT-KMTKVFTHQGKVALY 2020
Cdd:TIGR02169  171 KKEKALEELEEVEENIERLDL--------IIDEKRQQLERLRREREKAERYQALLKEKREYEGYeLLKEKEALERQKEAI 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2021 GKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEeknnpveewdsEMRAAEKELEQLKTEEEELQRNLL 2100
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEE-----------EQLRVKEKIGELEAEIASLERSIA 311

                          170       180       190
                   ....*....|....*....|....*....|.
gi 444299649  2101 ELEVQKEQTLAQIDFMQKQRNRTEELLDQLS 2131
Cdd:TIGR02169  312 EKERELEDAEERLAKLEAEIDKLLAEIEELE 342
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2025-2134 2.75e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.47  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2025 QSAQNER-EKLQIKIDEMDK--ILKKIDNCLTEMETETKNLEDEEKNnpVEEWDSEMRAAEKELEQLKT-------EEEE 2094
Cdd:COG1196   208 QAEKAERyRELKEELKELEAelLLLKLRELEAELEELEAELEELEAE--LEELEAELAELEAELEELRLeleelelELEE 285

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 444299649 2095 LQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQLSLSE 2134
Cdd:COG1196   286 AQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL 325
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2024-2130 2.82e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2024 VQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDE--EKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLE 2101
Cdd:TIGR02169  793 IPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEiqELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEE 872

                           90       100
                   ....*....|....*....|....*....
gi 444299649  2102 LEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:TIGR02169  873 LEAALRDLESRLGDLKKERDELEAQLREL 901
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2027-2130 3.38e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 3.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2027 AQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLED--EEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLELEV 2104
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKelEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761

                           90       100
                   ....*....|....*....|....*.
gi 444299649  2105 QKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:TIGR02168  762 EIEELEERLEEAEEELAEAEAEIEEL 787
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2022-2136 3.73e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.91  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2022 KLVQSAQNEREKLQIKIDEMDKILKKIDNC---LTEMETETKNLEDEEKNNPVEEwdsEMRAAEKELEQLKTEEEELQRN 2098
Cdd:COG4717    78 EELKEAEEKEEEYAELQEELEELEEELEELeaeLEELREELEKLEKLLQLLPLYQ---ELEALEAELAELPERLEELEER 154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 444299649 2099 LL---ELEVQKEQTLAQIdfmQKQRNRTEELLDQLSLSEWD 2136
Cdd:COG4717   155 LEelrELEEELEELEAEL---AELQEELEELLEQLSLATEE 192
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1942-2130 4.20e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 4.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  1942 KIQIYREDCEARRQKIEEL--KLSASNQDKLLvdinkNLWEKMRhcsdkELKAfgiylnKIKSCftkmtkvfthQGKVAL 2019
Cdd:TIGR02169  259 EISELEKRLEEIEQLLEELnkKIKDLGEEEQL-----RVKEKIG-----ELEA------EIASL----------ERSIAE 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2020 YGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTE-------METETKNLED---------EEKNNPVEEWDSEMRAAEK 2083
Cdd:TIGR02169  313 KERELEDAEERLAKLEAEIDKLLAEIEELEREIEEerkrrdkLTEEYAELKEeledlraelEEVDKEFAETRDELKDYRE 392

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 444299649  2084 ELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:TIGR02169  393 KLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINEL 439
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2022-2126 4.46e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.83  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2022 KLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLE 2101
Cdd:PRK03918  619 KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEK 698

                          90       100
                  ....*....|....*....|....*...
gi 444299649 2102 LEVQKE---QTLAQIDFMQKQRNRTEEL 2126
Cdd:PRK03918  699 LKEELEereKAKKELEKLEKALERVEEL 726
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 165-187 5.10e-04

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.96  E-value: 5.10e-04
                           10        20
                   ....*....|....*....|....
gi 444299649   165 NDQTVIF-SDENQMDLTSSHTVMI 187
Cdd:pfam19221    2 GDKTVVFsSDANDMDITKSHTVNI 25
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1948-2134 6.15e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.05  E-value: 6.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 1948 EDCEARRQKIEELKlsasnqdKLLVDINKNLWE-KMRHCSDKELKAFGIYLNKIKSCFTKMTKvfthqGKVAlygKLVQS 2026
Cdd:PRK03918  331 KELEEKEERLEELK-------KKLKELEKRLEElEERHELYEEAKAKKEELERLKKRLTGLTP-----EKLE---KELEE 395

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2027 AQNEREKLQIKIDEM-DKI--LKKIDNCLTEMETETKN-----------LEDEEKNNPVEEWDSEMRAAEKELEQLKTEE 2092
Cdd:PRK03918  396 LEKAKEEIEEEISKItARIgeLKKEIKELKKAIEELKKakgkcpvcgreLTEEHRKELLEEYTAELKRIEKELKEIEEKE 475

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 444299649 2093 EELQRNLLELE--VQKEQTLAQIDFMQKQRNRTEELLDQLSLSE 2134
Cdd:PRK03918  476 RKLRKELRELEkvLKKESELIKLKELAEQLKELEEKLKKYNLEE 519
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2014-2139 8.44e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 8.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2014 QGKVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMET--ETKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTE 2091
Cdd:COG1196   238 EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELelEEAQAEEYELLAELARLEQDIARLEERRRELEER 317

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 444299649 2092 EEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQLSLSEWDVVE 2139
Cdd:COG1196   318 LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEE 365
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 500-520 1.03e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.19  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|...
gi 444299649   500 EKTIY--SGEENMDITKSHTVAI 520
Cdd:pfam19221    3 DKTVVfsSDANDMDITKSHTVNI 25
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1176-1200 1.26e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 38.19  E-value: 1.26e-03
                           10        20
                   ....*....|....*....|....*
gi 444299649  1176 PMDKTVLFTDNYSDLEVTDSHTVFI 1200
Cdd:pfam19221    1 PGDKTVVFSSDANDMDITKSHTVNI 25
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 2041-2126 1.27e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.41  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2041 MDKILKKIDncltEMETETKNLEDEEKnnpveEWDSEMRAAEKELEQLkteEEELQRNLLELEVQKEQTLAQI-----DF 2115
Cdd:pfam03938    7 MQKILEESP----EGKAAQAQLEKKFK-----KRQAELEAKQKELQKL---YEELQKDGALLEEEREEKEQELqkkeqEL 74

                           90
                   ....*....|.
gi 444299649  2116 MQKQRNRTEEL 2126
Cdd:pfam03938   75 QQLQQKAQQEL 85
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
2020-2130 1.77e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2020 YGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEeknnpVEEWDSEMRAAEKELEQLKTEEEELQRNL 2099
Cdd:COG4372     8 VGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREE-----LEQAREELEQLEEELEQARSELEQLEEEL 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 444299649 2100 LELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG4372    83 EELNEQLQAAQAELAQAQEELESLQEEAEEL 113
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2016-2130 1.78e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2016 KVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDN---------CLTEMETETKNLEDEeknnpVEEWDSEMRAAEK--- 2083
Cdd:COG4913   611 KLAALEAELAELEEELAEAEERLEALEAELDALQErrealqrlaEYSWDEIDVASAERE-----IAELEAELERLDAssd 685

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 444299649 2084 ELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG4913   686 DLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDEL 732
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1940-2131 2.12e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  1940 RPKIQIYREDCEARRQKIEELKLSASNQDKLLVDINKNLWEKMRHCSDKELKAFGIYLNKIKSCFTKMTKVFTH------ 2013
Cdd:TIGR02169  743 EEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREieqkln 822

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649  2014 --QGKVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEeknnpVEEWDSEMRAAEKELEQLKTE 2091
Cdd:TIGR02169  823 rlTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAA-----LRDLESRLGDLKKERDELEAQ 897

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 444299649  2092 EEELQRNLLELEVQKEQTLAQIDFMQKQRnrtEELLDQLS 2131
Cdd:TIGR02169  898 LRELERKIEELEAQIEKKRKRLSELKAKL---EALEEELS 934
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2021-2130 2.17e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2021 GKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNnpVEEWDSEMRAAEKELE--QLKTEEEELQRN 2098
Cdd:COG4717    63 GRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAE--LEELREELEKLEKLLQllPLYQELEALEAE 140

                          90       100       110
                  ....*....|....*....|....*....|..
gi 444299649 2099 LLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG4717   141 LAELPERLEELEERLEELRELEEELEELEAEL 172
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2014-2134 2.31e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2014 QGKVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEknnpvEEWDSEMRAAEKELEQLKTEEE 2093
Cdd:COG1196   287 QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL-----EELEEELEEAEEELEEAEAELA 361

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 444299649 2094 ELQRNLLELEVQKEQTLAQID-----FMQKQRNRTEELLDQLSLSE 2134
Cdd:COG1196   362 EAEEALLEAEAELAEAEEELEelaeeLLEALRAAAELAAQLEELEE 407
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2016-2130 2.62e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2016 KVALYGKLVQSAQnEREKLQIKIDEMDKILKKIDncLTEMETETKNLEDEeknnpVEEWDSEMRAAEKELEQLKTEEEEL 2095
Cdd:COG4913   250 QIELLEPIRELAE-RYAAARERLAELEYLRAALR--LWFAQRRLELLEAE-----LEELRAELARLEAELERLEARLDAL 321

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 444299649 2096 QRNLLELEVQ--------KEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG4913   322 REELDELEAQirgnggdrLEQLEREIERLERELEERERRRARL 364
MELT pfam19221
MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome ...
 1141-1162 2.63e-03

MELT motif; The outer kinetochore protein scaffold KNL1 is essential for error-free chromosome segregation during mitosis and meiosis. A critical feature of KNL1 is an array of repeats containing MELT-like motifs. When phosphorylated, these motifs form docking sites for the BUB1-BUB3 dimer that regulates chromosome biorientation and the spindle assembly checkpoint. This entry mainly represents vertebrate proteins although MELT motifs are found much more widely.


Pssm-ID: 466004  Cd Length: 25  Bit Score: 37.03  E-value: 2.63e-03
                           10        20
                   ....*....|....*....|..
gi 444299649  1141 KTILYSCGQDDMEITRSHTTAL 1162
Cdd:pfam19221    4 KTVVFSSDANDMDITKSHTVNI 25
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1999-2136 2.70e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 1999 KIKSCFTKMTKVFTHQGKVALYGKLVQSAQNEREKLQIKIDEMDKIL---------KKIDNCLTEMETETKNLEDEEKnn 2069
Cdd:COG4717    79 ELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLqllplyqelEALEAELAELPERLEELEERLE-- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2070 PVEEWDSEMRAAEKELEQLKTEEEELQR---------------NLLELEVQKEQTLAQIDFMQKQRNRTEELLDQLSLSE 2134
Cdd:COG4717   157 ELRELEEELEELEAELAELQEELEELLEqlslateeelqdlaeELEELQQRLAELEEELEEAQEELEELEEELEQLENEL 236


                  ..
gi 444299649 2135 WD 2136
Cdd:COG4717   237 EA 238
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
2023-2126 3.34e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2023 LVQSAQNEREKLQIKIDEMDKILKKIDNcLTEMETETKNLE----------DEEKNNPVEEWDSEMRAAEKELEQLKTEE 2092
Cdd:COG4717   130 LYQELEALEAELAELPERLEELEERLEE-LRELEEELEELEaelaelqeelEELLEQLSLATEEELQDLAEELEELQQRL 208

                          90       100       110
                  ....*....|....*....|....*....|....
gi 444299649 2093 EELQRNLLELEVQKEQTLAQIDFMQKQRNRTEEL 2126
Cdd:COG4717   209 AELEEELEEAQEELEELEEELEQLENELEAAALE 242
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
2013-2138 3.47e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.54  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2013 HQGKVALYGKLVQSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKnlEDEEKNNPVEEWDSEMRAAEKELEQLKTEE 2092
Cdd:COG2433   411 EEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEER--REIRKDREISRLDREIERLERELEEERERI 488

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 444299649 2093 EELQRNLLELEvqkeqTLAQIDFMQKQ----------RNRTEELLDQLSLSEWDVV 2138
Cdd:COG2433   489 EELKRKLERLK-----ELWKLEHSGELvpvkvvekftKEAIRRLEEEYGLKEGDVV 539
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2063-2130 3.52e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 3.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 444299649 2063 EDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLLELEVQKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEER 84
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 2033-2138 4.71e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 42.38  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2033 KLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNNPVE---EWDSEMRAAEKELEQLKT---EEEELQRNLLELEVQK 2106
Cdd:COG0542   401 RVRMEIDSKPEELDELERRLEQLEIEKEALKKEQDEASFErlaELRDELAELEEELEALKArweAEKELIEEIQELKEEL 480

                          90       100       110
                  ....*....|....*....|....*....|..
gi 444299649 2107 EQTLAQIDFMQKQRNRTEELLDQLSLSEWDVV 2138
Cdd:COG0542   481 EQRYGKIPELEKELAELEEELAELAPLLREEV 512
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2025-2130 7.15e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 7.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444299649 2025 QSAQNEREKLQIKIDEMDKILKKIDNCLTEMETETKNLEDEEKNNpvEEWDSEMRAAEKELEQLKTEEEELQRNLLELEV 2104
Cdd:COG1196   281 LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEEL--AELEEELEELEEELEELEEELEEAEEELEEAEA 358

                          90       100
                  ....*....|....*....|....*.
gi 444299649 2105 QKEQTLAQIDFMQKQRNRTEELLDQL 2130
Cdd:COG1196   359 ELAEAEEALLEAEAELAEAEEELEEL 384
PilO COG3167
Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];
2077-2131 7.77e-03

Type IV pilus assembly protein PilO [Cell motility, Extracellular structures];


Pssm-ID: 442400 [Multi-domain]  Cd Length: 202  Bit Score: 39.93  E-value: 7.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 444299649 2077 EMRAAEKELEQLKTEEEELQR---NLLELEVQKEQTLAQIDFMQKQ---RNRTEELLDQLS 2131
Cdd:COG3167    47 ELEELEAEEAQLKQELEKKQAkaaNLPALKAQLEELEQQLGELLKQlpsKAEVPALLDDIS 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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