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Conserved domains on  [gi|24762244|ref|NP_733777|]
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homeobox protein Meis2 isoform a [Homo sapiens]

Protein Classification

homeobox protein( domain architecture ID 11243274)

homeobox protein is involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 110-194 6.42e-60

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


:

Pssm-ID: 465140  Cd Length: 86  Bit Score: 189.09  E-value: 6.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762244   110 GGDVCSSDSFNEDIAVFAKQV-RAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV 188
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIeRAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 24762244   189 IDERDG 194
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 295-333 6.33e-21

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 84.87  E-value: 6.33e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24762244   295 LFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 110-194 6.42e-60

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 189.09  E-value: 6.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762244   110 GGDVCSSDSFNEDIAVFAKQV-RAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV 188
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIeRAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 24762244   189 IDERDG 194
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 295-333 6.33e-21

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 84.87  E-value: 6.33e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24762244   295 LFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 280-333 7.18e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 63.03  E-value: 7.18e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24762244 280 RGIFPKVATNIMRAWlFQHltHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:cd00086   4 RTRFTPEQLEELEKE-FEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 280-333 2.44e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 61.50  E-value: 2.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24762244    280 RGIFPKVATNIMRAWlFQHltHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:smart00389   5 RTSFTPEQLEELEKE-FQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 110-194 6.42e-60

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 189.09  E-value: 6.42e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762244   110 GGDVCSSDSFNEDIAVFAKQV-RAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLV 188
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIeRAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 24762244   189 IDERDG 194
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 295-333 6.33e-21

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 84.87  E-value: 6.33e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24762244   295 LFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 280-333 7.18e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 63.03  E-value: 7.18e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24762244 280 RGIFPKVATNIMRAWlFQHltHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:cd00086   4 RTRFTPEQLEELEKE-FEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 280-333 2.44e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 61.50  E-value: 2.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 24762244    280 RGIFPKVATNIMRAWlFQHltHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:smart00389   5 RTSFTPEQLEELEKE-FQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
Homeodomain pfam00046
Homeodomain;
295-333 9.31e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.87  E-value: 9.31e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24762244   295 LFQHltHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333
Cdd:pfam00046  18 EFQE--NPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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