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Conserved domains on  [gi|26190616|ref|NP_751943|]
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kelch domain-containing protein 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
63-327 2.38e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 117.95  E-value: 2.38e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  63 GELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDetyiWEKITDFegqPPTPRDKLSCWVYKDRLIYFGGY 142
Cdd:COG3055   7 PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNT----WSELAPL---PGPPRHHAAAVAQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616 143 GCRRHSelqdcfdvhdasweeqifWGWHNDVHIFDTKTQTWfqpeIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMN 222
Cdd:COG3055  80 TGANPS------------------STPLNDVYVYDPATNTW----TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616 223 DLHYLNLDTWTWsgriTINGESPKHRSWHTLTPIADDKLFLCGGLSADniplsdgwihnVTTNCWKQLTHLPKtrPRLWH 302
Cdd:COG3055 138 WVEVYDPATGTW----TQLAPLPTPRDHLAAAVLPDGKILVIGGRNGS-----------GFSNTWTTLAPLPT--ARAGH 200

                       250       260
                ....*....|....*....|....*...
gi 26190616 303 TACLGKeNEIMVFGGSK---DDLLALDT 327
Cdd:COG3055 201 AAAVLG-GKILVFGGESgfsDEVEAYDP 227
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-93 2.37e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 51.70  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  10 AEERSGHCAVVDGNFLYVWGGYVSIednevylpNDEIWTYDIDSGLWRMHlmeGELPASMSGSCGACINGKLYIFGGYDD 89
Cdd:COG3055 194 PTARAGHAAAVLGGKILVFGGESGF--------SDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVYVIGGETK 262


                ....
gi 26190616  90 KGYS 93
Cdd:COG3055 263 PGVR 266
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
63-327 2.38e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 117.95  E-value: 2.38e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  63 GELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDetyiWEKITDFegqPPTPRDKLSCWVYKDRLIYFGGY 142
Cdd:COG3055   7 PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNT----WSELAPL---PGPPRHHAAAVAQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616 143 GCRRHSelqdcfdvhdasweeqifWGWHNDVHIFDTKTQTWfqpeIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMN 222
Cdd:COG3055  80 TGANPS------------------STPLNDVYVYDPATNTW----TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616 223 DLHYLNLDTWTWsgriTINGESPKHRSWHTLTPIADDKLFLCGGLSADniplsdgwihnVTTNCWKQLTHLPKtrPRLWH 302
Cdd:COG3055 138 WVEVYDPATGTW----TQLAPLPTPRDHLAAAVLPDGKILVIGGRNGS-----------GFSNTWTTLAPLPT--ARAGH 200

                       250       260
                ....*....|....*....|....*...
gi 26190616 303 TACLGKeNEIMVFGGSK---DDLLALDT 327
Cdd:COG3055 201 AAAVLG-GKILVFGGESgfsDEVEAYDP 227
PLN02153 PLN02153
epithiospecifier protein
 183-317 8.21e-12

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 65.78  E-value: 8.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  183 WFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRM--NDLHYLNLDTWTWSgRITINGESPKHRSWHTLTPIADDK 260
Cdd:PLN02153   9 WIKVEQKGGKGPGPRCSHGIAVVGDKLYSFGGELKPNEHidKDLYVFDFNTHTWS-IAPANGDVPRISCLGVRMVAVGTK 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  261 LFLCGGLSAdNIPLSDGWIHNVTTNCWKQLTHLPKT---RPRLWHTAClGKENEIMVFGG 317
Cdd:PLN02153  88 LYIFGGRDE-KREFSDFYSYDTVKNEWTFLTKLDEEggpEARTFHSMA-SDENHVYVFGG 145
Kelch_4 pfam13418
Galactose oxidase, central domain;
247-294 6.25e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 48.76  E-value: 6.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 26190616   247 HRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLP 294
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSLP 48
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-93 2.37e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 51.70  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  10 AEERSGHCAVVDGNFLYVWGGYVSIednevylpNDEIWTYDIDSGLWRMHlmeGELPASMSGSCGACINGKLYIFGGYDD 89
Cdd:COG3055 194 PTARAGHAAAVLGGKILVFGGESGF--------SDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVYVIGGETK 262


                ....
gi 26190616  90 KGYS 93
Cdd:COG3055 263 PGVR 266
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 13-54 5.26e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 42.94  E-value: 5.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 26190616    13 RSGHCAVVDGNFLYVWGGYVSIEDNevylPNDEIWTYDIDSG 54
Cdd:pfam13854   4 RYGHCAVTVGDYIYLYGGYTGGEGQ----PSDDVYVLSLPTF 41
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
63-327 2.38e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 117.95  E-value: 2.38e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  63 GELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDetyiWEKITDFegqPPTPRDKLSCWVYKDRLIYFGGY 142
Cdd:COG3055   7 PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNT----WSELAPL---PGPPRHHAAAVAQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616 143 GCRRHSelqdcfdvhdasweeqifWGWHNDVHIFDTKTQTWfqpeIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMN 222
Cdd:COG3055  80 TGANPS------------------STPLNDVYVYDPATNTW----TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616 223 DLHYLNLDTWTWsgriTINGESPKHRSWHTLTPIADDKLFLCGGLSADniplsdgwihnVTTNCWKQLTHLPKtrPRLWH 302
Cdd:COG3055 138 WVEVYDPATGTW----TQLAPLPTPRDHLAAAVLPDGKILVIGGRNGS-----------GFSNTWTTLAPLPT--ARAGH 200

                       250       260
                ....*....|....*....|....*...
gi 26190616 303 TACLGKeNEIMVFGGSK---DDLLALDT 327
Cdd:COG3055 201 AAAVLG-GKILVFGGESgfsDEVEAYDP 227
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
11-214 6.75e-23

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 97.15  E-value: 6.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  11 EERSGHCAVVDGNFLYVWGGYVSIEDNEVYLpnDEIWTYDIDSGLWRMHlmeGELPASMSGSCGACINGKLYIFGGYDDK 90
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGFTGANPSSTPL--NDVYVYDPATNTWTKL---APMPTPRGGATALLLDGKIYVVGGWDDG 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  91 GYSNRLYFVNLRTRDetyiWEKITDFegqpPTPRDKLSCWV-YKDRLIYFGGYGcrrhselqdcFDVHDASWEE------ 163
Cdd:COG3055 134 GNVAWVEVYDPATGT----WTQLAPL----PTPRDHLAAAVlPDGKILVIGGRN----------GSGFSNTWTTlaplpt 195

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26190616 164 ------------QIF-----WGWHNDVHIFDTKTQTWfqpeIKGGVPPQPRAAHTCAVLGNKGYIFGG 214
Cdd:COG3055 196 araghaaavlggKILvfggeSGFSDEVEAYDPATNTW----TALGELPTPRHGHAAVLTDGKVYVIGG 259
PLN02153 PLN02153
epithiospecifier protein
 183-317 8.21e-12

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 65.78  E-value: 8.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  183 WFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRM--NDLHYLNLDTWTWSgRITINGESPKHRSWHTLTPIADDK 260
Cdd:PLN02153   9 WIKVEQKGGKGPGPRCSHGIAVVGDKLYSFGGELKPNEHidKDLYVFDFNTHTWS-IAPANGDVPRISCLGVRMVAVGTK 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  261 LFLCGGLSAdNIPLSDGWIHNVTTNCWKQLTHLPKT---RPRLWHTAClGKENEIMVFGG 317
Cdd:PLN02153  88 LYIFGGRDE-KREFSDFYSYDTVKNEWTFLTKLDEEggpEARTFHSMA-SDENHVYVFGG 145
Kelch_4 pfam13418
Galactose oxidase, central domain;
247-294 6.25e-08

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 48.76  E-value: 6.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 26190616   247 HRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLP 294
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSLP 48
PHA03098 PHA03098
kelch-like protein; Provisional
 13-162 6.53e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 54.39  E-value: 6.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   13 RSGHCAVVDGNFLYVWGGyvsIEDNEVYLPNDEIwtYDIDSGLWRMHLMegeLPASMSGSCGACINGKLYIFGGY---DD 89
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGG---ISKNDELLKTVEC--FSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGIsyiDN 451

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26190616   90 KGYSNRLYFVNLRTrdETYIWEKITDFegqpptPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWE 162
Cdd:PHA03098 452 IKVYNIVESYNPVT--NKWTELSSLNF------PRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
PLN02153 PLN02153
epithiospecifier protein
 110-290 7.71e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 53.84  E-value: 7.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  110 WEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGygcrrhsELQDcfdvhdaswEEQIfwgwHNDVHIFDTKTQTWFQPEIK 189
Cdd:PLN02153   9 WIKVEQKGGKGPGPRCSHGIAVVGDKLYSFGG-------ELKP---------NEHI----DKDLYVFDFNTHTWSIAPAN 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  190 GGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHylNLDT----WTWSGRITINGeSPKHRSWHTLTPiADDKLFLCG 265
Cdd:PLN02153  69 GDVPRISCLGVRMVAVGTKLYIFGGRDEKREFSDFY--SYDTvkneWTFLTKLDEEG-GPEARTFHSMAS-DENHVYVFG 144

                        170       180       190
                 ....*....|....*....|....*....|
gi 26190616  266 GLSAD---NIPLSDGWI--HNVTTNCWKQL 290
Cdd:PLN02153 145 GVSKGglmKTPERFRTIeaYNIADGKWVQL 174
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-93 2.37e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 51.70  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  10 AEERSGHCAVVDGNFLYVWGGYVSIednevylpNDEIWTYDIDSGLWRMHlmeGELPASMSGSCGACINGKLYIFGGYDD 89
Cdd:COG3055 194 PTARAGHAAAVLGGKILVFGGESGF--------SDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVYVIGGETK 262


                ....
gi 26190616  90 KGYS 93
Cdd:COG3055 263 PGVR 266
PRK14131 PRK14131
N-acetylneuraminate epimerase;
64-214 1.17e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.01  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   64 ELPASMSGSCGACINGKLYI-FGGYDDKGYSnrlyfvnLRTRDETYIWEKITDFEGQPptpRDKLSCWVYKDRLIYFGGY 142
Cdd:PRK14131  24 DLPVPFKNGTGAIDNNTVYVgLGSAGTSWYK-------LDLNAPSKGWTKIAAFPGGP---REQAVAAFIDGKLYVFGGI 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26190616  143 GcrrhselqdcfDVHDASwEEQIFwgwhNDVHIFDTKTQTWFQPEIKggvPPQPRAAHTCAVL-GNKGYIFGG 214
Cdd:PRK14131  94 G-----------KTNSEG-SPQVF----DDVYKYDPKTNSWQKLDTR---SPVGLAGHVAVSLhNGKAYITGG 147
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 13-54 5.26e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 42.94  E-value: 5.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 26190616    13 RSGHCAVVDGNFLYVWGGYVSIEDNevylPNDEIWTYDIDSG 54
Cdd:pfam13854   4 RYGHCAVTVGDYIYLYGGYTGGEGQ----PSDDVYVLSLPTF 41
PLN02153 PLN02153
epithiospecifier protein
 13-254 6.88e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 47.67  E-value: 6.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   13 RSGHCAVVDGNFLYVWGGYVSiednevylPNDEI----WTYDIDSGLWRMHLMEGELPA-SMSGSCGACINGKLYIFGGY 87
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGELK--------PNEHIdkdlYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   88 DDKGYSNRLYFVNLRTRDETYIWEkiTDFEGQPPTpRDKLSCWVYKDRLIYFGGY---GCRRHSE---LQDCFDVHDASW 161
Cdd:PLN02153  95 DEKREFSDFYSYDTVKNEWTFLTK--LDEEGGPEA-RTFHSMASDENHVYVFGGVskgGLMKTPErfrTIEAYNIADGKW 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  162 EE-------------------------------QIFWGWHND-----VHIFDTKTQTWFQPEIKGGvPPQPRAAHTCAVL 205
Cdd:PLN02153 172 VQlpdpgenfekrggagfavvqgkiwvvygfatSILPGGKSDyesnaVQFFDPASGKWTEVETTGA-KPSARSVFAHAVV 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 26190616  206 GNKGYIFGGRVLQ---------TRMNDLHYLNLDTWTWSgRITINGESPKHRSWHTLT 254
Cdd:PLN02153 251 GKYIIIFGGEVWPdlkghlgpgTLSNEGYALDTETLVWE-KLGECGEPAMPRGWTAYT 307
PLN02193 PLN02193
nitrile-specifier protein
 54-317 1.76e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.87  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   54 GLWRMHLMEGELPASMSGSCGACINGKLYIFGG--YDDKGYSNRLYFVNLRTRdetyIWEkITDFEGQPPTprdkLSCWV 131
Cdd:PLN02193 151 GKWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGefTPNQPIDKHLYVFDLETR----TWS-ISPATGDVPH----LSCLG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  132 YK-----DRLIYFGGygcrrhselqdcfdvHDASWEeqifwgwHNDVHIFDTKTQTW--FQPEIKGgvpPQPRAAHTCAV 204
Cdd:PLN02193 222 VRmvsigSTLYVFGG---------------RDASRQ-------YNGFYSFDTTTNEWklLTPVEEG---PTPRSFHSMAA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  205 LGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSgRITINGESPKHRSWHTLTpIADDKLFLCGGLSADNIplSDGWIHNVTT 284
Cdd:PLN02193 277 DEENVYVFGGVSATARLKTLDSYNIVDKKWF-HCSTPGDSFSIRGGAGLE-VVQGKVWVVYGFNGCEV--DDVHYYDPVQ 352

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 26190616  285 NCWKQLTHL---PKTRpRLWHTACLGKenEIMVFGG 317
Cdd:PLN02193 353 DKWTQVETFgvrPSER-SVFASAAVGK--HIVIFGG 385
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 196-235 6.38e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.90  E-value: 6.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 26190616   196 PRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWS 235
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40
Kelch_3 pfam13415
Galactose oxidase, central domain;
206-256 1.01e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 1.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 26190616   206 GNKGYIFGGRVL--QTRMNDLHYLNLDTWTWsgriTINGESPKHRSWHTLTPI 256
Cdd:pfam13415   1 GDKLYIFGGLGFdgQTRLNDLYVYDLDTNTW----TQIGDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
12-216 3.12e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 42.69  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   12 ERSGHCAVVDGNFLYVWGGY-VSIEDNEVYLPNDeIWTYDIDSGLWrmHLMEGELPASMSGSCGACING-KLYIFGGYdD 89
Cdd:PRK14131  74 PREQAVAAFIDGKLYVFGGIgKTNSEGSPQVFDD-VYKYDPKTNSW--QKLDTRSPVGLAGHVAVSLHNgKAYITGGV-N 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   90 KGYSNRlYF--VNLRTRDETYIWEKITDFEGQPPtprdklscwvyKDrliYFggygcrrhselqdcfdvhdasweeqifw 167
Cdd:PRK14131 150 KNIFDG-YFedLAAAGKDKTPKDKINDAYFDKKP-----------ED---YF---------------------------- 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 26190616  168 gWHNDVHIFDTKTQTWfqpEIKGGVPPQPRAAHTCAVLGNKGYIFGGRV 216
Cdd:PRK14131 187 -FNKEVLSYDPSTNQW---KNAGESPFLGTAGSAVVIKGNKLWLINGEI 231
PLN02772 PLN02772
guanylate kinase
 172-245 6.17e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 41.75  E-value: 6.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  172 DVHIFDTKTQTWFQPEIKgGVPPQPRAAHTCAVLgNKGYIFGGRVLQTRMNDLHYLNLDTW--------------TWSGR 237
Cdd:PLN02772  52 GVQILDKITNNWVSPIVL-GTGPKPCKGYSAVVL-NKDRILVIKKGSAPDDSIWFLEVDTPfvreqkkllgtevvAWSKG 129


                 ....*...
gi 26190616  238 ITINGESP 245
Cdd:PLN02772 130 VRGNAEKP 137
Kelch_4 pfam13418
Galactose oxidase, central domain;
67-115 3.09e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 3.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 26190616    67 ASMSGSCGACINGKLYIFGGYDDKG-YSNRLYFVNLRTRdetyIWEKITD 115
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGtLLSDLWVFDLSTN----EWTRLGS 46
PHA03098 PHA03098
kelch-like protein; Provisional
 77-321 3.76e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 39.37  E-value: 3.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616   77 INGKLYIFGGYDDKGYSNRlYFVNLRTRdeTYIWEKITDFEgqppTPRDKLSCWVYKDRLIYFGGYGcrrhselqdcfdv 156
Cdd:PHA03098 293 LNNVIYFIGGMNKNNLSVN-SVVSYDTK--TKSWNKVPELI----YPRKNPGVTVFNNRIYVIGGIY------------- 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  157 hdasweeqiFWGWHNDVHIFDTKTQTWFQ-PEIKggvppQPRAAHTCAVLGNKGYIFGGRVL-QTRMNDLHYLNLDTWTW 234
Cdd:PHA03098 353 ---------NSISLNTVESWKPGESKWREePPLI-----FPRYNPCVVNVNNLIYVIGGISKnDELLKTVECFSLNTNKW 418

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26190616  235 SgritINGESPKHRSWHTlTPIADDKLFLCGGLSADNIPLSDGWI--HNVTTNCWKQL--THLPKTRPRLWHTaclgkEN 310
Cdd:PHA03098 419 S----KGSPLPISHYGGC-AIYHDGKIYVIGGISYIDNIKVYNIVesYNPVTNKWTELssLNFPRINASLCIF-----NN 488

                        250
                 ....*....|.
gi 26190616  311 EIMVFGGSKDD 321
Cdd:PHA03098 489 KIYVVGGDKYE 499
Kelch_6 pfam13964
Kelch motif;
196-235 5.46e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 5.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 26190616   196 PRAAHTCAVLGNKGYIFGGRVLQ-TRMNDLHYLNLDTWTWS 235
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWE 41
Kelch_4 pfam13418
Galactose oxidase, central domain;
13-58 6.10e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.51  E-value: 6.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 26190616    13 RSGHCAVVDGN-FLYVWGGYvsIEDNEVYlpnDEIWTYDIDSGLWRM 58
Cdd:pfam13418   2 RAYHTSTSIPDdTIYLFGGE--GEDGTLL---SDLWVFDLSTNEWTR 43
Kelch_3 pfam13415
Galactose oxidase, central domain;
78-124 6.97e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.57  E-value: 6.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 26190616    78 NGKLYIFGGYDDKG--YSNRLYFVNLrtrdETYIWEKItdfeGQPPTPR 124
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDL----DTNTWTQI----GDLPPPR 41
Kelch_6 pfam13964
Kelch motif;
75-124 8.26e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 8.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 26190616    75 ACINGKLYIFGGYDDKG-YSNRLYFVNLRTRDetyiWEKItdfeGQPPTPR 124
Cdd:pfam13964   8 VSVGGYIYVFGGYTNASpALNKLEVYNPLTKS----WEEL----PPLPTPR 50
Kelch_4 pfam13418
Galactose oxidase, central domain;
196-235 8.44e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 8.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 26190616   196 PRAAHTCAVLGN-KGYIFGGRVLQ-TRMNDLHYLNLDTWTWS 235
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGGEGEDgTLLSDLWVFDLSTNEWT 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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