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Conserved domains on  [gi|27262641|ref|NP_758442|]
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sperm-associated antigen 6 isoform 2 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
112-423 1.10e-19

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 91.49  E-value: 1.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 112 KHSPQLaQAIVDCGALDTLVICLEDFDPGVKE-AAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASA 190
Cdd:COG5064 102 ETSPPI-QPVIDAGVVPRFVEFMDEIQRDMLQfEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 191 LSDIAKHSPELAQTVVDAGAVAHLAQMILN--PDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVK 268
Cdd:COG5064 181 LGNIAGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 269 KNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSEnLAMAVIISKGVPQLSVCLSEEP 348
Cdd:COG5064 261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD-DQTQVIINCGALKAFRSLLSSP 339

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27262641 349 EDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYmsteSSEDLQVKSKK--AIKNILQKCTYLPALEPFLYD 423
Cdd:COG5064 340 KENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLL----SSAEYKIKKEAcwAISNATSGGLNRPDIIRYLVS 412
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
112-423 1.10e-19

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 91.49  E-value: 1.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 112 KHSPQLaQAIVDCGALDTLVICLEDFDPGVKE-AAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASA 190
Cdd:COG5064 102 ETSPPI-QPVIDAGVVPRFVEFMDEIQRDMLQfEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 191 LSDIAKHSPELAQTVVDAGAVAHLAQMILN--PDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVK 268
Cdd:COG5064 181 LGNIAGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 269 KNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSEnLAMAVIISKGVPQLSVCLSEEP 348
Cdd:COG5064 261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD-DQTQVIINCGALKAFRSLLSSP 339

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27262641 349 EDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYmsteSSEDLQVKSKK--AIKNILQKCTYLPALEPFLYD 423
Cdd:COG5064 340 KENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLL----SSAEYKIKKEAcwAISNATSGGLNRPDIIRYLVS 412
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 3.13e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.68  E-value: 3.13e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 27262641   114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 1.22e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27262641    114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 121-223 3.30e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641   121 IVDCGALDTLVICL-EDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVL--------CIQ-EPEIALKRIAASA 190
Cdd:PLN03200  227 VLDAGAVKQLLKLLgQGNEVSVRAEAAGALEALSSQSKEAKQAIADAGGIPALINatvapskeFMQgEFAQALQENAMGA 306

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 27262641   191 LSDI-------------AKHSPELAQTVVDA-GAVAHlAQMILNPDA 223
Cdd:PLN03200  307 LANIcggmsalilylgeLSESPRSPAPIADTlGALAY-ALMVFDSSA 352
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
112-423 1.10e-19

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 91.49  E-value: 1.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 112 KHSPQLaQAIVDCGALDTLVICLEDFDPGVKE-AAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASA 190
Cdd:COG5064 102 ETSPPI-QPVIDAGVVPRFVEFMDEIQRDMLQfEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWA 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 191 LSDIAKHSPELAQTVVDAGAVAHLAQMILN--PDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVK 268
Cdd:COG5064 181 LGNIAGDSEGCRDYVLQCGALEPLLGLLLSsaIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 269 KNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSEnLAMAVIISKGVPQLSVCLSEEP 348
Cdd:COG5064 261 VDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD-DQTQVIINCGALKAFRSLLSSP 339

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27262641 349 EDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYmsteSSEDLQVKSKK--AIKNILQKCTYLPALEPFLYD 423
Cdd:COG5064 340 KENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLL----SSAEYKIKKEAcwAISNATSGGLNRPDIIRYLVS 412
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
11-300 2.78e-13

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 71.85  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641  11 EQYQKARTQFVQMVAElATRPQnIETLQNAGVMSLLRTLLLDVVPTIQQ-TAALALGRLANYNDDLAEAVVKCDILPQLV 89
Cdd:COG5064  86 EQQLQAVYKFRKLLSK-ETSPP-IQPVIDAGVVPRFVEFMDEIQRDMLQfEAAWALTNIASGTTQQTKVVVDAGAVPLFI 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641  90 YSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLED--------------------------------- 136
Cdd:COG5064 164 QLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSsaihismlrnatwtlsnlcrgknpppdwsnisq 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 137 -----------FDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTV 205
Cdd:COG5064 244 alpilakliysRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVI 323

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 206 VDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKH---T 282
Cdd:COG5064 324 INCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGglnR 403

                       330
                ....*....|....*...
gi 27262641 283 PELSQLVVNAGGVAAVID 300
Cdd:COG5064 404 PDIIRYLVSQGFIKPLCD 421
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
14-360 5.95e-13

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 70.69  E-value: 5.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641  14 QKARTQFVQMVAELATrpQNIEtLQNAGVMSLLRTLLLDVVPTIQQtaalalgrlanynddlaeaVVKCDILPQLVYSLA 93
Cdd:COG5064  67 QQFYSELPQLTQQLFS--DDIE-QQLQAVYKFRKLLSKETSPPIQP-------------------VIDAGVVPRFVEFMD 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641  94 E-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
Cdd:COG5064 125 EiQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 173 VLCIQE--PEIALKRIAASALSDI--AKHSPELAQTVvdAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
Cdd:COG5064 205 LGLLLSsaIHISMLRNATWTLSNLcrGKNPPPDWSNI--SQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVL 282

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 249 EAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLA 328
Cdd:COG5064 283 DVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQI 362

                       330       340       350
                ....*....|....*....|....*....|..
gi 27262641 329 MAVIISKGVPQLsVCLSEEPEDHIKAAAAWAL 360
Cdd:COG5064 363 QAVIDANLIPPL-IHLLSSAEYKIKKEACWAI 393
HEAT COG1413
HEAT repeat [General function prediction only];
37-195 2.31e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.63  E-value: 2.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641  37 LQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANynddlAEAVvkcdilPQLVYSLAEQNRFYKKAAAFVLRAVGkhspq 116
Cdd:COG1413  12 LGDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPDPEVRAAAAEALGRIG----- 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27262641 117 laqaivDCGALDTLVICLEDFDPGVKEAAAWALRYIArhnaelsqavvDAGAVPLLVLCIQEPEIALKRIAASALSDIA 195
Cdd:COG1413  76 ------DPEAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRRAAARALGRLG 137
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 3.13e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.68  E-value: 3.13e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 27262641   114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
57-235 2.26e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 2.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641  57 IQQTAALALGRLANynddlAEAVvkcdilPQLVYSLAEQNRFYKKAAAFVLRAVGkhspqlaqaivDCGALDTLVICLED 136
Cdd:COG1413   1 VRRAAARALGRLGD-----PAAV------PALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 137 FDPGVKEAAAWALRYIArhnaelsqavvDAGAVPLLVLCIQEPEIALKRIAASALSDIAkhspelaqtvvDAGAVAHLAQ 216
Cdd:COG1413  59 PDPEVRAAAAEALGRIG-----------DPEAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLE 116

                       170
                ....*....|....*....
gi 27262641 217 MILNPDAKLKHQILSALSQ 235
Cdd:COG1413 117 ALKDPDWEVRRAAARALGR 135
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 114-154 1.22e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27262641    114 SPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIAR 154
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
34-238 2.38e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 46.81  E-value: 2.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641  34 IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEavvkcdilpqlvyslaeqnrfykkaaafvlravgkh 113
Cdd:COG5064 278 IQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQ------------------------------------ 321

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 114 spqlaqAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSD 193
Cdd:COG5064 322 ------VIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISN 395

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 27262641 194 IAKHS---PELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSK 238
Cdd:COG5064 396 ATSGGlnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILK 443
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 5.50e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.43  E-value: 5.50e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 27262641   156 NAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIA 195
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
141-278 1.26e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.84  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641 141 VKEAAAWALRYIArhnaelsqavvDAGAVPLLVLCIQEPEIALKRIAASALSDIAkhspelaqtvvDAGAVAHLAQMILN 220
Cdd:COG1413   1 VRRAAARALGRLG-----------DPAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKD 58

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 27262641 221 PDAKLKHQILSALSQVSkhsvdlaemvvEAEIFPVVLTCLKDKDEYVKKNASTLIREI 278
Cdd:COG1413  59 PDPEVRAAAAEALGRIG-----------DPEAVPALIAALKDEDPEVRRAAAEALGRL 105
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 198-234 2.27e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 27262641   198 SPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALS 234
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALS 37
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 121-223 3.30e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27262641   121 IVDCGALDTLVICL-EDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVL--------CIQ-EPEIALKRIAASA 190
Cdd:PLN03200  227 VLDAGAVKQLLKLLgQGNEVSVRAEAAGALEALSSQSKEAKQAIADAGGIPALINatvapskeFMQgEFAQALQENAMGA 306

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 27262641   191 LSDI-------------AKHSPELAQTVVDA-GAVAHlAQMILNPDA 223
Cdd:PLN03200  307 LANIcggmsalilylgeLSESPRSPAPIADTlGALAY-ALMVFDSSA 352
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 139-194 4.77e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 4.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27262641   139 PGVKEAAAWALRYIARHNAELSQAVVDAgAVPLLVLCIQEPEIALKRIAASALSDI 194
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 198-238 6.44e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.33  E-value: 6.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27262641    198 SPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSK 238
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-196 8.65e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 33.94  E-value: 8.65e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 27262641    156 NAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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