NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27370380|ref|NP_766489|]
View 

probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial [Mus musculus]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
49-380 1.55e-176

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 494.59  E-value: 1.55e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380    49 GGRHTVAMIPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTSTSN--EEEINNALMAIRRNRVALKGNIATNHNLPArYK 126
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDgkTEIPDEAVESIKRNKVALKGPLETPIGKGG-HR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   127 SHNTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYAFKLAQ 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   207 KMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   287 GSGIVPGANYGDSYAIFEMGSKEIGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVCTPDIGGQ 366
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 27370380   367 GNTASTVEYILHHM 380
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 49-380 1.55e-176

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 494.59  E-value: 1.55e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380    49 GGRHTVAMIPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTSTSN--EEEINNALMAIRRNRVALKGNIATNHNLPArYK 126
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDgkTEIPDEAVESIKRNKVALKGPLETPIGKGG-HR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   127 SHNTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYAFKLAQ 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   207 KMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   287 GSGIVPGANYGDSYAIFEMGSKEIGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVCTPDIGGQ 366
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 27370380   367 GNTASTVEYILHHM 380
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 44-380 2.96e-119

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 350.32  E-value: 2.96e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   44 PSPKYGGRHTVAMIPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTSTSNE--EEInnaLMAIRRNRVALKGNIATNHNl 121
Cdd:PLN00123  23 PRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDMKKvpEEV---LESIRRNKVCLKGGLATPVG- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  122 pARYKSHNTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYA 201
Cdd:PLN00123  99 -GGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  202 FKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSIC 281
Cdd:PLN00123 178 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  282 TGLVGGSGIVPGANYGDSYAIFEMGSK--EIGKD-LAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAV 358
Cdd:PLN00123 258 AGIAGGTGVMPGGNVGADHAVFEQGASagNVGNEkLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKY 337

                        330       340
                 ....*....|....*....|..
gi 27370380  359 CTPDIGGQGNTASTVEYILHHM 380
Cdd:PLN00123 338 RTKDLGGSSTTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 51-380 2.50e-107

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 319.26  E-value: 2.50e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  51 RHTVAMIPGDGIGPELMVHVKKIF----RSNCVPVDFEEVWV-------TSTSNEEEinnALMAIRRNRVALKGNIATNH 119
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLeaaaERFGLDFEFEEADIggaaydkTGTPLPDE---TLEALRKADAILLGAVGGPK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 120 NLPA-RYKSHNTKFRTILDLYASVVHFKTFPGVMTRHK-----DIDILVVRENTEGEYTNLEHESVKG----VVESLKIV 189
Cdd:COG0473  78 WDDGvRPESGLLALRKELDLYANLRPAKLYPGLPSPLKpeiveGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 190 TKTKSVRIADYAFKLAQKMgRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVM 269
Cdd:COG0473 158 TRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 270 PNLYGNIINSICTGLVGGSGIVPGANYGDSY-AIFE--MGSKEigkDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIR 346
Cdd:COG0473 237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEpvHGSAP---DIAGKGIANPIATILSAAMMLRHLGEEEAADAIE 313

                       330       340       350
                ....*....|....*....|....*....|....
gi 27370380 347 SAVMASLQNKaVCTPDIGGQGNTASTVEYILHHM 380
Cdd:COG0473 314 AAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
53-376 9.17e-80

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 248.75  E-value: 9.17e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380    53 TVAMIPGDGIGPELMVHVKKIFRS--NCVP--VDFEEVWVTSTSNEEEIN----NALMAIRRNRVALKGNIATNHNLPAR 124
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAalEKAPleFEFEERDVGGAAIDETGEplpdETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   125 YKSHN--TKFRTILDLYASVVHFKTFP--GVMTRHK----DIDILVVRENTEGEYTNLEHE---SVKGVVESLKIVTKTK 193
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPplGDASPLKneveGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   194 SVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLY 273
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   274 GNIINSICTGLVGGSGIVPGANYGDS-YAIFE--MGSkeiGKDLAHRNIANPVAMLLTSCIMLDY-LDLQPYATHIRSAV 349
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANgFGIFEpvHGS---APDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAV 317

                         330       340
                  ....*....|....*....|....*..
gi 27370380   350 MASLQNKaVCTPDIGGQGNTASTVEYI 376
Cdd:pfam00180 318 LKVLESG-IRTGDLAGSATYVSTSEFG 343
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 49-380 1.55e-176

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 494.59  E-value: 1.55e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380    49 GGRHTVAMIPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTSTSN--EEEINNALMAIRRNRVALKGNIATNHNLPArYK 126
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDgkTEIPDEAVESIKRNKVALKGPLETPIGKGG-HR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   127 SHNTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYAFKLAQ 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   207 KMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   287 GSGIVPGANYGDSYAIFEMGSKEIGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVCTPDIGGQ 366
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 27370380   367 GNTASTVEYILHHM 380
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 44-380 2.96e-119

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 350.32  E-value: 2.96e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   44 PSPKYGGRHTVAMIPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTSTSNE--EEInnaLMAIRRNRVALKGNIATNHNl 121
Cdd:PLN00123  23 PRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDMKKvpEEV---LESIRRNKVCLKGGLATPVG- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  122 pARYKSHNTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYA 201
Cdd:PLN00123  99 -GGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  202 FKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSIC 281
Cdd:PLN00123 178 FEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  282 TGLVGGSGIVPGANYGDSYAIFEMGSK--EIGKD-LAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAV 358
Cdd:PLN00123 258 AGIAGGTGVMPGGNVGADHAVFEQGASagNVGNEkLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKY 337

                        330       340
                 ....*....|....*....|..
gi 27370380  359 CTPDIGGQGNTASTVEYILHHM 380
Cdd:PLN00123 338 RTKDLGGSSTTQEVVDAVIANL 359
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 53-380 3.36e-108

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 322.60  E-value: 3.36e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   53 TVAMIPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTST----SNEEEINNALMAIRRNRVALKGNIATNhnLPARYKSH 128
Cdd:PLN00118  43 TATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTvdprTGSFLTWESLESVRRNKVGLKGPMATP--IGKGHRSL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  129 NTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYAFKLAQKM 208
Cdd:PLN00118 121 NLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTH 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  209 GRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGS 288
Cdd:PLN00118 201 GRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  289 GIVPGANYGDSYAIFEMGSKEIGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVCTPDIGGQGN 368
Cdd:PLN00118 281 GLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSST 360

                        330
                 ....*....|..
gi 27370380  369 TASTVEYILHHM 380
Cdd:PLN00118 361 TTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 51-380 2.50e-107

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 319.26  E-value: 2.50e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  51 RHTVAMIPGDGIGPELMVHVKKIF----RSNCVPVDFEEVWV-------TSTSNEEEinnALMAIRRNRVALKGNIATNH 119
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLeaaaERFGLDFEFEEADIggaaydkTGTPLPDE---TLEALRKADAILLGAVGGPK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 120 NLPA-RYKSHNTKFRTILDLYASVVHFKTFPGVMTRHK-----DIDILVVRENTEGEYTNLEHESVKG----VVESLKIV 189
Cdd:COG0473  78 WDDGvRPESGLLALRKELDLYANLRPAKLYPGLPSPLKpeiveGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVY 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 190 TKTKSVRIADYAFKLAQKMgRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVM 269
Cdd:COG0473 158 TRKGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 270 PNLYGNIINSICTGLVGGSGIVPGANYGDSY-AIFE--MGSKEigkDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIR 346
Cdd:COG0473 237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEpvHGSAP---DIAGKGIANPIATILSAAMMLRHLGEEEAADAIE 313

                       330       340       350
                ....*....|....*....|....*....|....
gi 27370380 347 SAVMASLQNKaVCTPDIGGQGNTASTVEYILHHM 380
Cdd:COG0473 314 AAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 53-380 3.10e-101

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 303.56  E-value: 3.10e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   53 TVAMIPGDGIGPELMVHVKKIF-RSNC-VPVDFEEVWVTSTSNEEEI--NNALMAIRRNRVALKGNIATNhnLPARYKSH 128
Cdd:PRK08997   4 TITVIPGDGIGPSIIDATLKILdKLGCdFEYEFADAGLTALEKHGELlpQRTLDLIEKNKIALKGPLTTP--VGEGFTSI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  129 NTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHE-SVKG-VVESLKIVTKTKSVRIADYAFKLAQ 206
Cdd:PRK08997  82 NVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYELAR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  207 KMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVG 286
Cdd:PRK08997 162 KEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  287 GSGIVPGANYGDSYAIFEM--GSkeiGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVCTPDIG 364
Cdd:PRK08997 242 GLGMAPGANIGRDAAIFEAvhGS---APDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLG 318

                        330
                 ....*....|....*.
gi 27370380  365 GQGNTASTVEYILHHM 380
Cdd:PRK08997 319 GTHGTTDFTQAVIDRL 334
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
53-363 4.09e-84

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 264.45  E-value: 4.09e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   53 TVAmiPGDGIGPELMVHVKKIFRSNCVPVDFEEVWVTSTSNEEEINN-----ALMAIRRNRVALKGNIATnhnlP--ARY 125
Cdd:PRK09222   8 TVA--YGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEKVYKKGWTSgispsAWESIRRTKVLLKAPITT----PqgGGY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  126 KSHNTKFRTILDLYASV---VHFktFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYAF 202
Cdd:PRK09222  82 KSLNVTLRKTLGLYANVrpcVSY--HPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIRYAF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  203 KLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICT 282
Cdd:PRK09222 160 EYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  283 GLVGGSGIVPGANYGDSYAIFEM--GSkeiGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNkAVCT 360
Cdd:PRK09222 240 EISGSVGLAGSANIGEEYAMFEAvhGS---APDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLED-GIHT 315


                 ...
gi 27370380  361 PDI 363
Cdd:PRK09222 316 ADI 318
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
53-376 9.17e-80

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 248.75  E-value: 9.17e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380    53 TVAMIPGDGIGPELMVHVKKIFRS--NCVP--VDFEEVWVTSTSNEEEIN----NALMAIRRNRVALKGNIATNHNLPAR 124
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAalEKAPleFEFEERDVGGAAIDETGEplpdETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   125 YKSHN--TKFRTILDLYASVVHFKTFP--GVMTRHK----DIDILVVRENTEGEYTNLEHE---SVKGVVESLKIVTKTK 193
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPplGDASPLKneveGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   194 SVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLY 273
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   274 GNIINSICTGLVGGSGIVPGANYGDS-YAIFE--MGSkeiGKDLAHRNIANPVAMLLTSCIMLDY-LDLQPYATHIRSAV 349
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANgFGIFEpvHGS---APDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAV 317

                         330       340
                  ....*....|....*....|....*..
gi 27370380   350 MASLQNKaVCTPDIGGQGNTASTVEYI 376
Cdd:pfam00180 318 LKVLESG-IRTGDLAGSATYVSTSEFG 343
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 52-380 4.65e-77

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 241.58  E-value: 4.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   52 HTVAMIPGDGIGPELM---VHVKKifrsnCVPVDFEEVWV---------TSTSNEEEinnALMAIRRNRVALKGNIATNH 119
Cdd:PRK14025   2 HKICVIEGDGIGKEVVpaaLHVLE-----ATGLPFEFVYAeagdevfekTGKALPEE---TIEAAKEADAVLFGAAGETA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  120 nlparyKSHNTKFRTILDLYASVVHFKTFPGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIAD 199
Cdd:PRK14025  74 ------ADVIVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  200 YAFKLAQK----MGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGN 275
Cdd:PRK14025 148 FAFEMAKRrkkmGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGD 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  276 IINSICTGLVGGSGIVPGANYGDSYAIFE--MGSkeiGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASL 353
Cdd:PRK14025 228 ILSDGAAGLVGGLGLAPSANIGDKYGLFEpvHGS---APDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVL 304

                        330       340
                 ....*....|....*....|....*..
gi 27370380  354 QNKAVcTPDIGGQGNTASTVEYILHHM 380
Cdd:PRK14025 305 ALGLT-TPDLGGNLSTMEMAEEVAKRV 330
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
 53-363 7.81e-68

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 221.94  E-value: 7.81e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380    53 TVAMipGDGIGPELMVHVKKIFRSNCVPVDFEEV----------WVTSTSNEeeinnALMAIRRNRVALKGNIATNHNlp 122
Cdd:TIGR02924   4 TVAY--GDGIGPEIMEAVLLILKEAEAPIDIETIeigekvykkgWPSGISPS-----SWESIRRTKVLLKAPITTPQG-- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   123 ARYKSHNTKFRTILDLYASVVHFKTF-PGVMTRHKDIDILVVRENTEGEYTNLEHESVKGVVESLKIVTKTKSVRIADYA 201
Cdd:TIGR02924  75 GGHKSLNVTLRKTLGLYANIRPCVSYhPFIETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRYA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   202 FKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSIC 281
Cdd:TIGR02924 155 FEYARKHNRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   282 TGLVGGSGIVPGANYGDSYAIFEM--GSkeiGKDLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNkAVC 359
Cdd:TIGR02924 235 AEISGSVGLAGSANIGEEYAMFEAvhGS---APDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTLED-GVH 310


                  ....
gi 27370380   360 TPDI 363
Cdd:TIGR02924 311 TADI 314
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 52-374 1.83e-51

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 176.06  E-value: 1.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   52 HTVAMIPGDGIGPELMVHVKKIFRsncvpvdfeevWVTSTSNEE-EINNALM---AIRrnrvalkgniATNHNLPA---- 123
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLD-----------AVAEKFGFDfEFEEALVggaAID----------AHGVPLPEetle 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  124 ----------------RYKSHNT---------KFRTILDLYASVVHFKTFPGVMT-------RHKDIDILVVRENTEGEY 171
Cdd:PRK00772  62 acraadavllgavggpKWDNLPPdvrpergllALRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIY 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  172 --------TNLEHESVkgvVESLkIVTKTKSVRIADYAFKLAQKMgRKKVTVVHKANIMKlGDGLFLQCCKDVAAHYPQI 243
Cdd:PRK00772 142 fgeprgreGLGGEERA---FDTM-VYTREEIERIARVAFELARKR-RKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDV 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  244 TLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGIVPGANYGDS-YAIFE--MGSkeiGKDLAHRNIA 320
Cdd:PRK00772 216 ELSHMYVDNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEpiHGS---APDIAGKGIA 292

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 27370380  321 NPVAMLLTSCIMLDY-LDLQPYATHIRSAVMASLqNKAVCTPDIGGQGNTASTVE 374
Cdd:PRK00772 293 NPIATILSAAMMLRYsLGLEEAADAIEAAVEKVL-AQGYRTADIAEGGGKVSTSE 346
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 53-382 7.22e-43

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 152.95  E-value: 7.22e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   53 TVAMIPGDGIGPELMVHVKKIFRS-----NCVPVDFEEV-WvtstSNEEEINNALMAIRRNRVALK----------GNia 116
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAvaevhGGLKFEFTEFpW----SCEYYLEHGEMMPEDGLEQLKqfdaiflgavGN-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  117 tnhnlPARYKSHNT------KFRTILDLYASVVHFKTFPGV---MTRHKDIDILVVRENTEGEYTNL-------EHEsvk 180
Cdd:PRK08194  79 -----PKLVPDHISlwglliKIRREFEQVINIRPAKQLRGIkspLANPKDFDLLVVRENSEGEYSEVggrihrgEDE--- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  181 gVVESLKIVTKTKSVRIADYAFKLAQKMgRKKVTVVHKAN----IMKLGDGLFlqccKDVAAHYPQITLESMIIDNTTMQ 256
Cdd:PRK08194 151 -IAIQNAVFTRKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  257 LVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGIVPGAN---YGDSYAIFE--MGSkeiGKDLAHRNIANPVAMLLTSCI 331
Cdd:PRK08194 225 FVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANinvNGKYPSMFEpvHGS---APDIAGKGIANPIGQIWTAKL 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 27370380  332 MLDYLDLQPYATHIRSaVMASLQNKAVCTPDIGGQGNTASTVEYILHHMKE 382
Cdd:PRK08194 302 MLDHFGEEELGSHLLD-VIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKK 351
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 52-357 1.84e-39

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 143.91  E-value: 1.84e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   52 HTVAMIPGDGIGPELMVHVKKIFRSNCVP-VDFE--------EVWVTS--TSNEEEinnaLMAIRRNRVALKGNIATnhn 120
Cdd:PRK03437   5 MKLAVIPGDGIGPEVVAEALKVLDAVAAGgPGVEtteydlgaRRYLRTgeTLPDSV----LAELRQHDAILLGAIGD--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  121 lpARYKSHNT------KFRTILDLYASVVHFKTFPGVMTRHK---DIDILVVRENTEGEYT--------NLEHEsvkgVV 183
Cdd:PRK03437  78 --PSVPSGVLerglllKLRFALDHYVNLRPSKLYPGVTSPLAgpgDIDFVVVREGTEGPYTgnggalrvGTPHE----VA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  184 ESLKIVTKTKSVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVAAHYPQITLESMIIDNTTMQLVSKPQQ 263
Cdd:PRK03437 152 TEVSVNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  264 FDVMVMPNLYGNIINSICTGLVGGSGIVPGANY---GDSYAIFE--MGSkeiGKDLAHRNIANPVAMLLTSCIMLDYLDL 338
Cdd:PRK03437 232 FDVIVTDNLFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFEpvHGS---APDIAGQGIADPTAAILSVALLLDHLGE 308

                        330
                 ....*....|....*....
gi 27370380  339 QPYATHIRSAVMASLQNKA 357
Cdd:PRK03437 309 EDAAARIEAAVEADLAERG 327
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
42-363 9.29e-38

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 140.74  E-value: 9.29e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   42 VPPSPkyggrhTVAMIPGDGIGPELMVHVKKIFR---SNCVPVDFEEVWVTSTSNE--EEINN------ALMAIRRNRVA 110
Cdd:PRK06451  20 VPKKP------IILYVEGDGIGPEITHAAMKVINkavEKAYGSDREIKWVEVLAGDkaEKLTGnrfpkeSEELIEKYRVL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  111 LKGNIATnhNLPARYKSHNTKFRTILDLYASVVHFKTFPGVMTRHKD---IDILVVRENTEGEYTNLEH----------- 176
Cdd:PRK06451  94 LKGPLET--PIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLKNpekIDLIIFRENTDDLYRGIEYpydseeakkir 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  177 ----ESVKGVVES-----LKIVTKTKSVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGLFLQCCKDVA---------- 237
Cdd:PRK06451 172 dflrKELGVEVEDdtgigIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVAlkefrdyvvt 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  238 -----------AHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGIVPGANYGDSYAIFEMG 306
Cdd:PRK06451 252 eeevtknyngvPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAI 331

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27370380  307 SKEIGKdLAHRNIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVcTPDI 363
Cdd:PRK06451 332 HGTAPK-YAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDL 386
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 42-363 3.17e-33

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 128.31  E-value: 3.17e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  42 VPPSPkyggrhTVAMIPGDGIGPELMVHVKKIFR-------SNCVPVDFEEV------------WVTstsneEEinnALM 102
Cdd:COG0538  15 VPDNP------IIPFIEGDGIGPEITRAIWKVIDaavekayGGKRDIEWKEVdagekardetgdWLP-----DE---TAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 103 AIRRNRVALKGNIATnhnlP--ARYKSHNTKFRTILDLYASVVHFKTFPGVMTRHK---DIDILVVRENTEGEYTNLEHE 177
Cdd:COG0538  81 AIKEYGVGIKGPLTT----PvgGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKhpeKVDIVIFRENTEDIYAGIEWK 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 178 S----VKGVVESL-------------------KIVTKTKSVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGLFlqccK 234
Cdd:COG0538 157 AgspeALKLIFFLedemgvtvirfpedsgigiKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAF----K 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380 235 DVA-----AHYP-------------------QITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGI 290
Cdd:COG0538 233 DWGyevaeEEFGdkfitegpwekykgpkpagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGI 312

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27370380 291 VPGANYGDSY-AIFEM--GS--KEIGKDlahrnIANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAVcTPDI 363
Cdd:COG0538 313 APGANIGDDGgAEFEAthGTapKYAGKD-----STNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDL 384
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 42-358 4.15e-30

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 119.78  E-value: 4.15e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   42 VPPSPkyggrhTVAMIPGDGIGPEL---MVHV------------KKIfrsncvpvdfeeVWVTSTSNEEEIN-------- 98
Cdd:PRK07006  16 VPNNP------IIPFIEGDGIGPDItpaMLKVvdaavekaykgeRKI------------SWMEIYAGEKATKvygedvwl 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   99 --NALMAIRRNRVALKGNIATnhnlP--ARYKSHNTKFRTILDLYA---SVVHFKTFPGVMTRHKDIDILVVRENTEGEY 171
Cdd:PRK07006  78 peETLDLIREYRVAIKGPLTT----PvgGGIRSLNVALRQELDLYVclrPVRYFKGVPSPVKRPEDTDMVIFRENSEDIY 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  172 TNLEHES----VKGVVESL-------------------KIVTKTKSVRIADYAFKLAQKMGRKKVTVVHKANIMKLGDGL 228
Cdd:PRK07006 154 AGIEWKAgsaeAKKVIKFLqeemgvkkirfpetsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  229 FLQCCKDVA-----------AHYPQ---------ITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGS 288
Cdd:PRK07006 234 FKDWGYQLAeeefgdelidgGPWDKiknpetgkeIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGI 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27370380  289 GIVPGANYGDSYAIFE----MGSKEIGKDLahrniANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAV 358
Cdd:PRK07006 314 GIAPGANINDGHAIFEathgTAPKYAGLDK-----VNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTV 382
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 33-368 6.26e-26

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 108.24  E-value: 6.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   33 FRSFCShcAVPPSPKyggRHTVAMIPGDGIGPELMVHVKKIFRS----NCVPVDFEEVWV---------------TSTSN 93
Cdd:PLN02329  33 YRIRCA--AASPGKK---RYNIALLPGDGIGPEVISVAKNVLQKagslEGLEFDFQEMPVggaaldlvgvplpeeTFTAA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   94 EEEINNALMAI-----RRNRVALKGNIATNHnlparykshntkFRTILDLYASVVHFKTFPGVM---TRHKDI----DIL 161
Cdd:PLN02329 108 KQSDAILLGAIggykwDKNEKHLRPEMALFY------------LRRDLKVFANLRPATVLPQLVdasTLKKEVaegvDMM 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  162 VVRENTEGEYTNLE-----HESVKGVVESLKIVTKTKSVRIADYAFKLAQKMgRKKVTVVHKANIMKlGDGLFLQCCKDV 236
Cdd:PLN02329 176 IVRELTGGIYFGEPrgitiNENGEEVGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTAL 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  237 AAHYPQITLESMIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGIVPGANYGDS-YAIFE--MGSkeiGKD 313
Cdd:PLN02329 254 ASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEpiHGS---APD 330

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 27370380  314 LAHRNIANPVAMLLTSCIMLDY-LDLQPYATHIRSAVMASLqNKAVCTPDIGGQGN 368
Cdd:PLN02329 331 IAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDAL-NKGFRTGDIYSPGN 385
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
98-358 1.05e-23

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 102.48  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380   98 NNALMAIRRNRVALKGNIATNhnLPARYKSHNTKFRTILDLYASVVHFKTFPGVMTRHK---DIDILVVRENTEGEYTNL 174
Cdd:PRK07362  88 EDTLEAIREYGVAIKGPLTTP--IGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKnpeKLDVIVYRENTEDIYMGI 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  175 EHESVKGVVESL----------------------------KIVTKTKSVRIADYAFKLAQKMGRKK--VTVVHKANIMKL 224
Cdd:PRK07362 166 EWEAGDEIGDKLikhlneevipaspelgkrqiplgsgigiKPVSKTGSQRHIRRAIEHALRLPGDKrhVTLVHKGNIMKY 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  225 GDGLFLQCCKDVAA--------------------HYPQITLES------------------------------------- 247
Cdd:PRK07362 246 TEGAFRDWGYELATtefrdecvtereswilsnkeKNPNISIEDnarmiepgydsltpekkaaicaevkevldsiwsshgn 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370380  248 -----------MIIDNTTMQLVSKPQQFDVMVMPNLYGNIINSICTGLVGGSGIVPGANYGDSYAIFE----MGSKEIGK 312
Cdd:PRK07362 326 gkwkekvlvddRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEathgTAPKHAGL 405

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 27370380  313 DLahrniANPVAMLLTSCIMLDYLDLQPYATHIRSAVMASLQNKAV 358
Cdd:PRK07362 406 DR-----INPGSVILSGVMMLEYLGWQEAADLITKGLSAAIANKQV 446
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH